Role of embB in natural and acquired resistance to ethambutol in mycobacteria

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 10, 1997, Pages 2270-2273

  Alcaide, Fernando ^a   Pfyffer, Gaby E ^b   Telenti, Amalio ^a,c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ETHAMBUTOL;

ANTIBIOTIC RESISTANCE; ARTICLE; LEPROSY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIOSIS; MYCOBACTERIUM CHELONEI; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; TUBERCULOSIS;

EID: 0030756416     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.10.2270     Document Type: Article

References (35)

1. Belanger, A. E., G. S. Besra, M. E. Ford, K. Mikusová, J. T. Belisle, P. J. Brennan, and J. I. Inamine. 1996. The embAB genes of Mycobacterium avium encode an arahinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc. Natl. Acad. Sci. USA 93:11919-11924.
2. Böttger, E. C., B. Hirschel, and M. B. Coyle. 1993. Mycobacterium genavense sp. nov. Int. J. Syst. Bacteriol. 42:841-843.
3. Escuyer, V., and M. A. Lety. 1997. A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatis, abstr. B-39. ASM Conference on Tuberculosis: Past, Present, and Future.
4. Escuyer, V., M. A. Lety, and P. Berche. 1996. Analysis of molecular mechanism(s) of Mycobacterium smegmatis resistance to ethambutol, abstr. C141, p. 59. In Abstracts of the 36th International Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
5. Falkinham, J. O., III. 1996. Epidemiology of infection by nontuberculous mycobacteria. Clin. Microbiol. Rev. 9:177-215.
6. Good, R. C., V. A. Silcox, J. O. Kilburn, and B. D. Plikaytis. 1985. Identification and drug susceptibility test results for Mycobacterium spp. Clin. Microbiol. Newsl. 7:133-136.
7. Guillemin, I., E. Cambau, and V. Jarlier. 1995. Sequences of a conserved region in the A subunit of DNA gyrase from nine species of the genus Mycobacterium: phylogenetic analysis and implications for intrinsic susceptibility to quinolones. Antimicrob. Agents Chemother. 39:2145-2149.
8. Hacek, D. 1992. Modified proportion agar dilution test for slowly growing mycobacteria, p. 5.13.1-5.13.15. In H. D. Isenberg (ed.), Clinical microbiology procedures handbook. American Society for Microbiology, Washington, D.C.
9. Heifets, L. B. 1991. Drug susceptibility in the chemotherapy of mycobacterial infection. CRC Press, Inc., Boca Raton, Fla.
10. Heifets, L. B., M. D. Iseman, and P. J. Lindholm-Levy. 1986. Ethambutol MICs and MBCs for Mycobacterium avium complex and Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 30:927-932.
11. Inderlied, C. B., and K. A. Nash. 1995. Antimycobacterial agents: in vitro susceptibility testing, spectra of activity, mechanisms of action and resistance, and assays for activity in biology fluids, p. 127-175. In V. Lorian (ed.), Antibiotics in laboratory medicine. The Williams & Wilkins Co., Baltimore, Md.
12. Johnson, J. D., W. L. Hand, J. B. Francis, N. King-Thompson, and R. W. Corwin. 1980. Antibiotic uptake by alveolar macrophages. J. Lab. Clin. Med. 95:429.
13. Katoch, V. M., K. Katoch, C. T. Shivannavar, V. D. Sharma, M. A. Patil, and V. P. Bharadwaj. 1989. Application of ATP assay for in vitro drug screening testing against human derived M. leprae. Indian J. Leprosy 61:333-344.
14. Kent, P. T., and G. P. Kubica. 1985. Public health mycobacteriology. A guide for level III laboratories. Centers for Disease Control, Atlanta, Ga.
15. Laszlo, A., M. Rahman, M. Raviglione, F. Bustreo, and The WHO/IUATLD Network of Supranational Reference Laboratories. Quality assurance programme for drug susceptibility testing of Mycobacterium tuberculosis in the WHO/IUATLD supranational laboratory network: first round of proficiency testing. Int. J. Tuberculosis Lung Dis., in press.
16. Lee, C. N., and L. B. Heifets. 1987. Determination of minimal inhibitory concentration of antituberculosis drugs by radiometric and conventional methods. Am. Rev. Respir. Dis. 136:349.
17. Maddry, J. A., W. J. Suling, and R. C. Reynolds. 1996. Glycosyl transferases as targets for inhibition of cell wall synthesis in M. tuberculosis and M. avium. Res. Microbiol. 147:106-112.
18. Peloquin, C. A. 1996. Therapeutic drug monitoring of the antimycobacterial drugs. Clin. Lab. Med. 16:717-729.
19. Pfaltgraff, R. E. 1969. A pilot trial of ethambutol in leprosy. Int. J. Leprosy 37:408-411.
20. Rastogi, N., K. Seng Goh, and H. L. David. 1990. Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis. Antimicrob. Agents Chemother. 34:759-764.
21. Shepard, C. C., and Y. T. Chang. 1964. Activity of antituberculosis drugs against Mycobacterium leprae: studies with experimental infection of mouse foot pads. Int. J. Leprosy 32:260-271.
22. Siddiqi, S. H. 1992. Radiometric (BACTEC) tests for slowly growing mycobacteria, p. 5.14.1-5.14.14. In H. D. Isenberg (ed.), Clinical microbiology procedures handbook. American Society for Microbiology, Washington, D.C.
23. Snapper, S. B., R. E. Melton, S. Mustafa, T. Kieser, and W. R. Jacobs, Jr. 1990. Isolation and characterization of efficient transformation mutants of Mycobacterium smegmatis. Mol. Microbiol. 4:1911-1919.
24. Spratt, B. G. 1994. Resistance to antibiotics mediated by target alterations. Science 264:388-392.
25. Sreevatsan, S., K. E. Stochbauer, X. Pan, B. N. Kreiswirth, S. L. Moghazeh, W. R. Jacobs, Jr., A. Telenti, and J. M. Musser. 1997. Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations. Antimicrob. Agents Chemother. 41:1677-1681.
26. Swenson, J. M., C. Thornsberry, and V. A. Silcox. 1982. Rapidly growing mycobacteria: testing of susceptibility to 34 antimicrobial agents by broth microdilution. Antimicrob. Agents Chemother. 22:186-192.
27. Takayama, K., and J. O. Kilburn. 1989. Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis. Antimicrob. Agents Chemother. 33:1493-1499.
28. Telenti, A., P. Imboden, F. Marchesi, T. Schmidheini, and T. Bodmer. 1993. Direct, automated detection of rifampin-resistant Mycobacterium tuberculosis by polymerase chain reaction and single-strand conformation polymorphism. Antimicrob. Agents Chemother. 37:2054-2058.
29. Telenti, A., F. Marchesi, M. Balz, F. Bally, E. C. Bottger, and T. Bodmer. 1993. Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J. Clin. Microbiol. 31:175-178.
30. Telenti, A., and D. H. Persing. 1996. Novel strategies for the detection of drug resistance in Mycobacterium tuberculosis. Res. Microbiol. 147:73-79.
31. Telenti, A., W. Philipp, S. Sreevatsan, C. Bernasconi, K. E. Stockbauer, B. Wieles, J. M. Musser, and W. R. Jacobs, Jr. 1997. The emb operon, a unique gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Nat. Med. 3:567-570.
32. Wang, Y., W. M. Huang, and D. E. Taylor. 1993. Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. Antimicrob. Agents Chemother. 37:457-463.
33. Wilkinson, R. G., R. G. Sheperd, J. P. Thomas, and C. Baughn. 1961. Stereospecificity of a new type of synthetic antituberculosis agent. J. Am. Chem. Soc. 83:2212-2213.
34. Woodley, C. L. 1986. Evaluation of streptomycin and ethambutol concentrations for susceptibility testing of Mycobacterium tuberculosis by radiometric and conventional procedures. J. Clin. Microbiol. 23:385-386.
35. Yajko, D. M., J. J. Madej, V. L. Cawthon, C. A. Sanders, and W. K. Hadley. 1995. Antimicrobial susceptibility of clinical isolates of Mycobacterium genavense, abstr. E8, p. 86. Abstracts of the 35th International Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.