Assessing the molecular genetics of attention networks

BMC Neuroscience

Volumn 3, Issue , 2002, Pages

  Fossella, John ^a   Sommer, Tobias ^b   Fan, Jin ^a   Wu, Yanhong ^b   Swanson, James M ^a   Pfaff, Donald W ^c   Posner, Michael I ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b PEKING UNIVERSITY   (China)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); CATECHOL METHYLTRANSFERASE; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; CARRIER PROTEIN; DOPAMINE; DOPAMINE 2 RECEPTOR; DRD4 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; SLC6A3 PROTEIN, HUMAN;

ATTENTION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MENTAL DISEASE; MENTAL PERFORMANCE; MOLECULAR GENETICS; NERVE CELL NETWORK; PHENOTYPE; REACTION TIME; REVIEW; VALIDATION PROCESS; ADOLESCENT; ADULT; ALLELE; ARTICLE; CLINICAL TRIAL; COGNITION; COMPARATIVE STUDY; FEMALE; GENE FREQUENCY; GENETIC SCREENING; GENETICS; MALE; METABOLISM; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PHYSIOLOGY; REFERENCE VALUE; SEX DIFFERENCE; STATISTICS;

ADOLESCENT; ADULT; ALLELES; ATTENTION; CATECHOL O-METHYLTRANSFERASE; COGNITION; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; GENE FREQUENCY; GENETIC SCREENING; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MONOAMINE OXIDASE; NERVE NET; NERVE TISSUE PROTEINS; NEUROPSYCHOLOGICAL TESTS; REACTION TIME; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; REFERENCE VALUES; SEX FACTORS;

EID: 0037020547     PISSN: 14712202     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2202-3-14     Document Type: Review

References (93)

1. Geyer MA, Braff DL: Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophr Bull 1987, 13:643-68
2. Matthysse S, Holzman PS, Lange K: The genetic transmission of schizophrenia: application of Mendelian latent structure analysis to eye tracking dysfunctions in schizophrenia and affective disorder. J Psychiatr Res 1986, 20:57-67
3. Pantelis C, Barber FZ, Barnes TR, Nelson HE, Owen AM, Robbins TW: Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage. Schizophr Res 1999, 37:251-70
4. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen JD: Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry 1998, 155:1285-7
5. Swaab-Barneveld H, de Sonneville L, Cohen-Kettenis P, Gielen A, Buitelaar J, Van Engeland H: Visual sustained attention in a child psychiatric population. J Am Acad Child Adolesc Psychiatry 2000, 39:651-9
6. Townsend J, Courchesne E, Covington J, Westerfield M, Harris NS, Lyden P, Lowry TP, Press GA: Spatial attention deficits in patients with acquired or developmental cerebellar abnormality. J Neurosci 1999, 19:5632-43
7. Parasuraman R, Greenwood PM, Haxby JV, Grady CL: Visuospatial attention in dementia of the Alzheimer type. Brain 1992, 115:711-33
8. eds.). City 1999 [http://www.nimh.nih.gov/publist/984268.htm]
9. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT: Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study. J Abnorm Psychol 1999, 108:176-81
10. Falconer: Introduction to Quantitative Genetics. Harlow Essex: Addison Wesley Longman Ltd. 1996
11. Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L: The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res 1988, 26:223-38
12. Bartfai A, Pedersen NL, Asarnow RF, Schalling D: Genetic factors for the span of apprehension test: a study of normal twins. Psychiatry Res 1991, 38:115-24
13. Myles-Worsley M, Coon H: Genetic and developmental factors in spontaneous selective attention: a study of normal twins. Psychiatry Res 1997, 71:163-74
14. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, Finkelstein J, Hietanen M, Kaprio J, Koskenvuo M: The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 2000, 67:369-82
15. Pardo PJ, Knesevich MA, Vogler GP, Pardo JV, Towne B, Cloninger CR, Posner MI: Genetic and state variables of neurocognitive dysfunction in schizophrenia: a twin study. Schizophr Bull 2000, 26:459-77
16. Goldsmith HH, Lemery KS, Buss KA, Campos JJ: Genetic analyses of focal aspects of infant temperament. Dev Psychol 1999, 35:972-85
17. Greenwood PM, Sunderland T, Friz JL, Parasuraman R: Genetics and visual attention: Selective deficits in healthy adult carriers of the varepsilon 4 allele of the apolipoprotein E gene. Proc Natl Acad Sci U S A 2000, 97:11661-11666
18. Schmidt LA, Fox NA, Perez-Edgar K, Hu S, Hamer DH: Association of DRD4 with attention problems in normal childhood development. Psychiatr Genet 2001, 11:25-9
19. Corbetta M, Kincade JM, Ollinger JM, McAvoy MP, Shulman GL: Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nat Neurosci 2000, 3:292-7
20. Mesulam MM: A cortical network for directed attention and unilateral neglect. Ann Neurol 1981, 10:309-25
21. Posner MI, Petersen SE: The attention system of the human brain. Annu Rev Neurosci 1990, 13:25-42
22. Posner MI, Fan J: Attention as an Organ System. To appear in Neurobiology of Perception and Communication:From Synapse to Society the IVth De Lange Conference. (Edited by: J Pomerantz) Cambridge UK: Cambridge University Press
23. Thompson PM, Cannon TD, Narr KL, van Erp T, Poutanen VP, Huttunen M, Lonnqvist J, Standertskjold-Nordenstam CG, Kaprio J, Khaledy M, et al: Genetic influences on brain structure. Nat Neurosci 2001, 4:1253-8
24. Fan J, McCandliss BD, Sommer T, Raz A, Posner MI: Testing the efficiency and independence of attentional networks. J Cognitive Neurosci 2001
25. Fan J, Wu Y, Fossella JA, Posner MI: Assessing the heritability of attentional networks. BMC Neurosci 2001, 2:14
26. Stanwood GD, Washington RA, Shumsky JS, Levitt P: Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of the cerebral cortex. Neuroscience 2001, 106:5-14
27. McCulloch J, Savaki HE, McCulloch MC, Jehle J, Sokoloff L: The distribution of alterations in energy metabolism in the rat brain produced by apomorphine. Brain Res 1982, 243:67-80
28. Geraud G, Arne-Bes MC, Guell A, Bes A: Reversibility of hemodynamic hypofrontality in schizophrenia. J Cereb Blood Flow Metab 1987, 7:9-12
29. Witte EA, Marrocco RT: Alteration of brain noradrenergic activity in rhesus monkeys affects the alerting component of covert orienting. Psychopharmacology (Berl) 1997, 132:315-23
30. [http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1815]
31. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH: Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995, 65:1157-65
32. Faraone SV, Doyle AE, Mick E, Biederman J: Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 2001, 158:1052-7
33. Barr CL: Genetics of childhood disorders: XXII. ADHD, Part 6: The dopamine D4 receptor gene. J Am Acad Child Adolesc Psychiatry 2001, 40:118-21
34. Okuyama Y, Ishiguro H, Toru M, Arinami T: A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia. Biochem Biophys Res Commun 1999, 258:292-5
35. Auerbach JG, Benjamin J, Faroy M, Geller V, Ebstein R: DRD4 related to infant attention and information processing: a developmental link to ADHD? Psychiatr Genet 2001, 11:31-5
36. Cruz C, Camarena B, King N, Paez F, Sidenberg D, de la Fuente JR, Nicolini H: Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics. Neurosci Lett 1997, 231:1-4
37. Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Dietz G, Saucier G, MacMurray JP: Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes. Clin Genet 2000, 57:178-96
38. Kaiser R, Konneker M, Henneken M, Dettling M, Muller-Oerlinghausen B, Roots I, Brockmoller J: Dopamine D4 receptor 48-bp repeat polymorphism: no association with response to antipsychotic treatment, but association with catatonic schizophrenia. Mol Psychiatry 2000, 5:418-24
39. Paterson AD, Sunohara GA, Kennedy JL: Dopamine D4 receptor gene: novelty or nonsense? Neuropsychopharmacology 1999, 21:3-16
40. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH: Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet 1996, 12:78-80
41. Lakatos K, Nemoda Z, Toth I, Ronai Z, Ney K, Sasvari-Szekely M, Gervai J: Further evidence for the role of the dopamine D4 receptor (DRD4) gene in attachment disorganization: interaction of the exon III 48-bp repeat and the -521 C/T promoter polymorphisms. Mol Psychiatry 2002, 7:27-31
42. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH: Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet 1996, 12:81-4
43. [http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6531]
44. Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Logan J, Ding YS, Hitzemann R, Pappas N: Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 1998, 155:1325-31
45. Dresel S, Krause J, Krause KH, LaFougere C, Brinkbaumer K, Kung HF, Hahn K, Tatsch K: Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. Eur J Nucl Med 2000, 27:1518-24
46. Mitchell RJ, Howlett S, Earl L, White NG, McComb J, Schanfield MS, Briceno I, Papiha SS, Osipova L, Livshits G, et al: Distribution of the 3′ VNTR polymorphism in the human dopamine transporter gene in world populations. Hum Biol 2000, 72:295-304
47. Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J: Prediction of dopamine transporter binding availability by genotype: a preliminary report. Am J Psychiatry 2000, 157:1700-3
48. Cook E: Molecular Genetic Studies of Attention Deficit Hyperactivity Disorder. In: Wenner-Gren Foundations International Symposium: Neurobiology of ADHD; Stockholm. 2000
49. Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Kelsoe JR: Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. Am J Med Genet 2001, 105:145-51
50. Ueno S, Nakamura M, Mikami M, Kondoh K, Ishiguro H, Arinami T, Komiyama T, Mitsushio H, Sano A, Tanabe H: Identification of a novel polymorphism of the human dopamine transporter (DAT1) gene and the significant association with alcoholism. Mol Psychiatry 1999, 4:552-7
51. Samochowiec J, Rybakowski F, Czerski P, Zakrzewska M, Stepien G, Pelka-Wysiecka J, Horodnicki J, Rybakowski JK, Hauser J: Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers. Neuropsychobiology 2001, 43:248-53
52. [http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1312]
53. Sesack SR, Hawrylak VA, Guido MA, Levey AI: Cellular and subcellular localization of the dopamine transporter in rat cortex. Adv Pharmacol 1998, 42:171-4
54. Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF: Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Am J Med Genet 1996, 67:468-72
55. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: Effect of COMT Val108/ 158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 2001, 98:6917-22
56. Eisenberg J, Mei-Tal G, Steinberg A, Tartakovsky E, Zohar A, Gritsenko I, Nemanov L, Ebstein RP: Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. Am J Med Genet 1999, 88:497-502
57. Niehaus DJ, Kinnear CJ, Corfield VA, du Toit PL, van Kradenburg J, Moolman-Smook JC, Weyers JB, Potgieter A, Seedat S, Emsley RA, et al: Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population. J Affect Disord 2001, 65:61-5
58. Schindler KM, Richter MA, Kennedy JL, Pato MT, Pato CN: Association between homozygosity at the COMT gene locus and obsessive compulsive disorder. Am J Med Genet 2000, 96:721-4
59. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA: Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci U S A 1997, 94:4572-5
60. Kinnear C, Niehaus DJ, Seedat S, Moolman-Smook JC, Corfield VA, Malherbe G, Potgieter A, Lombard C, Stein DJ: Obsessive-compulsive disorder and a novel polymorphism adjacent to the oestrogen response element (ERE 6) upstream from the COMT gene. Psychiatr Genet 2001, 11:85-7
61. Rotondo A, Mazzanti C, L Dell'Osso, Rucci P, Sullivan P, Bouanani S, Gonnelli C, Goldman D, Cassano GB: Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am J Psychiatry 2002, 159:23-9
62. Benjamin J, Osher Y, Kotler M, Gritsenko I, Nemanov L, Belmaker RH, Ebstein RP: Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT). Mol Psychiatry 2000, 5:96-100
63. [http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=4128]
64. Zametkin A, Rapoport JL, Murphy DL, Linnoila M, Ismond D: Treatment of hyperactive children with monoamine oxidase inhibitors. I. Clinical efficacy. Arch Gen Psychiatry 1985, 42:962-6
65. Brunner NM HG, Breakefield XO, Ropers HH, van Oost BA: Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993, 262:578-580
66. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R: Role of genotype in the cycle of violence in maltreated children. Science 2002, 297:851-4
67. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet C, Shih JC, et al: Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995, 268:1763-6
68. Sabol SZ, Hu S, Hamer D: A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 1998, 103:273-9
69. Payton A, Holmes J, Barrett JH, Hever T, Fitzpatrick H, Trumper AL, Harrington R, McGuffin P, O'Donovan M, Owen M, et al: Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Am J Med Genet 2001, 105:464-70
70. Craddock N, Roberts Q, Williams N, McGuffin P, Owen MJ: Association study of bipolar disorder using a functional polymorphism (Ser311->Cys) in the dopamine D2 receptor gene. Psychiatr Genet 1995, 5:63-5
71. Furlong RA, Ho L, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC: Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter. Am J Med Genet 1999, 88:398-406
72. Lim LC, Powell J, Sham P, Castle D, Hunt N, Murray R, Gill M: Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder. Am J Med Genet 1995, 60:325-31
73. Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nothen MM, Maffei P, Franke P, Fritze J, et al: Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 1999, 8:621-4
74. Samochowiec J, Lesch KP, Rottmann M, Smolka M, Syagailo YV, Okladnova O, Rommelspacher H, Winterer G, Schmidt LG, Sander T: Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. Psychiatry Res 1999, 86:67-72
75. Vanyukov MM, Moss HB, Yu LM, Tarter RE, Deka R: Preliminary evidence for an association of a dinucleotide repeat polymorphism at the MAOA gene with early onset alcoholism/ substance abuse. Am J Med Genet 1995, 60:122-6
76. Melis A, Soetens E, van der Molen MW: Process-specific slowing with advancing age: evidence derived from the analysis of sequential effects. Brain Cogn 2002, 49:420-35
77. Ladosky W, Figueiredo BC, Schneider HT: Hypothalamic nuclei catechol-O-methyl-transferase and the process of brain sexual differentiation. Braz J Med Biol Res 1984, 17:107-17
78. Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A 1998, 95:9991-6
79. Alsobrook JP, Zohar AH 2nd, Leboyer M, Chabane N, Ebstein RP, Pauls DL: Association between the COMT locus and obsessive-compulsive disorder in females but not males. Am J Med Genet 2002, 114:116-20
80. Ennis S, Maniatis N, Collins A: Allelic association and disease mapping. Brief Bioinform 2001, 2:375-87
81. Swanson J, Oosterlaan J, Murias M, Schuck S, Flodman P, Spence MA, Wasdell M, Ding Y, Chi HC, Smith M, et al: Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci U S A 2000, 97:4754-9
82. Ding YC, Chi HC, Grady DL, Morishima A, Kidd JR, Kidd KK, Flodman P, Spence MA, Schuck S, Swanson JM, et al: Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci U S A 2002, 99:309-14
83. Ladavas E, Nicoletti R, Umilta C, Rizzolatti G: Right hemisphere interference during negative affect: a reaction time study. Neuropsychologia 1984, 22:479-85
84. Liotti M, Tucker DM: Right hemisphere sensitivity to arousal and depression. Brain Cogn 1992, 18:138-51
85. Luciana M, Collins PF, Depue RA: Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions. Cereb Cortex 1998, 8:218-26
86. Luciana M, Sullivan J, Nelson CA: Associations between phenylalanine-to-tyrosine ratios and performance on tests of neuropsychological function in adolescents treated early and continuously for phenylketonuria. Child Dev 2001, 72:1637-52
87. [http://140.251.58.136/~jinfan/ant/ant.html]
88. Lander E, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995, 11:241-7
89. Seaman MI, Fisher JB, Chang F, Kidd KK: Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4). Am J Med Genet 1999, 88:705-9
90. Daly G, Hawi Z, Fitzgerald M, Gill M: Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 1999, 4:192-6
91. Daniels JK, Williams NM, Williams J, Jones LA, Cardno AG, Murphy KC, Spurlock G, Riley B, Scambler P, Asherson P, et al: No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity. Am J Psychiatry 1996, 153:268-70
92. Hotamisligil GS, Breakefield XO: Human monoamine oxidase A gene determines levels of enzyme activity. Am J Hum Genet 1991, 49:383-92
93. Weir BS: Genetic Data Analysis II. Sinauer Associates, Inc. Sunderland, MA. 1996