Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro

Molecular Biology of the Cell

Volumn 18, Issue 11, 2007, Pages 4261-4278

  Halbleib, Jennifer M ^a   Sääf, Annika M ^a   Brown, Patrick O ^a   Nelson, W James ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL POLARITY; CELL PROLIFERATION; CELL SPECIFICITY; CELL STRAIN CACO 2; CELL STRUCTURE; CELL TRANSPORT; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTESTINE CELL; MICROVILLUS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; TIGHT JUNCTION; TRANSCRIPTION REGULATION;

ACTINS; CACO-2 CELLS; CELL ADHESION; CELL DIFFERENTIATION; CELL POLARITY; CYTOSKELETON; DESMOSOMES; ENTEROCYTES; EPITHELIAL CELLS; EPITHELIUM; EXTRACELLULAR MATRIX; EYE PROTEINS; GAP JUNCTIONS; GENE EXPRESSION PROFILING; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT; RHO GTP-BINDING PROTEINS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 35848942606     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-04-0308     Document Type: Article

References (130)

1. Aijaz, S., Balda, M. S., and Matter, K. (2006). Tight junctions: molecular architecture and function. Int. Rev. Cytol. 248, 261-298.
2. Aspenstrom, P. (2005). The verprolin family of proteins: regulators of cell morphogenesis and endocytosis. FEBS Lett. 579, 5253-5259.
3. Athman, R., Louvard, D., and Robine, S. (2002). The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells? Am. J. Physiol. Gastrointest. Liver Physiol. 283, G496-G502.
4. Bacallao, R., Antony, C., Dotti, C., Karsenti, E., Stelzer, E. H., and Simons, K. (1989). The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium. J. Cell Biol. 109, 2817-2832.
5. Balda, M. S., Garrett, M. D., and Matter, K. (2003). The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J. Cell Biol. 160, 423-432.
6. Barlowe, C. (2002). COPII-dependent transport from the endoplasmic reticulum. Curr. Opin. Cell Biol. 14, 417-422.
7. Barr, F. A., and Short, B. (2003). Golgins in the structure and dynamics of the Golgi apparatus. Curr. Opin. Cell Biol. 15, 405-413.
8. Bilder, D. (2004). Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 18, 1909-1925.
9. Bilder, D., Schober, M., and Perrimon, N. (2003). Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat. Cell Biol. 5, 53-58.
10. Brady-Kalnay, S. M., and Tonks, N. K. (1995). Protein tyrosine phosphatases as adhesion receptors. Curr. Opin. Cell Biol. 7, 650-657.
11. Bre, M. H., Kreis, T. E., and Karsenti, E. (1987). Control of microtubule nucleation and stability in Madin-Darby canine kidney cells: the occurrence of noncentrosomal, stable detyrosinated microtubules. J. Cell Biol. 105, 1283-1296.
12. Bulinski, J. C., McGraw, T. E., Gruber, D., Nguyen, H. L., and Sheetz, M. P. (1997). Overexpression of MAP4 inhibits organelle motility and trafficking in vivo. J. Cell Sci. 110(Pt 24), 3055-3064.
13. Busson-Mabillot, S., Chambaut-Guerin, A. M., Ovtracht, L., Muller, P., and Rossignol, B. (1982). Microtubules and protein secretion in rat lacrimal glands: localization of short-term effects of colchicine on the secretory process. J. Cell Biol. 95, 105-117.
14. Calnek, D., and Quaroni, A. (1993). Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation. Differentiation 53, 95-104.
15. Carlsson, L., Nystrom, L. E., Sundkvist, I., Markey, F., and Lindberg, U. (1977). Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J. Mol. Biol. 115, 465-483.
16. Chantret, I., Barbat, A., Dussaulx, E., Brattain, M. G., and Zweibaum, A. (1988). Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines. Cancer Res. 48, 1936-1942.
17. Chen, Y. A., and Scheller, R. H. (2001). SNARE-mediated membrane fusion. Nat. Rev. Mol. Cell Biol. 2, 98-106.
18. Chen, Z. Y., Hasson, T., Zhang, D. S., Schwender, B. J., Derfler, B. H., Mooseker, M. S., and Corey, D. P. (2001). Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. Genomics 72, 285-296.
19. Cheney, R. E., and Mooseker, M. S. (1992). Unconventional myosins. Curr. Opin. Cell Biol. 4, 27-35.
20. Clatworthy, J. P., and Subramanian, V. (2001). Stem cells and the regulation of proliferation, differentiation and patterning in the intestinal epithelium: emerging insights from gene expression patterns, transgenic and gene ablation studies. Mech. Dev. 101, 3-9.
21. Clayburgh, D. R., Rosen, S., Witkowski, E. D., Wang, F., Blair, S., Dudek, S., Garcia, J. G., Alverdy, J. C., and Turner, J. R. (2004). A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J. Biol. Chem. 279, 55506-55513.
22. Clevers, H., and Batlle, E. (2006). EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer Res. 66, 2-5.
23. Colegio, O. R., Van Itallie, C., Rahner, C., and Anderson, J. M. (2003). Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am. J. Physiol. Cell Physiol. 284, C1346-C1354.
24. Croce, A., Cassata, G., Disanza, A., Gagliani, M. C., Tacchetti, C., Malabarba, M. G., Carlier, M. F., Scita, G., Baumeister, R., and Di Fiore, P. P. (2004). A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabdilis elegans. Nat. Cell Biol. 6, 1173-1179.
25. D'Souza-Schorey, C., and Chavrier, P. (2006). ARF proteins: roles in membrane traffic and beyond. Nat. Rev. Mol. Cell Biol. 7, 347-358.
26. Dang, X., Doble, B. W., and Kardami, E. (2003). The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth. Mol. Cell Biochem. 242, 35-38.
27. De Arcangelis, A., Neuville, P., Boukamel, R., Lefebvre, O., Kedinger, M., and Simon-Assmann, P. (1996). Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation. J. Cell Biol. 133, 417-430.
28. Delacour, D., Cramm-Behrens, C. I., Drobecq, H., Le Bivic, A., Naim, H. Y., and Jacob, R. (2006). Requirement for galectin-3 in apical protein sorting. Curr. Biol. 16, 408-414.
29. Delacour, D. et al. (2005). Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. J. Cell Biol. 169, 491-501.
30. DeMali, K. A., Wennerberg, K., and Burridge, K. (2003). Integrin signaling to the actin cytoskeleton. Curr. Opin. Cell Biol. 15, 572-582.
31. Disanza, A., Carlier, M. F., Stradal, T. E., Didry, D., Frittoli, E., Confalonieri, S., Croce, A., Wehland, J., Di Fiore, P. P., and Scita, G. (2004). Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nat. Cell Biol. 6, 1180-1188.
32. Ehrlich, J. S., Hansen, M. D., and Nelson, W. J. (2002). Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev. Cell 3, 259-270.
33. Etienne-Manneville, S., and Hall, A. (2003). Cell polarity: Par6, aPKC and cytoskeletal crosstalk. Curr. Opin. Cell Biol. 15, 67-72.
34. Evans, W. H., De Vuyst, E., and Leybaert, L. (2006). The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem. J. 397, 1-14.
35. Fakih, M. G., and Padmanabhan, A. (2006). CEA monitoring in colorectal cancer. What you should know. Oncology (Williston Park) 20, 579-587; discussion 588, 594, 596 passim.
36. Folsch, H. (2005). The building blocks for basolateral vesicles in polarized epithelial cells. Trends Cell Biol. 15, 222-228.
37. Franke, W. W., Schmid, E., Osborn, M., and Weber, K. (1978). Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc. Natl. Acad. Sci. USA 75, 5034-5038.
38. Fujita, Y., and Braga, V. (2005). Epithelial cell shape and Rho small GTPases. Novartis Found Symp. 269, 144-155; discussion 155-148, 223-230.
39. Furuse, M., Furuse, K., Sasaki, H., and Tsukita, S. (2001). Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J. Cell Biol. 153, 263-272.
40. Garrod, D. R., Merritt, A. J., and Nie, Z. (2002). Desmosomal Cadherins. Curr. Opin. Cell Biol. 14, 537-545.
41. Gates, J., and Peifer, M. (2005). Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions. Cell 123, 769-772.
42. Getsios, S., Huen, A. C., and Green, K. J. (2004). Working out the strength and flexibility of desmosomes. Nat. Rev. Mol. Cell Biol. 5, 271-281.
43. Gilbert, T., Le Bivic, A., Quaroni, A., and Rodriguez-Boulan, E. (1991). Microtubular organization and its involvement in the biogenetic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells. J. Cell Biol. 113, 275-288.
44. Grasset, E., Bernabeu, J., and Pinto, M. (1985). Epithelial properties of human colonic carcinoma cell line Caco-2: effect of secretagogues. Am. J. Physiol. 248, C410-C418.
45. Gumbiner, B. M. (2005). Regulation of cadherin-mediated adhesion in morphogenesis. Nat. Rev. Mol. Cell Biol. 6, 622-634.
46. Gut, A., Kappeier, F., Hyka, N., Balda, M. S., Hauri, H. P., and Matter, K. (1998). Carbohydrate-mediated Golgi to cell surface transport and apical targeting of membrane proteins. EMBO J. 17, 1919-1929.
47. Hahn, B. S., and Labouesse, M. (2001). Tissue integrity: hemidesmosomes and resistance to stress. Curr. Biol. 11, R858-R861.
48. Hara-Kuge, S., Ohkura, T., Ideo, H., Shimada, O., Atsumi, S., and Yamashita, K. (2002). Involvement of VIP36 in intracellular transport and secretion of glycoproteins in polarized Madin-Darby canine kidney (MDCK) cells. J. Biol. Chem. 277, 16332-16339.
49. Hauri, H., Appenzeller, C., Kuhn, F., and Nufer, O. (2000). Lectins and traffic in the secretory pathway. FEBS Lett. 476, 32-37.
50. Hendrix, M. J., Seftor, E. A., Chu, Y. W., Trevor, K. T., and Seftor, R. E. (1996). Role of intermediate filaments in migration, invasion and metastasis. Cancer Metastasis Rev. 15, 507-525.
51. Henrique, D., and Schweisguth, F. (2003). Cell polarity: the ups and downs of the Par6/aPKC complex. Curr. Opin. Genet. Dev. 13, 341-350.
52. Homma, N., Takei, Y., Tanaka, Y., Nakata, T., Terada, S., Kikkawa, M., Noda, Y., and Hirokawa, N. (2003). Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell 114, 229-239.
53. Husoy, T., Knutsen, H. K., Cruciani, V., Olstorn, H. B., Mikalsen, S. O., Loberg, E. M., and Alexander, J. (2005). Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. Int. J. Cancer 116, 351-358.
54. Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
55. Iacobuzio-Donahue, C. A., Argani, P., Hempen, P. M., Jones, J., and Kern, S. E. (2002). The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types. Cancer Res. 62, 5351-5357.
56. Irie, K., Shimizu, K., Sakisaka, T., Ikeda, W., and Takai, Y. (2004). Roles and modes of action of nectins in cell-cell adhesion. Semin. Cell Dev. Biol. 15, 643-656.
57. Jaffe, A. B., and Hall, A. (2005). Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269.
58. Jaffer, Z. M., and Chernoff, J. (2002). p21-activated kinases: three more join the Pak. Int. J. Biochem. Cell Biol. 34, 713-717.
59. Jou, T. S., Schneeberger, E. E., and Nelson, W. J. (1998). Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142, 101-115.
60. Kakinuma, T., Ichikawa, H., Tsukada, Y., Nakamura, T., and Toh, B. H. (2004). Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. Exp. Cell Res. 298, 388-398.
61. Karki, S., and Holzbaur, E. L. (1999). Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr. Opin. Cell Biol. 11, 45-53.
62. Kobielak, A., and Fuchs, E. (2004). Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat. Rev. Mol. Cell Biol. 5, 614-625.
63. Kreitzer, G., Schmoranzer, J., Low, S. H., Li, X., Gan, Y., Weimbs, T., Simon, S. M., and Rodriguez-Boulan, E. (2003). Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nat. Cell Biol. 5, 126-136.
64. Kureishy, N., Sapountzi, V., Prag, S., Anilkumar, N., and Adams, J. C. (2002). Fascins, and their roles in cell structure and function. Bioessays 24, 350-361.
65. Laukoetter, M. G., Bruewer, M., and Nusrat, A. (2006). Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr. Opin. Gastroenterol. 22, 85-89.
66. Le Bivic, A., Quaroni, A., Nichols, B., and Rodriguez-Boulan, E. (1990a). Biogenetic pathways of plasma membrane proteins in Caco-2, a human intestinal epithelial cell line. J. Cell Biol. 111, 1351-1361.
67. Le Bivic, A., Real, F. X., and Rodriguez-Boulan, E. (1989). Vectorial targeting of apical and basolateral plasma membrane proteins in a human adenocarcinoma epithelial cell line. Proc. Natl. Acad. Sci. USA 86, 9313-9317.
68. Le Bivic, A., Sambuy, Y., Mostov, K., and Rodriguez-Boulan, E. (1990b). Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. J. Cell Biol. 110, 1533-1539.
69. Lee, S. Y., Yang, J. S., Hong, W., Premont, R. T., and Hsu, V. W. (2005). ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. J. Cell Biol. 168, 281-290.
70. Leivo, I., Tani, T., Laitinen, L., Bruns, R., Kivilaakso, E., Lehto, V. P., Burgeson, R. E., and Virtanen, I. (1996). Anchoring complex components laminin-5 and type VII collagen in intestine: association with migrating and differentiating enterocytes. J. Histochem. Cytochem. 44, 1267-1277.
71. Luca, M., Hunt, B., Bucana, C. D., Johnson, J. P., Fidler, I. J., and Bar-Eli, M. (1993). Direct correlation between MUC18 expression and metastatic potential of human melanoma cells. Melanoma Res. 3, 35-41.
72. Martin-Belmonte, F., Gassama, A., Datta, A., Yu, W., Rescher, U., Gerke, V., and Mostov, K. (2007). PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell 128, 383-397.
73. Matter, K., Brauchbar, M., Bucher, K., and Hauri, H. P. (1990a). Sorting of endogenous plasma membrane proteins occurs from two sites in cultured human intestinal epithelial cells (Caco-2). Cell 60, 429-437.
74. Matter, K., Bucher, K., and Hauri, H. P. (1990b). Microtubule perturbation retards both the direct and the indirect apical pathway but does not affect sorting of plasma membrane proteins in intestinal epithelial cells (Caco-2). EMBO J. 9, 3163-3170.
75. Matter, K., Stieger, B., Klumperman, J., Ginsel, L., and Hauri, H. P. (1990c). Endocytosis, recycling, and lysosomal delivery of brush border hydrolases in cultured human intestinal epithelial cells (Caco-2). J. Biol. Chem. 265, 3503-3512.
76. Mollenhauer, J., Wiemann, S., Scheurlen, W., Korn, B., Hayashi, Y., Wilgenbus, K. K., von Deimling, A., and Poustka, A. (1997). DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat. Genet. 17, 32-39.
77. Momiyama, M., Omori, Y., Ishizaki, Y., Nishikawa, Y., Tokairin, T., Ogawa, J., and Enomoto, K. (2003). Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells. Cancer Sci. 94, 501-507.
78. Monlauzeur, L., Breuza, L., and Le Bivic, A. (1998). Putative O-glycosylation sites and a membrane anchor are necessary for apical delivery of the human neurotrophin receptor in Caco-2 cells. J. Biol. Chem. 273, 30263-30270.
79. Mooseker, M. S. (1985). Organization, chemistry, and assembly of the cytoskeletal apparatus of the intestinal brush border. Annu. Rev. Cell Biol. 1, 209-241.
80. Mori, M., Shiraishi, T., Tanaka, S., Yamagata, M., Mafune, K., Tanaka, Y., Ueo, H., Barnard, G. F., and Sugimachi, K. (1999). Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Br. J. Cancer 79, 211-213.
81. Nelson, C. M., and Bissell, M. J. (2005). Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin. Cancer Biol. 15, 342-352.
82. Nelson, W. J. (2003). Adaptation of core mechanisms to generate cell polarity. Nature 422, 766-774.
83. Nelson, W. J., and Nusse, R. (2004). Convergence of Wnt, beta-catenin, and Cadherin pathways. Science 303, 1483-1487.
84. Nikolopoulos, S. N., Spengler, B. A., Kisselbach, K., Evans, A. E., Biedler, J. L., and Ross, R. A. (2000). The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells. Oncogene 19, 380-386.
85. Noda, Y., Okada, Y., Saito, N., Setou, M., Xu, Y., Zhang, Z., and Hirokawa, N. (2001). KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes. J. Cell Biol. 155, 77-88.
86. O'Brien, L. E., Zegers, M. M., and Mostov, K. E. (2002). Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat. Rev. Mol. Cell Biol. 3, 531-537.
87. Offenhauser, N., Borgonovo, A., Disanza, A., Romano, P., Ponzanelli, I., Iannolo, G., Di Fiore, P. P., and Scita, G. (2004). The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol. Biol. Cell 15, 91-98.
88. Orian-Rousseau, V., Aberdam, D., Fontao, L., Chevalier, L., Meneguzzi, G., Kedinger, M., and Simon-Assmann, P. (1996). Developmental expression of laminin-5 and HD1 in the intestine: epithelial to mesenchymal shift for the laminin gamma-2 chain subunit deposition. Dev. Dyn. 206, 12-23.
89. Ostman, A., Hellberg, C., and Bohmer, F. D. (2006). Protein-tyrosine phosphatases and cancer. Nat. Rev. Cancer 6, 307-320.
90. Permana, S., Hisanaga, S., Nagatomo, Y., Iida, J., Hotani, H., and Itoh, T. J. (2005). Truncation of the projection domain of MAP4 (microtubule- associated protein 4) leads to attenuation of microtubule dynamic instability. Cell Struct. Funct. 29, 147-157.
91. Piddini, E., Schmid, J. A., de Martin, R., and Dotti, C. G. (2001). The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. EMBO J. 20, 4076-4087.
92. Pinto, D., and Clevers, H. (2005). Wnt control of stem cells and differentiation in the intestinal epithelium. Exp. Cell Res. 306, 357-363.
93. Pinto, M., Robine-Leon, S., Appay, M. D., Kedinger, M., and Triadou, N. (1983). Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2. Biol. Cell 47, 323-330.
94. Pollard, T. D., and Borisy, G. G. (2003). Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453-465.
95. Ponnambalam, S., and Baldwin, S. A. (2003). Constitutive protein secretion from the trans-Golgi network to the plasma membrane. Mol. Membr. Biol. 20, 129-139.
96. Preisinger, C., Short, B., De Corte, V., Bruyneel, E., Haas, A., Kopajtich, R., Gettemans, J., and Barr, F. A. (2004). YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. J. Cell Biol. 164, 1009-1020.
97. Rodriguez-Boulan, E., Kreitzer, G., and Musch, A. (2005). Organization of vesicular trafficking in epithelia. Nat. Rev. Mol. Cell Biol. 6, 233-247.
98. Roh, M. H., and Margolis, B. (2003). Composition and function of PDZ protein complexes during cell polarization. Am. J. Physiol. Renal. Physiol. 285, F377-F387.
99. Rossman, K. L., Der, C. J., and Sondek, J. (2005). GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180.
100. Sääf, A. M., Halbleib, J. M., Chen, X., Yuen, S. T., Leung, S. Y., Nelson, W. J., and Brown, P. O. (2007). Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal and colon cancer. Mol. Biol. Cell 18, 4245-4260.
101. Saez, J. C., Berthoud, V. M., Branes, M. C., Martinez, A. D., and Beyer, E. C. (2003). Plasma membrane channels formed by connexins: their regulation and functions. Physiol. Rev. 83, 1359-1400.
102. Seemann, J., Jokitalo, E., Pypaert, M., and Warren, G. (2000). Matrix proteins can generate the higher order architecture of the Golgi apparatus. Nature 407, 1022-1026.
103. Segretain, D., and Falk, M. M. (2004). Regulation of connexin biosynthesis, assembly, gap junction formation, and removal. Biochim. Biophys. Acta 1662, 3-21.
104. Sherr, C. J. (1995). D-type cyclins. Trends Biochem. Sci. 20, 187-190.
105. Simon-Assmann, P., Lefebvre, O., Bellissent-Waydelich, A., Olsen, J., Orian-Rousseau, V., and De Arcangelis, A. (1998). The laminins: role in intestinal morphogenesis and differentiation. Ann. NY Acad. Sci. 859, 46-64.
106. Soole, K. L., Jepson, M. A., Hazlewood, G. P., Gilbert, H. J., and Hirst, B. H. (1995). Epithelial sorting of a glycosylphosphatidylinositol-anchored bacterial protein expressed in polarized renal MDCK and intestinal Caco-2 cells. J. Cell Sci. 108(Pt 1), 369-377.
107. Sourisseau, T., Georgiadis, A., Tsapara, A., Ali, R. R., Pestell, R., Matter, K., and Balda, M. S. (2006). Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. Mol. Cell. Biol. 26, 2387-2398.
108. Su, L. K., Burrell, M., Hill, D. E., Gyuris, J., Brent, R., Wiltshire, R., Trent, J., Vogelstein, B., and Kinzler, K. W. (1995). APC binds to the novel protein EB1. Cancer Res. 55, 2972-2977.
109. Sundberg, U., Beauchemin, N., and Obrink, B. (2004). The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells. J. Cell Sci. 117, 1091-1104.
110. Takito, J., and Al-Awqati, Q. (2004). Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin. J. Cell Biol. 166, 1093-1102.
111. Takito, J., Yan, L., Ma, J., Hikita, C., Vijayakumar, S., Warburton, D., and Al-Awqati, Q. (1999). Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am. J. Physiol. 277, F277-F289.
112. Tanentzapf, G., and Tepass, U. (2003). Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat. Cell Biol. 5, 46-52.
113. Tirnauer, J. S., and Bierer, B. E. (2000). EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. J. Cell Biol. 149, 761-766.
114. Turck, N., Gross, I., Gendry, P., Stutzmann, J., Freund, J. N., Kedinger, M., Simon-Assmann, P., and Launay, J. F. (2005). Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells. Exp. Cell Res. 303, 494-503.
115. Vadlamudi, R. K., Barnes, C. J., Rayala, S., Li, F., Balasenthil, S., Marcus, S., Goodson, H. V., Sahin, A. A., and Kumar, R. (2005). p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. Mol. Cell. Biol. 25, 3726-3736.
116. van Adelsberg, J., Edwards, J. C., Takito, J., Kiss, B., and al-Awqati, Q. (1994). An induced extracellular matrix protein reverses the polarity of band 3 in intercalated epithelial cells. Cell 76, 1053-1061.
117. Van Itallie, C. M., and Anderson, J. M. (2006). Claudins and epithelial paracellular transport. Annu. Rev. Physiol. 68, 403-429.
118. Vidrich, A., Buzan, J. M., and Cohn, S. M. (2003). Intestinal stem cells and mucosal gut development. Curr. Opin. Gastroenterol. 19, 583-590.
119. Wei, C. J., Xu, X., and Lo, C. W. (2004). Connexins and cell signaling in development and disease. Annu. Rev. Cell Dev. Biol. 20, 811-838.
120. Welch, M. D. (1999). The world according to Arp: regulation of actin nucleation by the Arp2/3 complex. Trends Cell Biol. 9, 423-427.
121. Wice, B. M., Trugnan, G., Pinto, M., Rousset, M., Chevalier, G., Dussaulx, E., Lacroix, B., and Zweibaum, A. (1985). The intracellular accumulation of UDP-N-acetylhexosamines is concomitant with the inability of human colon cancer cells to differentiate. J. Biol. Chem. 260, 139-146.
122. Xia, C., Ma, W., Stafford, L. J., Marcus, S., Xiong, W. C., and Liu, M. (2001). Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1. Proc. Natl. Acad. Sci. USA 98, 6174-6179.
123. Xu, Y., Takeda, S., Nakata, T., Noda, Y., Tanaka, Y., and Hirokawa, N. (2002). Role of KIFC3 motor protein in Golgi positioning and integration. J. Cell Biol. 158, 293-303.
124. Yeaman, C., Grindstaff, K. K., Hansen, M. D., and Nelson, W. J. (1999a). Cell polarity: Versatile scaffolds keep things in place. Curr. Biol. 9, R515-R517.
125. Yeaman, C., Grindstaff, K. K., and Nelson, W. J. (1999b). New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol. Rev. 79, 73-98.
126. Yeaman, C., Grindstaff, K. K., Wright, J. R., and Nelson, W. J. (2001). Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. J. Cell Biol. 155, 593-604.
127. Yoshimori, T., Keller, P., Roth, M. G., and Simons, K. (1996). Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells. J. Cell Biol. 133, 247-256.
128. Zamir, E., and Geiger, B. (2001). Molecular complexity and dynamics of cell-matrix adhesions. J. Cell Sci. 114, 3583-3590.
129. Zerial, M., and McBride, H. (2001). Rab proteins as membrane organizers. Nat. Rev. Mol. Cell Biol. 2, 107-117.
130. Zhang, J. T., and Nicholson, B. J. (1989). Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J. Cell Biol. 109, 3391-3401.