Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 23, 2000, Pages 2661-2664

  Crespo, María I ^a   Gràcia, Jordi ^a   Puig, Carles ^a   Vega, Armando ^a   Bou, Josep ^a   Beleta, Jordi ^a   Doménech, Teresa ^a   Ryder, Hamish ^a   Segarra, Víctor ^a   Palacios, José M ^a  

^a Research Centre ^*  (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIHYDROPYRAZOLO[4,3 C]QUINOLINE 3 DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BINDING AFFINITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; EOSINOPHILIA; GUINEA PIG; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; VOMITING;

ANIMALS; ANTI-ASTHMATIC AGENTS; EMETICS; GUINEA PIGS; MODELS, MOLECULAR; PHOSPHODIESTERASE INHIBITORS; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

CAVIA PORCELLUS; SUS SCROFA;

EID: 0034606467     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00548-5     Document Type: Article

References (14)