PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancer

Cancer Letters

Volumn 258, Issue 2, 2007, Pages 241-252

  Shen, Xiaoli ^a   Rychahou, Piotr G ^a   Evers, B Mark ^a,b   Falzon, Miriam ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Colon cancer; Integrin 6 4; Phosphatidylinositol 3 kinase; PTHrP

Indexed keywords

ALPHA6BETA4 INTEGRIN; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANALYTIC METHOD; ARTICLE; CANCER INHIBITION; CELL ANCHORAGE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; COLON CANCER; COLON MUCOSA; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA6BETA4; MALE; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASMS, EXPERIMENTAL; PARATHYROID HORMONE-RELATED PROTEIN; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN;

EID: 36049009987     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.09.010     Document Type: Article

References (41)

1. Parker S.L., Tong T., Bolden S., and Wingo P.A. Cancer statistics. CA Cancer J. Clin. 46 (1996) 5-27
2. Martin R., Paty P., Fong Y., Grace A., Cohen A., DeMatteo R., Jarnagin W., and Blumgart L. Simultaneous liver and colorectal resections are safe for synchronous colorectal liver metastasis. J. Am. Coll. Surg. 197 (2003) 233-241
3. Declan Fleming R.Y. Colorectal cancer screening and follow-up. Surg. Oncol. 7 (1998) 125-137
4. Kohn E.C., and Liotta L.A. Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55 (1995) 1856-1862
5. Goltzman D. Mechanisms of development of osteoblastic metastases. Cancer (Suppl.) 80 (1997) 1581-1587
6. Yoneda T., Sasaki A., and Mundy G.R. Osteolytic bone metastasis in breast cancer. Breast Cancer Res. Treat. 32 (1994) 73-84
7. Nishihara M., Ito M., Tomioka T., Ohtsuru A., Tagashi T., and Kanematsu T. Clinicopathological implications of parathyroid hormone-related protein in human colorectal tumours. J. Path. 187 (1999) 217-222
8. Fearon E.R. Cancer progression. Curr. Biol. 9 (1999) R873-R875
9. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
10. Chao C., Lotz M.M., Clarke A.C., and Mercurio A.M. A function for the integrin α6β4 in the invasive properties of colorectal carcinoma cells. Cancer Res. 56 (1996) 4811-4819
11. Shaw L.M., Rabinovitz I., Wang H.H.-F., Toker A., and Mercurio A.M. Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion. Cell 91 (1997) 949-960
12. Rigot V., Andre F., Lehmann M., Lissitzky J.C., Marvaldi J., and Luis J. Biogenesis of α6β4 integrin in a human colonic adenocarcinoma cell line involvement of calnexin. Eur. J. Biochem. 261 (1999) 659-666
13. Mercurio A.M. Receptors for the laminins. Achieving specificity through cooperation. Trends Cell Biol. 5 (1995) 419-423
14. Fruman D.A., Meyers R.E., and Cantley L.C. Phosphoinositide kinases. Annu. Rev. Biochem. 67 (1998) 481-507
15. Vanhaesebroeck B., and Waterfield M.D. Signaling by distinct classes of phosphoinositide 3-kinases. Exp. Cell Res. 253 (1999) 239-254
16. Shen X., Mula R.V.R., Evers B.M., and Falzon M. Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines. Reg. Peptides 141 (2007) 61-72
17. Shao J., Evers B.M., and Sheng H. Roles of phosphatidylinositol 3′-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res. 64 (2004) 229-235
18. Semba S., Itoh N., Ito M., Youssef E.M., Harado M., Kimura W., and Yamakawa M. Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. Clin. Cancer Res. 8 (2002) 3824-3831
19. Rychahou P.G., Murillo C.A., and Evers B.M. Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). Surgery 138 (2005) 391-397
20. Ikenoue T., Kanai F., Hibika Y., Kunai F., Obata T., Tanaka Y., Imamura J., Ohta M., Jazag A., Guleng B., Tateishi K., Asaoka Y., Matsumura M., Kawabe T., and Omata M. Functional analysis of PI3K3CA gene mutations in human colorectal cancer. Cancer Res. 65 (2005) 4562-4567
21. Rychahou P.G., Jackson L.N., Silva S.R., Rajaraman S., and Evers B.M. Targeted molecular therapy of the PI3K pathway. Therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Ann. Surg. 243 (2006) 833-844
22. Shen X., and Falzon M. PTH-related protein enhances LoVo colon cancer cell proliferation, adhesion, and integrin expression. Reg. Peptides 125 (2005) 17-27
23. Mitra S.K., and Swarup G. Inhibition of anchorage-independent cell growth, adhesion, and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase. Exp. Cell Res. 270 (2001) 32-44
24. Wang Q., Li N., Wang X., Kim M.M., and Evers B.M. Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3′-kinase inhibition in the KM20 human colon cancer cell lines. Clin. Cancer Res. 8 (2002) 1940-1947
25. Reiner A., Neumeister B., Spona J., Reiner G., Schemper M., and Jakesz R. Immunocytochemical localization of estrogen and progesterone receptor and prognosis in human primary breast cancer. Cancer Res. 50 (1990) 7057-7061
26. Guise T.A. Molecular mechanisms of osteolytic bone metastases. Cancer 88 12 Suppl. (2000) 2892-2898
27. Rabbani S.A., Gladu J., Harakidas P., Jamison B., and Goltzman D. Over-production of parathyroid hormone-related peptide results in increased osteolytic metastasis by prostate cancer cells in vivo. Int. J. Cancer 80 (1999) 257-264
28. Ye Y., Seitz P.K., and Cooper C.W. Parathyroid hormone-related protein overexpression in the human colon cancer cell line HT-29 enhances adhesion of the cells to collagen type I. Reg. Peptides 101 (2001) 19-23
29. Ye Y., Falzon M., Seitz P.K., and Cooper C.W. Overexpression of parathyroid hormone-related protein promotes cell growth in the rat intestinal cell line IEC-6. Reg. Peptides 99 (2001) 169-174
30. Rabinovitz I., and Mercurio A.M. The integrin alpha6beta4 and the biology of carcinoma. Biochem. Cell Biol. 74 (1996) 811-821
31. Rabinovitz I., and Mercurio A.M. The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J. Cell. Biol. 139 (1997) 1873-1884
32. Guo W., Pylayeva Y., Pepe A., Yoshioka T., Muller W.J., Inghirami G., and Giancotti F.G. β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126 (2006) 489-502
33. Zhou Y., and Brattain M.G. Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis. Cancer Res. 65 (2005) 5848-5856
34. Hu Y.P., Venkateswarlu S., Sergina N., Howell G., Clair P.St., Humphrey L.E., Li W., Hauser J., Zborowska E., Willson J.K.V., and Brattain G. Reorganization of ErbB2 family and cell survival signaling after knock-down of ErbB2 in colon cancer cells. J. Biol. Chem. 280 (2005) 27383-27392
35. Gershtein E.S., Shatskaya V.A., Ermilova V.D., Kushlinsky N.E., and Krasil'nikov M.A. Phosphatidylinositol 3-kinase expression in human breast cancer. Clin. Chim. Acta 287 (1999) 59-67
36. Maniero F., Pepe A., Wary K.K., Spinardi L., Mohammadi M., Schlessinger J., and Giancotti F.G. Signal transduction of the α6β4 integrin: distinct β4 subunit sites mediate recruitment of the Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14 (1995) 4470-4481
37. Maniero F., Murgia C., Wary K.K., Curatola A.M., Pepe A., Blumemberg M., Westwick J.K., Der C.J., and Giancotti F.G. The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J. 16 (1997) 2365-2375
38. Fresno Vara J.A., Casado E., de Castro E.J., Cejas P., Belda-Iniesta C., and Gonzalez-Barón M. PI3K/Akt signalling pathway and cancer. Cancer Treat. Res. 30 (2004) 193-204
39. Roy H.K., Olusola B.F., Clemens D.L., Karolski W.J., Ratashak A., Lynch H.T., and Smyrk T.C. AKT proto-oncogene overexpression is an early event during sporadic colon carcinoma. Carcinogenesis 23 (2002) 201-205
40. Khaleghpour K., Li Y., Banville D., Yu Z., and Shen S.-H. Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis 25 (2004) 241-248
41. Itoh N., Semba S., Ito M., Takeda H., Kawata S., and Yamakawa M. Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 94 (2002) 3127-3134