Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy

Nature Structural Biology

Volumn 9, Issue 11, 2002, Pages 844-848

  Sindelar, Charles V ^a   Budny, Mary Jane ^a   Rice, Sarah ^b   Naber, Nariman ^a   Fletterick, Robert ^a   Cooke, Roger ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; KINESIN;

ARTICLE; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; HUMAN; MICROTUBULE; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; KINESIN; LITHIUM COMPOUNDS; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR MOTOR PROTEINS; PHOSPHATES; PROTEIN CONFORMATION; SULFATES;

EID: 0036830220     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb852     Document Type: Article

References (32)

1. Goldstein, L.S. Proc. Natl. Acad. Sci. USA 98, 6999-7003 (2001).
2. Hirokawa, N. Science 279, 519-526 (1998).
3. Howard, J. Mechanics of Motor Proteins and the Cytoskeleton (Sinauer Associates, Sunderland; 2001).
4. Block, S.M. J. Cell. Biol. 140, 1281-1284 (1998).
5. Woehlke, G. Schliwa, M. Nature Rev. Mol. Cell. Biol. 1, 50-58 (2000).
6. Rice, S. et al. Nature 402, 778-784 (1999).
7. Case, R.B., Rice, S., Hart, C.L., Ly, B. Vale, R.D. Curr. Biol. 10, 157-160 (2000).
8. Vale, R.D., Case, R., Sablin, E., Hart, C. Fletterick, R. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355, 449-457 (2000).
9. Rosenfeld, S.S., Jefferson, G.M. King, P.H. J. Biol. Chem. 276, 40167-40174 (2001).
10. Kull, F.J., Sablin, E.P., Lau, R., Fletterick, R.J. Vale, R.D. Nature 380, 550-555 (1996).
11. Kozielski, F. et al. Cell 91, 985-994 (1997).
12. Sack, S. et al. Biochemistry 36, 16155-16165 (1997).
13. Sablin, E.P., Kull, F.J., Cooke, R., Vale, R.D. Fletterick, R. J. Nature 380, 555-559 (1996).
14. Muller, J., Marx, A., Sack, S., Song, Y.H. Mandelkow, E. Biol. Chem. 380, 981-992 (1999).
15. Song, Y.H. et al. EMBO J. 20, 6213-6225 (2001).
16. Turner, J. et al. J. Biol. Chem. 276, 25496-25502 (2001).
17. Kikkawa, M. et al. Nature 411, 439-445 (2001).
18. Xing, J. et al. J. Biol. Chem. 275, 35413-35423 (2000).
19. Rosenfeld, S.S., Correia, J.J., Xing, J., Rener, B. Cheung, H.C. J. Biol. Chem. 271, 30212-30221 (1996).
20. Rosenfeld, S.S., Rener, B., Correia, J, J., Mayo, M.S. Cheung, H.C. J. Biol. Chem. 271, 9473-9482 (1996).
21. Vale, R.D. Milligan, R.A. Science 288, 88-95 (2000).
22. Sablin, E.P. Fletterick, R.J. Curr. Opin. Struct. Biol. 11, 716-724 (2001).
23. Woehlke, G. et al. Cell 90, 207-216 (1997).
24. Sosa, H. et al. Cell 90, 217-224 (1997).
25. Baldwin, R.L. Biophys. J. 71, 2056-2063 (1996).
26. Naber, N., Cooke, R. Pate, E. Biochemistry 36, 9681-9689 (1997).
27. Otwinowski, Z. Minor, W. Methods Enzymol. 276, 307-326 (1997).
28. Kissinger, C.R., Gehlhaar, D.K. Fogel, D.B. Acta Crystallogr. D 55, 484-491 (1999).
29. Berman, H.M. et al. Nucleic Acids Res. 28, 235-242 (2000).
30. Brünger, A.T. et al. Acta Crystallogr. D 54, 905-921 (1998).
31. Vriend, G. J. Mol. Graph. 8, 52-56 (1990).
32. Guex, N. Peitsch, M.C. Electrophoresis 18, 2714-2723 (1997).