-
1
-
-
0002115597
-
Folate chemistry and metabolism
-
Bailey LB, editor, New York: Marcel Dekker;
-
Shane B. Folate chemistry and metabolism. In: Bailey LB, editor. Folate in health and disease. New York: Marcel Dekker; 1995. p. 1-22.
-
(1995)
Folate in health and disease
, pp. 1-22
-
-
Shane, B.1
-
2
-
-
0031442693
-
Folate and antifolate pharmacology
-
Kamen B. Folate and antifolate pharmacology. Semin Oncol 1997;24:S18-30-S18-39.
-
(1997)
Semin Oncol
, vol.24
-
-
Kamen, B.1
-
3
-
-
0032916128
-
Roles of folylpoly-γ-glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: An overview
-
Moran RG. Roles of folylpoly-γ-glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: an overview. Semin Oncol 1999;26:24-32.
-
(1999)
Semin Oncol
, vol.26
, pp. 24-32
-
-
Moran, R.G.1
-
4
-
-
0023935785
-
Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug
-
Pizzorno G, Mini E, Coronnello M, et al. Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug. Cancer Res 1988;48:2149-55.
-
(1988)
Cancer Res
, vol.48
, pp. 2149-2155
-
-
Pizzorno, G.1
Mini, E.2
Coronnello, M.3
-
5
-
-
0025817134
-
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines
-
McCloskey DE, McGuire JJ, Russell CA, et al. Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. J Biol Chem 1991;266:6181-7.
-
(1991)
J Biol Chem
, vol.266
, pp. 6181-6187
-
-
McCloskey, D.E.1
McGuire, J.J.2
Russell, C.A.3
-
6
-
-
18244378306
-
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis
-
Mauritz R, Peters GJ, Priest DG, et al. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochem Pharmacol 2002;63:105-15.
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 105-115
-
-
Mauritz, R.1
Peters, G.J.2
Priest, D.G.3
-
7
-
-
0037455808
-
Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines
-
Liani E, Rothem L, Bunni MA, Smith CA, Jansen G, Assaraf YG. Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer 2003;103:587-99.
-
(2003)
Int J Cancer
, vol.103
, pp. 587-599
-
-
Liani, E.1
Rothem, L.2
Bunni, M.A.3
Smith, C.A.4
Jansen, G.5
Assaraf, Y.G.6
-
8
-
-
0033578752
-
Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-γ- glutamate synthetase by site-directed mutagenesis
-
Sanghani SP, Sanghani PC, Moran RG. Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-γ- glutamate synthetase by site-directed mutagenesis. J Biol Chem 1999;274:27018-27.
-
(1999)
J Biol Chem
, vol.274
, pp. 27018-27027
-
-
Sanghani, S.P.1
Sanghani, P.C.2
Moran, R.G.3
-
9
-
-
0034714363
-
Molecular analysis of murine leukemia cell lines resistant to 5,10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase
-
Zhao R, Titus S, Gao F, Moran RG, Goldman ID. Molecular analysis of murine leukemia cell lines resistant to 5,10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. J Biol Chem 2000;275:26599-606.
-
(2000)
J Biol Chem
, vol.275
, pp. 26599-26606
-
-
Zhao, R.1
Titus, S.2
Gao, F.3
Moran, R.G.4
Goldman, I.D.5
-
10
-
-
0030954945
-
Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme
-
Roy K, Egan MG, Sirlin S, Sirotnak FM. Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme. J Biol Chem 1997;272:6903-8.
-
(1997)
J Biol Chem
, vol.272
, pp. 6903-6908
-
-
Roy, K.1
Egan, M.G.2
Sirlin, S.3
Sirotnak, F.M.4
-
11
-
-
0027442503
-
Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-γ-glutamate synthetase in methotrexate metabolism and cytotoxicity
-
Kim JS, Lowe KE, Shane B. Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-γ-glutamate synthetase in methotrexate metabolism and cytotoxicity. J Biol Chem 1993;268:21680-5.
-
(1993)
J Biol Chem
, vol.268
, pp. 21680-21685
-
-
Kim, J.S.1
Lowe, K.E.2
Shane, B.3
-
12
-
-
0033591840
-
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo
-
Aghi M, Kramm CM, Breakefield XO. Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo. J Natl Cancer Inst 1999;91:1233-41.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1233-1241
-
-
Aghi, M.1
Kramm, C.M.2
Breakefield, X.O.3
-
13
-
-
0038387494
-
5-fluorouracil: Mechanisms of action and clinical strategies
-
Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003;3:330-8.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 330-338
-
-
Longley, D.B.1
Harkin, D.P.2
Johnston, P.G.3
-
14
-
-
0024578676
-
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2′- deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft
-
Radparvar S, Houghton PJ, Houghton JA. Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2′- deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft. Biochem Pharmacol 1989;38:335-42.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 335-342
-
-
Radparvar, S.1
Houghton, P.J.2
Houghton, J.A.3
-
15
-
-
0025981649
-
Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin
-
Romanini A, Lin JT, Niedzwiecki D, Bunni M, Priest DG, Bertino JR. Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin. Cancer Res 1991;51:789-93.
-
(1991)
Cancer Res
, vol.51
, pp. 789-793
-
-
Romanini, A.1
Lin, J.T.2
Niedzwiecki, D.3
Bunni, M.4
Priest, D.G.5
Bertino, J.R.6
-
16
-
-
0027317751
-
Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance
-
Wang FS, Aschele C, Sobrero A, Chang YM, Bertino JR. Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance. Cancer Res 1993;53:3677-80.
-
(1993)
Cancer Res
, vol.53
, pp. 3677-3680
-
-
Wang, F.S.1
Aschele, C.2
Sobrero, A.3
Chang, Y.M.4
Bertino, J.R.5
-
17
-
-
0343924557
-
Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: Experimental data
-
Cheradame S, Etienne MC, Chazal M, et al. Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: experimental data. Eur J Cancer 1997;33:950-9.
-
(1997)
Eur J Cancer
, vol.33
, pp. 950-959
-
-
Cheradame, S.1
Etienne, M.C.2
Chazal, M.3
-
18
-
-
9344238265
-
Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate
-
Sohn KJ, Smirnakis F, Moskovitz DN, et al. Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. Gut 2004;53:1825-31.
-
(2004)
Gut
, vol.53
, pp. 1825-1831
-
-
Sohn, K.J.1
Smirnakis, F.2
Moskovitz, D.N.3
-
19
-
-
0033845077
-
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates
-
Backus HH, Pinedo HM, Wouters D, et al. Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates. Int J Cancer 2000;87:771-8.
-
(2000)
Int J Cancer
, vol.87
, pp. 771-778
-
-
Backus, H.H.1
Pinedo, H.M.2
Wouters, D.3
-
20
-
-
0035313188
-
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells
-
Zhao R, Gao F, Goldman ID. Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochem Pharmacol 2001;61:857-65.
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 857-865
-
-
Zhao, R.1
Gao, F.2
Goldman, I.D.3
-
21
-
-
0026686811
-
Expression cloning of a human cDNA encoding folylpoly(γ-glutamate) synthetase and determination of its primary structure
-
Garrow TA, Admon A, Shane B. Expression cloning of a human cDNA encoding folylpoly(γ-glutamate) synthetase and determination of its primary structure. Proc Natl Acad Sci U S A 1992;89:9151-5.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 9151-9155
-
-
Garrow, T.A.1
Admon, A.2
Shane, B.3
-
22
-
-
0031610120
-
Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines
-
McGuire JJ, Russell CA. Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines. Oncol Res 1998;10:193-200.
-
(1998)
Oncol Res
, vol.10
, pp. 193-200
-
-
McGuire, J.J.1
Russell, C.A.2
-
23
-
-
0035360869
-
Effects of overexpression of γ-glutamyl hydrolase on methotrexate metabolism and resistance
-
Cole PD, Kamen BA, Gorlick R, et al. Effects of overexpression of γ-glutamyl hydrolase on methotrexate metabolism and resistance. Cancer Res 2001;61:4599-604.
-
(2001)
Cancer Res
, vol.61
, pp. 4599-4604
-
-
Cole, P.D.1
Kamen, B.A.2
Gorlick, R.3
-
24
-
-
0035992440
-
Methotrexate intracellular disposition in acute lymphoblastic leukemia: A mathematical model of γ-glutamyl hydrolase activity
-
Panetta JC, Wall A, Pui CH, Relling MV, Evans WE. Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of γ-glutamyl hydrolase activity. Clin Cancer Res 2002;8:2423-9.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2423-2429
-
-
Panetta, J.C.1
Wall, A.2
Pui, C.H.3
Relling, M.V.4
Evans, W.E.5
-
25
-
-
0000746151
-
Microbiologicl assay of folate
-
Picciano MF, Stokstad ELR, Gregory III JF, editors, New York: Wiley-Liss;
-
Tamura T. Microbiologicl assay of folate. In: Picciano MF, Stokstad ELR, Gregory III JF, editors. Folic acid metabolism in health and disease. New York: Wiley-Liss; 1990. p. 121-37.
-
(1990)
Folic acid metabolism in health and disease
, pp. 121-137
-
-
Tamura, T.1
-
26
-
-
0023683407
-
Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles
-
Kamen BA, Wang MT, Streckfuss AJ, Peryea X, Anderson RG. Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J Biol Chem 1988;263:13602-9.
-
(1988)
J Biol Chem
, vol.263
, pp. 13602-13609
-
-
Kamen, B.A.1
Wang, M.T.2
Streckfuss, A.J.3
Peryea, X.4
Anderson, R.G.5
-
27
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
Skehan P, Storeng R, Scudiero D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990;82:1107-12.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
-
28
-
-
1042292043
-
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate
-
Sohn KJ, Croxford R, Yates Z, Lucock M, Kim YI. Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J Natl Cancer Inst 2004;96:134-44.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 134-144
-
-
Sohn, K.J.1
Croxford, R.2
Yates, Z.3
Lucock, M.4
Kim, Y.I.5
-
29
-
-
0027287554
-
Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism
-
Peters GJ, Wets M, Keepers YP, et al. Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism. Int J Cancer 1993;54:450-5.
-
(1993)
Int J Cancer
, vol.54
, pp. 450-455
-
-
Peters, G.J.1
Wets, M.2
Keepers, Y.P.3
-
31
-
-
33847364471
-
Pemetrexed: Biochemical and cellular pharmacology, mechanisms, and clinical applications
-
Chattopadhyay S, Moran RG, Goldman ID. Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Mol Cancer Ther 2007;6:404-17.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 404-417
-
-
Chattopadhyay, S.1
Moran, R.G.2
Goldman, I.D.3
-
32
-
-
0025816073
-
Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties
-
Lin JT, Bertino JR. Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties. Cancer Invest 1991;9:159-72.
-
(1991)
Cancer Invest
, vol.9
, pp. 159-172
-
-
Lin, J.T.1
Bertino, J.R.2
-
33
-
-
0032525917
-
Effects of antisense-based folypoly-γ-glutamate synthetase down-regulation on reduced folates and cellular proliferation in CCRF-CEM cells
-
Liu Y, Raghunathan K, Hill C, et al. Effects of antisense-based folypoly-γ-glutamate synthetase down-regulation on reduced folates and cellular proliferation in CCRF-CEM cells. Biochem Pharmacol 1998;55:2031-7.
-
(1998)
Biochem Pharmacol
, vol.55
, pp. 2031-2037
-
-
Liu, Y.1
Raghunathan, K.2
Hill, C.3
-
34
-
-
0030905828
-
Decreased folylpolyglutamate synthetase activity in tumors resistant to fluorouracil-folinic acid treatment: Clinical data
-
Chazal M, Cheradame S, Formento JL, et al. Decreased folylpolyglutamate synthetase activity in tumors resistant to fluorouracil-folinic acid treatment: clinical data. Clin Cancer Res 1997;3:553-7.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 553-557
-
-
Chazal, M.1
Cheradame, S.2
Formento, J.L.3
-
35
-
-
0033292028
-
Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors
-
Mini E, Biondi C, Morganti M, et al. Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors. Oncol Res 1999;11:437-45.
-
(1999)
Oncol Res
, vol.11
, pp. 437-445
-
-
Mini, E.1
Biondi, C.2
Morganti, M.3
-
36
-
-
0346103806
-
Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients
-
Odin E, Wettergren Y, Nilsson S, et al. Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. Clin Cancer Res 2003;9:6012-9.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 6012-6019
-
-
Odin, E.1
Wettergren, Y.2
Nilsson, S.3
-
37
-
-
0033486036
-
-
J Natl Cancer Inst
-
Jansen G, Peters GJ, Pinedo HM, Priest DG, Assaraf YG. Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo. J Natl Cancer Inst 1999;91:2047-50.
-
(1999)
Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo
, vol.91
, pp. 2047-2050
-
-
Jansen, G.1
Peters, G.J.2
Pinedo, H.M.3
Priest, D.G.4
Assaraf, Y.G.5
-
38
-
-
0032916531
-
Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: Role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration
-
Jansen G, Barr H, Kathmann I, et al. Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. Mol Pharmacol 1999;55:761-9.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 761-769
-
-
Jansen, G.1
Barr, H.2
Kathmann, I.3
-
39
-
-
15144346421
-
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance
-
Jansen G, Mauritz R, Drori S, et al. A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem 1998;273:30189-98.
-
(1998)
J Biol Chem
, vol.273
, pp. 30189-30198
-
-
Jansen, G.1
Mauritz, R.2
Drori, S.3
-
40
-
-
0033229854
-
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions
-
Peters GJ, Smitskamp-Wilms E, Smid K, Pinedo HM, Jansen G. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions. Cancer Res 1999;59:5529-35.
-
(1999)
Cancer Res
, vol.59
, pp. 5529-5535
-
-
Peters, G.J.1
Smitskamp-Wilms, E.2
Smid, K.3
Pinedo, H.M.4
Jansen, G.5
-
41
-
-
0032475855
-
Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites
-
Tse A, Moran RG. Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites. J Biol Chem 1998;273:25944-52.
-
(1998)
J Biol Chem
, vol.273
, pp. 25944-25952
-
-
Tse, A.1
Moran, R.G.2
-
42
-
-
0032965322
-
Overview of phase II trials of MTA in solid tumors
-
O'Dwyer PJ, Nelson K, Thornton DE. Overview of phase II trials of MTA in solid tumors. Semin Oncol 1999;26:99-104.
-
(1999)
Semin Oncol
, vol.26
, pp. 99-104
-
-
O'Dwyer, P.J.1
Nelson, K.2
Thornton, D.E.3
-
43
-
-
32944481592
-
Breast cancer: Achievements in adjuvant systemic therapies in the pre-genomic era
-
Colozza M, de Azambuja E, Cardoso F, Bernard C, Piccart MJ. Breast cancer: achievements in adjuvant systemic therapies in the pre-genomic era. The Oncologist 2006;11:111-25.
-
(2006)
The Oncologist
, vol.11
, pp. 111-125
-
-
Colozza, M.1
de Azambuja, E.2
Cardoso, F.3
Bernard, C.4
Piccart, M.J.5
|