The choline binding site of phospholipase C (Bacillus cereus): Insights into substrate specificity

Biochemistry

Volumn 39, Issue 12, 2000, Pages 3410-3415

  Martin, Stephen F ^a   Follows, Bruce C ^a   Hergenrother, Paul J ^a   Trotter, Bonnie K ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHEXANOYLGLYCERO 3 PHOSPHOCHOLINE; 1,2 DIHEXANOYLGLYCERO 3 PHOSPHOETHANOLAMINE; 1,2 DIHEXANOYLGLYCERO 3 PHOSPHOSERINE; CHOLINE; CHOLINE DERIVATIVE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPASE C; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BACILLUS CEREUS; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BACILLUS CEREUS; BINDING SITES; CATALYSIS; CHOLINE; GLUTAMIC ACID; HYDROLYSIS; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLSERINES; PHOSPHOLIPASE C; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TYROSINE;

BACILLUS CEREUS; BACTERIA (MICROORGANISMS); FELIS CATUS;

EID: 0034724255     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9919798     Document Type: Article

References (25)

1. Hough, E., Hansen, L. K., Birkness, B., Jynge, K., Hansen, S., Hordvik, A., Little, C., Dodson, E., and Derewenda, Z. (1989) Nature 338, 357-360.
2. Hergenrother, P. J., and Martin, S. F. (1997) Anal. Biochem. 251, 45-49.
3. Exton, J. H. (1997) Eur. J. Biochem. 243, 10-20.
4. Clark, M. A., Shorr, R. G. L., and Bomalaski, J. S. (1986) Biochem. Biophys. Res. Comm. 140, 114-119.
5. Hansen, S., Hansen, L. K., and Hough, E. (1992) J. Mol. Biol. 225, 543-549.
6. Hansen, S., Hansen, L. K., and Hough, E. (1993) J. Mol. Biol. 231, 870-876.
7. Hansen, S., Hough, E., Svensson, L. A., Wong, Y.-L., and Martin, S. F. (1993) J. Mol. Biol. 234, 179-187.
8. Strater, N., Lipscomb, W. N., Klabunde, T., and Krebs, B. (1996) Angew. Chem., Int. Ed. Engl. 35, 2024-2055.
9. Martin, S. F., and Hergenrother, P. J. (1999) Biochemistry 38, 4403-4408.
10. Martin, S. F., and Hergenrother, P. J. (1998) Biochemistry 37, 5755-5760.
11. Martin, S. F., Spaller, M. R., and Hergenrother, P. J. (1996) Biochemistry 35, 12970-12977.
12. Martin, S. F., and Hergenrother, P. J. (1998) Bioorg. Med. Chem. Lett. 8, 593-596.
13. Dougherty, D. A. (1996) Science 271, 163-168.
14. Burley, S. K., and Petsko, G. A. (1988) Adv. Protein Chem. 39, 125-189.
15. Scrutton, N. S., and Raine, A. R. C. (1996) Biochem. J. 319, 1-8.
16. Ma, J. C., and Dougherty, D. A. (1997) Chem. Rev. 97, 1303-1324.
17. Masson, P., Legrand, P., Bartels, C. F., Froment, M.-T., Schopfer, L. M., and Lockridge, O. (1997) Biochemistry 36, 2266-2277.
18. Basran, J., Mewies, M., Mathews, F. S., and Scrutton, N. (1997) Biochemistry 36, 1989-(1998).
19. Ting, A., Shin, I., Lucero, C., and Schultz, P. G. (1998) J. Am. Chem. Soc. 120, 7135-7136.
20. Wouters, J. (1998) Protein Sci. 7, 2472-2475.
21. Gallivan, J. P., and Dougherty, D. A. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 9459-9464.
22. El-Sayed, M. Y., and Roberts, M. F. (1985) Biochim. Biophys. Acta 831, 133-141.
23. Ikeda, K., Inoue, S., Amasaki, C., Teshima, K., and Ikezawa, H. (1991) J. Biochem. 110, 88-95.
24. Yu, B.-Z., Berg, O. G., and Jain, M. K. (1999) Biochemistry 38, 10449-10456.
25. Ordentlich, A., Barak, D., Kronman, C., Flashner, Y., Leitner, M., Segall, Y., Ariel, N., Cohen, S., Velan, B., and Shafferman, A. (1993) J. Biol. Chem. 268, 17083-17095.