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Volumn 5, Issue 1, 1999, Pages 32-39

Virulence factors of Helicobacter pylori: Implications for vaccine development

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL VACCINE;

EID: 0032619623     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(98)01390-2     Document Type: Review
Times cited : (23)

References (54)
  • 1
    • 0031906782 scopus 로고    scopus 로고
    • Epidemiology of Helicobacter pylori: Acquisition, transmission, population prevalence and disease-to-infection ratio
    • Feldman, R.A., Eccersley, A.J. and Hardie, J.M. (1998) Epidemiology of Helicobacter pylori: acquisition, transmission, population prevalence and disease-to-infection ratio, Br. Med. Bull. 54, 39-53
    • (1998) Br. Med. Bull. , vol.54 , pp. 39-53
    • Feldman, R.A.1    Eccersley, A.J.2    Hardie, J.M.3
  • 4
    • 0029815909 scopus 로고    scopus 로고
    • The effect of environmental pH on the proton motive force of Helicobacter pylori
    • Meyer Rosberg, K. et al. (1996) The effect of environmental pH on the proton motive force of Helicobacter pylori, Gastroenterology 111, 886-900
    • (1996) Gastroenterology , vol.111 , pp. 886-900
    • Meyer Rosberg, K.1
  • 5
    • 0028122564 scopus 로고
    • Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori
    • Eaton, K. A. and Krakowka, S. (1994) Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori, Infect. Immun. 62, 3604-3607
    • (1994) Infect. Immun. , vol.62 , pp. 3604-3607
    • Eaton, K.A.1    Krakowka, S.2
  • 6
    • 0028925321 scopus 로고
    • Essential role of Helicobacter pylori urease in gastric colonization: Definite proof using a urease-negative mutant constructed by gene replacement
    • Tsuda, M. et al. (1994) Essential role of Helicobacter pylori urease in gastric colonization: definite proof using a urease-negative mutant constructed by gene replacement, Eur. J. Gastroenterol. Hepatol. 6, 49-52
    • (1994) Eur. J. Gastroenterol. Hepatol. , vol.6 , pp. 49-52
    • Tsuda, M.1
  • 7
    • 0029086241 scopus 로고
    • Inability of an isogenic urease-negative mutant strain of Helicobacter mustelae to colonize the ferret stomach
    • Andrutis, K.A. et al. (1995) Inability of an isogenic urease-negative mutant strain of Helicobacter mustelae to colonize the ferret stomach, Infect. Immun. 63, 3722-3725
    • (1995) Infect. Immun. , vol.63 , pp. 3722-3725
    • Andrutis, K.A.1
  • 8
    • 0030058092 scopus 로고    scopus 로고
    • Helicobacter pylori utilises urea for amino acid synthesis
    • Williams, C.L. et al. (1996) Helicobacter pylori utilises urea for amino acid synthesis, FEMS Immunol. Med. Microbiol. 13, 87-94
    • (1996) FEMS Immunol. Med. Microbiol. , vol.13 , pp. 87-94
    • Williams, C.L.1
  • 9
    • 0025324062 scopus 로고
    • Helicobacter pylori urease activity is toxic to human gastric epithelial cells
    • Smoot, D.T. et al. (1990) Helicobacter pylori urease activity is toxic to human gastric epithelial cells, Infect. Immun. 58, 1992-1994
    • (1990) Infect. Immun. , vol.58 , pp. 1992-1994
    • Smoot, D.T.1
  • 10
    • 0031887519 scopus 로고    scopus 로고
    • Highly significant role of Helicobacter pylori urease in phagocytosis and production of oxygen metabolites by human granulocytes
    • Makristathis, A. et al. (1998) Highly significant role of Helicobacter pylori urease in phagocytosis and production of oxygen metabolites by human granulocytes, J. Infect. Dis. 177, 803-806
    • (1998) J. Infect. Dis. , vol.177 , pp. 803-806
    • Makristathis, A.1
  • 11
    • 0032543222 scopus 로고    scopus 로고
    • The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: A mechanism for T helper cell type 1-mediated damage
    • Fan, X. et al. (1998) The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for T helper cell type 1-mediated damage, J. Exp. Med. 187, 1659-1669
    • (1998) J. Exp. Med. , vol.187 , pp. 1659-1669
    • Fan, X.1
  • 12
    • 0026096795 scopus 로고
    • Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella
    • Kostrzynska, M., Betts, J.D., Austin, J.W. and Trust, T.J. (1991) Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella, J. Bacteriol. 173, 937-946
    • (1991) J. Bacteriol. , vol.173 , pp. 937-946
    • Kostrzynska, M.1    Betts, J.D.2    Austin, J.W.3    Trust, T.J.4
  • 13
    • 0027252455 scopus 로고
    • Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange
    • Suerbaum, S., Josenhans, C. and Labigne, A. (1993) Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange, J. Bacteriol. 175, 3278-3288
    • (1993) J. Bacteriol. , vol.175 , pp. 3278-3288
    • Suerbaum, S.1    Josenhans, C.2    Labigne, A.3
  • 14
    • 0029019564 scopus 로고
    • Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: Both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species
    • Josenhans, C., Labigne, A. and Suerbaum, S. (1995) Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: Both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species, J. Bacteriol. 177, 3010-3020
    • (1995) J. Bacteriol. , vol.177 , pp. 3010-3020
    • Josenhans, C.1    Labigne, A.2    Suerbaum, S.3
  • 15
    • 0030835739 scopus 로고    scopus 로고
    • The complete genome sequence of the gastric pathogen Helicobacter pylori
    • Tomb, J-F. et al. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori, Nature 388, 539-547
    • (1997) Nature , vol.388 , pp. 539-547
    • Tomb, J.-F.1
  • 16
    • 0030945164 scopus 로고    scopus 로고
    • Infection of the ferret stomach by isogenic flagellar mutant strains of Helicobacter mustelae
    • Andrutis, K. A. et al. (1997) Infection of the ferret stomach by isogenic flagellar mutant strains of Helicobacter mustelae, Infect. Immun. 65, 1962-1966
    • (1997) Infect. Immun. , vol.65 , pp. 1962-1966
    • Andrutis, K.A.1
  • 17
    • 0030002653 scopus 로고    scopus 로고
    • Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes
    • Eaton, K.A., Suerbaum, S., Josenhans, C. and Krakowka, S. (1996) Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes, Infect. Immun. 64, 2445-2448
    • (1996) Infect. Immun. , vol.64 , pp. 2445-2448
    • Eaton, K.A.1    Suerbaum, S.2    Josenhans, C.3    Krakowka, S.4
  • 18
    • 0031872407 scopus 로고    scopus 로고
    • Meaning and therapeutic potential of microbial recognition of host glycoconjugates
    • Karlsson, K.A. (1998) Meaning and therapeutic potential of microbial recognition of host glycoconjugates, Mol. Microbiol. 29, 1-11
    • (1998) Mol. Microbiol. , vol.29 , pp. 1-11
    • Karlsson, K.A.1
  • 19
    • 15444357984 scopus 로고    scopus 로고
    • Helicobacter pylori adhesin binding fucosylated histoblood group antigens revealed by retagging
    • Ilver, D. et al. (1998) Helicobacter pylori adhesin binding fucosylated histoblood group antigens revealed by retagging, Science 279, 373-377
    • (1998) Science , vol.279 , pp. 373-377
    • Ilver, D.1
  • 20
    • 85056014912 scopus 로고    scopus 로고
    • Genetic and functional characterization of the AlpAB gene locus essential for adhesion of Helicobacter pylori to human gastric tissue
    • in press
    • Odenbreit, S. et al. Genetic and functional characterization of the AlpAB gene locus essential for adhesion of Helicobacter pylori to human gastric tissue, Mol. Microbiol. in press
    • Mol. Microbiol.
    • Odenbreit, S.1
  • 21
    • 0029923910 scopus 로고    scopus 로고
    • The vacuolating cytotoxin of Helicobacter pylori
    • Cover, T.L. (1996) The vacuolating cytotoxin of Helicobacter pylori, Mol. Microbiol. 20, 241-246
    • (1996) Mol. Microbiol. , vol.20 , pp. 241-246
    • Cover, T.L.1
  • 22
    • 0028818757 scopus 로고
    • Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant
    • De Bernard, M. et al. (1995) Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant, J. Biol Chem. 270, 23 937-23 940
    • (1995) J. Biol Chem. , vol.270 , pp. 23937-23940
    • De Bernard, M.1
  • 23
    • 0028067979 scopus 로고
    • Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments
    • Papini, E. et al. (1994) Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments, Proc. Natl. Acad. Sci. U. S. A. 91, 9720-9724
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 9720-9724
    • Papini, E.1
  • 24
    • 0031929493 scopus 로고    scopus 로고
    • H. pylori virulence factors
    • Atherton, J.C. (1998) H. pylori virulence factors, Br. Med. Bull. 54, 105-120
    • (1998) Br. Med. Bull. , vol.54 , pp. 105-120
    • Atherton, J.C.1
  • 25
    • 0027230726 scopus 로고
    • Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production
    • Tummuru, M.K., Cover, T.L. and Blaser, M.J. (1993) Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production, Infect. Immun. 61, 1799-1809
    • (1993) Infect. Immun. , vol.61 , pp. 1799-1809
    • Tummuru, M.K.1    Cover, T.L.2    Blaser, M.J.3
  • 26
    • 0029963677 scopus 로고    scopus 로고
    • Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    • Censini, S. et al. (1996) Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors, Proc. Natl. Acad. Sci. U. S. A. 93, 14648-14653
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14648-14653
    • Censini, S.1
  • 27
    • 0031573690 scopus 로고    scopus 로고
    • A secreted/shed product of Helicobacter pylori activates transcription factor nuclear factor-kappa B
    • Münzenmaier, A. et al. (1997) A secreted/shed product of Helicobacter pylori activates transcription factor nuclear factor-kappa B, J. Immunol. 159, 6140-6147
    • (1997) J. Immunol. , vol.159 , pp. 6140-6147
    • Münzenmaier, A.1
  • 28
    • 0027365355 scopus 로고
    • Helicobacter pylori: Comparison of DNA fingerprints provides evidence for intrafamilial infection
    • Bamford, K.B. et al. (1993) Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection, Gut 34, 1348-1350
    • (1993) Gut , vol.34 , pp. 1348-1350
    • Bamford, K.B.1
  • 29
    • 13144251208 scopus 로고    scopus 로고
    • Free recombination within Helicobacter pylori
    • Suerbaum, S. et al. (1998) Free recombination within Helicobacter pylori, Proc. Natl. Acad. Sci. U. S. A. 95, 12619-12624
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 12619-12624
    • Suerbaum, S.1
  • 30
    • 0032944936 scopus 로고    scopus 로고
    • Emergence of recombinant strains of Helicobacter pylori during human infection
    • in press
    • Kersulyte, D., Chalkauskas, H. and Berg, D.E. Emergence of recombinant strains of Helicobacter pylori during human infection, Mol. Microbiol. (in press)
    • Mol. Microbiol.
    • Kersulyte, D.1    Chalkauskas, H.2    Berg, D.E.3
  • 32
    • 0026536465 scopus 로고
    • Immunisation against gastric Helicobacter infection in a mouse/Helicobacter felis model
    • Chen, M., Lee, A. and Hazell, S. (1992) Immunisation against gastric Helicobacter infection in a mouse/Helicobacter felis model, Lancet 339, 1120-1121
    • (1992) Lancet , vol.339 , pp. 1120-1121
    • Chen, M.1    Lee, A.2    Hazell, S.3
  • 33
    • 0027265078 scopus 로고
    • Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization
    • Czinn, S.J., Cai, A. and Nedrud, J.G. (1993) Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization, Vaccine 11, 637-642
    • (1993) Vaccine , vol.11 , pp. 637-642
    • Czinn, S.J.1    Cai, A.2    Nedrud, J.G.3
  • 34
    • 0028205426 scopus 로고
    • Therapeutic immunisation against Helicobacter infection
    • Doidge, C. et al. (1994) Therapeutic immunisation against Helicobacter infection , Lancet 343, 914-915
    • (1994) Lancet , vol.343 , pp. 914-915
    • Doidge, C.1
  • 35
    • 0029079502 scopus 로고
    • Oral immunisation with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice
    • Corthésy-Theulaz, I. et al. (1995) Oral immunisation with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice, Gastroenterology 109, 115-121
    • (1995) Gastroenterology , vol.109 , pp. 115-121
    • Corthésy-Theulaz, I.1
  • 36
    • 0028918767 scopus 로고
    • Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants
    • Douce, G. et al. (1995) Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants, Proc. Nail. Acad. Sci. U. S. A. 92, 1644-1648
    • (1995) Proc. Nail. Acad. Sci. U. S. A. , vol.92 , pp. 1644-1648
    • Douce, G.1
  • 37
    • 0032054708 scopus 로고    scopus 로고
    • LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp
    • Chong, C., Friberg, M. and Clements, J.D. (1998) LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp., Vaccine 16, 732-740
    • (1998) Vaccine , vol.16 , pp. 732-740
    • Chong, C.1    Friberg, M.2    Clements, J.D.3
  • 38
    • 0030728943 scopus 로고    scopus 로고
    • Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection
    • Ghiara, P. et al. (1997) Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection, Infect. Immun. 65, 4996-5002
    • (1997) Infect. Immun. , vol.65 , pp. 4996-5002
    • Ghiara, P.1
  • 39
    • 0028068834 scopus 로고
    • Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease
    • Michetti, P. et al. (1994) Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease, Gastroenterology 107, 1002-1011
    • (1994) Gastroenterology , vol.107 , pp. 1002-1011
    • Michetti, P.1
  • 40
    • 0029069313 scopus 로고
    • Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis
    • Lee, C.K. et al. (1995) Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis, J. Infect. Dis. 172, 161-172
    • (1995) J. Infect. Dis. , vol.172 , pp. 161-172
    • Lee, C.K.1
  • 41
    • 0027971660 scopus 로고
    • Recombinant antigens prepared from the urease subunits of Helicobacter spp.: Evidence of protection in a mouse model of gastric infection
    • Ferrero, R.L., Thiberge, J-M., Huerre, M. and Labigne, A. (1994) Recombinant antigens prepared from the urease subunits of Helicobacter spp.: Evidence of protection in a mouse model of gastric infection, Infect. Immun. 62, 4981-4989
    • (1994) Infect. Immun. , vol.62 , pp. 4981-4989
    • Ferrero, R.L.1    Thiberge, J.-M.2    Huerre, M.3    Labigne, A.4
  • 42
    • 0028052002 scopus 로고
    • Helicobacter pylori hspA-hspB heat shock gene cluster: Nucleotide sequence, expression, putative function and immunogenicity
    • Suerbaum, S. et al. (1994) Helicobacter pylori hspA-hspB heat shock gene cluster: nucleotide sequence, expression, putative function and immunogenicity, Mol. Microbiol. 14, 959-974
    • (1994) Mol. Microbiol. , vol.14 , pp. 959-974
    • Suerbaum, S.1
  • 43
    • 0029056004 scopus 로고
    • The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice
    • Ferrero, R.L. et al. (1995) The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice, Proc. Natl. Acad. Sci. U. S. A. 92, 6499-6503
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 6499-6503
    • Ferrero, R.L.1
  • 44
    • 0030728943 scopus 로고    scopus 로고
    • Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection
    • Ghiara, P et al. (1997) Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection, Infect. Immun. 65, 4996-5002
    • (1997) Infect. Immun. , vol.65 , pp. 4996-5002
    • Ghiara, P.1
  • 45
    • 0030831941 scopus 로고    scopus 로고
    • Detoxification of the Helicobacter pylori cytotoxin
    • Manetti, R. et al. (1997) Detoxification of the Helicobacter pylori cytotoxin, Infect. Immun. 65, 4615-4619
    • (1997) Infect. Immun. , vol.65 , pp. 4615-4619
    • Manetti, R.1
  • 46
    • 0029738910 scopus 로고    scopus 로고
    • Immunogenicity and safety of recombinant Helicobacter pylori urease in a nonhuman primate
    • Stadtlander, C.T. et al. (1996) Immunogenicity and safety of recombinant Helicobacter pylori urease in a nonhuman primate, Dig. Dis. Sci. 41, 1853-1862
    • (1996) Dig. Dis. Sci. , vol.41 , pp. 1853-1862
    • Stadtlander, C.T.1
  • 47
    • 0029940288 scopus 로고    scopus 로고
    • Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets
    • Cuenca, R. et al. (1996) Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets, Gastroenterology 110, 1770-1775
    • (1996) Gastroenterology , vol.110 , pp. 1770-1775
    • Cuenca, R.1
  • 48
    • 0030014767 scopus 로고    scopus 로고
    • Safety of oral immunisation with recombinant urease in patients with Helicobacter pylori infection
    • Kreiss, C. et al. (1996) Safety of oral immunisation with recombinant urease in patients with Helicobacter pylori infection, Lancet 347, 1630-1631
    • (1996) Lancet , vol.347 , pp. 1630-1631
    • Kreiss, C.1
  • 49
    • 0001324363 scopus 로고    scopus 로고
    • Oral immunization of H. pylori infected adults with recombinant urease and LT adjuvant
    • Michetti, P. et al. (1997) Oral immunization of H. pylori infected adults with recombinant urease and LT adjuvant, Gastroenterology 112, A1042
    • (1997) Gastroenterology , vol.112
    • Michetti, P.1
  • 50
    • 0032078331 scopus 로고    scopus 로고
    • Systemic immunization with urease protects mice against Helicobacter pylori infection
    • Guy, B. et al. (1998) Systemic immunization with urease protects mice against Helicobacter pylori infection, Vaccine 16, 850-856
    • (1998) Vaccine , vol.16 , pp. 850-856
    • Guy, B.1
  • 51
    • 0032033279 scopus 로고    scopus 로고
    • Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B
    • Gomez-Duarte, O.G. et al. (1998) Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B, Vaccine 16, 460-471
    • (1998) Vaccine , vol.16 , pp. 460-471
    • Gomez-Duarte, O.G.1
  • 52
    • 2642708349 scopus 로고    scopus 로고
    • Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits
    • Corthésy-Theulaz, I.E. et al. (1998) Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits, Infect. Immun. 66, 581-586
    • (1998) Infect. Immun. , vol.66 , pp. 581-586
    • Corthésy-Theulaz, I.E.1
  • 53
    • 0030829775 scopus 로고    scopus 로고
    • Gastritis in urease-immunized mice after Helicobacter felis challenge may be due to residual bacteria
    • Ermak, T.H. et al. (1997) Gastritis in urease-immunized mice after Helicobacter felis challenge may be due to residual bacteria, Gastroenterology 113, 1118-1128
    • (1997) Gastroenterology , vol.113 , pp. 1118-1128
    • Ermak, T.H.1
  • 54
    • 0030732291 scopus 로고    scopus 로고
    • Catalase, a novel antigen for Helicobacter pylori vaccination
    • Radcliff, F.J. et al. (1997) Catalase, a novel antigen for Helicobacter pylori vaccination, Infect. Immun. 65, 4668-4674
    • (1997) Infect. Immun. , vol.65 , pp. 4668-4674
    • Radcliff, F.J.1


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