A cool look at the structural changes in kinesin motor domains

Journal of Cell Science

Volumn 120, Issue 22, 2007, Pages 3919-3927

  Amos, Linda A ^a   Hirose, Keiko ^b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Cryo electron microscopy; Image reconstruction; Microtubule motors

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA TUBULIN; BETA TUBULIN; DIMER; KINESIN; MOLECULAR MOTOR; NUCLEOTIDE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CELL COMMUNICATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME STRUCTURE; HUMAN; HYDROLYSIS; MICROTUBULE; NOTE; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; DIMERIZATION; HUMANS; KINESIN; MICROTUBULES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TUBULIN;

EID: 37249034254     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.016931     Document Type: Note

References (44)

1. Al-Bassam, J., Cui, Y., Klopfenstein, D., Carragher, B. O., Vale, R. D. and Milligan, R. A. (2003). Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transition. J. Cell Biol. 163, 743-753.
2. Alonso, M. C., Vanderkerckhove, J. and Cross, R. A. (1998). Proteolytic mapping of kinesin/ncd-microtubule interface: Nucleotide-dependent conformational changes in the loops L8 and L12. EMBO J. 17, 945-951.
3. Alonso, M. C., Drummond, D. R., Kain, S., Hoeng, J., Amos, L. A. and Cross, R. A. (2007). An ATP gate controls tubulin binding by the tethered head of kinesin-1. Science 316, 120-123.
4. Arnal, I. and Wade, R. H. (1998). Nucleotide-dependent conformations of the kinesin dimer interacting with microtubules. Structure 6, 33-38.
5. Carter, N. J. and Cross, R. A. (2005). Mechanics of the kinesin step. Nature 435, 308-312.
6. Cohn, S. A., Ingold, A. L. and Scholey, J. M. (1989). Quantitative analysis of sea urchin egg kinesin-driven microtubule motility. J. Biol. Chem. 264, 4290-4297.
7. Cross, R. A., Crevel, I., Carter, N. J., Alonso, M. C., Hirose, K. and Amos, L. A. (2000). The conformational cycle of kinesin. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355, 459-464.
8. Endres, N. F., Yoshioka, C., Milligan, R. A. and Vale, R. D. (2006). A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature 439, 875-878.
9. Hackney, D. D. (2007). Processive motor movement. Science 316, 58-59.
10. Hancock, W. O. and Howard, J. (1998). Processivity of the motor protein kinesin requires two heads. J. Cell Biol. 140, 1395-1405.
11. Hirose, K., Lockhart, A., Cross, R. A. and Amos, L. A. (1996). Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules. Proc. Natl. Acad. Sci. USA 93, 9539-9544.
12. Hirose, K., Cross, R. A. and Amos, L. A. (1998). Nucleotide-dependent structural changes in dimeric NCD molecules complexed to microtubules. J. Mol. Biol. 278, 389-400.
13. Hirose, K., Löwe, J., Alonso, M., Cross, R. A. and Amos, L. A. (1999). Congruent docking of dimeric kinesin and ncd into three-dimensional electron cryomicroscopy maps of microtubule-motor ADP complexes. Mol. Biol. Cell 10, 2063-2074.
14. Hirose, K., Akimaru, E., Akiba, T., Endow, S. A. and Amos, L. A. (2006). Large conformational changes in a kinesin motor catalysed by interaction with microtubules. Mol. Cell 23, 913-923.
15. Hoenger, A., Sack, S., Thormahlen, M., Marx, A., Muller, J., Gross, H. and Mandelkow, E. (1998). Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with X-ray structure and implications for motility. J. Cell Biol. 141, 419-430.
16. Hoenger, A., Thormahlen, M., Diaz-Avalos, R., Doerhoefer, M., Goldie, K. N., Muller, J. and Mandelkow, E. (2000). A new look at the microtubule binding patterns of dimeric kinesins. J. Mol. Biol. 297, 1087-1103.
17. Kikkawa, M. (2004). A new theory and algorithm for reconstructing helical structures with a seam. J. Mol. Biol. 343, 943-955.
18. Kikkawa, M. and Hirokawa, N. (2006). High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations. EMBO J. 25, 4187-4194.
19. Kikkawa, M., Sablin, E. P., Okada, Y., Yajima, H., Fletterick, R. J. and Hirokawa, N. (2001). Switch-based mechanism of kinesin motors. Nature 411, 439-445.
20. Klumpp, L. M., Hoenger, A. and Gilbert, S. P. (2004). Kinesin's second step. Proc. Natl. Acad. Sci. USA 101, 3444-3449.
21. Kozielski, F., Sack, S., Marx, A., Thormahlen, M., Schonbrunn, E., Biou, V., Thompson, A., Mandelkow, E. M. and Mandelkow, E. (1997). The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell 91, 985-994.
22. Kozielski, F., De Bonis, S., Burmeister, W. P., Cohen-Addad, C. and Wade, R. H. (1999). The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations. Structure 7, 1407-1416.
23. Kull, F. J., Sablin, E. P., Lau, R., Fletterick, R. J. and Vale, R. D. (1996). Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature 380, 550-555.
24. Li, H., DeRosier, D. J., Nicholson, W. V., Nogales, E. and Downing, K. H. (2002). Microtubule structure at 8 A resolution. Structure 10, 1317-1328.
25. Löwe, J., Li, H., Downing, K. H. and Nogales, E. (2001). Refined structure of alpha beta-tubulin at 3.5 A resolution. J. Mol. Biol. 313, 1045-1057.
26. Moores, C. A. and Milligan, R. A. (2006). Lucky 13 - microtubule depolymerisation by kinesin-13 motors. J. Cell Sci. 119, 3905-3913.
27. Neumann, E., Garcia-Saez, I., DeBonis, S., Wade, R. H., Kozielski, F. and Conway, J. F. (2006). Human kinetochore-associated kinesin CENP-E visualized at 17 A resolution bound to microtubules. J. Mol. Biol. 362, 203-211.
28. Nitta, R., Kikkawa, M., Okada, Y. and Hirokawa, N. (2004). KIF1A alternately uses two loops to bind microtubules. Science 305, 678-683.
29. Ogawa, T., Nitta, R., Okada, Y. and Hirokawa, N. (2004). A common mechanism for microtubule destabilizers - M type kinesins stabilize curling of the protofilament using the class-specific neck and loops. Cell 116, 591-602.
30. Rice, S., Lin, A. W., Safer, D., Hart, C. L., Naber, N., Carragher, B. O., Cain, S. M., Pechatnikova, E., Wilson-Kubalek, E. M., Whittaker, M. et al. (1999). A structural change in the kinesin motor protein that drives motility. Nature 402, 778-784.
31. Sablin, E. P., Case, R. B., Dai, S. C., Hart, C. L., Ruby, A., Vale, R. D. and Fletterick, R. J. (1998). Direction determination in the minus-end-directed kinesin motor ncd. Nature 395, 813-816.
32. Sack, S., Müller, J., Marx, A., Thormählen, M., Mandelkow, E. M., Brady, S. T. and Mandelkow, E. (1997). X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry 36, 16155-16165.
33. Schnitzer, M. J. and Block, S. M. (1997). Kinesin hydrolyses one ATP per 9-nm step. Nature 388, 386-390.
34. Sindelar, C. V. and Downing, K. H. (2007). ne beginning of kinesin's force-generating cycle visualized at 9-A resolution. J. Cell Biol. 177, 377-385.
35. Sindelar, C. V., Budny, M. J., Rice, S., Naber, N., Fletterick, R. and Cooke, R. (2002). Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat. Struct. Biol. 9, 844-848.
36. Sosa, H., Hoenger, A. and Milligan, R. A. (1997). Three different approaches for calculating the three-dimensional structure of microtubules decorated with kinesin motor domains. J. Struct. Biol. 118, 149-158.
37. Turner, J., Anderson, R., Guo, J., Beraud, C., Fletterick, R. and Sakowicz, R. (2001). Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker. J. Biol. Chem. 276, 25496-25502.
38. Vale, R. D. and Milligan, R. A. (2000). The way things move: looking under the hood of molecular motor proteins. Science 288, 88-95.
39. Vale, R. D., Funatsu, T., Pierce, D. W., Romberg, L., Harada, Y. and Yanagida, T. (1996). Direct observation of single kinesin molecules moving along microtubules. Nature 380, 451-453.
40. Wendt, T. G., Volkmann, N., Skiniotis, G., Goldie, K. N., Muller, J., Mandelkow, E. and Hoenger, A. (2002). Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO J. 21, 5969-5978.
41. Woehlke, G., Ruby, A. K., Hart, C. L., Ly, B., Hom-Booher, N. and Vale, R. D. (1997). Microtubule interaction site of the kinesin motor. Cell 90, 207-216.
42. Young, E. C., Mahtani, H. K. and Gelles, J. (1998). One-headed kinesin derivatives move by a nonprocessive, low-duty ratio mechanism unlike that of two-headed kinesin. Biochemistry 37, 3467-3479.
43. Yun, M., Zhang, X., Park, C. G., Park, H. W. and Endow, S. A. (2001). A structural pathway for activation of the kinesin motor ATPase. EMBO J. 20, 2611-2618.
44. Yun, M., Bronner, C. E., Park, C. G., Cha, S. S., Park, H. W. and Endow, S. A. (2003). Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. EMBO J. 22, 5382-5389.