-
1
-
-
0018914018
-
The Hypoxic tumor cell: A target for selective cancer chemotherapy
-
Kennedy, K. A., Teicher, B. A., Rockwell, S. et al., The Hypoxic tumor cell: a target for selective cancer chemotherapy. Biochem. Pharmacol. 29, 1 (1980)
-
(1980)
Biochem. Pharmacol.
, vol.29
, pp. 1
-
-
Kennedy, K.A.1
Teicher, B.A.2
Rockwell, S.3
-
2
-
-
0035415493
-
Prodrug strategies in cancer therapy
-
Denny, W. A., Prodrug strategies in cancer therapy. Eur. J. Med. Chem. 36, 577 (2001)
-
(2001)
Eur. J. Med. Chem.
, vol.36
, pp. 577
-
-
Denny, W.A.1
-
3
-
-
0034285733
-
The role of hypoxia-activated prodrugs in cancer therapy
-
Denny, W. A., The role of hypoxia-activated prodrugs in cancer therapy. Oncology 1, 25 (2000)
-
(2000)
Oncology
, vol.1
, pp. 25
-
-
Denny, W.A.1
-
4
-
-
0036910635
-
The hypoxic core: A possible answer to the cancer paradox
-
Guppy, M., The hypoxic core: a possible answer to the cancer paradox. Biochem. Biophys. Res. Commun. 299, 676 (2002)
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 676
-
-
Guppy, M.1
-
6
-
-
0032053823
-
The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
-
Brown, J. M., Giaccia A. J., The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 58, 1408 (1998)
-
(1998)
Cancer Res.
, vol.58
, pp. 1408
-
-
Brown, J.M.1
Giaccia, A.J.2
-
7
-
-
0033405294
-
The hypoxic cell: A target for selective cancer therapy -eighteenth Bruce E cain memorial award lecture
-
Brown, J. M., The hypoxic cell: a target for selective cancer therapy -eighteenth Bruce E cain memorial award lecture. Cancer Res. 59, 5863 (1999)
-
(1999)
Cancer Res.
, vol.59
, pp. 5863
-
-
Brown, J.M.1
-
8
-
-
0034176782
-
Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies
-
Brown, J. M., Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies. Mol. Med. Today 6, 157 (2000)
-
(2000)
Mol. Med. Today
, vol.6
, pp. 157
-
-
Brown, J.M.1
-
9
-
-
0036173591
-
Hypoxia as a target for combined modality treatments
-
Wouters, B. G., Weppler, S. A., Koritzinsky, M. et al., Hypoxia as a target for combined modality treatments. Eur. J. Cancer 38, 240 (2002)
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 240
-
-
Wouters, B.G.1
Weppler, S.A.2
Koritzinsky, M.3
-
10
-
-
16244365120
-
La radioterapia en relación con la hipoxia tumoral y la anemia
-
Villa, M. A., La radioterapia en relación con la hipoxia tumoral y la anemia. Radiobiologia 1, 7 (2001)
-
(2001)
Radiobiologia
, vol.1
, pp. 7
-
-
Villa, M.A.1
-
11
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber, T. G., Osmanian, C., Jacks, T. et al., Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88 (1996)
-
(1996)
Nature
, vol.379
, pp. 88
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
-
12
-
-
0037480606
-
Hypoxic cervical cancers with low apoptotic index are highly aggressive
-
Hockel, M., Schlenger, K., Hockel, S. et al., Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res. 59, 4525 (1999)
-
(1999)
Cancer Res.
, vol.59
, pp. 4525
-
-
Hockel, M.1
Schlenger, K.2
Hockel, S.3
-
13
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel, M., Schlenger, K., Aral, B. et al., Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56, 4509 (1996)
-
(1996)
Cancer Res.
, vol.56
, pp. 4509
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
-
14
-
-
0029955072
-
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
-
Nordsmark, M., Overgaard, M., Overgaard, J., Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41, 31 (1996)
-
(1996)
Radiother. Oncol.
, vol.41
, pp. 31
-
-
Nordsmark, M.1
Overgaard, M.2
Overgaard, J.3
-
15
-
-
0032708195
-
Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
-
Brizel, D. M., Dodge, R. K., Clough, R. W. et al., Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother. Oncol. 53, 113 (1999)
-
(1999)
Radiother. Oncol.
, vol.53
, pp. 113
-
-
Brizel, D.M.1
Dodge, R.K.2
Clough, R.W.3
-
16
-
-
0031716020
-
Oxigenation predict radiation response and survival in patients with cervix cancer
-
Fyles, A. W., Milosevic, M., Wong, R. et al., Oxigenation predict radiation response and survival in patients with cervix cancer. Radiother. Oncol. 48, 149 (1998)
-
(1998)
Radiother. Oncol.
, vol.48
, pp. 149
-
-
Fyles, A.W.1
Milosevic, M.2
Wong, R.3
-
17
-
-
0033022176
-
Influence of the hypoxic subvolume on the survival of patients with head and neck cancer
-
Stadler, P., Becker, A., Feldmann, H. J. et al., Influence of the hypoxic subvolume on the survival of patients with head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 44, 749 (1999)
-
(1999)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.44
, pp. 749
-
-
Stadler, P.1
Becker, A.2
Feldmann, H.J.3
-
18
-
-
0032585864
-
2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix
-
2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother. Oncol. 53, 99 (1999)
-
(1999)
Radiother. Oncol.
, vol.53
, pp. 99
-
-
Knocke, T.H.1
Weitmann, H.D.2
Feldmann, H.J.3
-
19
-
-
0034823234
-
Oxigenation of human tumors-implications for combined therapy
-
Feldmann, H. J., Oxigenation of human tumors-implications for combined therapy. Lung Cancer Suppl. 1, 77 (2001)
-
(2001)
Lung Cancer Suppl.
, vol.1
, pp. 77
-
-
Feldmann, H.J.1
-
20
-
-
0038293080
-
Prognostic significance of tumor oxygenation in humans
-
Evans, S. M., Koch, C. J., Prognostic significance of tumor oxygenation in humans. Cancer Lett. 195, 1 (2003)
-
(2003)
Cancer Lett.
, vol.195
, pp. 1
-
-
Evans, S.M.1
Koch, C.J.2
-
21
-
-
0015451983
-
Potential bioreductive alkylating agents. 1. Benzoquinone derivatives
-
Lin, A. J., Cosby, L. A., Shansky, C. W. et al., Potential bioreductive alkylating agents. 1. Benzoquinone derivatives. J. Med. Chem. 15, 1247 (1972)
-
(1972)
J. Med. Chem.
, vol.15
, pp. 1247
-
-
Lin, A.J.1
Cosby, L.A.2
Shansky, C.W.3
-
22
-
-
0031742631
-
Bioreductive therapies: An overview of drugs and their mechanisms of action
-
Rauth, A. M., Melo, T., Misra, V., Bioreductive therapies: an overview of drugs and their mechanisms of action. Int. J. Radiat. Oncol. Biol. Phys. 42, 755 (1998)
-
(1998)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.42
, pp. 755
-
-
Rauth, A.M.1
Melo, T.2
Misra, V.3
-
23
-
-
0026417645
-
Therapeutic advantage of hypoxic cells in tumors: A theoretical study
-
Brown, J. M., Koong, A. J., Therapeutic advantage of hypoxic cells in tumors: a theoretical study. J. Natl. Cancer Inst. 83, 178 (1991)
-
(1991)
J. Natl. Cancer Inst.
, vol.83
, pp. 178
-
-
Brown, J.M.1
Koong, A.J.2
-
24
-
-
0033063810
-
Cisplatin anti-tumor potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin
-
Kovacs, M. S., Hocking, D. J., Evans, J. W. et al., Cisplatin anti-tumor potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin. Br. J. Cancer 80, 1245 (1999)
-
(1999)
Br. J. Cancer
, vol.80
, pp. 1245
-
-
Kovacs, M.S.1
Hocking, D.J.2
Evans, J.W.3
-
25
-
-
0034009248
-
New quinoxalinecarbonitrile 1,4-di-N-oxides derivates as hypoxic-cytotoxic agents
-
Ortega, M. A., Morancho, M. J., Martínez-Crespo, F. J. et al., New quinoxalinecarbonitrile 1,4-di-N-oxides derivates as hypoxic-cytotoxic agents. Eur. J. Med. Chem. 35, 21 (2000)
-
(2000)
Eur. J. Med. Chem.
, vol.35
, pp. 21
-
-
Ortega, M.A.1
Morancho, M.J.2
Martínez-Crespo, F.J.3
-
26
-
-
0035346937
-
Quinoxaline 1,4-dioxides as anticancer hypoxia-selective drugs
-
Gali-Muhtasib, H. U., Haddadin, M. J., Rahhal, D. N. et al., Quinoxaline 1,4-dioxides as anticancer hypoxia-selective drugs. Oncol. Rep. 8, 679 (2001)
-
(2001)
Oncol. Rep.
, vol.8
, pp. 679
-
-
Gali-Muhtasib, H.U.1
Haddadin, M.J.2
Rahhal, D.N.3
-
27
-
-
0036214054
-
Quinoxaline 1,4-Dioxides: Hipoxia-Selective Therapeutic Agents
-
Diab-Assef, M., Haddadin, M. J., Yared, P. et al., Quinoxaline 1,4-Dioxides: hipoxia-Selective Therapeutic Agents. Mol. Carcinog. 33, 198 (2002)
-
(2002)
Mol. Carcinog.
, vol.33
, pp. 198
-
-
Diab-Assef, M.1
Haddadin, M.J.2
Yared, P.3
-
28
-
-
0022493495
-
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman, E. M., Brown, J. M., Lemmon, M. J. et al., SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 12, 1239 (1986)
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1239
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
-
29
-
-
0030738399
-
Adaptation of human tumour cells to tirapazamine under aerobic conditions-implications of increased antioxidant enzyme activity to mechanism of aerobic toxicity
-
Elwell, J. H., Siim, B. G., Evans, J. W. et al., Adaptation of human tumour cells to tirapazamine under aerobic conditions-implications of increased antioxidant enzyme activity to mechanism of aerobic toxicity. Biochem. Pharmacol. 54, 249 (1997)
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 249
-
-
Elwell, J.H.1
Siim, B.G.2
Evans, J.W.3
-
30
-
-
0029027637
-
Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides
-
Monge, A., Palop, J. A., López de Cerain, A. et al., Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides. J. Med. Chem. 38, 1786 (1995)
-
(1995)
J. Med. Chem.
, vol.38
, pp. 1786
-
-
Monge, A.1
Palop, J.A.2
López De Cerain, A.3
-
31
-
-
0028877272
-
Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides
-
Monge, A., Martinez-Crespo, F. J., López de Cerain, A. et al., Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides. J. Med. Chem. 38, 4488 (1995)
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4488
-
-
Monge, A.1
Martinez-Crespo, F.J.2
López De Cerain, A.3
-
32
-
-
0030794153
-
Physicochemical properties and stability of the new hypoxia-selective agent 7-cloro-3-[[(N,N,-dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride
-
Zamalloa, E., Aldana, I., Bachiller, C. M. et al., Physicochemical properties and stability of the new hypoxia-selective agent 7-cloro-3-[[(N,N,- dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride. Arzneim.-Forsch./Drug Res. 47 (II), 873 (1997)
-
(1997)
Arzneim.-Forsch./Drug Res.
, vol.47
, Issue.2
, pp. 873
-
-
Zamalloa, E.1
Aldana, I.2
Bachiller, C.M.3
-
33
-
-
84988130977
-
Experimental studies upon lymphocytes: I. The reactions of lymphocytes under various experimental conditions
-
Pappenheimer, A. M., Experimental studies upon lymphocytes: I. The reactions of lymphocytes under various experimental conditions. J. Exp. Med. 25, 633 (1917)
-
(1917)
J. Exp. Med.
, vol.25
, pp. 633
-
-
Pappenheimer, A.M.1
-
34
-
-
0034830902
-
Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxides
-
Ganley, B., Chowdhury, G., Bhansali, J. et al., Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxides. Bioorg. Med. Chem. 9, 2395 (2001)
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 2395
-
-
Ganley, B.1
Chowdhury, G.2
Bhansali, J.3
|