Genetics and neuroimaging of attention and hypnotizability may elucidate placebo

International Journal of Clinical and Experimental Hypnosis

Volumn 56, Issue 1, 2008, Pages 99-116

  Raz, Amir ^a,b,c  

^a New York State Psychiatric Institute ^*  (United States)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CLONIDINE; GUANFACINE; METHYLPHENIDATE; SCOPOLAMINE;

ATTENTION; ATTENTION DEFICIT DISORDER; COGNITION; GENETIC POLYMORPHISM; HUMAN; HYPNOSIS; HYPNOTIC SUSCEPTIBILITY; MEDICAL RESEARCH; NEUROANATOMY; NEUROIMAGING; NONHUMAN; PHENOTYPE; REVIEW;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; HUMANS; HYPNOSIS; MAGNETIC RESONANCE IMAGING; NERVE NET; PLACEBO EFFECT; RECEPTORS, DOPAMINE D4;

EID: 36849018969     PISSN: 00207144     EISSN: 17445183     Source Type: Journal    
DOI: 10.1080/00207140701506482     Document Type: Review

References (98)

1. Avale, M. E., Falzone, T. L., Gelman, D. M., Low, M. J., Grandy, D. K., & Rubinstein, M. (2004). The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder. Molecular Psychiatry, 9, 718-726.
2. Bachner-Melman, R., & Ebstein, R. (2002). No link between hypnotizability and the Self-Monitoring Scale. American Journal of Clinical Hypnosis, 45, 21-30.
3. Bauman, D. E., & Bul', P. I. (1981). Human inheritability of hypnotizability. Genetika, 17, 352-356.
4. Baumeister, R. F., & Vohs, K. D. (2004). Handbook of self regulation. New York: Guilford.
5. Beauregard, M., Levesque, J., & Bourgouin, P. (2001). Neural correlates of conscious selfregulation of emotion. Journal of Neuroscience, 21(18), RC165.
6. Benjamin, J., Osher, Y., Lichtenberg, P., Bachner-Melman, R., Gritsenko, I., Kotler, M., et al. (2000). An interaction between the catechol O-methyltransferase and serotonin transporter promoter region polymorphisms contributes to tridimensional personality questionnaire persistence scores in normal subjects. Neuropsychobiology, 41, 48-53.
7. Berger, A., Jones, L., Rothbart, M. K., & Posner, M. I. (2000). Computerized games to study the development of attention in childhood. Behavior Research Methods, Instruments, & Computers, 32, 297-303.
8. Bilder, R. M., Volavka, J., Czobor, P., Malhotra, A. K., Kennedy, J. L., Ni, X., et al. (2002). Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biology of Psychiatry, 52, 701-707.
9. Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J., et al. (2003). A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. American Journal of Human Genetics, 73, 152-161.
10. Bush, G. (2004). Multimodal studies of cingulate cortex. In M. I. Posner (Ed.), Cognitive Neuroscience of Attention (pp. 207-218). New York: Guilford.
11. Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Science, 4, 215-222.
12. Chen, C. H., Lee, Y. R., Liu, M. Y., Wei, F. C., Koong, F. J., Hwu, H. G., et al. (1996). Identification of a BglI polymorphism of catechol-O- methyltransferase (COMT) gene, and association study with schizophrenia. American Journal of Medical Genetics, 67, 556-559.
13. Chen, X., Wang, X., O'Neill, A. F., Walsh, D., & Kendler, K. S. (2004). Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families. Molecular Psychiatry, 9, 962-967.
14. Churchland, P. S. (2002). Brain-wise: Studies in neurophilosophy. Cambridge, MA: MIT Press.
15. Corbetta, M., Kincade, J. M., Ollinger, J. M., McAvoy, M. P., & Shulman, G. L. (2000). Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Natural Neuroscience, 3, 292-297.
16. Cumming, P., Brown, E., Damsma, G., & Fibiger, H. (1992). Formation and clearance of interstitial metabolites of dopamine and serotonin in the rat striatum: An in vivo microdialysis study. Journal of Neurochemistry, 59, 1905-1914.
17. de Chaldee, M., Corbex, M., Campion, D., Jay, M., Samolyk, D., Petit, M., et al. (2001). No evidence for linkage between COMT and schizophrenia in a French population. Psychiatry Research, 102, 87-90.
18. Diamond, A., Briand, L., Fossella, J., & Gehlbach, L. (2004). Genetic and neurochemical modulation of prefrontal cognitive functions in children. American Journal of Psychiatry, 161, 125-132.
19. Ding, Y. C., Chi, H. C., Grady, D. L., Morishima, A., Kidd, J. R., Kidd, K. K., et al. (2002). Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proceedings of the National Academy of Science USA, 99, 309-314.
20. Ebstein, R. P., Bachner-Melman, R., & Lichtenberg, P. (1999). Genetic and cognitive factors in hypnotizability: Association between the low enzyme activity catechol O- methyl transferase (COMT) MET allele and high hypnotizability. Molecular Psychiatry, 4(240), Suppl.
21. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., et al. (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Science USA, 98, 6917-6922.
22. Enoch, M. A., Xu, K., Ferro, E., Harris, C. R., & Goldman, D. (2003). Genetic origins of anxiety in women: A role for a functional catechol-O-methyltransferase polymorphism. Psychiatric Genetics, 13, 33-41.
23. Falzone, T. L., Gelman, D. M., Young, J. I., Grandy, D. K., Low, M. J., & Rubinstein, M. (2002). Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear. European Journal of Neuroscience, 15, 158-164.
24. Fan, J., Fossella, J., Sommer, T., Wu, Y., & Posner, M. I. (2003). Mapping the genetic variation of executive attention onto brain activity. Proceedings of the National Academy of Science USA, 100, 7406-7411.
25. Fan, J., McCandliss, B. D., Sommer, T., Raz, A., & Posner, M. I. (2002). Testing the efficiency and independence of attentional networks. Journal of Cognitive Neuroscience, 14, 340-347.
26. Fan, J., Wu, Y., Fossella, J. A., & Posner, M. I. (2001). Assessing the heritability of attentional networks. BMC Neuroscience, 2, 14.
27. Fan, J. B., Chen, W. Y., Tang, J. X., Li, S., Gu, N. F., Feng, G. Y., et al. (2002). Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population. Molecular Psychiatry, 7, 446-447.
28. Fossella, J., Sommer, T., Fan, J., Wu, Y., Swanson, J. M., Pfaff, D. W., et al. (2002). Assessing the molecular genetics of attention networks. BMC Neuroscience, 3, 14.
29. Garavan, H., Kelley, D., Rosen, A., Rao, S. M., & Stein, E. A. (2004). Practice-related functional activation changes in a working memory task. Microscopy Research and Technique, 51, 54-63.
30. Grady, D. K., & Kruzich, P. J. (2004). A molecular genetic approach to the neurobiology of attention utilizing dopamine receptor-deficient mice. In M. I. Posner (Ed.), Cognitive neuroscience of attention (pp. 260-268). New York: Guilford.
31. Grady, D. L., Chi, H. C., Ding, Y. C., Smith, M., Wang, E., Schuck, S., et al. (2003). High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. Molecular Psychiatry, 8, 536-545.
32. Hofbauer, R. K., Rainville, P., Duncan, G. H., & Bushnell, M. C. (2001). Cortical representation of the sensory dimension of pain. Journal of Neurophysiology, 86, 402-411.
33. Hopfinger, J. B., Buonocore, M. H., & Mangun, G. R. (2000). The neural mechanisms of top-down attentional control. Natural Neuroscience, 3, 284-291.
34. Horton, J. E., Crawford, H. J., Harrington, G., & Downs, J. H., 3rd (2004). Increased anterior corpus callosum size associated positively with hypnotizability and the ability to control pain. Brain, 127(Pt 8), 1741-1747.
35. Klingberg, T., Fernell, E., Olesen, P. J., Johnson, M., Gustafsson, P., Dahlstrom, K., et al. (2005). Computerized training of working memory in children with ADHD - A randomized, controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 177-186.
36. Klingberg, T., Forssberg, H., & Westerberg, H. (2002). Training of working memory in children with ADHD. Journal of Clinical and Experimental Neuropsychology, 24, 781-791.
37. Kosslyn, S. M., Thompson, W. L., Costantini-Ferrando, M. F., Alpert, N. M., & Spiegel, D. (2000). Hypnotic visual illusion alters color processing in the brain. American Journal of Psychiatry, 157, 1279-1284.
38. Kotler, M., Barak, P., Cohen, H., Averbuch, I. E., Grinshpoon, A., Gritsenko, I., et al. (1999). Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity. American Journal of Medical Genetics, 88, 628-633.
39. LaHoste, G. J., Swanson, J. M., Wigal, S. B., Glabe, C., Wigal, T., King, N., et al. (1996). Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Molecular Psychiatry, 1, 121-124.
40. Landau, S. M., Schumacher, E. H., Garavan, H., Druzgal, T. J., & D'Esposito, M. (2004). A functional MRI study of the influence of practice on component processes of working memory. Neuroimage, 22, 211-221.
41. Li, T., Sham, P. C., Vallada, H., Xie, T., Tang, X., Murray, R. M., et al. (1996). Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatric Genetics, 6, 131-133.
42. Lichtenberg, P., Bachner-Melman, R., Ebstein, R. P., & Crawford, H. J. (2004). Hypnotic susceptibility: Multidimensional relationships with Cloninger's Tridimensional Personality Questionnaire, COMT polymorphisms, absorption, and attentional characteristics. International Journal of Clinical and Experimental Hypnosis, 52, 47-72.
43. Lotta, T., Vidgren, J., Tilgmann, C., Ulmanen, I., Melen, K., Julkunen, I., et al. (1995). Kinetics of human soluble and membrane-bound catechol O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 34, 4202-4210.
44. Manly, T., Anderson, V., Nimmo-Smith, I., Turner, A., Watson, P., & Robertson, I. H. (2001). The differential assessment of children's attention: The Test of Everyday Attention for Children (TEA-Ch), normative sample and ADHD performance. Journal of Child Psychology and Psychiatry, 42, 1065-1081.
45. Marrocco, R. T., & Davidson, M. C. (1998). Neurochemistry of attention. In R. Parasuraman (Ed.), The Attentional Brain (pp. 35-50). Cambridge, MA: MIT Press.
46. Matsumoto, C., Shinkai, T., Hori, H., Ohmori, O., & Nakamura, J. (2004). Polymorphisms of dopamine degradation enzyme (COMT and MAO) genes and tardive dyskinesia in patients with schizophrenia. Psychiatry Research, 127, 1-7.
47. Matsumoto, M., Weickert, C. S., Beltaifa, S., Kolachana, B., Chen, J., Hyde, T. M., et al. (2003). Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia. Neuropsychopharmacology, 28, 1521-1530.
48. Nolan, K. A., Volavka, J., Czobor, P., Cseh, A., Lachman, H., Saito, T., et al. (2000). Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatric Genetics, 10, 117-124.
49. Norton, N., Kirov, G., Zammit, S., Jones, G., Jones, S., Owen, R., et al. (2002). Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis. American Journal of Medical Genetics, 114, 491-496.
50. Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. (2002). Rethinking feelings: An fMRI study of the cognitive regulation of emotion. Journal of Cognitive Neuroscience, 14, 1215-1229.
51. Ochsner, K. N., Kosslyn, S. M., Cosgrove, G. R., Cassem, E. H., Price, B. H., Nierenberg, A. A., et al. (2001). Deficits in visual cognition and attention following bilateral anterior cingulotomy. Neuropsychologia, 39, 219-230.
52. Olesen, P. J., Westerberg, H., & Klingberg, T. (2004). Increased prefrontal and parietal activity after training of working memory. Natural Neuroscience, 7, 75-79.
53. Palmatier, M. A., Pakstis, A. J., Speed, W., Paschou, P., Goldman, D., Odunsi, A., et al. (2004). COMT haplotypes suggest P2 promoter region relevance for schizophrenia. Molecular Psychiatry, 9, 859-870.
54. Parasuraman, R., Greenwood, P. M., & Sunderland, T. (2002). The apolipoprotein E gene, attention, and brain function. Neuropsychology, 16, 254-274.
55. Parasuraman, R., Warm, J., & See, J. (1998). Brain systems of vigilance. In R. Parasuraman (Ed.), Varieties of attention (pp. 221-256). Cambridge, MA: MIT Press.
56. Piccione, C., Hilgard, E. R., & Zimbardo, P. G. (1989). On the degree of stability of measured hypnotizability over a 25-year period. Journal of Personality and Social Psychology, 56, 289-295.
57. Posner, M. I. (2004). Cognitive neuroscience of attention. New York: Guilford.
58. Posner, M. I., & Raichle, M. E. (1996). Images of mind (revised). Washington, DC: Scientific American Books.
59. Posner, M. I., & Rothbart, M. K. (1998). Attention, self-regulation and consciousness. Philosophical Transactions of the Royal Society B: Biological Sciences, 353, 1915-1927.
60. Rainville, P. (2002). Brain mechanisms of pain affect and pain modulation. Current Opinions in Neurobiology, 12, 195-204.
61. Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997). Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science, 277, 968-971.
62. Rainville, P., Hofbauer, R. K., Bushnell, M. C., Duncan, G. H., & Price, D. D. (2002). Hypnosis modulates activity in brain structures involved in the regulation of consciousness. Journal of Cognitive Neuroscience, 14, 887-901.
63. Rawlings, R. M. (1978). The genetics of hypnotisability. Dissertation, University of New South Wales, Australia.
64. Raz, A. (2004). Atypical attention: Hypnosis and conflict reduction. In M. I. Posner (Ed.), Cognitive neuroscience of attention (pp. 420-429). New York: Guilford.
65. Raz, A. (2006a). Perspectives on the efficacy of antidepressants for child and adolescent depression. PLoS Medicine, 3, e9.
66. Raz, A. (2006b). Individual differences and attentional varieties. Europa Medicophysica, 42, 53-58.
67. Raz, A., & Buhle, J. (2006). Typologies of attentional networks. Nature Reviews Neuroscience, 7, 367-379.
68. Raz, A., Fan, J., & Posner, M. I. (2005). Hypnotic suggestion reduces conflict in the human brain. Proceedings of the National Academy of Science USA, 102, 9978-9983.
69. Raz, A., Fan, J., & Posner, M. I. (2006). Neuroimaging and genetic associations of attentional and hypnotic processes. Journal of Physiology - Paris, 99, 483-491.
70. Raz, A., Kirsch, I., Pollard, J., & Nitkin-Kaner, Y. (2006). Suggestion reduces the Stroop effect. Psychological Science, 17, 91-95.
71. Raz, A., Landzberg, K. S., Schweizer, H. R., Zephrani, Z. R., Shapiro, T., Fan, J., et al. (2003). Posthypnotic suggestion and the modulation of Stroop interference under cycloplegia. Consciousness and Cognition, 12, 332-346.
72. Raz, A., Moreno-Íñiguez, M., Martin, L., & Zhu, H. (2007). Suggestion overrides the Stroop effect in highly hypnotizable individuals. Consciousness and Cognition, 16, 331-338.
73. Rees, G., Russell, C., Frith, C. D., & Driver, J. (1999). Inattentional blindness versus inattentional amnesia for fixated but ignored words. Science, 286, 2504-2507.
74. Robertson, I. H., Ward, T., Ridgeway, V., & Nimmo-Smith, I. (1996). The structure of normal human attention: The Test of Everyday Attention. Journal of the International Neuropsychological Society, 2, 525-534.
75. Rothbart, M. K., & Bates, J. E. (1998). Temperament. In N. Eisenberg (Ed.), Handbook of Child Psychology (Vol. 3 Social, emotional, personality development, pp. 105-176). New York: Wiley.
76. Rueda, M. R., Posner, M. I., & Rothbart, M. K. (2004). Attentional control and self regulation. In R. F. Baumeister & K. D. Vohs (Eds.), Handbook of self-regulation (pp. 283-300). New York: Guilford.
77. Rueda, M. R., Rothbart, M. K., McCandliss, B. D., Saccomanno, L., & Posner, M. I. (2005). Training, maturation, and genetic influences on the development of executive attention. Proceedings of the National Academy of Science USA, 102, 14931-14936.
78. Searle, J. R. (2000). Consciousness. Annual Review of Neuroscience, 23, 557-578.
79. Shifman, S., Bronstein, M., Sternfeld, M., Pisante, A., Weizman, A., Reznik, I., et al. (2004). COMT: A common susceptibility gene in bipolar disorder and schizophrenia. American Journal Medical Genetics, 128B, 61-64.
80. Shifman, S., Bronstein, M., Sternfeld, M., Pisante-Shalom, A., Lev-Lehman, E., Weizman, A., et al. (2002). A highly significant association between a COMT haplotype and schizophrenia. American Journal of Human Genetics, 71, 1296-1302.
81. Sommer, T., Fossella, J. A., Fan, J., & Posner, M. I. (2003). Inhibitory control: Cognitive subfunctions, individual differences and variation in dopaminergic genes. In I. Reinvang, M. W. Greenlee, & M. Herrmann (Eds.), The cognitive neuroscience of individual differences - New perspectives (pp. 27-44). Oldenburg, Germany: Bibliotheks- and Informations system der Universitat Oldenburg.
82. Spiegel, D., & King, R. (1992). Hypnotizability and CSF HVA levels among psychiatric patients. Biological Psychiatry, 31, 95-98.
83. Strous, R. D., Nolan, K. A., Lapidus, R., Diaz, L., Saito, T., & Lachman, H. M. (2003). Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: A replication study. American Journal of Medical Genetics, 120B, 29-34.
84. Swanson, J., Oosterlaan, J., Murias, M., Schuck, S., Flodman, P., Spence, M.A., et al. (2000). Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proceedings of the National Academy of Science USA, 97, 4754-4759.
85. Swanson, J., Posner, M., Fusella, J., Wasdell, M., Sommer, T., & Fan, J. (2001). Genes and attention deficit hyperactivity disorder. Current Psychiatry Reports, 3, 92-100.
86. Swanson, J. M., Flodman, P., Kennedy, J., Spence, M. A., Moyzis, R., Schuck, S., et al. (2000). Dopamine genes and ADHD. Neuroscience & Biobehavioral Reviews, 24, 21-25.
87. Swanson, J. M., Sunohara, G. A., Kennedy, J. L., Regino, R., Fineberg, E., Wigal, T., et al. (1998). Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): A family-based approach. Molecular Psychiatry, 3, 38-41.
88. Tiihonen, J., Hallikainen, T., Lachman, H., Saito, T., Volavka, J., Kauhanen, J., et al. (1999). Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Molecular Psychiatry, 4, 286-289.
89. Tunbridge, E., Burnet, P. W., Sodhi, M. S., & Harrison, P. J. (2004). Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression. Synapse, 51, 112-118.
90. Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., et al. (2001). The sequence of the human genome. Science, 291, 1304-1351.
91. Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., et al. (2004). Placebo-induced changes in fMRI in the anticipation and experience of pain. Science, 303, 1162-1167.
92. Wang, E., Ding, Y. C., Flodman, P., Kidd, J. R., Kidd, K. K., Grady, D. L., et al. (2004). The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. American Journal of Human Genetics, 74, 931-944.
93. Wegner, D. M. (2002). The illusion of conscious will. New York: Bradford Books/MIT Press.
94. Wei, J., & Hemmings, G. P. (1999). Lack of evidence for association between the COMT locus and schizophrenia. Psychiatric Genetics, 9, 183-186.
95. Weitzenhoffer, A. M., & Hilgard, E. R. (1962). Stanford Hypnotic Susceptibility Scale, Form C. Palo Alto, CA: Consulting Psychological Press.
96. Wonodi, I., Stine, O. C., Mitchell, B. D., Buchanan, R. W., & Thaker, G. K. (2003). Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia. American Journal of Medical Genetics, 120B, 47-50.
97. Zammit, S., Jones, G., Jones, S. J., Norton, N., Sanders, R. D., Milham, C., et al. (2004). Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics, 128B, 19-20.
98. Zubieta, J. K., Heitzeg, M. M., Smith, Y. R., Bueller, J. A., Xu, K., Xu, Y., et al. (2003). COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science, 299, 1240-1243.