Overview of anti-tuberculosis (TB) drugs and their resistance mechanisms

Mini-Reviews in Medicinal Chemistry

Volumn 7, Issue 11, 2007, Pages 1177-1185

  Shi, Ruiru ^a,b   Itagaki, Nobunori ^a   Sugawara, Isamu ^a  

^a RESEARCH INSTITUTE OF TUBERCULOSIS   (Japan)

^b Institute of Tuberculosis   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOSALICYLIC ACID; CAPREOMYCIN; CIPROFLOXACIN; CLINAFLOXACIN; CYCLOSERINE; ETHAMBUTOL; ETHIONAMIDE; GATIFLOXACIN; ISONIAZID; ISONIAZID DERIVATIVE; LEVOFLOXACIN; MOXIFLOXACIN; NALIDIXIC ACID; NORFLOXACIN; OFLOXACIN; POLYPEPTIDE ANTIBIOTIC AGENT; PYRAZINAMIDE; PYRAZINOIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFABUTIN; RIFAMPICIN; RIFAMYCIN DERIVATIVE; RIFAPENTINE; SPARFLOXACIN; STREPTOMYCIN; THIOAMIDE; TUBERCULOSTATIC AGENT; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; CAUSE OF DEATH; CLINICAL TRIAL; DRUG ACTIVATION; DRUG DIFFUSION; DRUG EFFICACY; DRUG EXCRETION; DRUG HYPERSENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TREATMENT FAILURE; GENETIC POLYMORPHISM; HIGH RISK PATIENT; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REVIEW; SHORT COURSE THERAPY; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS; UNSPECIFIED SIDE EFFECT;

ANTITUBERCULAR AGENTS; DRUG RESISTANCE, MICROBIAL; HUMANS; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, GENETIC; TUBERCULOSIS;

EID: 36749044962     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955707782331740     Document Type: Review

References (77)

1. Heifets, L. B. Semin. Respir. Infect., 1994, 9, 84.
2. Bernstein, J.; Lott, W. A.; Steinberg, B. A.; Yale, H. L. Am. Rev. Tuberc., 1952, 65, 357.
3. Zabinski, R.F.; Blanchard, J.S. J. Am. Chem. Soc., 1997, 119, 2331.
4. Johnsson, K.; Schultz, P.G. J. Am. Chem. Soc., 1994, 116, 7425.
5. Bartmann, K. Isoniazid. In Antituberculosis Drugs: Handhook of Eperimental Pharmacology, Bartmann, K. Ed.; Springer-Verlag, Berlin, 1998; pp. 113-134.
6. Bardou, F.; Raynaud, C.; Ramos, C. Microbiology, 1998, 144, 2539.
7. Zhang, Y.; Heym, B.; Allen, B. Nature, 1992, 358, 591.
8. Heym, B.; Zhang, Y.; Poulet, S. J. Bacteriol., 1993, 175, 4255.
9. Johnsson, K.; Froland, W.A.; Schultz, P.G. J. Biol. Chem., 1997, 272, 2834.
10. Wengenack, N. L.; Rusnak, F. Biochemistry, 2001, 40, 8990.
11. Chouchane, S.; Lippai, I.; Maghozz, R. S. Biochemistry, 2000, 39, 9975.
12. Lei, B.; Wei, C. J.; Tu, S. C. J. Biol. Chem., 2000, 275, 2520.
13. Shoeb, H. A.; Bowman, Jr, B. U.; Ottolenghi, A. C. Antimicrob. Agents Chemother., 1985, 27, 404.
14. Shoeb, H. A.; Bowman, Jr, B. U.; Ottolenghi, A. C. Antimicrob. Agents Chemother., 1985, 27, 408.
15. Rozwarski, D. A.; Grant, G. A.; Barton, D. H. R. Science, 1998, 279, 98.
16. Takayama, K.; Schnoes, H. K.; Armstrong, E. L. J. Lipid Res., 1975, 16, 308.
17. Banerjee, A.; Dubnau, E.; Quemard, A. Science, 1994, 263, 227.
18. Basso, L. A.; Zheng, R.; Musser, J. M. J. Infect. Dis., 1998, 178, 769.
19. Dessen, A.; Quemard, A.; Blanchard, J. S. Science, 1995, 267, 1638.
20. Quemard, A.; Dessen, A.; Sugantino, M. J. Am. Chem. Soc., 1996, 118, 1561.
21. Mdluli, K.; Slayden, R. A.; Zhu, Y. Science, 1998, 280, 1607.
22. Moat, A. G.; Foster, J. W. Microbial Physiology. Wiley-Liss, New York, 1995.
23. Wilson, M.; Derisi, J.; Kristensen, H. H. Proc. Natl. Acad. Sci. USA, 1999, 96, 12833.
24. Sherman, D. R.; Mdluli, K.; Hickey, M. J. Science, 1996, 272, 1641.
25. Zhang, Y.; Heym, B.; Young, D.; Cole, S. Nature, 1992, 358, 591.
26. Rawat, R.; Whitty, A.; Tonge, P. J. Proc. Natl. Acad. Sci. USA, 2003, 100, 13881.
27. Mokrousov, I.; Bhanu, N. V.; Suffys, P. N.; Kadival, G. V.; Yap, S. F.; Cho, S. N.; Jordaan, A. M., Narvskaya, O.; Singh, U. B.; Gomes, H. M.; Lee, H.; Kulkami, S. P.; Lim, K. C.; Khan, B. K.; van Soolingen, D.; Victor, T. C.; Schouls, L. J. Microbiol. Methods, 2004, 57, 323.
28. Zhang, M.; Yue, J.; Yang, Y. P.; Zhang, H. M.; Lei, J. Q.; Jin, R. L.; Zhang, X. L.; Wang, H. H. J. Clin. Microbiol., 2005, 43, 5477.
29. Kapetanaki, S.; Chouchane, M. S.; Yu, S.; Zhao, X.; Magliozzo, R. S.; Schelvis, J. Biochemistry, 2005, 44, 243.
30. Wei, C.; Lei, B.; Musser, J. M. Antimicrob. Agents Chemother., 2003, 47, 670.
31. Sherman, D. R.; Mdluli, K.; Hickey, M.J.; Arain, T.M.; Morris, S. L.; Barry, C. E. 3rd.; Stover, C. K. Science, 1996, 272, 1641.
32. Screevatsan, S.; Pan, X.; Zhang, Y. Antimicrob. Agents Chemother., 1997, 41, 600.
33. Ramaswamy, S.V.; Dou, S.J.; Rendon, A.; Yang, Z.; Cave, M. D.; Graviss, E. A. J Med. Microbiol., 2004, 53, 107.
34. Vilcheze, C.; Weisbrod, T. R.; Chen, B.; Kremer, L.; Hazbon, M. H.; Wang, F.; Alland, D.; Saccettini, J. C.; Jacobs, W. R. Jr. Antimicrob. Agents Chemother., 2005, 49, 708.
35. Ramaswamy, S. V.; Reich, V. R.; Don, S. J.; Jasperse, L.; Pan, X.; Wanger, A.; Quitugua, T.; Graviss, E. A. Antimicrob. Agents Chemother., 2003, 47, 1241.
36. Hazbon, M.H.; Brimacombe, M.; Bobadilla del Valle, M.; Cavatore, M.; Guerrero, M. I.; Varma-Basil, M.; Billman-Jacobe, H.; Lavender, C.; Fyfe, J.; Garcia-Garcia, L.; Leon, C. L; Bose, M.; Chaves, F.; Murray, M.; Eisenach, K. D.; Sifuentes-Osomio, J.; Cave, M. D.; Ponce de Leon, A.; Alland, D. Antimicrob. Agents Chemother., 2006, 50, 2640.
37. Sensi, P. Rev. Infect. Dis., 1983, 5(Suppl. 3), S402.
38. Donald, P.R.; Sirgel, F.A.; Botha, F.J.; Seifart, H.L; Parkin, D.P.; Vandenplas, M.L.; Van de Wal, B.W.; Maritz, J.S.; Mitchison, D.A. Am. J. Respir. Crit. Care Med., 1997, 156, 895.
39. Sirgel, F.A.; Donald, P.R.; Odhiambo, J.; Githui, W.; Umapathy, K. C.; Paramasivan, C. N.; Tan, C. M.; Kam, K. M.; Lam, C. W.; Sole, K. M.; Mitchison, D. A. J. Antimicrob. Chemother., 2000, 45, 859.
40. Mitchison, D. A. Int. J. Tuberc. Lung Dis., 1998, 2, 10.
41. Mitchison, D. A. Int. J. Tuberc. Lung Dis., 2000, 45, 796.
42. Campbell, EA.; Korzheva, N.; Mustaev, A.; Murakami, K.; Nair, S.; Goldfarb, A.; Darst, S. A. Cell, 2001, 104, 901.
43. McCammon, M.T.; Gillette, J.S.; Thomas, D.P.; Ramaswamy, S. V.; Rosas, I. I.; Graviss, E. A.; Vijg, J.; Quitugua, T. N. Antimicrob. Agents Chemother., 2005, 49, 2200.
44. Mikhailovich, V.; Lapa, S.; Gryadunov, D.; Sobolev, A.; Strizhkov, B.; Chemyh, N.; Skotnikova, O.; Irtuganova, O.; Moroz, A.; Litvinov, V.; Vladimirskii, M.; Perelman, M.; Chemousova, L.; Erokhin, V.; Zasedatelev, A.; Mirzabekov, A. J. Clin. Microbiol., 2001, 39, 2531.
45. Telenti, A.; Imboden, P.; Marchesi, F.; Lowrie, D.; Cole, S.; Colston, M.J.; Matter, L.; Schopfer, K.; Bodmer, T. Lancet, 1993, 341, 647.
46. Forbes, M.; Kuck, N. A.; Peets, E. A. J. Bacteriol., 1965, 89, 1299.
47. Forbes, M.; Kuck, N.A.; Peets, E. A.. J. Bacteriol., 1962, 84, 1299.
48. Cheema, S.; Asotra, S.; Khuller, G. K. Int. Res. Common Sys. Med. Sci. Biochem., 1985, 13, 178.
49. Takayama, K.; Armstrong, E.L.; Kunugi, KA.; Kilburn, J.O. Antimicrob. Agents Chemother., 1979, 16, 240.
50. Paulin, L.G.; Brander, E.E.; Poso, H.J. Antimicrob. Agents Chemother., 1985, 28, 157.
51. Takayama, K.; Kilburn, J.O. Antimicrob. Agents Chemother., 1989, 33, 1493.
52. Mikusova, K.; Slayden, R.A.; Besra, G. S.; Brennan, P. J. Antimicrob. Agents Chemother., 1995, 39, 2484.
53. Wolucka, B.A.; McNeil, M.R.; de Hoffmann, E.; Chojnacki, T.; Brennan, P. J. J. Biol. Chem., 1994, 269, 23328.
54. Telenti, A.; Philipp, W.J.; Sreevatsan, S.; Bernasconi, C.; Stockbauer, K. E.; Wieles, B.; Musser, J. M.; Jacobs, W. R. Jr. Nat. Med., 1997, 3, 567.
55. Alcaide, F.; Pfyffer, G.E.; Telenti, A. Antimicrob. Agents Chemother., 1997, 41, 2270.
56. Chopra, L; Brennan, P. Tiber. Lung Dis., 1998, 78, 89.
57. Lety, M.A.; Nair, S.; Berche, P.; Escuyer, V. Antimicrob. Agents Chemother., 1997, 41, 2629.
58. Ramaswamy, S.V.; Amin, A.G.; Goksel, S.; Stager, C.E.; Dou, S.J.; El Sahly, H.; Moghazen, S.L.; Kreiswirth, B. N.; Musser, J. M. Antimicrob. Agents Chemother., 2000, 44, 326.
59. Van Rie, A.; Warren, R.; Mshanga, I.; Jordaan, A.M.; van der Spuy, G.D.; Richardson, M.; Simpson, J.; Gie, R.P.; Enarson, D.A.; Beyers, N.; van Helden, P.D.; Victor, T.C. J. Clin. Microbiol., 2001, 39, 636.
60. Rinder, H.; Mieskes, K.T.; Tortoli, E.; Richter, E.; Casal, M.; Vaquero, M.; Cambau, E.; Feldmann, K.; Loscher, T. Mol. Cell Probes, 2001, 15, 37.
61. Mokrousov, I.; Otten, T.; Vyshnevskiy, B.; Narvskaya, O. J Clin. Microbiol., 2002, 40, 3810.
62. Post, F.A.; Willcox, P.A.; Mathema, B.; Steyn, L.M.; Shean, K.; Ramaswamy, S.V.; Graviss, E.A.; Shashkina, E.; Kreiswirth, B.N.; Kaplan, G. J. Infect. Dis., 2004, 190, 99.
63. Hazbon, M. H.; Bobadilla del Valle, M.; Guerrero, M. I.; Varma-Basil, M.; Filliol, I.; Cavatore, M.; Colangeli, R.; Safi, H.; Billman-Jacobe, H.; Lavender, C.; Fyfe, J.; Garcia-Garcia, L.; Davidow, A.; Brimacombe, M.; Leon, C. I.; Porras, T.; Bose, M.; Chaves, F.; Eisenach, K.D.; Sifuentes-Osomio, J.; Ponce de Leon, A.; Cave, M. D.; Alland, D. Antimicrob. Agents Chemother., 2005, 9, 3794.
64. Miller, M.A.; Thibert, L.; Desjardins, F.; Siddiqi, S.H.; Dascal, A. J. Clin. Microbiol., 1995, 33, 2468.
65. Scorpio, A.; Lindholm-levy, P.; Heifets, L.; Gilman, R.; Sidiqi, S.; Cynamon, M.; Zhang, Y. Antimicrob. Agents Chemother., 1997, 41, 540.
66. Morlock, G.P.; Crawford, J.T.; Butler, W.R.; Brim, S.E.; Sikes, D.; Mazurek, G. H.; Woodley, C.L.; Cooksey, R.C. Antimicrob. Agents Chemother., 2000, 44, 2291.
67. Hannan, M.M.; Desmond, E.P.; Morlock, G.P.; Mazurek, G.H.; Crawford, J.T. J. Clin. Microbiol., 2001, 39, 647.
68. Lemaitre, N.; Sougakoff, W.; Truffot-Pernot, C.; Jarlier, V. Antimicroh. Agents Chemother., 1999, 43, 1761.
69. Bloom, B.R.; Murray, C.J.L. Science, 1992, 257, 1055.
70. Moazed, D.; Noller, H. F. Nature, 1987, 1, 394.
71. Galili, H.; Fromm, H.; Galun, E. Mol. Gen. Genet., 1989, 218, 289.
72. Liu, X.Q.; Gillham, N.W.; Boynton, J. E. J. Biol. Chem., 1989, 26, 16108.
73. Gauthier, A.; Turmel, M.; Lemieux, C. Mol. Gen. Genet., 1988, 214, 192.
74. Noller, H. Annu. Rev. Biochem., 1984, 53, 119.
75. O'Brien, R.J. Am. J. Respir. Crit. Care Med., 2003, 168, 1266.
76. Ginsburg, A.S.; Grosset, J.H.; Bishai, W. R. Lancet Infect. Dis., 2003, 3, 432.
77. World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis. (WHO/HTM/TB/2006.361). World Health Organization. Switzerland, Geneva, 2006.