Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 114, Issue 5, 2002, Pages 491-496

  Norton, Nadine ^a,b   Kirov, George ^a   Zammit, Stan ^a   Jones, Gaynor ^a   Jones, Susan ^a   Owen, Richard ^a   Krawczak, Michael ^a   Williams, Nigel M ^a   O'Donovan, Michael C ^a   Owen, Michael J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

Association; COMT; Epistasis; Functional; MAOA; Schizophrenia

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; CATECHOL METHYLTRANSFERASE; DOPAMINE;

ADULT; ARTICLE; CATECHOLAMINE METABOLISM; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINERGIC TRANSMISSION; EPISTASIS; EVIDENCE BASED MEDICINE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; ALLELES; CATECHOL O-METHYLTRANSFERASE; DNA; DNA MUTATIONAL ANALYSIS; EPISTASIS, GENETIC; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; MONOAMINE OXIDASE; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); SCHIZOPHRENIA;

GYMNOMYZA SAMOENSIS;

EID: 0037043064     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.10517     Document Type: Article

References (38)

1. The current state of the dopamine hypothesis of schizophrenia
2. Structure of the human gene for monoamine oxidase type A
3. No evidence for allelic associations between schizophrenia in a polymorphism determining high or low catechol-O-methyltransferase activity
4. A linkage study of schizophrenia to markers within Xp11 near the MAOB gene
5. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder
6. Progress in locating a gene for schizophrenia on the sex chromosomes
7. Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats
8. Analysis of the monoamine oxidase A, MAOA, gene in bipolar disorder by association studies, meta-analyses, and sequencing of the promoter
9. Monoamine oxidase type A: Differences in selectivity towards norepinephrine compared to serotonin
10. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
11. Human monoamine oxidase A and B genes exhibit identical exon-intron organization
12. Human monoamine oxidase A gene determines levels of enzyme activity
13. A genome-wide search for schizophrenia genes in an internal isolate of Finland suggests multiple susceptibility loci
14. Some observations upon a new inhibitor of monoamine oxidase in brain tissue
15. Identification of sequence variants and analysis of the role of the COMT gene in schizophrenia susceptibility
16. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder
17. Some puzzling pharmacological effects of monoamine oxidase inhibitors
18. COMT polymorphisms and schizophrenia: A transmission disequilibrium study in multiply affected families
19. Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphisms and its potential application to neuropsychiatric disorders
20. Association between catechol-O-methylatransferase genotype and violence in schizophrenia and schizoaffective disorder
21. Development of benzylamine oxidase A and B in man
22. Preferential transmission of the high activity allele of COMT in schizophrenia
23. High rates of schizophrenia in adults with velo-cardio-facial syndrome
24. The interaction of selection and linkage. I. General considerations: Heterotic models
25. Catechol-O-methyltransferase of erythrocytes in patients with endogenous psychoses
26. Schizophrenia
27. Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: Analysis and meta-analysis
28. A functional polymorphism in the monoamine oxidase gene promoter
29. Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders
30. Genomic organization of the human catechol-O-methyltransferase gene and its expression from two distinct promoters
31. Allelic association between dinuc leotide repeats at the monoamine oxidase loci and schizophrenia
32. A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs
33. SCAN: Schedules for the clinical assessment in neuropsychiatry
34. Reducedq monoamine oxidase activity in platelets: A possible genetic marker for vulnerability to schizophrenia