Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells

Journal of Cell Biology

Volumn 155, Issue 3, 2001, Pages 593-604

  Yeaman, Charles ^a   Grindstaff, Kent K ^a   Wright, Jessica R ^a   James Nelson, W ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Cell membrane metabolism; Cell polarity; Golgi apparatus secretion; Intercellular junctions physiology; Intracellular membranes metabolism

Indexed keywords

BREFELDIN A; CARRIER PROTEIN; PROTEIN KINASE; VIRUS PROTEIN; SEC6L1 PROTEIN, MOUSE; SEC8L1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL JUNCTION; CELL MEMBRANE; CELL VACUOLE; COMPLEX FORMATION; CONTROLLED STUDY; EXOCYTOSIS; FIBROBLAST; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STEADY STATE; TRANS GOLGI NETWORK; VESICULAR STOMATITIS VIRUS; ANIMAL; CELL LINE; CYTOLOGY; EPITHELIUM CELL; MAMMAL; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALIA; MAMMALIA; VESICULAR STOMATITIS VIRUS;

ANIMALS; CARRIER PROTEINS; CELL LINE; CELL MEMBRANE; EPITHELIAL CELLS; EXOCYTOSIS; FIBROBLASTS; MAMMALS; MICE; TRANS-GOLGI NETWORK;

EID: 0035969243     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200107088     Document Type: Article

References (45)

1. Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis
2. Role of tight junctions in establishing and maintaining cell polarity
3. SNARE membrane trafficking dynamics in vivo
4. Human syntaxin 3 is localized apically in human intestinal cells
5. Origins of cell polarity
6. Sec3p is a spatial landmark for polarized secretion in budding yeast
7. Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells
8. Endogenous syntaxins 2, 3 and 4 exhibit distinct but overlapping patterns of expression at the hepatocyte plasma membrane
9. Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells
10. rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin
11. Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins
12. Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
13. Exo84p is an exocyst protein essential for secretion
14. The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains
15. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin
16. Kinetic analysis of secretory protein traffic and characterization of Golgi to plasma membrane transport intermediates in living cells
17. The mammalian brain rsec6/8 complex
18. Different requirements for NSF, SNAP, and Rab proteins in apical and basolateral transport in MDCK cells
19. Turning on ARF: The Sec7 family of guanine-nucleotide-exchange factors
20. Membrane fusion and exocytosis
21. Subunit structure of the mammalian exocyst complex
22. Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network
23. Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells
24. The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells
25. Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+,K(+)-ATPase distributions in polarized epithelia
26. Endocytosis and molecular sorting
27. Intracellular trafficking and activation of the furin proprotein convertase: Localization to the TGN and recycling from the cell surface
28. Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cells
29. Order of events in the yeast secretory pathway
30. Regulation of desmosome assembly in epithelial cells: Kinetics of synthesis, transport, and stabilization of desmoglein I, a major protein of the membrane core domain
31. Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo
32. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes
33. Perturbation of the morphology of the trans-Golgi network following Brefeldin A treatment: Redistribution of a TGN-specific integral membrane protein, TGN38
34. Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI
35. + signaling complexes and regulates their activity
36. Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking
37. SNARE protein trafficking in polarized MDCK cells
38. Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4
39. The exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae
40. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae
41. The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth
42. Formation of the apical pole of epithelial (Madin-Darby canine kidney) cells: Polarity of an apical protein is independent of tight junctions while segregation of a basolateral marker requires cell-cell interactions
43. Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome
44. New perspectives on mechanisms involved in generating epithelial cell polarity