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Volumn 3, Issue 1, 2008, Pages 51-60

β-cell regeneration to treat type 1 diabetes mellitus

Author keywords

cell precursors; cell preservation; cell regeneration; Diabetes mellitus; Immune intervention; Stem cell

Indexed keywords

ALEMTUZUMAB; AZATHIOPRINE; C PEPTIDE; CD3 ANTIBODY; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOKERATIN 19; DACLIZUMAB; GLUCOSE; GRANULOCYTE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INSULIN; INSULIN ZINC SUSPENSION; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NICOTINAMIDE; OXYGEN; PLACEBO; PREDNISONE; RAPAMYCIN; RECOMBINANT HUMAN INSULIN; RITUXIMAB; THYMOCYTE ANTIBODY; VITAMIN D;

EID: 37549048001     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/17446651.3.1.51     Document Type: Review
Times cited : (6)

References (89)
  • 1
    • 1042302780 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes
    • American Diabetes Association
    • American Diabetes Association. Diagnosis and classification of diabetes. Diabetes Care 27(Suppl. I), S5-S10 (2004).
    • (2004) Diabetes Care , vol.27 , Issue.SUPPL. I
  • 2
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A et al. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care 27(5), 1047-1053 (2004).
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3
  • 4
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329(14), 977-986 (1993).
    • (1993) N. Engl. J. Med , vol.329 , Issue.14 , pp. 977-986
  • 5
    • 4544302034 scopus 로고    scopus 로고
    • Type 1 diabetes mellitus in childhood: A matched case control study in Lancashire and Cumbria, UK
    • Marshall AL, Chertwynd A, Morris JA et al. Type 1 diabetes mellitus in childhood: a matched case control study in Lancashire and Cumbria, UK. Diabet. Med. 21(9), 1035-1040 (2004).
    • (2004) Diabet. Med , vol.21 , Issue.9 , pp. 1035-1040
    • Marshall, A.L.1    Chertwynd, A.2    Morris, J.A.3
  • 6
    • 0035197969 scopus 로고    scopus 로고
    • Autoimmune Type 1 diabetes: Resolved and unresolved issues
    • Notkins AL, Lernmark A. Autoimmune Type 1 diabetes: resolved and unresolved issues. J. Clin. Invest. 108(9), 1247-1252 (2001).
    • (2001) J. Clin. Invest , vol.108 , Issue.9 , pp. 1247-1252
    • Notkins, A.L.1    Lernmark, A.2
  • 7
    • 0035430208 scopus 로고    scopus 로고
    • Autoimune diabetes not requiring insulin at diagnosis (latent autoimune diabetes of the adult)
    • Pozzilli P, Di Mario U. Autoimune diabetes not requiring insulin at diagnosis (latent autoimune diabetes of the adult). Diabetes Care 24(8), 1460-1467 (2001).
    • (2001) Diabetes Care , vol.24 , Issue.8 , pp. 1460-1467
    • Pozzilli, P.1    Di Mario, U.2
  • 8
    • 9144268894 scopus 로고    scopus 로고
    • C-peptide is the appropriate outcome measure for Type 1 diabetes clinical trials to preserve β-cell function
    • Palmer JP, Fleming GA, Greenbaum CJ et al. C-peptide is the appropriate outcome measure for Type 1 diabetes clinical trials to preserve β-cell function. Diabetes 53(1), 250-264 (2004).
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 250-264
    • Palmer, J.P.1    Fleming, G.A.2    Greenbaum, C.J.3
  • 9
    • 0033550904 scopus 로고    scopus 로고
    • Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with Type 1A diabetes: Prospective twin study
    • Redondo MJ, Rewers M, Yu L et al. Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with Type 1A diabetes: prospective twin study. BMJ 318(7319), 698-702 (1999).
    • (1999) BMJ , vol.318 , Issue.7319 , pp. 698-702
    • Redondo, M.J.1    Rewers, M.2    Yu, L.3
  • 10
    • 0030444451 scopus 로고    scopus 로고
    • Human Type 1A diabetes and the insulin gene: Principles of mapping polygenes
    • Bennett ST, Todd JA. Human Type 1A diabetes and the insulin gene: principles of mapping polygenes. Annu. Rev. Genet. 30, 343-370 (1996).
    • (1996) Annu. Rev. Genet , vol.30 , pp. 343-370
    • Bennett, S.T.1    Todd, J.A.2
  • 11
    • 0036010501 scopus 로고    scopus 로고
    • Type 1 diabetes: Virus infection or autoimmune disease?
    • Fairweather D L, Rose NR. Type 1 diabetes: virus infection or autoimmune disease? Nat. Immunol. 3(4), 383-340 (2002).
    • (2002) Nat. Immunol , vol.3 , Issue.4 , pp. 383-340
    • Fairweather, D.L.1    Rose, N.R.2
  • 12
    • 1642443489 scopus 로고    scopus 로고
    • Type 1 diabetes: Recent developments
    • Devendra D, Liu E, Eisenbarth GS. Type 1 diabetes: recent developments. BMJ 328(7442), 750-754 (2004).
    • (2004) BMJ , vol.328 , Issue.7442 , pp. 750-754
    • Devendra, D.1    Liu, E.2    Eisenbarth, G.S.3
  • 13
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death: The signal transduction of immune-mediated β-cell apoptosis
    • Eizirik DL, Mandrup-Poulsen T. A choice of death: the signal transduction of immune-mediated β-cell apoptosis. Diabetologia 44, 2115-2133 (2001).
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 14
    • 1942507406 scopus 로고    scopus 로고
    • Use of microarray analysis to unveil transcription factor and gene networks contributing to β-cell dysfunction and apoptosis
    • Eizirik DI, Kutlu B, Rasschaert J, Darville M, Cardozo AK. Use of microarray analysis to unveil transcription factor and gene networks contributing to β-cell dysfunction and apoptosis. Ann. NY Acad. Sci. 1005, 55-74, (2003).
    • (2003) Ann. NY Acad. Sci , vol.1005 , pp. 55-74
    • Eizirik, D.I.1    Kutlu, B.2    Rasschaert, J.3    Darville, M.4    Cardozo, A.K.5
  • 15
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic β-cell death in Type 1 and Type 2 diabetes: Many differences, few similarities
    • Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic β-cell death in Type 1 and Type 2 diabetes: many differences, few similarities. Diabetes 54(Suppl. 2), S97-S107 (2005).
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jörns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 16
    • 0037093012 scopus 로고    scopus 로고
    • The effect of intensive insulin therapy on the microvascular complications of Type 1 diabetes mellitus
    • The Epidemiology of Diabetes Interventions and Complications Research Group
    • The Epidemiology of Diabetes Interventions and Complications Research Group. The effect of intensive insulin therapy on the microvascular complications of Type 1 diabetes mellitus. JAMA 287(19), 2563-2569 (2002).
    • (2002) JAMA , vol.287 , Issue.19 , pp. 2563-2569
  • 17
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual β-cell function in patients with Type 1 diabetes in the Diabetes Control and Complications Trial
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. Effect of intensive therapy on residual β-cell function in patients with Type 1 diabetes in the Diabetes Control and Complications Trial. Ann. Intern. Med. 128(7), 517-523 (1998).
    • (1998) Ann. Intern. Med , vol.128 , Issue.7 , pp. 517-523
  • 18
    • 33847628397 scopus 로고    scopus 로고
    • Secondary prevention of Type 1 diabetes mellitus: Stopping immune destruction and promoting β-cell regeneration
    • Couri CE, Foss MC, Voltarelli JC. Secondary prevention of Type 1 diabetes mellitus: stopping immune destruction and promoting β-cell regeneration. Braz. J. Med. Biol Res. 39(10), 1271-1280 (2006).
    • (2006) Braz. J. Med. Biol Res , vol.39 , Issue.10 , pp. 1271-1280
    • Couri, C.E.1    Foss, M.C.2    Voltarelli, J.C.3
  • 19
    • 0019870514 scopus 로고
    • Partial preservation of pancreatic β-cell function in children with diabetes
    • Elliott RB, Berryman CC, Crossley JR, James AG. Partial preservation of pancreatic β-cell function in children with diabetes. Lancet, 19(2), 631-632 (1981).
    • (1981) Lancet , vol.19 , Issue.2 , pp. 631-632
    • Elliott, R.B.1    Berryman, C.C.2    Crossley, J.R.3    James, A.G.4
  • 20
    • 0022353991 scopus 로고
    • Increased in remission rate in newly diagnosed Type 1 diabetic subjects treated with azathioprine
    • Harrison LC, Colman PG, Dean B, Baxter R, Martin FI. Increased in remission rate in newly diagnosed Type 1 diabetic subjects treated with azathioprine. Diabetes 34(12), 1306-1308 (1985).
    • (1985) Diabetes , vol.34 , Issue.12 , pp. 1306-1308
    • Harrison, L.C.1    Colman, P.G.2    Dean, B.3    Baxter, R.4    Martin, F.I.5
  • 21
    • 0024813410 scopus 로고
    • Double-blind controlled trial of azathioprine in children with newly diagnosed Type I diabetes
    • Cook JJ, Hudson I, Harrison LC et al. Double-blind controlled trial of azathioprine in children with newly diagnosed Type I diabetes. Diabetes 38(6), 779-783(1989).
    • (1989) Diabetes , vol.38 , Issue.6 , pp. 779-783
    • Cook, J.J.1    Hudson, I.2    Harrison, L.C.3
  • 22
    • 0023735943 scopus 로고
    • Immunosupression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus
    • Silverstein J, Maclaren N, Riley W, Spillar R. Radjenovic D, Jonhson S. Immunosupression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. N. Engl. J. Med. 319(10), 599-604 (1988).
    • (1988) N. Engl. J. Med , vol.319 , Issue.10 , pp. 599-604
    • Silverstein, J.1    Maclaren, N.2    Riley, W.3    Spillar, R.4    Radjenovic, D.5    Jonhson, S.6
  • 23
    • 0025365614 scopus 로고
    • Plasma C-peptide levels and clinical remissions in recent-onset Type 1 diabetic patients treated with cyclosporin A and insulin
    • Assan R, Feutren G, Sirmai J et al. Plasma C-peptide levels and clinical remissions in recent-onset Type 1 diabetic patients treated with cyclosporin A and insulin. Diabetes 39 (7), 768-774 (1990).
    • (1990) Diabetes , vol.39 , Issue.7 , pp. 768-774
    • Assan, R.1    Feutren, G.2    Sirmai, J.3
  • 24
    • 0025049497 scopus 로고
    • Limited duration of remission of insulin dependency in children with recent overt Type I diabetes treated with low-dose cyclosporin
    • Bougnères F, Landais P, Boisson C et al. Limited duration of remission of insulin dependency in children with recent overt Type I diabetes treated with low-dose cyclosporin. Diabetes 39(10), 1264-1272 (1990).
    • (1990) Diabetes , vol.39 , Issue.10 , pp. 1264-1272
    • Bougnères, F.1    Landais, P.2    Boisson, C.3
  • 25
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibodiy in new-onset Type 1 diabetes mellitus
    • Herold KC, Hagopian W. Auger JA et al. Anti-CD3 monoclonal antibodiy in new-onset Type 1 diabetes mellitus. N. Engl. J. Med. 346(22), 1692-1698 (2002).
    • (2002) N. Engl. J. Med , vol.346 , Issue.22 , pp. 1692-1698
    • Herold, K.C.1    Hagopian, W.2    Auger, J.A.3
  • 26
    • 20544443927 scopus 로고    scopus 로고
    • Insulin needs after CD3-antibody therapy in new-onset Type 1 diabetes
    • Keymeulen B, Vandemeulebroucke E, Ziegler AG et al. Insulin needs after CD3-antibody therapy in new-onset Type 1 diabetes. N. Engl. J. Med. 352(25), 2598-2608 (2005).
    • (2005) N. Engl. J. Med , vol.352 , Issue.25 , pp. 2598-2608
    • Keymeulen, B.1    Vandemeulebroucke, E.2    Ziegler, A.G.3
  • 27
    • 0035944844 scopus 로고    scopus 로고
    • β-cell function in newly-onset Type 1 diabetes and immunomodulation with a heat shock protein peptide (DiaPep277): A randomised, double-blind, Phase II trial
    • Raz I, Elias D, Avron A, Metzger M, Cohen IR. β-cell function in newly-onset Type 1 diabetes and immunomodulation with a heat shock protein peptide (DiaPep277): a randomised, double-blind, Phase II trial. Lancet 358(9295), 1749-1753 (2001).
    • (2001) Lancet , vol.358 , Issue.9295 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Metzger, M.4    Cohen, I.R.5
  • 28
    • 85056050903 scopus 로고    scopus 로고
    • Polyclonal anti-T-cell therapy for Type 1 diabetes mellitus of recent onset
    • Saudek F, Havrdova T, Boucek P, Novota P, Skibova J. Polyclonal anti-T-cell therapy for Type 1 diabetes mellitus of recent onset. Rev. Diabet. Stud. 1(2), 80-88 (2004).
    • (2004) Rev. Diabet. Stud , vol.1 , Issue.2 , pp. 80-88
    • Saudek, F.1    Havrdova, T.2    Boucek, P.3    Novota, P.4    Skibova, J.5
  • 29
    • 0036464664 scopus 로고    scopus 로고
    • Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?
    • Burt RK. Slavin S, Burns WH, Marmont AM. Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Blood 99(3), 768-784 (2002).
    • (2002) Blood , vol.99 , Issue.3 , pp. 768-784
    • Burt, R.K.1    Slavin, S.2    Burns, W.H.3    Marmont, A.M.4
  • 30
    • 32044473487 scopus 로고    scopus 로고
    • Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus
    • Burt RK, Traynor A, Statkute L et al. Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus. JAMA 295(5), 527-535 (2006).
    • (2006) JAMA , vol.295 , Issue.5 , pp. 527-535
    • Burt, R.K.1    Traynor, A.2    Statkute, L.3
  • 31
    • 34247154341 scopus 로고    scopus 로고
    • Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed Type 1 diabetes mellitus
    • Voltarelli JC, Couri CEB, Stracieri ABPL et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed Type 1 diabetes mellitus. JAMA 297(14), 1568-1576 (2007).
    • (2007) JAMA , vol.297 , Issue.14 , pp. 1568-1576
    • Voltarelli, J.C.1    Couri, C.E.B.2    Stracieri, A.B.P.L.3
  • 32
  • 33
    • 1642277657 scopus 로고    scopus 로고
    • European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of Type 1 diabetes
    • European Nicotinamide Diabetes Intervention Trial Group
    • European Nicotinamide Diabetes Intervention Trial Group: European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of Type 1 diabetes. Lancet 363(9413),925-931 (2004).
    • (2004) Lancet , vol.363 , Issue.9413 , pp. 925-931
  • 34
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with Type 1 diabetes mellitus
    • Diabetes Prevention Trial, Type 1 Diabetes Study Group
    • Diabetes Prevention Trial - Type 1 Diabetes Study Group. Effects of insulin in relatives of patients with Type 1 diabetes mellitus. N. Engl. J. Med. 346(22), 1685-1691(2002).
    • (2002) N. Engl. J. Med , vol.346 , Issue.22 , pp. 1685-1691
  • 35
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with Type 1 diabetes
    • Diabetes Prevention Trial, Type 1 Study Group
    • Diabetes Prevention Trial - Type 1 Study Group. Effects of oral insulin in relatives of patients with Type 1 diabetes. Diabetes Care 28(5), 1068-1076 (2005).
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1068-1076
  • 36
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of Type 1 diabetes in NOD mice
    • Nakayama M, Abiru N, Moriyama H et al. Prime role for an insulin epitope in the development of Type 1 diabetes in NOD mice. Nature 435, 220-223 (2005).
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3
  • 37
    • 0035802695 scopus 로고    scopus 로고
    • Intake of vitamin D and risk of Type 1 diabetes: A birth-cohort study
    • Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of Type 1 diabetes: a birth-cohort study. Lancet 358(9292), 1500-1503(2004).
    • (2004) Lancet , vol.358 , Issue.9292 , pp. 1500-1503
    • Hypponen, E.1    Laara, E.2    Reunanen, A.3    Jarvelin, M.R.4    Virtanen, S.M.5
  • 38
    • 33847617787 scopus 로고    scopus 로고
    • Translational mini-review series on Type 1 diabetes: Immune-based therapeutic approaches for Type 1 diabetes
    • Staeva-Vieira T, Peakman M, von Herrath M. Translational mini-review series on Type 1 diabetes: immune-based therapeutic approaches for Type 1 diabetes. Clin. Exp. Immunol. 148, 17-31 (2007).
    • (2007) Clin. Exp. Immunol , vol.148 , pp. 17-31
    • Staeva-Vieira, T.1    Peakman, M.2    von Herrath, M.3
  • 39
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cell
    • Bonner-Weir S, Sharma A. Pancreatic stem cell. J. Pathol. 197(4), 519-526 (2002).
    • (2002) J. Pathol , vol.197 , Issue.4 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 40
    • 0026515343 scopus 로고
    • Pancreatic β-cell growth and diabetes mellitus
    • Swenne I. Pancreatic β-cell growth and diabetes mellitus. Diabetologia 35(3), 193-201 (1992).
    • (1992) Diabetologia , vol.35 , Issue.3 , pp. 193-201
    • Swenne, I.1
  • 41
    • 0030960835 scopus 로고    scopus 로고
    • Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets
    • Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138(4), 1750-1762 (1997).
    • (1997) Endocrinology , vol.138 , Issue.4 , pp. 1750-1762
    • Fernandes, A.1    King, L.C.2    Guz, Y.3    Stein, R.4    Wright, C.V.5    Teitelman, G.6
  • 42
    • 0028987251 scopus 로고
    • Dynamics of β-cell mass in the growing rat pancreas: Estimation with a simple mathematical model
    • Finegood DT, Scaglia R, Bonner-Weir S. Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 44(3), 249-256 (1995).
    • (1995) Diabetes , vol.44 , Issue.3 , pp. 249-256
    • Finegood, D.T.1    Scaglia, R.2    Bonner-Weir, S.3
  • 43
    • 0642364493 scopus 로고    scopus 로고
    • β-cell regeneration in a patient with Type 1 diabetes mellirus who was receiving immunosuppressive therapy
    • Kuroda A, Yamasaki Y, Imagawa A. β-cell regeneration in a patient with Type 1 diabetes mellirus who was receiving immunosuppressive therapy. Ann. Intern. Med. 139(10), 81 (2003).
    • (2003) Ann. Intern. Med , vol.139 , Issue.10 , pp. 81
    • Kuroda, A.1    Yamasaki, Y.2    Imagawa, A.3
  • 44
    • 15244348669 scopus 로고    scopus 로고
    • Stem cells: Science, policy and ethics
    • Fischbach GD, Fischbach RL. Stem cells: science, policy and ethics. J. Clin. Invest. 114(10), 1364-1370, (2004).
    • (2004) J. Clin. Invest , vol.114 , Issue.10 , pp. 1364-1370
    • Fischbach, G.D.1    Fischbach, R.L.2
  • 45
    • 1542328965 scopus 로고    scopus 로고
    • Plasticity of adults stem cells
    • Wagers AJ, Weissman IL. Plasticity of adults stem cells. Cell 116(5), 639-648 (2004).
    • (2004) Cell , vol.116 , Issue.5 , pp. 639-648
    • Wagers, A.J.1    Weissman, I.L.2
  • 46
    • 4444320484 scopus 로고    scopus 로고
    • Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
    • Seaberg R, Smulker SR, Kieffer TJ et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat. Biotechnol. 22(9), 1115-1124 (2004).
    • (2004) Nat. Biotechnol , vol.22 , Issue.9 , pp. 1115-1124
    • Seaberg, R.1    Smulker, S.R.2    Kieffer, T.J.3
  • 47
    • 9644266753 scopus 로고    scopus 로고
    • β cell replication is the primary mechanism of maintaining postnatal β cell mass
    • Georgia S, Blushan A. β cell replication is the primary mechanism of maintaining postnatal β cell mass. J Clin. Invest. 114 (7), 963-968 (2004).
    • (2004) J Clin. Invest , vol.114 , Issue.7 , pp. 963-968
    • Georgia, S.1    Blushan, A.2
  • 48
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429(6987), 41-46 (2004).
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 49
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by β cell regeneration
    • Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by β cell regeneration. J Clin. Invest. 117(9), 2553-2561 (2007).
    • (2007) J Clin. Invest , vol.117 , Issue.9 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 50
    • 3242784831 scopus 로고    scopus 로고
    • Prospective isolation of pancreatic multipotent progenitors using flow-cytometric cell sorting
    • Suzuki A, Nakauchi H, Tanigichi H. Prospective isolation of pancreatic multipotent progenitors using flow-cytometric cell sorting. Diabetes 53(8), 2143-2152 (2004).
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2143-2152
    • Suzuki, A.1    Nakauchi, H.2    Tanigichi, H.3
  • 51
    • 33947590955 scopus 로고    scopus 로고
    • Stem cells for the treatment of diabetes
    • Noguchi H. Stem cells for the treatment of diabetes. Endocr. J. 54(1), 7-16 (2007).
    • (2007) Endocr. J , vol.54 , Issue.1 , pp. 7-16
    • Noguchi, H.1
  • 52
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductal tissue
    • Bonner-Weir S, Taneja M, Weir GC et al. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl Acad. Sci. USA 97(14), 7999-8004 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.14 , pp. 7999-8004
    • Bonner-Weir, S.1    Taneja, M.2    Weir, G.C.3
  • 53
    • 0037303120 scopus 로고    scopus 로고
    • Stem/progenitor cells derived from adult tissues: Potential for the treatment of diabetes mellitus
    • Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 284(2), E259-E266 (2003).
    • (2003) Am. J. Physiol. Endocrinol. Metab , vol.284 , Issue.2
    • Lechner, A.1    Habener, J.F.2
  • 54
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111(6), 843-850 (2003).
    • (2003) J. Clin. Invest , vol.111 , Issue.6 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Hussain, M.A.4
  • 55
    • 10744233909 scopus 로고    scopus 로고
    • Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic β cells
    • Choi JB, Uchino H, Azuma K et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic β cells. Diabetologia 46(10), 1366-1374 (2003).
    • (2003) Diabetologia , vol.46 , Issue.10 , pp. 1366-1374
    • Choi, J.B.1    Uchino, H.2    Azuma, K.3
  • 56
    • 0037820427 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells initiate pancreatic regeneration
    • Hess D, Li L, Martin M et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat. Biotechnol. 21, 763-770 (2003).
    • (2003) Nat. Biotechnol , vol.21 , pp. 763-770
    • Hess, D.1    Li, L.2    Martin, M.3
  • 57
    • 0346099384 scopus 로고    scopus 로고
    • Recruitment of bone marrow-derived endothelial cells to sites of pancreitic β-cell injury
    • Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA. Recruitment of bone marrow-derived endothelial cells to sites of pancreitic β-cell injury. Diabetes 53, 91-98 (2004).
    • (2004) Diabetes , vol.53 , pp. 91-98
    • Mathews, V.1    Hanson, P.T.2    Ford, E.3    Fujita, J.4    Polonsky, K.S.5    Graubert, T.A.6
  • 58
    • 34249796113 scopus 로고    scopus 로고
    • Bone marrow (BM) transplantation promotes β-cell regeneration after acute injury through BM cell mobilization
    • Hasegawa Y, Ogiliara T, Yamada T et al. Bone marrow (BM) transplantation promotes β-cell regeneration after acute injury through BM cell mobilization. Endocrinology 148, 2006-2015 (2007).
    • (2007) Endocrinology , vol.148 , pp. 2006-2015
    • Hasegawa, Y.1    Ogiliara, T.2    Yamada, T.3
  • 59
    • 0033694301 scopus 로고    scopus 로고
    • Purified hematopoietic stem cell can differentiate into hepatocytes in vivo
    • Lagasse E, Connors H, Al-Dhalimy M et al. Purified hematopoietic stem cell can differentiate into hepatocytes in vivo. Nat. Med. 6(11), 1229-1234 (2000).
    • (2000) Nat. Med , vol.6 , Issue.11 , pp. 1229-1234
    • Lagasse, E.1    Connors, H.2    Al-Dhalimy, M.3
  • 60
    • 0033958372 scopus 로고    scopus 로고
    • Derivation of hepatocytes front bone marrow cells in mice after radiation-induced myeloablation
    • Theise ND, Badve S, Saxena R et al. Derivation of hepatocytes front bone marrow cells in mice after radiation-induced myeloablation. Hepatology, 31(1), 235-240 (2000).
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 235-240
    • Theise, N.D.1    Badve, S.2    Saxena, R.3
  • 61
    • 19444384955 scopus 로고    scopus 로고
    • Hematopoictic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established
    • Kang EM, Zickler MM, Burns S et al. Hematopoictic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established. Exp. Hematol. 33(6), 699-705(2005).
    • (2005) Exp. Hematol , vol.33 , Issue.6 , pp. 699-705
    • Kang, E.M.1    Zickler, M.M.2    Burns, S.3
  • 62
    • 34347373445 scopus 로고    scopus 로고
    • Hematopoietic stem cells derived from adult donors are not a source of pancreatic β-cells in adult nondiabetic humans
    • Butler AE, Huang A, Rao PN et al. Hematopoietic stem cells derived from adult donors are not a source of pancreatic β-cells in adult nondiabetic humans. Diabetes 56(7), 1810-1816 (2007).
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1810-1816
    • Butler, A.E.1    Huang, A.2    Rao, P.N.3
  • 63
    • 0030982123 scopus 로고    scopus 로고
    • Preexisting autoimmune diseasein patients with long term survival after allogeneic bone marrow transplantation
    • Nelson JL, Torres I, Louie FM et al. Preexisting autoimmune diseasein patients with long term survival after allogeneic bone marrow transplantation. J Rheumatol. 24(48), 23-29 (1997).
    • (1997) J Rheumatol , vol.24 , Issue.48 , pp. 23-29
    • Nelson, J.L.1    Torres, I.2    Louie, F.M.3
  • 64
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult bone marrow
    • Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult bone marrow. Nature 418(6893), 41-49 (2002).
    • (2002) Nature , vol.418 , Issue.6893 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 65
    • 4644310257 scopus 로고    scopus 로고
    • Differentiation of rat marrow mesenchymal stem cells into pancreatic islet kells
    • Chen LB, Jiang XB, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet kells. World J. Gastroenterol. 10(20), 3016-3020 (2004).
    • (2004) World J. Gastroenterol , vol.10 , Issue.20 , pp. 3016-3020
    • Chen, L.B.1    Jiang, X.B.2    Yang, L.3
  • 66
    • 3042785984 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow
    • Tang DQ Cao LZ, Burkhardt BR et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 53(7), 1721-1732 (2004).
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1721-1732
    • Tang, D.Q.1    Cao, L.Z.2    Burkhardt, B.R.3
  • 67
    • 33751232671 scopus 로고    scopus 로고
    • Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    • Lee HR, Seo MJ, Reger RL et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc. Natl Acad. Sci. USA 103(46), 17438-17443 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.46 , pp. 17438-17443
    • Lee, H.R.1    Seo, M.J.2    Reger, R.L.3
  • 68
    • 34248652441 scopus 로고    scopus 로고
    • Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro
    • Sun Y, Chen L, Hou XG et al. Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin. Med. J. (Engl.) 120 (9), 771-776 (2007).
    • (2007) Chin. Med. J. (Engl.) , vol.120 , Issue.9 , pp. 771-776
    • Sun, Y.1    Chen, L.2    Hou, X.G.3
  • 69
    • 32344451060 scopus 로고    scopus 로고
    • Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagons expressing cells
    • Timper K, Seboek D, Eberhardt M et al. Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagons expressing cells. Biochem. Biophys. Res. Commun. 341(4), 1155-1160 (2006).
    • (2006) Biochem. Biophys. Res. Commun , vol.341 , Issue.4 , pp. 1155-1160
    • Timper, K.1    Seboek, D.2    Eberhardt, M.3
  • 70
    • 20444457464 scopus 로고    scopus 로고
    • Differentiation of in vitro-modified human peripheral blood monocyres into hepatocyte-like and pancreatic islet-like cells
    • Ruhnke M, Ungefroren H, Nussler et al. Differentiation of in vitro-modified human peripheral blood monocyres into hepatocyte-like and pancreatic islet-like cells. Gastroenterology 128(7), 1774-1786 (2005).
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 1774-1786
    • Ruhnke, M.1    Ungefroren, H.2    Nussler3
  • 71
    • 37549009282 scopus 로고    scopus 로고
    • Autologous bone marrow mononuclear cell (ABMMC) transplantation in Type 1 and Type 2 insulin-dependent diabetes mellitus patients
    • Sydney, Australia 24-27 June
    • Tuma-Mubarak J, Fernandez-Viña R, Yalan AC et al. Autologous bone marrow mononuclear cell (ABMMC) transplantation in Type 1 and Type 2 insulin-dependent diabetes mellitus patients. International Society of Cell Therapy Meeting. Sydney, Australia 24-27 June (2007).
    • (2007) International Society of Cell Therapy Meeting
    • Tuma-Mubarak, J.1    Fernandez-Viña, R.2    Yalan, A.C.3
  • 72
    • 37549050304 scopus 로고    scopus 로고
    • The Conzi's effect in human diabetes mellitus: From bone marrow progenitor cells (BMPCs) to β cells
    • Novoa JE, Medina MA, Gordillo F et al. The Conzi's effect in human diabetes mellitus: from bone marrow progenitor cells (BMPCs) to β cells. Archivos de Medicina Interna 1(Suppl. 1), 34 (2007).
    • (2007) Archivos de Medicina Interna , vol.1 , Issue.SUPPL. 1 , pp. 34
    • Novoa, J.E.1    Medina, M.A.2    Gordillo, F.3
  • 73
    • 8544253255 scopus 로고    scopus 로고
    • Effect of human umbilical cord blood cells on glycemia and insulitis in Type 1 diabetic mice
    • Ende N, Chen R, Reddi AS. Effect of human umbilical cord blood cells on glycemia and insulitis in Type 1 diabetic mice. Biochem. Biophys. Res. Commun. 325(3), 665-669 (2004).
    • (2004) Biochem. Biophys. Res. Commun , vol.325 , Issue.3 , pp. 665-669
    • Ende, N.1    Chen, R.2    Reddi, A.S.3
  • 74
    • 3543039431 scopus 로고    scopus 로고
    • Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in Type 2 diabetic mice
    • Ende N, Chen R, Reddi AS. Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in Type 2 diabetic mice. Biochem. Biophys. Res. Commun. 321(1), 168-71 (2004).
    • (2004) Biochem. Biophys. Res. Commun , vol.321 , Issue.1 , pp. 168-171
    • Ende, N.1    Chen, R.2    Reddi, A.S.3
  • 75
    • 20044366933 scopus 로고    scopus 로고
    • Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy
    • Naruse K, Hamada Y, Nakashima E et al. Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Diabetes 54(6), 1823-1828 (2005).
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1823-1828
    • Naruse, K.1    Hamada, Y.2    Nakashima, E.3
  • 76
    • 47249154111 scopus 로고    scopus 로고
    • Insulin requirements, HbAlc, and stimulated C-peptide following autologous umbilical cord blood transfusion in children with T1D
    • Haller MJ, Viener HL, Brusko T et al. Insulin requirements, HbAlc, and stimulated C-peptide following autologous umbilical cord blood transfusion in children with T1D. Abstracts ADA 67th Scientific Sessions. A82 (2007).
    • (2007) Abstracts ADA 67th Scientific Sessions
    • Haller, M.J.1    Viener, H.L.2    Brusko, T.3
  • 77
    • 0031938718 scopus 로고    scopus 로고
    • Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat
    • Petersen BE, Goff JP, Greenberger JS, Michalopoulos GK. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Hepatology 27(2), 433-445 (1998).
    • (1998) Hepatology , vol.27 , Issue.2 , pp. 433-445
    • Petersen, B.E.1    Goff, J.P.2    Greenberger, J.S.3    Michalopoulos, G.K.4
  • 78
    • 0037062515 scopus 로고    scopus 로고
    • In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
    • Yang L, Li S, Hatch H et al. In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc. Natl Acad. Sci. USA 99(12), 8078-8083 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.12 , pp. 8078-8083
    • Yang, L.1    Li, S.2    Hatch, H.3
  • 79
    • 34250349195 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration
    • Kim S, Shin JS, Kim HJ, Fisher RC, Lee MJ, Kim CW. Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration. Lab. Invest. 87(7), 702-712 (2007).
    • (2007) Lab. Invest , vol.87 , Issue.7 , pp. 702-712
    • Kim, S.1    Shin, J.S.2    Kim, H.J.3    Fisher, R.C.4    Lee, M.J.5    Kim, C.W.6
  • 81
    • 0033979603 scopus 로고    scopus 로고
    • Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    • Soria B, Roche E, Berna G, Leon-Quito T, Reig JA, Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49(2), 157-162 (2000).
    • (2000) Diabetes , vol.49 , Issue.2 , pp. 157-162
    • Soria, B.1    Roche, E.2    Berna, G.3    Leon-Quito, T.4    Reig, J.A.5    Martin, F.6
  • 82
    • 4644222526 scopus 로고    scopus 로고
    • Artifactual insulin release from differentiated embryonic stem cells
    • Hansson M, Tonning A, Frandsen U et al. Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53(10), 2603-2609 (2004).
    • (2004) Diabetes , vol.53 , Issue.10 , pp. 2603-2609
    • Hansson, M.1    Tonning, A.2    Frandsen, U.3
  • 83
    • 11144219959 scopus 로고    scopus 로고
    • Human cloning - the science and ethics of nuclear transplantation
    • Jaenisch R. Human cloning - the science and ethics of nuclear transplantation. N. Engl. J. Med. 351(27), 2787-2791 (2004).
    • (2004) N. Engl. J. Med , vol.351 , Issue.27 , pp. 2787-2791
    • Jaenisch, R.1
  • 84
    • 30344439127 scopus 로고    scopus 로고
    • Stem cells. How young Korean researchers helped unearth a scandal
    • Chong S, Normile D. Stem cells. How young Korean researchers helped unearth a scandal. Science 311(5757), 22-25 (2006).
    • (2006) Science , vol.311 , Issue.5757 , pp. 22-25
    • Chong, S.1    Normile, D.2
  • 85
    • 33847679951 scopus 로고    scopus 로고
    • Embryonic stem cells in new onset Type 2 diabetes mellitus
    • Smykoduh OI, Noritskaya AV. Embryonic stem cells in new onset Type 2 diabetes mellitus. Cytotherapy 6(4), 402 (2004).
    • (2004) Cytotherapy , vol.6 , Issue.4 , pp. 402
    • Smykoduh, O.I.1    Noritskaya, A.V.2
  • 86
    • 33847679951 scopus 로고    scopus 로고
    • Embryonic stem cells in pernicious decompensated Type 2 diabetes mellitus
    • Smykodub OI, Noritskaya AV. Embryonic stem cells in pernicious decompensated Type 2 diabetes mellitus. Cytotherapy 6(4), 402 (2004).
    • (2004) Cytotherapy , vol.6 , Issue.4 , pp. 402
    • Smykodub, O.I.1    Noritskaya, A.V.2
  • 87
  • 88
    • 34249730024 scopus 로고    scopus 로고
    • Colman A, Alliston D. ES Cell International and regenerative medicine. Regenerative Med. 1(2), 287-292 (2006).
    • Colman A, Alliston D. ES Cell International and regenerative medicine. Regenerative Med. 1(2), 287-292 (2006).
  • 89
    • 33947726341 scopus 로고    scopus 로고
    • Moving towards efficient therapies in Type 1 diabetes: To combine or not to combine?
    • Bresson D, von Herrath M. Moving towards efficient therapies in Type 1 diabetes: to combine or not to combine? Autoinumune Rev. 6(5), 315-322 (2007).
    • (2007) Autoinumune Rev , vol.6 , Issue.5 , pp. 315-322
    • Bresson, D.1    von Herrath, M.2


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