Development of a thermo-reversible insulin liquid suppository with bioavailability enhancement

International Journal of Pharmaceutics

Volumn 189, Issue 2, 1999, Pages 137-145

  Yun, Mi Ok ^a   Choi, Han Gon ^a   Jung, Jae Hee ^b   Kim, Chong Kook ^a  

^a Seoul National University   (South Korea)

^b DongWha Pharm Ind Co   (South Korea)

Author keywords

Insulin; Liquid suppository; Pharmacodynamics; Poloxamer; Polycarbophil; Sodium salicylate; Thermo reversible

Indexed keywords

GLUCOSE; INSULIN; PENETRATION ENHANCING AGENT; POLOXAMER; POLYCARBOPHIL; SALICYLATE SODIUM; TISSUE ADHESIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; GEL; GLUCOSE BLOOD LEVEL; HISTOLOGY; LIQUID; MALE; NONHUMAN; PHARMACODYNAMICS; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; RECTAL DRUG ADMINISTRATION; RECTUM MUCOSA; STREPTOZOCIN DIABETES; SUPPOSITORY; TEMPERATURE;

ADMINISTRATION, RECTAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BLOOD GLUCOSE; BODY TEMPERATURE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DIABETES MELLITUS, EXPERIMENTAL; DRUG STABILITY; GELS; INSULIN; INTESTINAL MUCOSA; MALE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECTUM; SODIUM SALICYLATE; SOLUTIONS; SUPPOSITORIES; SWINE; TEMPERATURE;

EID: 0032861804     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00227-6     Document Type: Article

References (20)

1. Asada H., Douen T., Waki M., Adachi S., Fujita T., Yamamoto A., Muranishi S. Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine. J. Pharm. Sci. 84(6):1995;682-687.
2. Burczak K., Gamian E., Kochman A. Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas. Biomaterials. 17(24):1996;2351-2356.
3. Choi H.G., Oh Y.K., Kim C.K. In-situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability. Int. J. Pharm. 165:1998;23-32.
4. Choi H.G., Jung J.H., Ryu J.M., Yoon S.J., Oh Y.K., Kim C.K. Development of in-situ gelling and mucoadhesive acetaminophen liquid suppository. Int. J. Pharm. 165:1998;33-44.
5. Choi H.K., Jung J.H., Ryu J.M., Kim I.K., Lee B.J., Kim C.K. Effect of additives on the physicochemical properties of acetaminophen liquid suppository. Yakhak Hoeji. 42(3):1998;290-295.
6. Goriya Y., Bahoric A., Marliss E.B., Zinman B., Albisser A.M. Blood glucose control and insulin clearance in unrestrained diabetic dogs portally infused with a portable insulin delivery system. Diabetologia. 19:1980;452-457.
7. Hoffman A., Ziv E. Pharmacokinetic considerations of new insulin formulations and route of administration. Clin. Pharmacokinet. 33(4):1997;285-301.
8. Hosny E., Ahmady O.E., Shattawy H.E., Nabih E.M., Damancy H.E., Deen S.G., Kabbany N.E. Effect of sodium salicylate on insulin rectal absorption in humans. Farzneim. Drug Res. 44(1):1994;611-613.
9. Khaksa G., Nalini K., Bhat M., Udupa N. High-performance liquid chromatographic determination of insulin in rat and human plasma. Anal. Biochem. 260(1):1998;92-95.
10. Kim S., Nishihata T., Kawabe S., Okamura Y., Kamada A., Yagi T., Kawamori R., Shichiri M. Effect of gelation in the formulation on rectal insulin absorption in the presence of enamine in normal dogs and depancreatized dogs. Int. J. Pharm. 21:1984;179-186.
11. Kim C.K., Lee S.W., Choi H.G., Lee M.K., Gao Z.G., Kim I.S., Park K.M. Trials of in-situ gelling and mucoadhesive acetaminophen liquid suppository in human subjects. Int. J. Pharm. 174:1998;201-207.
12. Kim A., Oh Y.K., Kim C.K. Encapsulation and pharmacodynamics of insulin in polyethylene glycol-coated liposomes. Int. J. Pharm. 180:1999;75-81.
13. Liversidge G.G., Nishihata T., Engle K.K., Higuchi T. Effect of rectal suppository formulation on the release of insulin and on the glucose plasma levels in dogs. Int. J. Pharm. 23:1985;87-95.
14. Miyazaki S., Nakamura T., Yokouchi C., Tanaka M. Effect of pluronic gels on the rectal absorption of indomethacin in rabbits. Chem. Pharm. Bull. 35(3):1987;1243-1248.
15. Miyazaki S., Suisha F., Kawasaki N., Shirakawa M., Yamatoya K., Attwood D. Thermally reversible xyloglucan gels as vehicles for rectal drug delivery. J. Controlled Release. 56:1998;75-83.
16. Nishihata T., Okamura Y., Ingaki H., Sudho M., Kamada A., Yagi T., Kawamori R., Shichiri M. Trials of rectal insulin suppositories in healthy humans. Int. J. Pharm. 34:1986;157-161.
17. Reid A.S., Thomas N.W., Palin K.J., Gould P.L. Formulation of fenbufen suppositories. I. Quantitative histological assessment of the rectal mucosa of rats following treatment with suppository bases. Int. J. Pharm. 40:1987;181-185.
18. Richardson J.L., Illum L., Thomas N.W. Vaginal absorption on insulin in the rat: Effect of penetration enhancers on insulin uptake and mucosal histology. Pharm. Res. 9(7):1992;878-883.
19. Sato H., Terasaki T., Okmura K., Tsuji A. Effect of receptor up-regulation on insulin pharmacokinetics in streptozotocin-treated rats. Pharm. Res. 8:1991;563-569.
20. Scott-Moncrieff J.C., Shao Z., Mitra A.K. Enhancement of intestinal insulin absorption by bile salt-fatty acid mixed micelles in dogs. J. Pharm. Sci. 83(10):1994;1465-1469.