-
1
-
-
0017716458
-
Thymidylate synthetase-a target enzyme in cancer chemotherapy.
-
Danenberg PV (1977) Thymidylate synthetase-a target enzyme in cancer chemotherapy. Biochim Biophys Acta 473:73-92
-
(1977)
Biochim Biophys Acta
, vol.473
, pp. 73-92
-
-
Danenberg, P.V.1
-
2
-
-
0029036377
-
The catalytic mechanism and structure of thymidylate synthase.
-
Carreras CW, Santi DV (1995) The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 64:721-762
-
(1995)
Annu Rev Biochem
, vol.64
, pp. 721-762
-
-
Carreras, C.W.1
Santi, D.V.2
-
3
-
-
0037115911
-
Uracil in DNA-occurrence, consequences and repair.
-
Krokan HE, Drablos F, Slupphaug G (2002) Uracil in DNA-occurrence, consequences and repair. Oncogene 21:8935-8948
-
(2002)
Oncogene
, vol.21
, pp. 8935-8948
-
-
Krokan, H.E.1
Drablos, F.2
Slupphaug, G.3
-
4
-
-
0023667703
-
Kinetics and thermodynamics of the interaction of 5-fluoro-2′- deoxyuridylate with thymidylate synthase.
-
Santi DV, McHenry CS, Raines RT, Ivanetich KM (1987) Kinetics and thermodynamics of the interaction of 5-fluoro-2′-deoxyuridylate with thymidylate synthase. Biochemistry 26:8606-8613
-
(1987)
Biochemistry
, vol.26
, pp. 8606-8613
-
-
Santi, D.V.1
McHenry, C.S.2
Raines, R.T.3
Ivanetich, K.M.4
-
5
-
-
0031052281
-
Folate-based thymidylate synthase inhibitors in cancer chemotherapy.
-
Takemura Y, Jackman AL (1997) Folate-based thymidylate synthase inhibitors in cancer chemotherapy. Anticancer Drugs 8:3-16
-
(1997)
Anticancer Drugs
, vol.8
, pp. 3-16
-
-
Takemura, Y.1
Jackman, A.L.2
-
6
-
-
0031444484
-
Chemotherapy of colorectal cancer: History and new themes.
-
Bertino JR (1997) Chemotherapy of colorectal cancer: history and new themes. Semin Oncol 24:S18-13-S18-17
-
(1997)
Semin Oncol
, vol.24
-
-
Bertino, J.R.1
-
7
-
-
0031473805
-
Biomodulation of 5-fluorouracil with antifolates.
-
Bertino JR (1997) Biomodulation of 5-fluorouracil with antifolates. Semin Oncol 24:S18-52-S18-56
-
(1997)
Semin Oncol
, vol.24
-
-
Bertino, J.R.1
-
8
-
-
0021808075
-
Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.
-
Jenh CH, Geyer PK, Baskin F, Johnson LF (1985) Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines. Mol Pharmacol 28:80-85
-
(1985)
Mol Pharmacol
, vol.28
, pp. 80-85
-
-
Jenh, C.H.1
Geyer, P.K.2
Baskin, F.3
Johnson, L.F.4
-
9
-
-
0022344622
-
Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.
-
Berger SH, Jenh CH, Johnson LF, Berger FG (1985) Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. Mol Pharmacol 28:461-467
-
(1985)
Mol Pharmacol
, vol.28
, pp. 461-467
-
-
Berger, S.H.1
Jenh, C.H.2
Johnson, L.F.3
Berger, F.G.4
-
10
-
-
0025307988
-
Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase.
-
Barbour KW, Berger SH, Berger FG (1990) Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase. Mol Pharmacol 37:515-518
-
(1990)
Mol Pharmacol
, vol.37
, pp. 515-518
-
-
Barbour, K.W.1
Berger, S.H.2
Berger, F.G.3
-
11
-
-
0026503987
-
Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.
-
Houghton PJ, Rahman A, Will CL, Dolnick BJ, Houghton JA (1992) Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates. Cancer Res 52:558-565
-
(1992)
Cancer Res
, vol.52
, pp. 558-565
-
-
Houghton, P.J.1
Rahman, A.2
Will, C.L.3
Dolnick, B.J.4
Houghton, J.A.5
-
12
-
-
0023803472
-
A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2′-deoxyuridine in a human colon tumor cell line.
-
Berger SH, Barbour KW, Berger FG (1988) A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2′-deoxyuridine in a human colon tumor cell line. Mol Pharmacol 34:480-484
-
(1988)
Mol Pharmacol
, vol.34
, pp. 480-484
-
-
Berger, S.H.1
Barbour, K.W.2
Berger, F.G.3
-
13
-
-
0032707281
-
Mechanisms of acquired resistance to thymidylate synthase inhibitors: The role of enzyme stability.
-
Kitchens ME, Forsthoefel AM, Barbour KW, Spencer HT, Berger FG (1999) Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability. Mol Pharmacol 56:1063-1070
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1063-1070
-
-
Kitchens, M.E.1
Forsthoefel, A.M.2
Barbour, K.W.3
Spencer, H.T.4
Berger, F.G.5
-
14
-
-
0038387494
-
5-fluorouracil: Mechanisms of action and clinical strategies.
-
Longley DB, Harkin DP, Johnston PG (2003) 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3:330-338
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 330-338
-
-
Longley, D.B.1
Harkin, D.P.2
Johnston, P.G.3
-
15
-
-
0033044686
-
A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells.
-
Tillman DM, Petak I, Houghton JA (1999) A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. Clin Cancer Res 5:425-430
-
(1999)
Clin Cancer Res
, vol.5
, pp. 425-430
-
-
Tillman, D.M.1
Petak, I.2
Houghton, J.A.3
-
16
-
-
0034657911
-
Fas-dependent and -independent mechanisms of cell death following DNA damage in human colon carcinoma cells.
-
Petak I, Tillman DM, Harwood FG, Mihalik R, Houghton JA (2000) Fas-dependent and -independent mechanisms of cell death following DNA damage in human colon carcinoma cells. Cancer Res 60:2643-2650
-
(2000)
Cancer Res
, vol.60
, pp. 2643-2650
-
-
Petak, I.1
Tillman, D.M.2
Harwood, F.G.3
Mihalik, R.4
Houghton, J.A.5
-
17
-
-
2542496862
-
The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.
-
Longley DB, Allen WL, McDermott U, Wilson TR, Latif T, Boyer J, Lynch M, Johnston PG (2004) The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites. Clin Cancer Res 10:3562-3571
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3562-3571
-
-
Longley, D.B.1
Allen, W.L.2
McDermott, U.3
Wilson, T.R.4
Latif, T.5
Boyer, J.6
Lynch, M.7
Johnston, P.G.8
-
18
-
-
0034616122
-
Regulation of FasL by NF-kappaB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells.
-
Harwood FG, Kasibhatla S, Petak I, Vernes R, Green DR, Houghton JA (2000) Regulation of FasL by NF-kappaB and AP-1 in Fas-dependent thymineless death of human colon carcinoma cells. J Biol Chem 275:10023-10029
-
(2000)
J Biol Chem
, vol.275
, pp. 10023-10029
-
-
Harwood, F.G.1
Kasibhatla, S.2
Petak, I.3
Vernes, R.4
Green, D.R.5
Houghton, J.A.6
-
19
-
-
4644245083
-
Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil.
-
Wang S, El-Deiry WS (2004) Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil. Cancer Res 64:6666-6672
-
(2004)
Cancer Res
, vol.64
, pp. 6666-6672
-
-
Wang, S.1
El-Deiry, W.S.2
-
20
-
-
0037135130
-
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.
-
Millar CB, Guy J, Sansom OJ, Selfridge J, MacDougall E, Hendrich B, Keightley PD, Bishop SM, Clarke AR, Bird A (2002) Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science 297:403-405
-
(2002)
Science
, vol.297
, pp. 403-405
-
-
Millar, C.B.1
Guy, J.2
Sansom, O.J.3
Selfridge, J.4
MacDougall, E.5
Hendrich, B.6
Keightley, P.D.7
Bishop, S.M.8
Clarke, A.R.9
Bird, A.10
-
21
-
-
0042790463
-
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine.
-
Sansom OJ, Zabkiewicz J, Bishop SM, Guy J, Bird A, Clarke AR (2003) MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene 22:7130-7136
-
(2003)
Oncogene
, vol.22
, pp. 7130-7136
-
-
Sansom, O.J.1
Zabkiewicz, J.2
Bishop, S.M.3
Guy, J.4
Bird, A.5
Clarke, A.R.6
-
22
-
-
7044278257
-
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity.
-
Cortellino S, Turner D, Masciullo V, Schepis F, Albino D, Daniel R, Skalka AM, Meropol NJ, Alberti C, Larue L, Bellacosa A (2003) The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci USA 100:15071-15076
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15071-15076
-
-
Cortellino, S.1
Turner, D.2
Masciullo, V.3
Schepis, F.4
Albino, D.5
Daniel, R.6
Skalka, A.M.7
Meropol, N.J.8
Alberti, C.9
Larue, L.10
Bellacosa, A.11
-
23
-
-
4344644911
-
P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
-
Geller JI, Szekely-Szucs K, Petak I, Doyle B, Houghton JA (2004) P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells. Cancer Res 64:6296-6303
-
(2004)
Cancer Res
, vol.64
, pp. 6296-6303
-
-
Geller, J.I.1
Szekely-Szucs, K.2
Petak, I.3
Doyle, B.4
Houghton, J.A.5
-
24
-
-
0033576675
-
More than one way to die: Apoptosis, necrosis and reactive oxygen damage.
-
Fiers W, Beyaert R, Declercq W, Vandenabeele P (1999) More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 18:7719-7730
-
(1999)
Oncogene
, vol.18
, pp. 7719-7730
-
-
Fiers, W.1
Beyaert, R.2
Declercq, W.3
Vandenabeele, P.4
-
25
-
-
0038731167
-
Caspase-independent cell death in T lymphocytes.
-
Jaattela M, Tschopp J (2003) Caspase-independent cell death in T lymphocytes. Nat Immunol 4:416-423
-
(2003)
Nat Immunol
, vol.4
, pp. 416-423
-
-
Jaattela, M.1
Tschopp, J.2
-
26
-
-
2442480795
-
Multiple cell death pathways as regulators of tumour initiation and progression.
-
Jaattela M (2004) Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 23:2746-2756
-
(2004)
Oncogene
, vol.23
, pp. 2746-2756
-
-
Jaattela, M.1
-
28
-
-
0032494143
-
Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.
-
Vercammen D, Brouckaert G, Denecker G, Van de Craen M, Declercq W, Fiers W, Vandenabeele P (1998) Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J Exp Med 188:919-930
-
(1998)
J Exp Med
, vol.188
, pp. 919-930
-
-
Vercammen, D.1
Brouckaert, G.2
Denecker, G.3
Van De Craen, M.4
Declercq, W.5
Fiers, W.6
Vandenabeele, P.7
-
29
-
-
1542283719
-
A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: Caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.
-
Okada M, Adachi S, Imai T, Watanabe K, Toyokuni SY, Ueno M, Zervos AS, Kroemer G, Nakahata T (2004) A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity. Blood 103:2299-2307
-
(2004)
Blood
, vol.103
, pp. 2299-2307
-
-
Okada, M.1
Adachi, S.2
Imai, T.3
Watanabe, K.4
Toyokuni, S.Y.5
Ueno, M.6
Zervos, A.S.7
Kroemer, G.8
Nakahata, T.9
-
30
-
-
2642536197
-
Alkylating DNA damage stimulates a regulated form of necrotic cell death.
-
Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB (2004) Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18:1272-1282
-
(2004)
Genes Dev
, vol.18
, pp. 1272-1282
-
-
Zong, W.X.1
Ditsworth, D.2
Bauer, D.E.3
Wang, Z.Q.4
Thompson, C.B.5
-
31
-
-
0642318239
-
Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.
-
Suarez Y, Gonzalez L, Cuadrado A, Berciano M, Lafarga M, Munoz A (2003) Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Mol Cancer Ther 2:863-872
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 863-872
-
-
Suarez, Y.1
Gonzalez, L.2
Cuadrado, A.3
Berciano, M.4
Lafarga, M.5
Munoz, A.6
-
32
-
-
0032577934
-
Different modes of cell death induced by 5-fluoro-2′-deoxyuridine in two clones of the mouse mammary tumor FM3A cell line.
-
Kakutani T, Ebara Y, Kanja K, Hidaka M, Matsumoto Y, Nagano A, Wataya Y (1998) Different modes of cell death induced by 5-fluoro-2′-deoxyuridine in two clones of the mouse mammary tumor FM3A cell line. Biochem Biophys Res Commun 247:773-779
-
(1998)
Biochem Biophys Res Commun
, vol.247
, pp. 773-779
-
-
Kakutani, T.1
Ebara, Y.2
Kanja, K.3
Hidaka, M.4
Matsumoto, Y.5
Nagano, A.6
Wataya, Y.7
-
33
-
-
0035861744
-
Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. the role of intracellular oxidation.
-
Troyano A, Fernandez C, Sancho P, de Blas E, Aller P (2001) Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation. J Biol Chem 276:47107-47115
-
(2001)
J Biol Chem
, vol.276
, pp. 47107-47115
-
-
Troyano, A.1
Fernandez, C.2
Sancho, P.3
De Blas, E.4
Aller, P.5
-
35
-
-
4544342570
-
Nuclear factor-kappaB: The enemy within.
-
Aggarwal BB (2004) Nuclear factor-kappaB: the enemy within. Cancer Cell 6:203-208
-
(2004)
Cancer Cell
, vol.6
, pp. 203-208
-
-
Aggarwal, B.B.1
-
36
-
-
33745298519
-
Nuclear factor-kappaB in cancer development and progression.
-
Karin M (2006) Nuclear factor-kappaB in cancer development and progression. Nature 441:431-436
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
37
-
-
0030899121
-
I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
-
Whiteside ST, Epinat JC, Rice NR, Israel A (1997) I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. Embo J 16:1413-1426
-
(1997)
Embo J
, vol.16
, pp. 1413-1426
-
-
Whiteside, S.T.1
Epinat, J.C.2
Rice, N.R.3
Israel, A.4
-
38
-
-
0027081148
-
A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2′-deoxyuridine in mammalian and bacterial cells.
-
Barbour KW, Hoganson DK, Berger SH, Berger FG (1992) A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2′-deoxyuridine in mammalian and bacterial cells. Mol Pharmacol 42:242-248
-
(1992)
Mol Pharmacol
, vol.42
, pp. 242-248
-
-
Barbour, K.W.1
Hoganson, D.K.2
Berger, S.H.3
Berger, F.G.4
-
39
-
-
0033596121
-
Activators and target genes of Rel/NF-kappaB transcription factors.
-
Pahl HL (1999) Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18:6853-6866
-
(1999)
Oncogene
, vol.18
, pp. 6853-6866
-
-
Pahl, H.L.1
-
40
-
-
0030614456
-
IkappaB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-kappaB activation but not tumor necrosis factor-alpha-induced apoptosis.
-
Cai Z, Korner M, Tarantino N, Chouaib S (1997) IkappaB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-kappaB activation but not tumor necrosis factor-alpha-induced apoptosis. J Biol Chem 272:96-101
-
(1997)
J Biol Chem
, vol.272
, pp. 96-101
-
-
Cai, Z.1
Korner, M.2
Tarantino, N.3
Chouaib, S.4
-
41
-
-
0033558155
-
Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs.
-
Bentires-Alj M, Hellin AC, Ameyar M, Chouaib S, Merville MP, Bours V (1999) Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs. Cancer Res 59:811-815
-
(1999)
Cancer Res
, vol.59
, pp. 811-815
-
-
Bentires-Alj, M.1
Hellin, A.C.2
Ameyar, M.3
Chouaib, S.4
Merville, M.P.5
Bours, V.6
-
42
-
-
0035134514
-
The chemotherapeutic drug 5-fluorouracil induces apoptosis in mouse thymocytes in vivo via activation of the CD95(APO-1/Fas) system.
-
Eichhorst ST, Muerkoster S, Weigand MA, Krammer PH (2001) The chemotherapeutic drug 5-fluorouracil induces apoptosis in mouse thymocytes in vivo via activation of the CD95(APO-1/Fas) system. Cancer Res 61:243-248
-
(2001)
Cancer Res
, vol.61
, pp. 243-248
-
-
Eichhorst, S.T.1
Muerkoster, S.2
Weigand, M.A.3
Krammer, P.H.4
-
43
-
-
33644747383
-
Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin.
-
Zhang XD, Wu JJ, Gillespie S, Borrow J, Hersey P (2006) Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin. Clin Cancer Res 12:1355-1364
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1355-1364
-
-
Zhang, X.D.1
Wu, J.J.2
Gillespie, S.3
Borrow, J.4
Hersey, P.5
-
44
-
-
0030900980
-
Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis.
-
Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P (1997) Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 185:1481-1486
-
(1997)
J Exp Med
, vol.185
, pp. 1481-1486
-
-
Leist, M.1
Single, B.2
Castoldi, A.F.3
Kuhnle, S.4
Nicotera, P.5
-
45
-
-
2342465589
-
Regulation of the apoptosis-necrosis switch.
-
Nicotera P, Melino G (2004) Regulation of the apoptosis-necrosis switch. Oncogene 23:2757-2765
-
(2004)
Oncogene
, vol.23
, pp. 2757-2765
-
-
Nicotera, P.1
Melino, G.2
-
46
-
-
0034775927
-
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells.
-
Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RA, Kinzler KW, Vogelstein B (2001) Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med 7:1111-1117
-
(2001)
Nat Med
, vol.7
, pp. 1111-1117
-
-
Hwang, P.M.1
Bunz, F.2
Yu, J.3
Rago, C.4
Chan, T.A.5
Murphy, M.P.6
Kelso, G.F.7
Smith, R.A.8
Kinzler, K.W.9
Vogelstein, B.10
-
47
-
-
0037126392
-
The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis.
-
Liu G, Chen X (2002) The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. Oncogene 21:7195-7204
-
(2002)
Oncogene
, vol.21
, pp. 7195-7204
-
-
Liu, G.1
Chen, X.2
-
48
-
-
13544265296
-
Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.
-
Choi W, Gerner EW, Ramdas L, Dupart J, Carew J, Proctor L, Huang P, Zhang W, Hamilton SR (2005) Combination of 5-fluorouracil and N1,N11- diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. J Biol Chem 280:3295-3304
-
(2005)
J Biol Chem
, vol.280
, pp. 3295-3304
-
-
Choi, W.1
Gerner, E.W.2
Ramdas, L.3
Dupart, J.4
Carew, J.5
Proctor, L.6
Huang, P.7
Zhang, W.8
Hamilton, S.R.9
-
49
-
-
0043136753
-
Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling.
-
Maxwell PJ, Longley DB, Latif T, Boyer J, Allen W, Lynch M, McDermott U, Harkin DP, Allegra CJ, Johnston PG (2003) Identification of 5-fluorouracil- inducible target genes using cDNA microarray profiling. Cancer Res 63:4602-4606
-
(2003)
Cancer Res
, vol.63
, pp. 4602-4606
-
-
Maxwell, P.J.1
Longley, D.B.2
Latif, T.3
Boyer, J.4
Allen, W.5
Lynch, M.6
McDermott, U.7
Harkin, D.P.8
Allegra, C.J.9
Johnston, P.G.10
-
50
-
-
3042511585
-
Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer.
-
Voboril R, Hochwald SN, Li J, Brank A, Weberova J, Wessels F, Moldawer LL, Camp ER, MacKay SL (2004) Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer. J Surg Res 120:178-188
-
(2004)
J Surg Res
, vol.120
, pp. 178-188
-
-
Voboril, R.1
Hochwald, S.N.2
Li, J.3
Brank, A.4
Weberova, J.5
Wessels, F.6
Moldawer, L.L.7
Camp, E.R.8
MacKay, S.L.9
-
51
-
-
33646011538
-
Enhanced sensitivity to chemotherapy in esophageal cancer through inhibition of NF-kappaB.
-
Li J, Minnich DJ, Camp ER, Brank A, Mackay SL, Hochwald SN (2006) Enhanced sensitivity to chemotherapy in esophageal cancer through inhibition of NF-kappaB. J Surg Res 132:112-120
-
(2006)
J Surg Res
, vol.132
, pp. 112-120
-
-
Li, J.1
Minnich, D.J.2
Camp, E.R.3
Brank, A.4
MacKay, S.L.5
Hochwald, S.N.6
-
52
-
-
3242687235
-
Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer.
-
Camp ER, Li J, Minnich DJ, Brank A, Moldawer LL, MacKay SL, Hochwald SN (2004) Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer. J Am Coll Surg 199:249-258
-
(2004)
J Am Coll Surg
, vol.199
, pp. 249-258
-
-
Camp, E.R.1
Li, J.2
Minnich, D.J.3
Brank, A.4
Moldawer, L.L.5
MacKay, S.L.6
Hochwald, S.N.7
-
53
-
-
33745102414
-
Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL.
-
Konishi T, Sasaki S, Watanabe T, Kitayama J, Nagawa H (2006) Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. Oncogene 25:3160-3169
-
(2006)
Oncogene
, vol.25
, pp. 3160-3169
-
-
Konishi, T.1
Sasaki, S.2
Watanabe, T.3
Kitayama, J.4
Nagawa, H.5
-
54
-
-
27144547145
-
Betulinic acid as new activator of NF-kappaB: Molecular mechanisms and implications for cancer therapy.
-
Kasperczyk H, La Ferla-Bruhl K, Westhoff MA, Behrend L, Zwacka RM, Debatin KM, Fulda S (2005) Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene 24:6945-6956
-
(2005)
Oncogene
, vol.24
, pp. 6945-6956
-
-
Kasperczyk, H.1
La Ferla-Bruhl, K.2
Westhoff, M.A.3
Behrend, L.4
Zwacka, R.M.5
Debatin, K.M.6
Fulda, S.7
-
55
-
-
18144371109
-
NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis.
-
Poppelmann B, Klimmek K, Strozyk E, Voss R, Schwarz T, Kulms D (2005) NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis. J Biol Chem 280:15635-15643
-
(2005)
J Biol Chem
, vol.280
, pp. 15635-15643
-
-
Poppelmann, B.1
Klimmek, K.2
Strozyk, E.3
Voss, R.4
Schwarz, T.5
Kulms, D.6
-
56
-
-
0035067368
-
Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB.
-
Ravi R, Bedi GC, Engstrom LW, Zeng Q, Mookerjee B, Gelinas C, Fuchs EJ, Bedi A (2001) Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat Cell Biol 3:409-416
-
(2001)
Nat Cell Biol
, vol.3
, pp. 409-416
-
-
Ravi, R.1
Bedi, G.C.2
Engstrom, L.W.3
Zeng, Q.4
Mookerjee, B.5
Gelinas, C.6
Fuchs, E.J.7
Bedi, A.8
|