Enhanced bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucociliary transport properties

European Journal of Pharmaceutical Sciences

Volumn 32, Issue 4-5, 2007, Pages 296-307

  Zaki, Noha M ^a   Awad, Gehanne A ^a   Mortada, Nahed D ^a   Abd ElHady, Seham S ^a  

^a Ain Shams University   (Egypt)

Author keywords

Bioavailability; In situ gel; Intranasal delivery; Metoclopramide hydrochloride; Mucoadhesion; Mucociliary clearance; Poloxamer 407

Indexed keywords

MACROGOL; METOCLOPRAMIDE; POLOXAMER;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG RELEASE; DRUG STORAGE; FLOW KINETICS; GELATION; MALE; MUCOCILIARY TRANSPORT; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RABBIT; RAT; VISCOSITY;

ADHESIVENESS; ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL AVAILABILITY; DRUG EVALUATION, PRECLINICAL; GELS; MALE; METOCLOPRAMIDE; MOLECULAR STRUCTURE; MUCOCILIARY CLEARANCE; NASAL MUCOSA; RABBITS; RATS; RATS, MUTANT STRAINS; RHEOLOGY; TEMPERATURE; TIME FACTORS; VISCOSITY;

EID: 35948992244     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.08.006     Document Type: Article

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