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Synlett

Volumn , Issue 18, 2007, Pages 2882-2884

Click chemistry: A straightforward route to decorated prolines

(4) Pisaneschi, Federica a Cordero, Franca M a Lumini, Marco a Brandi, Alberto a

a UNIVERSITY OF FLORENCE (Italy)

Author keywords

substituted prolines; 1,2,3 triazoles; Alkynes; Amino acids; Azides

Indexed keywords

PROLINE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLOADDITION; GEL CHROMATOGRAPHY; MICROWAVE COOKING;

EID: 36549061413 PISSN: 09365214 EISSN: None Source Type: Journal
DOI: 10.1055/s-2007-991065 Document Type: Article

Times cited : (12)

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- 4, filtered, and concentrated under reduced pressure. The crude product was purified by chromatography on silica gel to afford analytically pure proline 9.

37
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- 1-Benzyl 2-Methyl (2R)-2, 1-(4-Ethoxy-4-oxobutyl)-1H-1,2,3-triazol-4-yl]methyl}pyrrolidine-1,2-dicarboxylate (9c, Rf0.28 (PE-Et2O, 1:1, 1H NMR (400 MHz, DMSO-d6, 110°C, δ, 7.52 (s, 1 H, triazole, 7.29-7.41 (m, 5 H, Ph, 5.12 (s, 2 H, CH2Ph, 4.34 (t, J, 6.9 Hz, 2 H, NCH2CH2CH2CO 2Et, 4.08 (q, J, 7.1 Hz, 2 H, CH2CH 3, 3.63 (br s, 3 H, OMe, 3.46-3.58 [m, 2 H, C(2)CHH, 5-Ha, 3.23 [d, J, 14.6 Hz, 1 H, C(2)CHH, 3.02-3.10 (m, 1 H, 5-H b, 2.24-2.32 (m, 1 H, 3-Ha, 2.27 (t, J, 7.3 Hz, 2 H, CH2CO2Et, 2.02-2.10 (m, 3 H, 3-Hb, CH2CH2CO2Et, 1.67-1.79 (m, 1 H, 4-Ha, 1.29-1.41 (m, 1 H, 4-Hb, 1.20 t, J, 7.1 Hz, 3
- 6: C, 60.25; H, 6.59; N, 12.22. Found: C, 59.98; H, 6.90; N, 11.98.

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