Intramuscular delivery of DNA releasing microspheres: Microsphere properties and transgene expression

Journal of Controlled Release

Volumn 112, Issue 1, 2006, Pages 120-128

  Jang, Jae Hyung ^a   Shea, Lonnie D ^b  

^a University of California   (United States)

^b Northwestern University   (United States)

Author keywords

Drug delivery; Gene therapy; Microspheres; Poly (lactide co glycolide)

Indexed keywords

DRUG DELIVERY; GENE THERAPY; MICROSPHERES; POLY (LACTIDE-CO-GLYCOLIDE);

CELLS; CRYOGENICS; DNA; DRUG THERAPY; MOLECULAR WEIGHT; TISSUE;

GENETIC ENGINEERING;

DNA; LUCIFERASE; MICROSPHERE; NAKED DNA; PLASMID DNA; POLYGLACTIN;

ANIMAL TISSUE; ARTICLE; BOLUS INJECTION; CELL INFILTRATION; CONTROLLED STUDY; DNA TRANSFECTION; DOSE RESPONSE; EMULSION; FOREIGN BODY REACTION; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENE TARGETING; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR WEIGHT; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TRANSGENE; WOUND HEALING;

ANIMALS; DNA; DRUG DELIVERY SYSTEMS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LACTIC ACID; LUCIFERASES; MALE; MICE; MICROSPHERES; MOLECULAR WEIGHT; MUSCLE, SKELETAL; POLYGLYCOLIC ACID; POLYMERS; TIME FACTORS; TRANSGENES;

EID: 33645795749     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.01.013     Document Type: Article

References (47)

1. Donnelly J.J., Wahren B., and Liu M.A. DNA vaccines: progress and challenges. J. Immunol. 175 2 (2005) 633-639
2. Kaufmann S.H., and Hess J. Immune response against Mycobacterium tuberculosis: implications for vaccine development. J. Biotechnol. 83 1-2 (2000) 13-17
3. www.wiley.com/legacy/wileychi/genmed/clinical/.
4. Weintraub H., Cheng P.F., and Conrad K. Expression of transfected DNA depends on DNA topology. Cell 46 1 (1986) 115-122
5. Barry M.E., Pinto-Gonzalez D., Orson F.M., McKenzie G.J., Petry G.R., and Barry M.A. Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection. Hum. Gene Ther. 10 15 (1999) 2461-2480
6. Luo D., and Saltzman W.M. Synthetic DNA delivery systems. Nat. Biotechnol. 18 1 (2000) 33-37
7. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturvedi P., Santos C.A., Vijayaraghavan K., Montgomery S., Bassett M., and Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature 386 6623 (1997) 410-414
8. Pannier A.K., and Shea L.D. Controlled release systems for DNA delivery. Molec. Ther. 10 1 (2004) 19-26
9. Oster C.G., Kim N., Grode L., Barbu-Tudoran L., Schaper A.K., Kaufmann S.H., and Kissel T. Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination. J. Control. Release 104 2 (2005) 359-377
10. Luo D., Han E., Belcheva N., and Saltzman W.M. A self-assembled, modular DNA delivery system mediated by silica nanoparticles. J. Control. Release 95 2 (2004) 333-341
11. Li Z., and Huang L. Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(d,l-lactide-co-4-hydroxy-l-proline). J. Control. Release 98 3 (2004) 437-446
12. Mir L.M., Bureau M.F., Gehl J., Rangara R., Rouy D., Caillaud J.M., Delaere P., Branellec D., Schwartz B., and Scherman D. High-efficiency gene transfer into skeletal muscle mediated by electric pulses. Proc. Natl. Acad. Sci. U. S. A. 96 8 (1999) 4262-4267
13. Doh S.G., Vahlsing H.L., Hartikka J., Liang X., and Manthorpe M. Spatial-temporal patterns of gene expression in mouse skeletal muscle after injection of lacZ plasmid DNA. Gene Ther. 4 7 (1997) 648-663
14. Wolff J.A., Malone R.W., Williams P., Chong W., Acsadi G., Jani A., and Felgner P.L. Direct gene transfer into mouse muscle in vivo. Science 247 4949 Pt 1 (1990) 1465-1468
15. Wolff J.A., Ludtke J.J., Acsadi G., Williams P., and Jani A. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1 6 (1992) 363-369
16. Bureau M.F., Naimi S., Torero Ibad R., Seguin J., Georger C., Arnould E., Maton L., Blanche F., Delaere P., and Scherman D. Intramuscular plasmid DNA electrotransfer: biodistribution and degradation. Biochim. Biophys. Acta 1676 2 (2004) 138-148
17. O'Hagan D.T., Singh M., and Ulmer J.B. Microparticles for the delivery of DNA vaccines. Immunol. Rev. 199 (2004) 191-200
18. Rizzuto G., Cappelletti M., Maione D., Savino R., Lazzaro D., Costa P., Mathiesen I., Cortese R., Ciliberto G., Laufer R., La Monica N., and Fattori E. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc. Natl. Acad. Sci. U. S. A. 96 11 (1999) 6417-6422
19. Truong-Le V.L., August J.T., and Leong K.W. Controlled gene delivery by DNA-gelatin nanospheres. Hum. Gene Ther. 9 12 (1998) 1709-1717
20. Baranov A., Glazkov P., Kiselev A., Ostapenko O., Mikhailov V., Ivaschenko T., Sabetsky V., and Baranov V. Local and distant transfection of mdx muscle fibers with dystrophin and LacZ genes delivered in vivo by synthetic microspheres. Gene Ther. 6 8 (1999) 1406-1414
21. Ozbas-Turan S., Aral C., Kabasakal L., Keyer-Uysal M., and Akbuga J. Co-encapsulation of two plasmids in chitosan microspheres as a non-viral gene delivery vehicle. J. Pharm. Pharm. Sci. 6 1 (2003) 27-32
22. Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., Slomkowski S., and Golomb G. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther. 7 22 (2000) 1896-1905
23. del Barrio G.G., Novo F.J., and Irache J.M. Loading of plasmid DNA into PLGA microparticles using TROMS (Total Recirculation One-Machine System): evaluation of its integrity and controlled release properties. J. Control. Release 86 1 (2003) 123-130
24. Kushibiki T., Tomoshige R., Fukunaka Y., Kakemi M., and Tabata Y. In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents. J. Control. Release 90 2 (2003) 207-216
25. Fukunaka Y., Iwanaga K., Morimoto K., Kakemi M., and Tabata Y. Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation. J. Control. Release 80 1-3 (2002) 333-343
26. Singh M., Briones M., Ott G., and O'Hagan D. Cationic microparticles: a potent delivery system for DNA vaccines. Proc. Natl. Acad. Sci. U. S. A. 97 2 (2000) 811-816
27. Jang J.H., and Shea L.D. Controllable delivery of non-viral DNA from porous scaffolds. J. Control. Release 86 1 (2003) 157-168
28. Ando S., Putnam D., Pack D.W., and Langer R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J. Pharm. Sci. 88 1 (1999) 126-130
29. Rosca I.D., Watari F., and Uo M. Microparticle formation and its mechanism in single and double emulsion solvent evaporation. J. Control. Release 99 2 (2004) 271-280
30. Jang J.H., Rives C.B., and Shea L.D. Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfection. Mol. Ther. 12 3 (2005) 475-483
31. Mikos A.G., McIntire L.V., Anderson J.M., and Babensee J.E. Host response to tissue engineered devices. Adv. Drug Deliv. Rev. 33 1-2 (1998) 111-139
32. Liang H.C., Chang W.H., Lin K.J., and Sung H.W. Genipin-crosslinked gelatin microspheres as a drug carrier for intramuscular administration: in vitro and in vivo studies. J. Biomed. Mater. Res. A 65 2 (2003) 271-282
33. Huang Y.C., Riddle K., Rice K.G., and Mooney D.J. Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds. Hum. Gene Ther. 16 5 (2005) 609-617
34. McLachlan G., Stevenson B.J., Davidson D.J., and Porteous D.J. Bacterial DNA is implicated in the inflammatory response to delivery of DNA/DOTAP to mouse lungs. Gene Ther. 7 5 (2000) 384-392
35. Babiuk S., Baca-Estrada M.E., Foldvari M., Middleton D.M., Rabussay D., Widera G., and Babiuk L.A. Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines. J. Biotechnol. 110 1 (2004) 1-10
36. Durieux A.C., Bonnefoy R., Busso T., and Freyssenet D. In vivo gene electrotransfer into skeletal muscle: effects of plasmid DNA on the occurrence and extent of muscle damage. J. Gene Med. 6 7 (2004) 809-816
37. Zaharoff D.A., Barr R.C., Li C.Y., and Yuan F. Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. Gene Ther. 9 19 (2002) 1286-1290
38. Brazeau G.A., Sciame M., al-Suwayeh S.A., and Fattal E. Evaluation of PLGA microsphere size effect on myotoxicity using the isolated rodent skeletal muscle model. Pharm. Dev. Technol. 1 3 (1996) 279-283
39. Dailey L.A., Schmehl T., Gessler T., Wittmar M., Grimminger F., Seeger W., and Kissel T. Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features. J. Control. Release 86 1 (2003) 131-144
40. Zweers M.L., Engbers G.H., Grijpma D.W., and Feijen J. In vitro degradation of nanoparticles prepared from polymers based on dl-lactide, glycolide and poly(ethylene oxide). J. Control. Release 100 3 (2004) 347-356
41. Butler S.M., Tracy M.A., and Tilton R.D. Adsorption of serum albumin to thin films of poly(lactide-co-glycolide). J. Control. Release 58 3 (1999) 335-347
42. Yoon J.J., and Park T.G. Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts. J. Biomed. Mater. Res. 55 3 (2001) 401-408
43. Holy C.E., Dang S.M., Davies J.E., and Shoichet M.S. In vitro degradation of a novel poly(lactide-co-glycolide) 75/25 foam. Biomaterials 20 13 (1999) 1177-1185
44. Bessho K., Carnes D.L., Cavin R., and Ong J.L. Experimental studies on bone induction using low-molecular-weight poly (dl-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2. J. Biomed. Mater. Res. 61 1 (2002) 61-65
45. Baldwin S.L., D'Souza C.D., Orme I.M., Liu M.A., Huygen K., Denis O., Tang A., Zhu L., Montgomery D., and Ulmer J.B. Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A. Tuber. Lung Dis. 79 4 (1999) 251-259
46. Mollenkopf H.J., Dietrich G., Fensterle J., Grode L., Diehl K.D., Knapp B., Singh M., O'Hagan D.T., Ulmer J.B., and Kaufmann S.H. Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles. Vaccine 22 21-22 (2004) 2690-2695
47. Kasper F.K., Kushibiki T., Kimura Y., Mikos A.G., and Tabata Y. In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol)fumarate) and cationized gelatin microspheres. J. Control. Release 107 3 (2005) 547-561