Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository

International Journal of Pharmaceutics

Volumn 165, Issue 1, 1998, Pages 33-44

  Choi, Han Gon ^a   Jung, Jae Hee ^b   Ryu, Jei Man ^b   Yoon, Sung June ^b   Oh, Yu Kyoung ^a   Kim, Chong Kook ^a  

^a Seoul National University   (South Korea)

^b DongWha Pharm Ind Co   (South Korea)

Author keywords

Acetaminophen; In situ gelling; Liquid suppository; Mucoadhesive; Poloxamer

Indexed keywords

CARBOMER; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; PARACETAMOL; POLOXAMER; POLYCARBOPHIL; POVIDONE;

ADHESION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FORCE; GEL; LIQUID; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RABBIT; RAT; RECTAL DRUG ADMINISTRATION; RECTUM; STRENGTH; SUPPOSITORY; TEMPERATURE SENSITIVITY;

EID: 0032550314     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00386-4     Document Type: Article

References (21)

1. Abhaham, C., 1994. Poloxamer gel systems with gelling temperatures higher than room temperature. Can. Patent No. 10 724 13.
2. Blackman, S.T., Ralske, I., 1989. Gel bases for pharmaceutical bases. US Patent No. 4 883 660.
3. Ch'ng H.S., Park H., Kelly P., Robinson J.R. Bioadhesive polymers as platforms for oral controlled drug delivery II: synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J. Pharm. Sci. 74:1985;399-405.
4. Dumortier G., Zuber M., Courarraze G., Chaumeil J.C., Grossiord J.L. Rheological study of a thermoreversible morphine gel. Drug Dev. Ind. Pharm. 17:1991;1255-1265.
5. Gilbert J.C., Richardson J.L., Davies M.C., Palin K.J. The effect of solutes and polymers on the gelation properties of Pluronic F-127 solutions for controlled drug delivery. J. Control. Release. 5:1987;113-118.
6. Holsman, J.L., Higuchi, T., Mlodozeniac, A.R., 1984. Topical drug delivery system utilizing thermosetting gels. US Patent No. 4 474 753.
7. Huang C.H., Tokumura T., Machida Y., Nagai T. Formulation of double-layered suppository for prolonged stay in lower rectum. Yakuzaigaku. 47:1987;42-48.
8. Kramaric, A., Resman, A., Kofler, B., and Zmitek, J., 1992. Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation. Eur. Patent No. 05 516 26 (A1).
9. Khosla R., Davis S.S. The effect of polycarbophil on the gastric emptying of pellets. J. Pharm. Pharmacol. 39:1987;47-49.
10. Lenaerts V., Triqueneaux C., Quarton M., Falson F.R., Couvreur P. Temperature-dependent rheological behavior of Pluronic F-127 aqueous solutions. Int. J. Pharm. 31:1987;121-127.
11. Leung S.S., Robinson J.R. Bioadhesives in drug delivery. Polym. News. 15:1990;333-342.
12. Lehr C.M., Bouwstra J.A., Tukker J.J., Junginger H.E. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat: a comparative study with copolymers and blends based on poly (acrylic acid). J. Control. Release. 13:1990;51-62.
13. Lowenthal W., Borzelleca J.F., Corder C.D. Drug absorption from the rectum III. Aspirin and some aspirin derivatives. J. Pharm. Sci. 59:1970;1353-1355.
14. Miyazaki S., Nakamura T., Takada M. Thermo-sensitive sol-gel transition of Pluronic F-127. Yakuzaigaku. 51:1991;36-43.
15. Robert C.R., Buri P.A., Peppas N.A. Experimental method for bioadhesive testing of various polymers. Acta Pharm. Technol. 34:1988;95-98.
16. Robinson S.S., Robinson J.R. Polymer structure features contributing to mucoadhesion. II. J. Control. Release. 12:1990;187-194.
17. Schick M.J. Configuration of the polyoxyethylene chain in bulk, nonionic surfactant. Surfactant Sci. 1:1966;753-793.
18. Schmolka I.R. Artificial skin I. Preparation and properties of Pluronic F-127 gels for treatment of burns. J. Biomed. Mater. Res. 6:1972;571-582.
19. Schmolka, I.R., 1973. Polyoxyethylene-polyoxypropylene aqueous gels. US Patent No. 3 740 421.
20. Schmolka, I.R., 1985. Clear analgesic gels with reduced tackiness. US Patent No. 4 511 563.
21. Sidman P., Alvan G., Andrews R.S., Labross A. Relative bioavailability of a paracetamol suppository. Eur. J. Clin. Pharmacol. 17:1980;465-473.