Structure of kaitocephalin, A novel glutamate receptor antagonist produced by eupenicillium shearii

Tetrahedron Letters

Volumn 38, Issue 40, 1997, Pages 7079-7082

  Shin Ya, Kazuo ^a   Kim, Jung Sik ^a   Furihata, Kazuo ^a   Hayakawa, Yoichi ^a   Seto, Haruo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID; KAITOCEPHALIN; UNCLASSIFIED DRUG;

ACTINOMYCES; ANIMAL CELL; ARTICLE; CELL CULTURE; CHICKEN; CONTROLLED STUDY; CYTOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; NERVE CELL; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; TELENCEPHALON;

ACTINOMYCES; ANIMALIA; EUPENICILLIUM SHEARII; GALLUS GALLUS;

EID: 0030854238     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01653-5     Document Type: Article

References (9)

1. D. W. Choi: J. Neurosci., 10, 2493 (1990).
2. J. T. Coyle: Puttfarcken, P. Science, 262, 689 (1993).
3. M. J. Sheardown, E. Ø. Nielsen, A. J. Hansen, P. Jacobsen and T. Honoré: Science, 247, 571 (1990)
4. T. Yamamoto and T. Taguchi: Neurosci. Lett., 139, 205 (1992) and references cited therein.
5. -1; 3410, 1640, 1560, 1485, 1385
6. 2O at 125 MHz): 177.8 (C-17), 175.0 (C-18), 171.3 (C-1), 168.2 (C-10), 153.8 (C-14), 128.6 (C-12,16), 125.5 (C-11), 123.0 (C-13,15), 77.1 (C-4), 71.4 (C-3), 59.7 (C-7), 56.2 (C-2), 54.2 (C-9), 35.6 (C-8), 32.7 (C-5), 30.4 (C-6).
7. 15N-HMBC spectrum by using formamide (112 ppm) as an external standard.
8. S. Omura, K. Matsuzaki, T. Fujimoto, K. Kosuge, T. Furuya, S. Fujita and A. Nakagawa: J. Antibiotics, 44, 117 (1991)
9. H. Seto, T. Fujioka, K. Furihata, I. Kaneko and S. Takahashi: Tetrahedron Lett., 30, 4987 (1989).