Role of individual drugs in the chemotherapy of tuberculosis

International Journal of Tuberculosis and Lung Disease

Volumn 4, Issue 9, 2000, Pages 796-806

  Mitchison, D A ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bactericidal; Drug resistance; Isoniazid; Phases of chemotherapy; Pyrazinamide; Rifampicin; Tuberculosis

Indexed keywords

AMINOSALICYLIC ACID; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN; RIFAPENTINE; STREPTOMYCIN; THIOACETAZONE;

BACTERICIDAL ACTIVITY; CHEMOTHERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; HUMAN; LUNG TUBERCULOSIS; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; REVIEW;

ANTIBIOTICS, ANTITUBERCULAR; ANTITUBERCULAR AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; HUMANS; ISONIAZID; MICROBIAL SENSITIVITY TESTS; PRIMARY PREVENTION; PYRAZINAMIDE; RIFAMPIN; SPUTUM; TIME FACTORS; TREATMENT OUTCOME; TUBERCULOSIS;

EID: 0033812380     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (59)

1. An international investigation of the efficacy of chemotherapy in previously untreated patients with pulmonary tuberculosis
2. Microbial Persistence I. The capacity of tubercle to survive sterilization in mouse tissues
3. Microbial Persistence II. Characteristics of the sterile state of tubercle bacilli
4. The sterilizing value of rifampicin and pyrazinamide in experimental short course chemotherapy
5. Controlled clinical trial of four short-course (6-month) regimens of chemotherapy for treatment of pulmonary tuberculosis
6. Controlled trial of 6-month and 9-month regimens of daily and intermittent streptomycin plus isoniazid plus pyrazinamide for pulmonary tuberculosis in Hong Kong. The results up to 30 months
7. Controlled Clinical trial of four 6-month regimens of chemotherapy for pulmonary tuberculosis. Second report
8. Controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis: The results up to 24 months
9. Clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis. The results up to 30 months
10. A controlled trial of six months chemotherapy in pulmonary tuberculosis. Second Report: Results during the 24 months after the end of chemotherapy
11. The early bactericidal activity of drugs in patients with pulmonary tuberculosis
12. The early bactericidal activity of isoniazid related to its dose size in pulmonary tuberculosis
13. Early bactericidal activity of ethambutol, pyrazinamide and the fixed combination of isoniazid, rifampicin and pyrazinamide (Rifater) in patients with pulmonary tuberculosis
14. A multi-centre study of the early bactericidal activity of antituberculosis drugs
15. Experimental models to explain the high sterilizing activity of rifampin in the chemotherapy of tuberculosis
16. The early bactericidal activity of rifabutin measured by sputum viable counts in Hong Kong patients with pulmonary tuberculosis
17. Studies on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units, 1946-1986, with relevant subsequent publications
18. Controlled clinical trial of five short-course (4-month) chemotherapy regimens in pulmonary tuberculosis: Second report of the 4th study
19. Controlled clinical trial of 4 short-course regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis: Final report
20. Clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis: The results up to 30 months
21. Clinical trial of three 6-month regimens of chemotherapy given intermittently in the continuation phase in the treatment of pulmonary tuberculosis
22. Assessment of a daily combined preparation of isoniazid, rifampin and pyrazinamide in a controlled trial of three 6-month regimens for smear-positive pulmonary tuberculosis
23. Rifapentine and isoniazid in the continuation phase of a 6-month regimen. Interim report: No activity of isoniazid in the continuation phase
24. Sterilizing activity of the main drugs on the mouse experimental tuberculosis
25. The action of antituberculosis drugs in short-course chemotherapy
26. Controlled clinical trial of four short-course regimens of chemotherapy for two durations in the treatment of pulmonary tuberculosis. Second Report of the Third Study
27. Controlled clinical trial of levamisole in short-course chemotherapy for pulmonary tuberculosis
28. The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. II. The conversion of tuberculous infection to the latent state by the administration of pyrazinamide and a companion drug
29. Bactericidal activity of streptomycin, isoniazid, rifampin, ethambutol, and pyrazinamide alone and in combination against Mycobacterium tuberculosis
30. Pyrazinamide is not effective against intracellularly growing Mycobacterium tuberculosis
31. Pyrazinamide sterilising activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations
32. A controlled comparison of a twice-weekly and three once-weekly regimens in the initial treatment of pulmonary tuberculosis
33. A controlled comparison of two fully supervised once-weekly regimens in the treatment of newly diagnosed pulmonary tuberculosis
34. Laboratory aspects of intermittent drug therapy
35. Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid
36. Cumulative effects of pulsed exposures of Mycobacterium tuberculosis to isoniazid
37. Controlled trial of intermittent regimens of rifampicin plus isoniazid for pulmonary tuberculosis in Singapore
38. Ethambutol plus isoniazid for the treatment of pulmonary tuberculosis - A controlled trial of four regimens
39. Concurrent comparison of isoniazid plus PAS with three regimens of isoniazid alone in the domiciliary treatment of pulmonary tuberculosis in South India
40. Treatment of Tuberculosis
41. Pyrazinamide and isoniazid used in the treatment of pulmonary tuberculosis
42. Controlled clinical trial of two 6-month regimens of chemotherapy in the treatment of pulmonary tuberculosis
43. A controlled trial of a 4-weekly supplement of rifampicin, pyrazinamide and streptomycin in the continuation phase of a 7-month daily chemotherapy regimen for pulmonary tuberculosis
44. Controlled chemoprophylaxis trials in tuberculosis. A general review
45. Efficacy of various durations of isoniazid preventive therapy for tuberculosis: Five years of follow-up in the IUAT trial
46. A double-blind placebo-controlled clinical trial of three antituberculosis chemoprophylaxis regimens in patients with silicosis in Hong Kong
47. Experimental short-course preventive therapy of tuberculosis with rifampin and pyrazinamide
48. Twice weekly tuberculosis preventive therapy in HIV infection in Zambia
49. Randomised trial of isoniazid versus rifampicin and pyrazinamide for prevention of tuberculosis in HIV-1 infection
50. Bioavailability of rifampin in experimental murine tuberculosis
51. Preventive chemotherapy of tuberculosis in Cornell model mice with combinations of rifampin, isoniazid, and pyrazinamide
52. Pyrazinamide in the chemoprophylaxis of tuberculosis
53. Controlled clinical trial of 4 shortcourse regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis: Final report
54. Controlled trial of 2, 4 and 6 months of pyrazinamide in 6-month, 3x weekly regimens for smear-positive pulmonary tuberculosis, including an assessment of a combined preparation of isoniazid, rifampin and pyrazinamide
55. A double-blind placebo-controlled clinical trial of three antituberculosis chemoprophylaxis regimens in patients with silicosis in Hong Kong
56. US Public Health Service co-operative trial of three rifampin-isoniazid regimens in treatment of pulmonary tuberculosis
57. Comparison of three different regimens in the treatment of acute brucellosis: A multicenter multinational study