Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats

Developmental Neuroscience

Volumn 28, Issue 4-5, 2006, Pages 447-456

  Prins, M L ^a   Giza, C C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ketones; Monocarboxylate transporter 2; Traumatic brain injury

Indexed keywords

KETONE; MONOCARBOXYLATE TRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRAUMATIC BRAIN INJURY; WEANING; WESTERN BLOTTING;

AGING; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN INJURIES; CEREBRAL ARTERIES; CEREBRAL CORTEX; CYTOPROTECTION; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KETONES; MALE; MICROCIRCULATION; MONOCARBOXYLIC ACID TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; UP-REGULATION;

EID: 33748186181     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094170     Document Type: Article

References (47)

1. Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL: D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinsons disease. Proc Natl Acad Sci USA 2000;97:5440-5444.
2. Suzuki M, Suzuki M, Sato K, Dohi S, Sato T, Matsuura A, Hiraide A: Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats. Jpn J Pharmacol 2001;87:143-150.
3. Suzuki M, Suzuki M, Kitamura Y, Mori S, Sato K, Dohi S, Sato T, Matsuura A, Hiraide A: Beta-hydroxybutyrate, a cerebral function improving agent, protects rate brain against ischemic damage caused by permanent and transient focal cerebral ischemia. Jpn J Pharmacol 2002;89:36-43.
4. Go KG, Prenen GHM, Korf J: Protective effects of fasting upon cerebral hypoxic-ischemic injury. Metab Br Dis 1988;3:257-263.
5. Marie C, Bralet AM, Gueldry S, Bralet J: Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis. Metab Br Dis 1990;5:65-75.
6. Katayama M, Hiraide A, Sugimoto H, Yoshioka T, Sugimoto T: Effect of ketone bodies on hyperglycemia and lactic acidemia in hemorrhagic stress. JPEN J Parenter Enteral Nutr 1994;18:442-446.
7. Izumi Y, Ishii K, Katsuki H, Benz AM, Zorumski CF: Beta-hydroxybutyrate fuels synaptic function during development. J Clin Invest 1998;101:1121-1132.
8. Massieu L, Haces ML, Montiel T, Hernandez-Fonseca K: Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition. Neurosci 2003;120:365-378.
9. Prins ML, Fujima LS, Hovda DA: Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res 2005;82:413-420.
10. Daniel PM, Love ER, Moorehouse SR, Pratt OE, Wilson P: Factors influencing utilization of ketone-bodies by brain in normal rats and rats with ketoacidosis. Lancet 1971;ii:637-638.
11. Hawkins RA, Williamson DH, Krebs HA: Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J 1971;122:13-18.
12. Ruderman NB, Ross PS, Berger M, Goodman MN: Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J 1974;138:1-10.
13. Moore TJ, Lione AP, Sugden MC, Regen DM: Beta-hydroxybutyrate transport in rat brain: developmental and dietary modulations. Am J Physiol 1976;230:619-630.
14. Zovein A, Flowers-Ziegler J, Thamotharan S, Shin D, Sankar R, Nguyen K, Gambhir S, Devaskar SU: Postnatal hypoxia-ischemic brain injury alters mechanisms mediating neuronal glucose transport. Am J Physiol Regul Integr Comp Physiol 2004;286:R273-R282.
15. Tseng MT, Chan SA, Schurr A: Ischemia-induced changes in monocarboxylate transporter 1 reactive cells in rat hippocampus. Neurol Res 2003;25:83-86.
16. Zhang F, Vannucci SJ, Philip NJ, Simpson IA: Monocarboxylate transporter expression in the spontaneous hypertensive rat: effect of stroke. J Neurosci Res 2005;79:139-145.
17. Pierre K, Debernardi R, Magistretti PJ, Pellerin L: Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neuron via translational regulation. J Neurochem 2003;86:1468-1476.
18. Cuff MA, Lambert DW, Shirazi-Beechey SP: Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J Physiol 2002;539:361-371.
19. Leino RL, Gerhart DZ, Duelli R, Enerson BE, Drewes LR: Diet-induced ketosis increases monocaboxylate transporter (MCT1) levels in rat brain. Neurochem Int 2001;38:519-527.
20. Dahlquist G, Persson B: The rate of cerebral utilization of glucose, ketone bodies, and oxygen: a comparative in vivo study of infant and adult rats. Pediatr Res 1976;10:910-917.
21. Vannucci SJ, Simpson IA: Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 2003;285:E1127-E1134.
22. Cremer JE, Braun LD, Oldendorf WH: Changes during development in transport processes of the blood-brain barrier. Biochim Biophys Acta 1976;448:633-637.
23. Sutton RL, Lescaudron L, Stein DG: Unilateral cortical contusion injury in the rat: vascular disruption and temporal development of cortical necrosis. J Neurochem 1993;10:135-149.
24. Rho JM, Kim DW, Robbins CA, Anderson GD, Schwartzkroin PA: Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet. Epil Res 1999;37:233-240.
25. Gerhart DZ, Enerson BE, Zhadankina OY, Leino RL, Drewes LR: Expression of the monocarboxylate transporter MCT2 by rat brain glia. Glia 1998;22:272-281.
26. Pierre K, Pellerin L: Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 2005;94:1-14.
27. Pierre K, Pellerin L, Debernardi R, Riederer BM, Magistretti PJ: Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy. Neuroscience 2000;100:617-627.
28. Maurer MH, Canis M, Kuschinsky W, Duelli R: Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain. Neurosci Letts 2004;355:105-108.
29. Koehler-Stec EM, Simpson IA, Vannucci SJ, Landschulz KT, Landschulz WH: Monocarboxylate transporter expression in mouse brain. Am J Physiol Endocrinol Metab 1998;275:E516-E524.
30. Debernardi R, Pierre K, Lengacher S, Magistretti PJ, Pellerin L: Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures. J Neurosci Res 2003;73:141-155.
31. Gerhart DZ, Enerson BE, Zhdankina OY, Leino RL, Drewes LR: Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. Am J Physiol 1997;273:E207-E213.
32. Leino RL, Gerhart DZ, Drewes LR: Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study. Dev Br Res 1999;113:47-54.
33. Broer S, Rahman B, Pellegri G, Pellerin L, Martin J, Verleysdonk S, Hamprecht B, Magistretti PJ: Comparison of lactate transporter in astroglial cells and monocarboxylate transporter 1 (MCT1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J Biol Chem 1997;272:30096-30102.
34. Hanu R, McKenna M, O'Neill A, Resneck WG, Bloch RJ: Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivo. Am J Physiol Cell Physiol 2000;278:C921-C930.
35. Gerhart DZ, Leino RL, Drewes LR: Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina. Neuroscience 1999;92:367-375.
36. Pierre K, Magistretti PJ, Pellerin L: MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. J Cereb Blood Flow Metab 2002;22:586-595.
37. Baud O, Fayol L, Gressens P, Pellerin L, Magistretti PJ, Evrard P, Verney C: Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. J Comp Neurol 2003;465:445-454.
38. Johannsson E, Lunde PK, Heddle C, Sjaastad I, Thomas MJ, Bergersen L, Halestrap AP, Blackstad TW, Ottersen OP, Sejersted OM: Upregulation of the cardiac monocarboxylate transporter MCT1 in a rat model of congestive heart failure. Circulation 2001;104:729-734.
39. Hasuo H, Akasu T: Monocarboxylate transporters contribute to the adaptation of neuronal activity to repeated glucose deprivation in the rat lateral septal nucleus. Synapse 2003;49:97-105.
40. Sakurai T, Yang B, Takata T, Yokono K: Synaptic adaptation to repeated hypoglycemia depends on the utilization of monocarboxylates in guinea pig hippocampal slices. Diabetes 2002;51:430-438.
41. Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U, Berd D, Leeper DB, Owen CS: Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther 2002;8:617-628.
42. Boussaouar F, Mauduit C, Tabone E, Pellerin L, Magistretti PJ, Benahmed M: Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cell. Biol Reprod 2003;69:1069-1078.
43. Smith JP, Drewes LR: Modulation of monocarboxylic acid transporter-1 kinetic function by the cAMP signaling pathway in rat brain endothelial cells. J Neurochem 2005;86:1468-1476.
44. Knott RM, Robertson M, Muckersie E, Folefac VA, Fairhurst FE, Wileman SM, Forrester JV: A model system for the study of human retinal angiogenesis: activation of monocytes and endothelial cells and the association with the expression of the monocarboxylate transporter type 1 (MCT-1). Diabetologia 1999;42:870-877.
45. Skold MK, Von Gertten C, Sandberg-Nordqvist AC, Mathiesen R, Holmin S: VEGF and VEGF receptor expression after experimental brain contusion in rat. J Neurotrauma 2005;22:353-367.
46. Yu R, Gao L, Jiang S, Guan P, Mao B: Association of HIF-1alpha expression and cell apoptosis after traumatic brain injury in the rat. Chin J Traumatol 2001;4:218-221.
47. McIntosh TK, Yu T, Gennarelli TA: Alterations in regional brain catecholamine concentrations after experimental brain injury in the rat. J Neurochem 1994;63:1426-1433.