α-alkyl-α-amino-β-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 20, 2001, Pages 2723-2725

  Becker, Daniel P ^a   DeCrescenzo, Gary ^a   Freskos, John ^a   Getman, Daniel P ^a   Hockerman, Susan L ^a   Li, Madeleine ^a   Mehta, Pramod ^a   Munie, Grace E ^a   Swearingen, Craig ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO BETA SULFONE HYDROXAMIC ACID DERIVATIVE; CGS 27023A; COLLAGENASE 3; GELATINASE A; INTERSTITIAL COLLAGENASE; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT;

ALKANES; COLLAGENASES; ENZYME INHIBITORS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035935192     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00557-1     Document Type: Article

References (10)