Inhibitory role of CXCR4 glycan in CD4-independent X4-tropic human immunodeficiency virus type 1 infection and its abrogation in CD4-dependent infection

Journal of General Virology

Volumn 88, Issue 11, 2007, Pages 3139-3144

  Kubo, Yoshinao ^a   Yokoyama, Masaru ^a,b   Yoshii, Hiroaki ^a   Mitani, Chiho ^a   Tominaga, Chika ^a   Tanaka, Yuetsu ^c   Sato, Hironori ^a,b   Yamamoto, Naoki ^a,b,d  

^a NAGASAKI UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GLYCAN; VIRUS ENVELOPE PROTEIN;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INCUBATION TIME; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS PARTICLE; VIRUS STRAIN; VIRUS TITRATION;

CELL LINE; HIV-1; HUMANS; MODELS, MOLECULAR; POLYSACCHARIDES; RECEPTORS, CXCR4; TRANSDUCTION, GENETIC; VIRUS ATTACHMENT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 36249032566     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.83202-0     Document Type: Article

References (46)

1. Berger, E. A., Doms, R. W., Fenyo, E. M., Korber, B. T., Littman, D. R., Moore, J. P., Sattentau, Q. J., Schuitemaker, H., Sodroski, J. & Weiss, R. A. (1998). A new classification for HIV-1. Nature 391, 240.
2. Bhattacharya, J., Peters, P. J. & Clapham, P. R. (2003). CD4-independent infection of HIV and SIV: implications for envelope conformation and cell tropism in vivo. AIDS 17 (Suppl. 4), S35-S43.
3. Brelot, A., Heveker, N., Pleskoff, O., Sol, N. & Alizon, M. (1997). Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity. J Virol 71, 4744-4751.
4. Brelot, A., Heveker, N., Montes, M. & Alizon, M. (2000). Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities. J Biol Chem 275, 23736-23744.
5. Chabot, D. J. & Broder, C. C. (2000). Substitutions in a homologous region of extraceflular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry. J Biol Chem 275, 23774-23782.
6. Chabot, D. J., Zhang, P. F., Quinnan, G. V. & Broder, C. C. (1999). Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates. J Virol 73, 6598-6609.
7. Chabot D. J., Chen, H., Dimitrov, D. S. & Broder, C. C. (2000). N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates. J Virol 74, 4404-4413.
8. Chang, L. J., Urlacher, V., Iwakuma, T., Cui, Y. & Zucali, J. (1999). Efficacy and safety analyses of a recombinant human immuno-deficiency virus type 1 derived vector system. Gene Ther 6, 715-728.
9. Dimitrov, D. S. (1997). How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. Cell 91, 721-730.
10. Doranz, B. J., Orsini, M. J., Turner, J. D., Hoffman, T. L., Berson, J. F., Hoxie, J. A., Peiper, S. C., Brass, L. F. & Doms, R. W. (1999). Identification of CXCR4 domains that support coreceptor and chemokine receptor functions. J Virol 73, 2752-2761.
11. Dumonceaux, J., Nisole, S., Chanel, C., Quivet, L., Amara, A., Baleux, F., Briand, P. & Hazan, U. (11998). Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype. J Virol 72, 512-519.
12. Edinger, A. L., Blanpain, C., Kunstman, K J., Wolinsky, S. M., Parmentier, M. & Doms, R. W. (1999). Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains. J Virol 73, 4062-4073.
13. Edwards, T. G., Hoffman, T. L, Baribaud, F., Wyss, S., LaBranche, C. C., Romano, J., Adkinson, J., Sharron, M., Hoxie, J. A. & Doms, R. W. (2001). Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein. J Virol 75, 5230-5239.
14. Hart, T. K., Kirsh, R., Ellenss, H., Sweet, R. W., Lambert D. M., Petteway, S. R., Jr, Leary, J. & Bugelski, P. J. (1991). Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120. Proc Natl Acad Sci U S A 88, 2189-2193.
15. Hoffman, T. L., LaBranche, C. C., Zhang, W., Canziani, G., Robinson, J., Chaiken, I., Hoxie, J. A. & Doms, R. W. (1999). Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc Natl Acad Sci U S A 96, 6359-6364.
16. Hoffman, T. L., Canziani, G., Jia, L., Rucker, J. & Doms, R. W. (2000). A biosensor assay for studying ligand-membrane receptor interactions: binding of antibodies and HIV-1 Env to chemokine receptors. Proc Natl Acad Sci U S A 97, 11215-11220.
17. Huang, X., Shen, J., Cul, M., Shen, L., Luo, X., Ling, K., Pei, G., Jiang, H. & Chen, K. (2003). Molecular dynamics simulations on SDF-1alpha: binding wi th CXCR4 receptor. Biophys J 84, 171-184.
18. Huang, C. C., Tang, M., Zhang, M. Y., Majeed, S., Montabana, E., Stanfield, R. L., Dimitrov, D. S., Korber, B., Sodroski, J. & other authors (2005). Structure of a V3-containing HIV-1 gp120 core. Science 310, 1025-1028.
19. Iwakuma, T., Cui, Y. & Chang, L. J. (1999). Self-inactivating lentiviral vectors with U3 and U5 modifications. Virology 261, 120-132.
20. Kajumo, F., Thompson, D. A., Guo, Y. & Dragic, T. (2000). Entry of R5X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4. Virology 271, 240-247.
21. Kinomoto, M., Yokoyama, M., Sato, H., Kojima, A., Kurata, T., Ikuta, K., Sata, T. & Tokunaga, K. (2005). Amino acid 36 in the human immunodeficiency virus type 1 gp41 ectodomain controls fusogenic activity-implications for the molecular mechanism of viral escape from a fusion inhibitor. J Virol 79, 5996-6004.
22. Kolchinsky, P., Kiprilov, E. & Sodroski, J. (2001). Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variants. J Virol 75, 2041-2050.
23. Kubo, Y., Ono, T., Ogura, M., Ishimoto, A. & Amanuma, H. (2002). A glycosylation-defective variant of the ecotropic murine retrovirus receptor is expressed in rat XC cells. Virology 303, 338-344.
24. Kubo, Y., Ishimoto, A. & Amanuma, H. (2003). N-Linked glycosylation is required for XC cell-specific syncytium formation by the R peptide-containing envelope protein of ecotropic murine leukemia viruses. J Virol 77, 7510-7516.
25. Kubo, Y., Ishimoto, A., Ono, T, Yoshii, H., Tominaga, C., Mitani, C., Amanuma, H. & Yamamoto, N. (2004). Determinant for the inhibition of ecotropic murine leukemia virus infection by N-linked glycosylation of the rat receptor. Virology 330, 82-91.
26. Marin, M., Lavillette, D., Kelly, S. M. & Kabat, D. (2003). N-linked glycosytation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. J Virol 77, 2936-2945.
27. Martin, K. A., Wyatt, R., Farzan, M., Choe, H., Marcon, L., Desjardins, E., Robinson, J., Sodroski, J., Gerard, C. & Gerard, N. P. (1997). CD4-independent binding of SIV gp120 to rhesus CCR5. Science 278, 1470-1473.
28. Moore, J. P., McKeating, J. A., Weiss, R. A. & Sattentau, O. J. (11990). Dissociation of gp120 from HIV-1 virions induced by soluble CD4. Science 250, 1139-1142.
29. Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M. & Trono, D. (1996). In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267.
30. Overbaugh, J., Miller, A. D. & Eiden, M. V. (2001). Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins. Microbiol Mol Biol Rev 65, 371-389 (table of contents).
31. Palczewski, K, Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T. & other authors (2000). Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289, 739-745.
32. Picard, L., Wilkinson, D. A., McKnight A., Gray, P. W., Hoxie, J. A., Clapham, P. R. & Weiss, R. A. (1997). Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry. Virology 231, 105-111.
33. Ponder, J. W. & Case, D. A. (2003). Force fields for protein simulations. Adv Protein Chem 66, 27-85.
34. Potempa, S., Picard, L., Reeves, J. D., Wilkinson, D., Weiss, R. A. & Talbot, S. J. (1997). CD4-independent infection by human immuno-deficiency virus type 2 strain ROD/B: the role of the N-terminal domain of CXCR-4 in fusion and entry. J Virol 71, 4419-4424.
35. Puffer, B. A., Pohlmann, S., Edinger, A. L., Carlin, D., Sanchez, M. D., Reitter, J., Watry, D. D., Fox, H. S., Desrosiers, R. C. & Doms, R. W. (2002). CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity. J Virol 76, 2595-2605.
36. Schenten, D., Marcon, L., Karlsson, G. B., Parolin, C., Kodama, T., Gerard, N. & Sodroski, J. (1999). Effects of soluble CD4 on simian immunodeficiency virus infection on CD4-positive and CD4-negative cells. J Virol 73, 5373-5380.
37. Soda, Y., Shimizu, N., Jinno, A., Liu, H. Y., Kanbe, K., Kitamura, T. & Hoshino, H. (11999). Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell line. Biochem Biophys Res Commun 258, 313-321.
38. Sommerfelt, M. A. (1999). Retrovirus, receptors. J Gen Virol 80, 3049-3064.
39. Tailor, C. S., Nouri, A. & Kabat, D. (2000). Cellular and species resistance to murine amphotropic, gibbon ape, and feline subgroup C leukemia viruses is strongly influenced by receptor expression levels and by receptor masking mechanisms. J Virol 74, 9797-9801.
40. Tanaka, R., Yoshida, A., Murakami, T., Baba, E., Lichtenfeld, J., Omori, T., Kimura, T., Tsurutani, N., Fujii, N. & other authors (2001). Unique monoclonal antibody recognizing the third extracenular loop of CXCR4 induces lymphocyte agglutination and enhances human immunodeficiency virus type 1-mediated syncytium formation and productive infection. J Virol 75, 11534-11543.
41. Thomas, E. R., Shotton, C., Weiss, R. A., Clapham, P. R. & McKnight A. (2003). CD4-dependent and CD4-independent HIV-2: consequences for neutralization. AIDS 17, 291-300.
42. Thordsen, I., Polzer, S. & Schreiber, M. (2002). Infection of cells expressing CXCR4 mutants lacking N-giycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1. BMC Infect Dis 2, 31.
43. Wang, J., Babcock, G. J., Choe, H., Farzan, M., Sodroski, J. & Gabuzda, D. (2004). N-linked glycosylation in the CXCR4 N-terminus inhibits binding to HIV-1 envelope glycoproteins. Virology 324, 140-150.
44. Wilson, C. A. & Eiden, M. V. (1991). Viral and cellular factors governing hamster cell infection by murine and gibbon ape leukemia viruses. J Virol 65, 5975-5982.
45. Zhou, N., Luo, Z., Luo, J., Liu, D., Hall, J. W., Pomerantz, R. J. & Huang, Z. (2001). Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies. J Biol Chem 276, 42826-42833.
46. Zhu, P., Liu, J., Bess, J., Jr, Chertova, E., Lifson, J. D., Grise, H., Ofek, G. A., Taylor, K. A. & Roux, K. H. (2006). Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature 441, 847-852.