Effect of amiodarone on the plasma levels of metoprolol

American Journal of Cardiology

Volumn 94, Issue 10, 2004, Pages 1319-1321

  Werner, Dierk ^a,e   Wuttke, Henrike ^d   Fromm, Martin F ^c   Schaefer, Simon ^b   Eschenhagen, Thomas ^d   Brune, Kay ^c   Daniel, Werner G ^b   Werner, Ulrike ^c  

^a HELIOS KLINIKEN SCHWERIN   (Germany)

^b Department of Cardiology ^*

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF HAMBURG   (Germany)

^e Helios Kliniken Wismarsche S   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; METOPROLOL; METOPROLOL TARTRATE;

ADULT; AGED; ALLELE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL PROTOCOL; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENOTYPE; HEART ATRIUM FIBRILLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

AGED; ALLELES; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; CYTOCHROME P-450 CYP2D6; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; GENOTYPE; HUMANS; MALE; METOPROLOL;

EID: 7944238518     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2004.07.125     Document Type: Article

References (15)

1. C. Funck-Brentano, E. Jacqz-Aigrain, A. Leenhardt, A. Roux, J.M. Poirier, P. Jaillon Influence of amiodarone on genetically determined drug metabolism in humans Clin Pharmacol Ther 50 1991 259 266
2. K. Ohyama, M. Nakajima, M. Suzuki, N. Shimada, H. Yamazaki, T. Yokoi Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions Br J Clin Pharmacol 49 2000 244 253
3. T. Rau, R. Heide, K. Bergmann, H. Wuttke, U. Werner, N. Feifel, T. Eschenhagen Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment Clin Pharmacol Ther 12 2002 465 472
4. A. Hemeryck, R.A. Lefebvre, C. De Vriendt, F.M. Belpaire Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers Clin Pharmacol Ther 67 2000 283 291
5. F. Wagner, D. Kalusche, D. Trenk, E. Jahnchen, H. Roskamm Drug interaction between propafenone and metoprolol Br J Clin Pharmacol 24 1987 213 220
6. T. Leemann, P. Dayer, U.A. Meyer Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers Eur J Clin Pharmacol 29 1986 739 741
7. T. Damy, F. Pousset, H. Caplain, J.S. Hulot, P. Lechat Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects Fundam Clin Pharmacol 18 2004 113 123
8. U. Werner, D. Werner, T. Rau, M.F. Fromm, B. Hinz, K. Brune Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans Clin Pharmacol Ther 74 2003 130 137
9. J. Leor, D. Levartowsky, C. Sharon, Z. Farfel Amiodarone and β-adrenegic blockers: an interaction with metoprolol but not with atenolol Am Heart J 116 1988 206 207
10. K.K. Teo, S. Yusuf, C.D. Furberg Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction JAMA 270 1993 1589 1595
11. G. Perret, Y.L. Yin, P. Nicolas, E. Pussard, R. Vassy, B. Uzzan, A. Berdeaux Amiodarone decreases cardiac β-adrenoreceptors through an antagonistic effect on 3,5,3′ triiodothyronine J Cardiovasc Pharmacol 19 1992 473 478
12. F. Boutitie, J.P. Boissel, S.J. Connolly, A.J. Camm, J.A. Caims, D.G. Julian, M. Gent, M.J. Janse, P. Dorian, G. Frangin Amiodarone interaction with β-blockers Analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases Circulation 99 1999 2268 2275
13. S. Giri, C.M. White, A.B. Dunn, K. Felton, L. Freeman-Bosco, P. Reddy, J.P. Tsikouris, H.A. Wilcox, J. Kluger Oral amiodarone for prevention of atrial fibrillation after open heart surgery, the Atrial Fibrillation Suppression Trial (AFIST): a randomised placebo-controlled trial Lancet 357 2001 830 836
14. B.A. Hamelin, A. Bouayad, J. Méthot, J. Jobin, P. Desgagnés, P. Poirier, J. Allaire, J. Dumesnil, J. Turgeon Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity Clin Pharmacol Ther 67 2000 466 477
15. W. Kirch, K. Ramsch, H.D. Janisch, E.E. Ohnhaus The influence of two histamine H2-receptor antagonists, cimetidine and ranitidine, on the plasma levels and clinical effect of nifedipine and metoprolol Arch Toxicol 7 suppl 1984 256 259