Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 54-59

  Hu, Baihua ^a   Quinet, Elaine ^a   Unwalla, Rayomand ^a   Collini, Mike ^a   Jetter, James ^a   Dooley, Rebecca ^a   Andraka, Diane ^a   Nogle, Lisa ^a   Savio, Dawn ^a   Halpern, Anita ^a   Goos Nilsson, Annika ^b   Wilhelmsson, Anna ^b   Nambi, Ponnal ^a   Wrobel, Jay ^a  

^a PFIZER INC   (United States)

^b Karo Bio   (Sweden)

Author keywords

Carboxylic acids; LXR agonists; Quinolines; Selectivity in binding assays

Indexed keywords

ABC TRANSPORTER A1; ACETIC ACID; CARBOXYLIC ACID; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR BETA; NAPHTHALENE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; QUINOLINE DERIVATIVE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG; WAY 254011;

ARTICLE; ATHEROSCLEROSIS; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; IC 50; LIVER CELL; MACROPHAGE; MOLECULAR MODEL; TRANSACTIVATION;

ANIMALS; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; GENE EXPRESSION; HUMANS; LIGANDS; MACROPHAGES; MICE; MODELS, MOLECULAR; QUINOLINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUBSTRATE SPECIFICITY; TRANS-ACTIVATION (GENETICS);

EID: 37549069719     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.013     Document Type: Article

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