Helicobacter pylori vaccine development: Optimisation of strategies and importance of challenging strain and animal model

International Journal of Medical Microbiology

Volumn 298, Issue 1-2, 2008, Pages 151-159

  Hoffelner, Herbert ^a   Rieder, Gabriele ^a   Haas, Rainer ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Bacterial ghosts; Gerbil model; H. pylori; Lysis gene cassette; Vaccination

Indexed keywords

CYCLOSPORIN; HELICOBACTER PYLORI VACCINE; INTERLEUKIN 2; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; VACUOLATING TOXIN;

BACTERIAL STRAIN; BACTERIAL VIRULENCE; DRUG EFFICACY; FEASIBILITY STUDY; GASTROINTESTINAL INFECTION; GENE OVEREXPRESSION; GENE REPRESSION; GERBIL; GRAM NEGATIVE BACTERIUM; HELICOBACTER PYLORI; HUMAN; IMMUNIZATION; NONHUMAN; PROMOTER REGION; SHORT SURVEY;

EID: 36849020509     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2007.07.006     Document Type: Short Survey

References (54)

1. Algood H.M., Torres V.J., Unutmaz D., and Cover T.L. Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin. Infect. Immun. 75 (2007) 334-341
2. Allen L.A., Schlesinger L.S., and Kang B. Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages. J. Exp. Med. 191 (2000) 115-128
3. Blaser M.J. Ecology of Helicobacter pylori in the human stomach. J. Clin. Invest. 100 (1997) 759-762
4. Blaser M.J., Perez-Perez G.I., Kleanthous H., Cover T.L., Peek R.M., Chyou P.H., Stemmermann G.N., and Nomura A. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 55 (1995) 2111-2115
5. Boncristiano M., Paccani S.R., Barone S., Ulivieri C., Patrussi L., Ilver D., Boncristiano M., Paccani S.R., Barone S., Ulivieri C., Patrussi L., Ilver D., Amedei A., D'Elios M.M., Telford J.L., and Baldari C.T. The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J. Exp. Med. 198 (2003) 1887-1897
6. Bowe F., O' Gaora P., Maskell D., Cafferkey M., and Dougan G. Virulence, persistence, and immunogenicity of Yersinia enterocolitica O:8 aroA mutants. Infect. Immun. 57 (1989) 3234-3236
7. Brest P., Hofman V., Lassalle S., Cesaro A., Ricci V., Selva E., Auberger P., and Hofman P. Human polymorphonuclear leukocytes are sensitive in vitro to Helicobacter pylori VacA toxin. Helicobacter 11 (2006) 544-555
8. Covacci A., Censini S., Bugnoli M., Petracca R., Burroni D., Macchia G., Massone A., Papini E., Xiang Z., Figura N., and Rappuoli R. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl. Acad. Sci. USA 90 (1993) 5791-5795
9. Cover T.L., and Blaser M.J. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J. Biol. Chem. 267 (1992) 10570-10575
10. Del Giudice G., Covacci A., Telford J.L., Montecucco C., and Rappuoli R. The design of vaccines against Helicobacter pylori and their development. Annu. Rev. Immunol. 19 (2001) 523-563
11. Ermak T.H., Giannasca P.J., Nichols R., Myers G.A., Nedrud J., Weltzin R., Lee C.K., Kleanthous H., and Monath T.P. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J. Exp. Med. 188 (1998) 2277-2288
12. Fassbinder F., van Vliet A.H., Gimmel V., Kusters J.G., Kist M., and Bereswill S. Identification of iron-regulated genes of Helicobacter pylori by a modified fur titration assay (FURTA-Hp). FEMS Microbiol. Lett. 184 (2000) 225-229
13. Gebert B., Fischer W., Weiss E., Hoffmann R., and Haas R. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 301 (2003) 1099-1102
14. Gomez-Duarte O.G., Bumann D., and Meyer T.F. The attenuated Salmonella vaccine approach for the control of Helicobacter pylori-related diseases. Vaccine 17 (1999) 1667-1673
15. Hatakeyama M. Helicobacter pylori CagA - a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins. Microbes Infect. 5 (2003) 143-150
16. Hensel A., van Leengoed L.A., Szostak M., Windt H., Weissenbock H., Stockhofe-Zurwieden N., Katinger A., Stadler M., Ganter M., Bunka S., Pabst R., and Lubitz W. Induction of protective immunity by aerosol or oral application of candidate vaccines in a dose-controlled pig aerosol infection model. J. Biotechnol. 44 (1996) 171-181
17. Hensel A., Huter V., Katinger A., Raza P., Strnistschie C., Roesler U., Brand E., and Lubitz W. Intramuscular immunization with genetically inactivated (ghosts) Actinobacillus pleuropneumoniae serotype 9 protects pigs against homologous aerosol challenge and prevents carrier state. Vaccine 18 (2000) 2945-2955
18. Hess J., and Kaufmann S.H. Live antigen carriers as tools for improved anti-tuberculosis vaccines. FEMS Immunol. Med. Microbiol. 23 (1999) 165-173
19. Heuermann D., and Haas R. A stable shuttle vector system for efficient genetic complementation of Helicobacter pylori strains by transformation and conjugation. Mol. Gen. Genet. 257 (1998) 519-528
20. Höfler C., Fischer W., Hofreuter D., and Haas R. Cryptic plasmids in Helicobacter pylori: putative functions in conjugative transfer and microcin production. Int. J. Med. Microbiol. 94 (2004) 141-148
21. Hofreuter D., and Haas R. Characterization of two cryptic Helicobacter pylori plasmids: a putative source for horizontal gene transfer and gene shuffling. J. Bacteriol. 184 (2002) 2755-2766
22. Jalava K., Eko F.O., Riedmann E., and Lubitz W. Bacterial ghosts as carrier and targeting systems for mucosal antigen delivery. Expert Rev. Vaccines 2 (2003) 45-51
23. Jechlinger W., Szostak M.P., Witte A., and Lubitz W. Altered temperature induction sensitivity of the lambda pR/cI857 system for controlled gene E expression in Escherichia coli. FEMS Microbiol. Lett. 173 (1999) 347-352
24. Kavermann H., Burns B.P., Angermüller K., Odenbreit S., Fischer W., Melchers K., and Haas R. Identification and characterization of Helicobacter pylori genes essential for gastric colonization. J. Exp. Med. 197 (2003) 813-822
25. Kranzer K., Sollner L., Aigner M., Lehn N., Deml L., Rehli M., and Schneider-Brachert W. Impact of Helicobacter pylori virulence factors and compounds on activation and maturation of human dendritic cells. Infect. Immun. 73 (2005) 4180-4189
26. Lee A., O′Rourke J., de Ungria M.C., Robertson B., Daskalopoulos G., and Dixon M.F. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 112 (1997) 1386-1397
27. Linz B., Balloux F., Moodley Y., Manica A., Liu H., Roumagnac P., Falush D., Stamer C., Prugnolle F., van der Merwe S.W., Yamaoka Y., Graham D.Y., Perez-Trallero E., Wadstrom T., Suerbaum S., and Achtman M. An African origin for the intimate association between humans and Helicobacter pylori. Nature 445 (2007) 915-918
28. McClain M.S., Cao P., Iwamoto H., Vinion-Dubiel A.D., Szabo G., Shao Z., and Cover T.L. A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation. J. Bacteriol. 183 (2001) 6499-6508
29. Molinari M., Salio M., Galli C., Norais N., Rappuoli R., Lanzavecchia A., and Montecucco C. Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J. Exp. Med. 187 (1998) 135-140
30. Nardelli-Haefliger D., Kraehenbuhl J.P., Curtiss R., Schodel F., Potts A., Kelly S., and Degrandi P. Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain. Infect. Immun. 64 (1996) 5219-5224
31. Odenbreit S., and Haas R. Helicobacter pylori: impact of gene transfer and the role of the cag pathogenicity island for host adaptation and virulence. Curr. Top. Microbiol. Immunol. 264 (2002) 1-22
32. Odenbreit S., Püls J., Sedlmaier B., Gerland E., Fischer W., and Haas R. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287 (2000) 1497-1500
33. Pagliaccia C., de Bernard M., Lupetti P., Ji X., Burroni D., Cover T.L., Papini E., Rappuoli R., Telford J.L., and Reyrat J.M. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity. Proc. Natl. Acad. Sci. USA 95 (1998) 10212-10217
34. Panthel K., Faller G., and Haas R. Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: effect of vaccination and implications for innate and acquired immunity. Infect. Immun. 71 (2003) 794-800
35. Panthel K., Jechlinger W., Matis A., Rohde M., Szostak M., Lubitz W., and Haas R. Generation of Helicobacter pylori ghosts by PhiX protein E-mediated inactivation and their evaluation as vaccine candidates. Infect. Immun. 71 (2003) 109-116
36. Paukner S., Kohl G., and Lubitz W. Bacterial ghosts as novel advanced drug delivery systems: antiproliferative activity of loaded doxorubicin in human Caco-2 cells. J. Control. Rel. 94 (2004) 63-74
37. Peek R.M., and Blaser M.J. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer 2 (2002) 28-37
38. Peek R.M., Wirth H.P., Moss S.F., Yang M., Abdalla A.M., Tham K.T., Zhang T., Tang L.H., Modlin I.M., and Blaser M.J. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Gastroenterology 118 (2000) 48-59
39. Rieder G., Fischer W., and Haas R. Interaction of Helicobacter pylori with host cells: function of secreted and translocated molecules. Curr. Opin. Microbiol. 8 (2005) 67-73
40. Rieder G., Merchant J.L., and Haas R. Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology 128 (2005) 1229-1242
41. Rüssmann H., Shams H., Poblete F., Fu Y., Galan J.E., and Donis R.O. Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science 281 (1998) 565-568
42. Salama N.R., Otto G., Tompkins L., and Falkow S. Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection. Infect. Immun. 69 (2001) 730-736
43. Sansonetti P.J., and Arondel J. Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis. Vaccine 7 (1989) 443-450
44. Schmitt W., Odenbreit S., Heuermann D., and Haas R. Cloning of the Helicobacter pylori recA gene and functional characterization of its product. Mol. Gen. Genet. 248 (1995) 563-572
45. Shi T., Liu W.Z., Gao F., Shi G.Y., and Xiao S.D. Intranasal CpG-oligodeoxynucleotide is a potent adjuvant of vaccine against Helicobacter pylori, and T helper 1 type response and interferon-gamma correlate with the protection. Helicobacter 10 (2005) 71-79
46. Suerbaum S., and Josenhans C. Virulence factors of Helicobacter pylori: implications for vaccine development. Mol. Med. Today 5 (1999) 32-39
47. Sundrud M.S., Torres V.J., Unutmaz D., and Cover T.L. Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc. Natl. Acad. Sci. USA 101 (2004) 7727-7732
48. Suzuki T., Matsuo K., Sawaki A., Ito H., Hirose K., Wakai K., Sato S., Nakamura T., Yamao K., Ueda R., and Tajima K. Systematic review and meta-analysis: importance of CagA status for successful eradication of Helicobacter pylori infection. Aliment. Pharmacol. Ther. 24 (2006) 273-280
49. Szostak M.P., Hensel A., Eko F.O., Klein R., Auer T., Mader H., Haslberger A., Bunka S., Wanner G., and Lubitz W. Bacterial ghosts: non-living candidate vaccines. J. Biotechnol. 44 (1996) 161-170
50. Terebiznik M.R., Vazquez C.L., Torbicki K., Banks D., Wang T., Hong W., Blanke S.R., Colombo M.I., and Jones N.L. Helicobacter pylori VacA toxin promotes bacterial intracellular survival in gastric epithelial cells. Infect. Immun. 74 (2006) 6599-6614
51. van Doorn N.E., Namavar F., Sparrius M., Stoof J., van Rees E.P., van Doorn L.J., and Vandenbroucke-Grauls C.M. Helicobacter pylori-associated gastritis in mice is host and strain specific. Infect. Immun. 67 (1999) 3040-3046
52. Watanabe T., Tada M., Nagai H., Sasaki S., and Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 115 (1998) 642-648
53. Witte A., Blasi U., Halfmann G., Szostak M., Wanner G., and Lubitz W. Phi X174 protein E-mediated lysis of Escherichia coli. Biochimie 72 (1990) 191-200
54. Witte A., Wanner G., Blasi U., Halfmann G., Szostak M., and Lubitz W. Endogenous transmembrane tunnel formation mediated by phi X174 lysis protein E. J. Bacteriol. 172 (1990) 4109-4114