-
1
-
-
0025991626
-
Biochemical pharmacology and analysis of fluoropyrimidine alone and in combination with modulators
-
Weckbecker, G. Biochemical pharmacology and analysis of fluoropyrimidine alone and in combination with modulators. Pharmacol. & Ther., 50: 367-381, 1991.
-
(1991)
Pharmacol. & Ther.
, vol.50
, pp. 367-381
-
-
Weckbecker, G.1
-
2
-
-
0019349301
-
Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinoma in mice
-
Houghton, J. A., Maroda, S. J., Phillips, J. O., and Houghton, P. J. Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinoma in mice. Cancer Res., 41: 144-149, 1981.
-
(1981)
Cancer Res.
, vol.41
, pp. 144-149
-
-
Houghton, J.A.1
Maroda, S.J.2
Phillips, J.O.3
Houghton, P.J.4
-
3
-
-
0015962412
-
Mechanisms of interaction of thymidylate synthase with 5-fluorodeoxyuridylate
-
Santi, D. V., McHenry, C. S., and Sommer, M. Mechanisms of interaction of thymidylate synthase with 5-fluorodeoxyuridylate. Biochemistry, 13: 471-480, 1974.
-
(1974)
Biochemistry
, vol.13
, pp. 471-480
-
-
Santi, D.V.1
McHenry, C.S.2
Sommer, M.3
-
4
-
-
0026597828
-
Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines
-
Boarman, D. M., and Allegra, C. J. Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines. Cancer Res., 52: 36-44, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 36-44
-
-
Boarman, D.M.1
Allegra, C.J.2
-
5
-
-
33947093786
-
Effects of 5, 10-methylene-tetrahydrofolate on the dissociation of 5-fluoro-2′-deoxyuridylate from thymidylate synthase: Evidence for an ordered mechanism
-
Danenberg, P. V., and Danenberg, K. D. Effects of 5, 10-methylene-tetrahydrofolate on the dissociation of 5-fluoro-2′-deoxyuridylate from thymidylate synthase: evidence for an ordered mechanism. Biochemistry, 17: 4018-4024, 1978.
-
(1978)
Biochemistry
, vol.17
, pp. 4018-4024
-
-
Danenberg, P.V.1
Danenberg, K.D.2
-
6
-
-
0022344622
-
Thymidylate synthase overproduction and gene amplification in fluorode-oxyuridine-resistant human cells
-
Berger, S. H., Jenh, C-H., Johnson, L. F., and Berger, F. G. Thymidylate synthase overproduction and gene amplification in fluorode-oxyuridine-resistant human cells. Mol. Pharmacol., 28: 461-467, 1985.
-
(1985)
Mol. Pharmacol.
, vol.28
, pp. 461-467
-
-
Berger, S.H.1
Jenh, C.-H.2
Johnson, L.F.3
Berger, F.G.4
-
7
-
-
0028097137
-
A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil
-
Beck, A., Etienne, M. C., Chéradame, S., Fischel, J. L., Formento, P., Guillot, T., and Milano, G. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil. Eur. J. Cancer, 30: 1517-1522, 1994.
-
(1994)
Eur. J. Cancer
, vol.30
, pp. 1517-1522
-
-
Beck, A.1
Etienne, M.C.2
Chéradame, S.3
Fischel, J.L.4
Formento, P.5
Guillot, T.6
Milano, G.7
-
8
-
-
0023111335
-
Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy
-
Clark, J. L., Berger, S. H., Mittelman, A., and Berger, F. G. Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy. Cancer Treat. Rep., 71: 261-264, 1987.
-
(1987)
Cancer Treat. Rep.
, vol.71
, pp. 261-264
-
-
Clark, J.L.1
Berger, S.H.2
Mittelman, A.3
Berger, F.G.4
-
9
-
-
0026560328
-
Quantification of thymidylate synthase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
-
Horikoshi, T., Danenberg, K. D., Stadlbauer, W., Volkenandt, M., Shea, L. C. C., Aigner, K., Gustavsson, B., Leichman, L., Frosing, R., Ray, M., Gibson, N. W., Spears, C. P., and Danenberg, P. V. Quantification of thymidylate synthase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res., 52: 108-116, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 108-116
-
-
Horikoshi, T.1
Danenberg, K.D.2
Stadlbauer, W.3
Volkenandt, M.4
Shea, L.C.C.5
Aigner, K.6
Gustavsson, B.7
Leichman, L.8
Frosing, R.9
Ray, M.10
Gibson, N.W.11
Spears, C.P.12
Danenberg, P.V.13
-
10
-
-
0028940399
-
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
-
Johnston, P. G., Lenz, H. J., Leichman, C. G., Danenberg, K. D., Allegra, C. J., Danenberg, P. V., and Leichman, L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res., 55: 1407-1412, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 1407-1412
-
-
Johnston, P.G.1
Lenz, H.J.2
Leichman, C.G.3
Danenberg, K.D.4
Allegra, C.J.5
Danenberg, P.V.6
Leichman, L.7
-
11
-
-
0029156922
-
Thymidylate synthase and drug resistance
-
Peters, G. J., Van der Wilt, C. L., Van Triest, B., Codacci-Pisanelli, G., Johnston, P. G., Van Groeningen, C. J., and Pinedo, H. M. Thymidylate synthase and drug resistance. Eur. J. Cancer, 31A: 1299-1305, 1995.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 1299-1305
-
-
Peters, G.J.1
Van der Wilt, C.L.2
Van Triest, B.3
Codacci-Pisanelli, G.4
Johnston, P.G.5
Van Groeningen, C.J.6
Pinedo, H.M.7
-
12
-
-
9044250848
-
Thymidylate synthase mRNA level in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival
-
Lenz, H. J., Leichman, C. G., Danenberg, K. D., Danenberg, P. V., Groshem, S., Cohen, H., Laine, L., Crookes, P., Silberman, H., Baranda, J., Garcia, Y., Li, J., and Leichman, L. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J. Clin. Oncol., 14: 176-182, 1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 176-182
-
-
Lenz, H.J.1
Leichman, C.G.2
Danenberg, K.D.3
Danenberg, P.V.4
Groshem, S.5
Cohen, H.6
Laine, L.7
Crookes, P.8
Silberman, H.9
Baranda, J.10
Garcia, Y.11
Li, J.12
Leichman, L.13
-
13
-
-
1842331518
-
Evaluation of thymidylate synthase mRNA by competitive polymerase chain reaction and clinical implication in 5-fluorouracil chemotherapy
-
Kasai, Y., Kondoh, K., Akiyama, S., Itoh, K., and Takagi, H. Evaluation of thymidylate synthase mRNA by competitive polymerase chain reaction and clinical implication in 5-fluorouracil chemotherapy. Proc. Am. Assoc. Cancer Res., 37: 194, 1996.
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 194
-
-
Kasai, Y.1
Kondoh, K.2
Akiyama, S.3
Itoh, K.4
Takagi, H.5
-
14
-
-
0013105002
-
Thymidylate synthase gene expression in normal and malignant colorectal tissues: Relation to in vivo response and survival
-
Ardalan, B., and Dang, Z. Thymidylate synthase gene expression in normal and malignant colorectal tissues: relation to in vivo response and survival. Proc. Am. Assoc. Cancer Res., 37: 201, 1996.
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 201
-
-
Ardalan, B.1
Dang, Z.2
-
15
-
-
0025981649
-
Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin
-
Romanini, A., Lin, J. T., Niedzwiecki, D., Bunni, M., Priest, D. G., and Bertino, J. R. Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin. Cancer Res., 57: 789-793, 1991.
-
(1991)
Cancer Res.
, vol.57
, pp. 789-793
-
-
Romanini, A.1
Lin, J.T.2
Niedzwiecki, D.3
Bunni, M.4
Priest, D.G.5
Bertino, J.R.6
-
16
-
-
0027317751
-
Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance
-
Wang, F. S., Aschele, C., Sobrero, A., Chang, Y. M., and Bertino, J. R. Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance. Cancer Res., 53: 3677-3680, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 3677-3680
-
-
Wang, F.S.1
Aschele, C.2
Sobrero, A.3
Chang, Y.M.4
Bertino, J.R.5
-
17
-
-
0024200997
-
Methods for thymidylate synthase pharmacodynamics: Serial biopsy, free and total TS, FdUMP and dUMP, and H4Pteglu and CH2-H4Pteglu assays
-
Y. Rustum and J. J. McGuire (eds.). New York: Plenum Press
-
Spears, C. P., and Gustavsson, B. G. Methods for thymidylate synthase pharmacodynamics: serial biopsy, free and total TS, FdUMP and dUMP, and H4Pteglu and CH2-H4Pteglu assays. In: Y. Rustum and J. J. McGuire (eds.), The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy, pp. 97-104. New York: Plenum Press, 1988.
-
(1988)
The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
, pp. 97-104
-
-
Spears, C.P.1
Gustavsson, B.G.2
-
18
-
-
0027323778
-
Single step LC method for determination of folylpolyglutamate synthetase activity and separation of polyglutamates
-
Montero, C., and Llorente, P. Single step LC method for determination of folylpolyglutamate synthetase activity and separation of polyglutamates. Chromatography, 37: 73-78, 1993.
-
(1993)
Chromatography
, vol.37
, pp. 73-78
-
-
Montero, C.1
Llorente, P.2
-
19
-
-
0024403634
-
Colorectal carcinomas: Diagnostic implications of their changing frequency and anatomic distribution
-
Ghahremani, G. G., and Dowlatshahi, K. Colorectal carcinomas: diagnostic implications of their changing frequency and anatomic distribution. World J. Surg., 13: 321-325, 1989.
-
(1989)
World J. Surg.
, vol.13
, pp. 321-325
-
-
Ghahremani, G.G.1
Dowlatshahi, K.2
-
20
-
-
0343417648
-
Chimiothérapie des métastases hépatiques d'origine colorectale
-
B. Nordlinger and D. Jack (eds.). Paris: Springer-Verlag
-
Rougier, P., Lasser, P., and Elias, D. Chimiothérapie des métastases hépatiques d'origine colorectale. In: B. Nordlinger and D. Jack (eds.), Traitement des métastases hépatiques des cancers colorectaux, pp. 119-140. Paris: Springer-Verlag, 1992.
-
(1992)
Traitement Des Métastases Hépatiques Des Cancers Colorectaux
, pp. 119-140
-
-
Rougier, P.1
Lasser, P.2
Elias, D.3
-
21
-
-
0026597027
-
Chemotherapeutic strategies in metastatic colorectal cancer: An overview of current clinical trials
-
Köhne-Wömpner, C. H., Schmoll, H. J., and Harstrick, A., Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials. Semin. Oncol., 19: 105-125, 1992.
-
(1992)
Semin. Oncol.
, vol.19
, pp. 105-125
-
-
Köhne-Wömpner, C.H.1
Schmoll, H.J.2
Harstrick, A.3
-
22
-
-
0028896166
-
Camptothecin and Taxol: Discovery to clinic
-
Thirteenth Bruce F. Cain Memorial Award Lecture
-
Wall, M. E., and Wani, M. C. Camptothecin and Taxol: discovery to clinic. Thirteenth Bruce F. Cain Memorial Award Lecture. Cancer Res., 55: 753-760, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 753-760
-
-
Wall, M.E.1
Wani, M.C.2
-
23
-
-
1842416549
-
P53 point mutation, thymidylate synthase gene expression and clinical response in gastrointestinal cancer
-
Lenz, H. J., Danenberg, K., Leichman, C. G., Hayashi, K., Metzger, R., Salonga, D., Baherjee, D., Bertino, J. R., Leichman, L., and Danenberg, P. V. p53 point mutation, thymidylate synthase gene expression and clinical response in gastrointestinal cancer. Proc. Am. Assoc. Cancer Res., 37: 198, 1996.
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 198
-
-
Lenz, H.J.1
Danenberg, K.2
Leichman, C.G.3
Hayashi, K.4
Metzger, R.5
Salonga, D.6
Baherjee, D.7
Bertino, J.R.8
Leichman, L.9
Danenberg, P.V.10
-
24
-
-
0013059976
-
Thymidylate synthase variation in human colonic tissues
-
Davis, R. A., Sticca, R. P., Dunlap, R. B., Berger, F. G., and Berger, S. H. Thymidylate synthase variation in human colonic tissues. Proc. Am. Assoc. Cancer Res., 37: 175, 1996.
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 175
-
-
Davis, R.A.1
Sticca, R.P.2
Dunlap, R.B.3
Berger, F.G.4
Berger, S.H.5
-
25
-
-
0026391210
-
Secretion of γ-glutamyl hydrolase in vitro
-
O'Connor, B. M., Rotundo, R. F., Nimec, Z., McGuire, J. J., and Galivan, J. Secretion of γ-glutamyl hydrolase in vitro. Cancer Res., 51: 3874-3881, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 3874-3881
-
-
O'Connor, B.M.1
Rotundo, R.F.2
Nimec, Z.3
McGuire, J.J.4
Galivan, J.5
-
26
-
-
0025302665
-
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis
-
Whitehead, V. M., Rosenblatt, D. S., Vuchich, M. J., Shuster, J. J., Witte, A., and Beaulieu, D. Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis. Blood, 76: 44-49, 1990.
-
(1990)
Blood
, vol.76
, pp. 44-49
-
-
Whitehead, V.M.1
Rosenblatt, D.S.2
Vuchich, M.J.3
Shuster, J.J.4
Witte, A.5
Beaulieu, D.6
-
27
-
-
0343924557
-
Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal fluorouracil efficacy. Experimental data
-
in press
-
Cheradame, S., Etienne, M. C., Chazal, M., Guillot, T., Fischel, J. L., Formento, P., and Milano, G. Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal fluorouracil efficacy. Experimental data. Eur. J. Cancer, in press, 1997.
-
(1997)
Eur. J. Cancer
-
-
Cheradame, S.1
Etienne, M.C.2
Chazal, M.3
Guillot, T.4
Fischel, J.L.5
Formento, P.6
Milano, G.7
-
28
-
-
0027006042
-
Measurement of folylpolyglutamate synthetase activity in head and neck squamous cell carcinoma cell lines and clinical samples using a new rapid separation procedure
-
Jansen, G., Schomagel, J. H., Kathmann, I., Westerhof, R., Hordijk, G. J., and van der Laam, B. F. A. M. Measurement of folylpolyglutamate synthetase activity in head and neck squamous cell carcinoma cell lines and clinical samples using a new rapid separation procedure. Oncol. Res., 4: 299-305, 1992.
-
(1992)
Oncol. Res.
, vol.4
, pp. 299-305
-
-
Jansen, G.1
Schomagel, J.H.2
Kathmann, I.3
Westerhof, R.4
Hordijk, G.J.5
Van der Laam, B.F.A.M.6
-
29
-
-
0028848276
-
Screening of colon tumor cells and tissues for folypoly-glutamate synthetase activity
-
Van der Wilt, C. L., Cloos, J., De Jong, M., Pinedo, H. M., and Peters, G. J. Screening of colon tumor cells and tissues for folypoly-glutamate synthetase activity. Oncol. Res., 7: 317-321, 1995.
-
(1995)
Oncol. Res.
, vol.7
, pp. 317-321
-
-
Van der Wilt, C.L.1
Cloos, J.2
De Jong, M.3
Pinedo, H.M.4
Peters, G.J.5
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