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Volumn 32, Issue 1, 2007, Pages 95-104

Alternative promoter usage and alternative splicing contribute to mRNA heterogeneity of mouse monocarboxylate transporter 2

Author keywords

Gene expression; Hypoxia; Lactate metabolism; mRNA diversity; Transcriptional regulation

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 2;

EID: 37449028557     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00192.2007     Document Type: Article
Times cited : (13)

References (64)
  • 1
    • 0027470203 scopus 로고
    • The structural and functional diversity of dystrophin
    • Ahn AH, Kunkel LM. The structural and functional diversity of dystrophin. Nat Genet 3: 283-291, 1993.
    • (1993) Nat Genet , vol.3 , pp. 283-291
    • Ahn, A.H.1    Kunkel, L.M.2
  • 3
    • 0029936752 scopus 로고    scopus 로고
    • Regulation of gene expression by alternative promoters
    • Ayoubi TA, Van De Ven WJ. Regulation of gene expression by alternative promoters. FASEB J 10: 453-460, 1996.
    • (1996) FASEB J , vol.10 , pp. 453-460
    • Ayoubi, T.A.1    Van De Ven, W.J.2
  • 4
    • 0032491492 scopus 로고    scopus 로고
    • Steroidogenic factor-1 regulates transcription of the human anti-mullerian hormone receptor
    • Barbara PS, Moniot B, Poulat F, Boizet B, Berta P. Steroidogenic factor-1 regulates transcription of the human anti-mullerian hormone receptor. J Biol Chem 273: 29654-29660, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 29654-29660
    • Barbara, P.S.1    Moniot, B.2    Poulat, F.3    Boizet, B.4    Berta, P.5
  • 5
    • 0141656234 scopus 로고    scopus 로고
    • Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain
    • Baud O, Fayol L, Gressens P, Pellerin L, Magistretti P, Evrard P, Verney C. Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. J Comp Neurol 465: 445-454, 2003.
    • (2003) J Comp Neurol , vol.465 , pp. 445-454
    • Baud, O.1    Fayol, L.2    Gressens, P.3    Pellerin, L.4    Magistretti, P.5    Evrard, P.6    Verney, C.7
  • 6
    • 0022799521 scopus 로고
    • Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas
    • Bentley DL, Groudine M. Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas. Mol Cell Biol 6: 3481-3489, 1986.
    • (1986) Mol Cell Biol , vol.6 , pp. 3481-3489
    • Bentley, D.L.1    Groudine, M.2
  • 8
    • 0041353619 scopus 로고    scopus 로고
    • Mouse kappa-opioid receptor mRNA differential transport in neurons
    • Bi J, Hu X, Loh HH, Wei LN. Mouse kappa-opioid receptor mRNA differential transport in neurons. Mol Pharmacol 64: 594-599, 2003.
    • (2003) Mol Pharmacol , vol.64 , pp. 594-599
    • Bi, J.1    Hu, X.2    Loh, H.H.3    Wei, L.N.4
  • 9
    • 0041360020 scopus 로고    scopus 로고
    • Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells
    • Boussouar F, Mauduit C, Tabone E, Pellerin L, Magistretti PJ, Benahmed M. Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells. Biol Reprod 69: 1069-1078, 2003.
    • (2003) Biol Reprod , vol.69 , pp. 1069-1078
    • Boussouar, F.1    Mauduit, C.2    Tabone, E.3    Pellerin, L.4    Magistretti, P.J.5    Benahmed, M.6
  • 11
    • 0030774069 scopus 로고    scopus 로고
    • Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons
    • Broer S, Rahman B, Pellegri G, Pellerin L, Martin JL, Verleysdonk S, Hamprecht B, Magistretti PJ. Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J Biol Chem 272: 30096-30102, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 30096-30102
    • Broer, S.1    Rahman, B.2    Pellegri, G.3    Pellerin, L.4    Martin, J.L.5    Verleysdonk, S.6    Hamprecht, B.7    Magistretti, P.J.8
  • 12
    • 0033514475 scopus 로고    scopus 로고
    • Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle
    • Brooks GA, Dubouchaud H, Brown M, Sicurello JP, Butz CE. Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. Proc Natl Acad Sci USA 96: 1129-1134, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1129-1134
    • Brooks, G.A.1    Dubouchaud, H.2    Brown, M.3    Sicurello, J.P.4    Butz, C.E.5
  • 13
    • 0032546972 scopus 로고    scopus 로고
    • Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway
    • Chen CY, Del Gatto-Konczak F, Wu Z, Karin M. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science 280: 1945-1949, 1998.
    • (1998) Science , vol.280 , pp. 1945-1949
    • Chen, C.Y.1    Del Gatto-Konczak, F.2    Wu, Z.3    Karin, M.4
  • 14
    • 34347242128 scopus 로고    scopus 로고
    • Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway
    • Chenal J, Pellerin L. Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. J Neurochem 102: 389-397, 2007.
    • (2007) J Neurochem , vol.102 , pp. 389-397
    • Chenal, J.1    Pellerin, L.2
  • 15
    • 0036290173 scopus 로고    scopus 로고
    • The human monocarboxylate transporter, MCT1: Genomic organization and promoter analysis
    • Cuff MA, Shirazi-Beechey SP. The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. Biochem Biophys Res Commun 292: 1048-1056, 2002.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 1048-1056
    • Cuff, M.A.1    Shirazi-Beechey, S.P.2
  • 16
    • 0031835957 scopus 로고    scopus 로고
    • Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
    • Ebert BL, Bunn HF. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol 18: 4089-4096, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 4089-4096
    • Ebert, B.L.1    Bunn, H.F.2
  • 17
    • 0025193384 scopus 로고
    • Expression of P0- and P3-RNA from the normal and translocated c-myc allele in Burkitt's lymphoma cells
    • Eick D, Polack A, Kofler E, Lenoir GM, Rickinson AB, Bornkamm GW. Expression of P0- and P3-RNA from the normal and translocated c-myc allele in Burkitt's lymphoma cells. Oncogene 5: 1397-1402, 1990.
    • (1990) Oncogene , vol.5 , pp. 1397-1402
    • Eick, D.1    Polack, A.2    Kofler, E.3    Lenoir, G.M.4    Rickinson, A.B.5    Bornkamm, G.W.6
  • 18
    • 0036301412 scopus 로고    scopus 로고
    • Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle
    • Fishbein WN, Merezhinskaya N, Foellmer JW. Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle. Muscle Nerve 26: 101-112, 2002.
    • (2002) Muscle Nerve , vol.26 , pp. 101-112
    • Fishbein, W.N.1    Merezhinskaya, N.2    Foellmer, J.W.3
  • 19
    • 0028909335 scopus 로고
    • cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1
    • Garcia CK, Brown MS, Pathak RK, Goldstein JL. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J Biol Chem 270: 1843-1849, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 1843-1849
    • Garcia, C.K.1    Brown, M.S.2    Pathak, R.K.3    Goldstein, J.L.4
  • 22
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343: 281-299, 1999.
    • (1999) Biochem J , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 24
    • 0027362649 scopus 로고
    • Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis
    • Harada N, Utsumi T, Takagi Y. Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc Natl Acad Sci USA 90: 11312-11316, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11312-11316
    • Harada, N.1    Utsumi, T.2    Takagi, Y.3
  • 25
    • 0030909127 scopus 로고    scopus 로고
    • Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation
    • Jackson VN, Price NT, Carpenter L, Halestrap AP. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. Biochem J 324: 447-453, 1997.
    • (1997) Biochem J , vol.324 , pp. 447-453
    • Jackson, V.N.1    Price, N.T.2    Carpenter, L.3    Halestrap, A.P.4
  • 26
    • 0344873719 scopus 로고    scopus 로고
    • Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
    • Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM. Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells. Exp Mol Med 35: 350-357, 2003.
    • (2003) Exp Mol Med , vol.35 , pp. 350-357
    • Joung, Y.H.1    Park, J.H.2    Park, T.3    Lee, C.S.4    Kim, O.H.5    Ye, S.K.6    Yang, U.M.7    Lee, K.J.8    Yang, Y.M.9
  • 27
    • 0030933001 scopus 로고    scopus 로고
    • Lactate-proton cotransport in skeletal muscle
    • Juel C. Lactate-proton cotransport in skeletal muscle. Physiol Rev 77: 321-358, 1997.
    • (1997) Physiol Rev , vol.77 , pp. 321-358
    • Juel, C.1
  • 28
    • 3042793425 scopus 로고    scopus 로고
    • Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
    • Kasischke KA, Vishwasrao HD, Fisher PJ, Zipfel WR, Webb WW. Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305: 99-103, 2004.
    • (2004) Science , vol.305 , pp. 99-103
    • Kasischke, K.A.1    Vishwasrao, H.D.2    Fisher, P.J.3    Zipfel, W.R.4    Webb, W.W.5
  • 30
    • 0242317345 scopus 로고    scopus 로고
    • Complex controls: The role of alternative promoters in mammalian genomes
    • Landry JR, Mager DL, Wilhelm BT. Complex controls: the role of alternative promoters in mammalian genomes. Trends Genet 19: 640-648, 2003.
    • (2003) Trends Genet , vol.19 , pp. 640-648
    • Landry, J.R.1    Mager, D.L.2    Wilhelm, B.T.3
  • 31
    • 0032582702 scopus 로고    scopus 로고
    • Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter
    • Lin RY, Vera JC, Chaganti RS, Golde DW. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem 273: 28959-28965, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 28959-28965
    • Lin, R.Y.1    Vera, J.C.2    Chaganti, R.S.3    Golde, D.W.4
  • 32
    • 0027274644 scopus 로고
    • Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues
    • Lynch JP, Lala DS, Peluso JJ, Luo W, Parker KL, White BA. Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol 7: 776-786, 1993.
    • (1993) Mol Endocrinol , vol.7 , pp. 776-786
    • Lynch, J.P.1    Lala, D.S.2    Peluso, J.J.3    Luo, W.4    Parker, K.L.5    White, B.A.6
  • 33
    • 0036095530 scopus 로고    scopus 로고
    • Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia
    • McClelland GB, Brooks GA. Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia. J Appl Physiol 92: 1573-1584, 2002.
    • (2002) J Appl Physiol , vol.92 , pp. 1573-1584
    • McClelland, G.B.1    Brooks, G.A.2
  • 36
    • 0020050314 scopus 로고
    • A catalogue of splice junction sequences
    • Mount SM. A catalogue of splice junction sequences. Nucleic Acids Res 10: 459-472, 1982.
    • (1982) Nucleic Acids Res , vol.10 , pp. 459-472
    • Mount, S.M.1
  • 37
    • 0031452563 scopus 로고    scopus 로고
    • Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site
    • Nanbru C, Lafon I, Audigier S, Gensac MC, Vagner S, Huez G, Prats AC. Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site. J Biol Chem 272: 32061-32066, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 32061-32066
    • Nanbru, C.1    Lafon, I.2    Audigier, S.3    Gensac, M.C.4    Vagner, S.5    Huez, G.6    Prats, A.C.7
  • 38
    • 0037414816 scopus 로고    scopus 로고
    • Translational regulation of human neuronal nitric-oxide synthase by an alternatively spliced 5-untranslated region leader exon
    • Newton DC, Bevan SC, Choi S, Robb GB, Millar A, Wang Y, Marsden PA. Translational regulation of human neuronal nitric-oxide synthase by an alternatively spliced 5-untranslated region leader exon. J Biol Chem 278: 636-644, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 636-644
    • Newton, D.C.1    Bevan, S.C.2    Choi, S.3    Robb, G.B.4    Millar, A.5    Wang, Y.6    Marsden, P.A.7
  • 40
    • 0032584084 scopus 로고    scopus 로고
    • Expression of monocarboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
    • Pellerin L, Pellegri G, Martin JL, Magistretti PJ. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci USA 95: 3990-3995, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3990-3995
    • Pellerin, L.1    Pellegri, G.2    Martin, J.L.3    Magistretti, P.J.4
  • 41
    • 0037067744 scopus 로고    scopus 로고
    • Endothelial argininosuccinate synthase mRNA 5′-untranslated region diversity. Infrastructure for tissue-specific expression
    • Pendleton LC, Goodwin BL, Flam BR, Solomonson LP, Eichler DC. Endothelial argininosuccinate synthase mRNA 5′-untranslated region diversity. Infrastructure for tissue-specific expression. J Biol Chem 277: 25363-25369, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 25363-25369
    • Pendleton, L.C.1    Goodwin, B.L.2    Flam, B.R.3    Solomonson, L.P.4    Eichler, D.C.5
  • 42
    • 14644415917 scopus 로고    scopus 로고
    • Identification of novel RARbeta2 transcript variants with short 5′-UTRs in normal and cancerous breast epithelial cells
    • Peng X, Mehta RG, Tonetti DA, Christov K. Identification of novel RARbeta2 transcript variants with short 5′-UTRs in normal and cancerous breast epithelial cells. Oncogene 24: 1296-1301, 2005.
    • (2005) Oncogene , vol.24 , pp. 1296-1301
    • Peng, X.1    Mehta, R.G.2    Tonetti, D.A.3    Christov, K.4
  • 43
    • 0141655180 scopus 로고    scopus 로고
    • Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation
    • Pierre K, Debernardi R, Magistretti PJ, Pellerin L. Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation. J Neurochem 86: 1468-1476, 2003.
    • (2003) J Neurochem , vol.86 , pp. 1468-1476
    • Pierre, K.1    Debernardi, R.2    Magistretti, P.J.3    Pellerin, L.4
  • 44
    • 0036254152 scopus 로고    scopus 로고
    • MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain
    • Pierre K, Magistretti PJ, Pellerin L. MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. J Cereb Blood Flow Metab 22: 586-595, 2002.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 586-595
    • Pierre, K.1    Magistretti, P.J.2    Pellerin, L.3
  • 45
    • 34548359349 scopus 로고    scopus 로고
    • Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice
    • Pierre K, Parent A, Jayet PY, Halestrap AP, Scherrer U, Pellerin L. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. J Physiol 583: 469-486, 2007.
    • (2007) J Physiol , vol.583 , pp. 469-486
    • Pierre, K.1    Parent, A.2    Jayet, P.Y.3    Halestrap, A.P.4    Scherrer, U.5    Pellerin, L.6
  • 46
    • 0032518981 scopus 로고    scopus 로고
    • Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
    • Price NT, Jackson VN, Halestrap AP. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J 329: 321-328, 1998.
    • (1998) Biochem J , vol.329 , pp. 321-328
    • Price, N.T.1    Jackson, V.N.2    Halestrap, A.P.3
  • 47
    • 33748186181 scopus 로고    scopus 로고
    • Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats
    • Prins ML, Giza CC. Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats. Dev Neurosci 28: 447-456, 2006.
    • (2006) Dev Neurosci , vol.28 , pp. 447-456
    • Prins, M.L.1    Giza, C.C.2
  • 49
    • 0242485280 scopus 로고    scopus 로고
    • Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain
    • Rafiki A, Boulland JL, Halestrap AP, Ottersen OP, Bergersen L. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neuroscience 122: 677-688, 2003.
    • (2003) Neuroscience , vol.122 , pp. 677-688
    • Rafiki, A.1    Boulland, J.L.2    Halestrap, A.P.3    Ottersen, O.P.4    Bergersen, L.5
  • 50
    • 0034966729 scopus 로고    scopus 로고
    • Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction
    • Sasaki H, Ray PS, Zhu L, Otani H, Asahara T, Maulik N. Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction. J Mol Cell Cardiol 33: 283-294, 2001.
    • (2001) J Mol Cell Cardiol , vol.33 , pp. 283-294
    • Sasaki, H.1    Ray, P.S.2    Zhu, L.3    Otani, H.4    Asahara, T.5    Maulik, N.6
  • 51
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells
    • Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN, Runge MS. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272: 601-608, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 601-608
    • Schmedtje Jr, J.F.1    Ji, Y.S.2    Liu, W.L.3    DuBois, R.N.4    Runge, M.S.5
  • 52
    • 0035937484 scopus 로고    scopus 로고
    • Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia
    • Schurr A, Payne RS, Miller JJ, Tseng MT, Rigor BM. Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. Brain Res 895: 268-272, 2001.
    • (2001) Brain Res , vol.895 , pp. 268-272
    • Schurr, A.1    Payne, R.S.2    Miller, J.J.3    Tseng, M.T.4    Rigor, B.M.5
  • 53
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 54
    • 0032190614 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
    • Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 8: 588-594, 1998.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 588-594
    • Semenza, G.L.1
  • 55
    • 0038664127 scopus 로고    scopus 로고
    • Identification and functional analysis of human transcriptional promoters
    • Trinklein ND, Aldred SJ, Saldanha AJ, Myers RM. Identification and functional analysis of human transcriptional promoters. Genome Res 13: 308-312, 2003.
    • (2003) Genome Res , vol.13 , pp. 308-312
    • Trinklein, N.D.1    Aldred, S.J.2    Saldanha, A.J.3    Myers, R.M.4
  • 56
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281: 9030-9037, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 57
    • 0024444105 scopus 로고
    • Developmentally regulated use of alternative promoters creates a novel platelet-derived growth factor receptor transcript in mouse teratocarcinoma and embryonic stem cells
    • Vu TH, Martin GR, Lee P, Mark D, Wang A, Williams LT. Developmentally regulated use of alternative promoters creates a novel platelet-derived growth factor receptor transcript in mouse teratocarcinoma and embryonic stem cells. Mol Cell Biol 9: 4563-4567, 1989.
    • (1989) Mol Cell Biol , vol.9 , pp. 4563-4567
    • Vu, T.H.1    Martin, G.R.2    Lee, P.3    Mark, D.4    Wang, A.5    Williams, L.T.6
  • 58
    • 0029933573 scopus 로고    scopus 로고
    • Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells
    • Wang X, Levi AJ, Halestrap AP. Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells. Am J Physiol Heart Circ Physiol 270: H476-H484, 1996.
    • (1996) Am J Physiol Heart Circ Physiol , vol.270
    • Wang, X.1    Levi, A.J.2    Halestrap, A.P.3
  • 59
    • 0036143131 scopus 로고    scopus 로고
    • An alternative promoter of the human neuronal nitric oxide synthase gene is expressed specifically in Leydig cells
    • Wang Y, Newton DC, Miller TL, Teichert AM, Phillips MJ, Davidoff MS, Marsden PA. An alternative promoter of the human neuronal nitric oxide synthase gene is expressed specifically in Leydig cells. Am J Pathol 160: 369-380, 2002.
    • (2002) Am J Pathol , vol.160 , pp. 369-380
    • Wang, Y.1    Newton, D.C.2    Miller, T.L.3    Teichert, A.M.4    Phillips, M.J.5    Davidoff, M.S.6    Marsden, P.A.7
  • 61
    • 0036737683 scopus 로고    scopus 로고
    • Splice variation in mouse full-length cDNAs identified by mapping to the mouse genome
    • Zavolan M, van Nimwegen E, Gaasterland T. Splice variation in mouse full-length cDNAs identified by mapping to the mouse genome. Genome Res 12: 1377-1385, 2002.
    • (2002) Genome Res , vol.12 , pp. 1377-1385
    • Zavolan, M.1    van Nimwegen, E.2    Gaasterland, T.3
  • 62
    • 12244304874 scopus 로고    scopus 로고
    • Monocarboxylate transporter expression in the spontaneous hypertensive rat: Effect of stroke
    • Zhang F, Vannucci SJ, Philp NJ, Simpson IA. Monocarboxylate transporter expression in the spontaneous hypertensive rat: effect of stroke. J Neurosci Res 79: 139-145, 2005.
    • (2005) J Neurosci Res , vol.79 , pp. 139-145
    • Zhang, F.1    Vannucci, S.J.2    Philp, N.J.3    Simpson, I.A.4
  • 63
    • 37449003178 scopus 로고    scopus 로고
    • Whole-body hypoxic preconditioning (WBHPC) protects mice against acute hypoxia by improving organ function in the lung (Abstract)
    • Zhang SX, Wang J, Miller JJ, Mwasaru EF, Gozal D, Wang Y. Whole-body hypoxic preconditioning (WBHPC) protects mice against acute hypoxia by improving organ function in the lung (Abstract). FASEB J 17: A1281, 2003.
    • (2003) FASEB J , vol.17
    • Zhang, S.X.1    Wang, J.2    Miller, J.J.3    Mwasaru, E.F.4    Gozal, D.5    Wang, Y.6
  • 64
    • 0345874728 scopus 로고    scopus 로고
    • Multiple variable first exons: A mechanism for cell- and tissue-specific gene regulation
    • Zhang T, Haws P, Wu Q. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Genome Res 14: 79-89, 2004.
    • (2004) Genome Res , vol.14 , pp. 79-89
    • Zhang, T.1    Haws, P.2    Wu, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.