Complex N-glycan and metabolic control in tumor cells

Cancer Research

Volumn 67, Issue 20, 2007, Pages 9771-9780

  Mendelsohn, Richard ^a   Cheung, Pam ^a   Berger, Lloyd ^a   Partridge, Emily ^a,c   Lau, Ken ^a   Datti, Alessandro ^a   Pawling, Judy ^a   Dennis, James W ^a,b,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIMETHOXY 1,4 NAPHTHOQUINONE; BETA1,6N ACETYLGLUCOSAMINYLTRANSFERASE 5; BREFELDIN A; CAMPTOTHECIN; DEMECOLCINE; GLUCOSE; GLYCAN DERIVATIVE; HYDROXYUREA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER CONTROL; CONTROLLED STUDY; DOWN REGULATION; GLUCOSE TRANSPORT; MOUSE; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL GROWTH PROCESSES; CELL LINE, TUMOR; GLUCOSE; GOLGI APPARATUS; MAMMARY NEOPLASMS, EXPERIMENTAL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; N-ACETYLGLUCOSAMINYLTRANSFERASES; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

EID: 35448962937     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-4580     Document Type: Article

References (48)

1. Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003;15:740-6.
2. Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 2006;443:651-7.
3. Ozdamar B, Bose R, Barrios-Rodiles M, et al. Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science 2005;307:1603-9.
4. Seoane J, Le HV, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004;117:211-23.
5. Matsuura I, Denissova NG, Wang G, et al. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004;430:226-31.
6. Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002;4:487-94.
7. Partridge EA, Le Roy C, Di Guglielmo GM, et al. Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 2004;306:120-4.
8. Lau K, Partridge EA, Silvescu CI, et al. Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 2007;129:123-4.
9. Grigorian A, Lee S-U, Tian W, et al. Control of T cell mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem 2007;282:20027-35.
10. Sasai K, Ikeda Y, Fujii T, Tsuda T, Taniguchi N. UDP-GlcNAc concentration is an important factor in the biosynthesis of β1,6-branched oligosaccharides: regulation based on the kinetic properties of N-acetylglucosaminyltransferase V. Glycobiology 2002;12:119-27.
11. Webster MA, Hutchinson JN, Rauh MJ, et al. Requirement for both Shc and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol 1998;18:2344-59.
12. Granovsky M, Fata J, Pawling J, et al. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat Med 2000;6:306-12.
13. Reynolds AR, Tischer C, Verveer PJ, Rocks O, Bastiaens PI. EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation. Nat Cell Biol 2003;5:447-53.
14. Offterdinger M, Georget V, Girod A, Bastiaens PI. Imaging phosphorylation dynamics of the epidermal growth factor receptor. J Biol Chem 2004;279:36972-81.
15. den Hertog J, Groen A, van der Wijk T. Redox regulation of protein-tyrosine phosphatases. Arch Biochem Biophys 2005;434:11-5.
16. Salmeen A, Andersen JN, Myers MP, et al. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 2003;423:769-73.
17. 2. J Biol Chem 2002;277:20336-42.
18. Nimnual AS, Taylor LJ, Bar-Sagi D. Redox-dependent downregulation of Rho by Rac. Nat Cell Biol 2003;5:236-41.
19. 2 for platelet-derived growth factor signal transduction. Science 1995;270:296-9.
20. 2. Mol Cell Biol 2004;24:4384-94.
21. Radisky DC, Levy DD, Littlepage LE, et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005;436:123-7.
22. Echtay KS, Roussel D, St-Pierre J, et al. Superoxide activates mitochondrial uncoupling proteins. Nature 2002;415:96-9.
23. Kim JH, Chu SC, Gramlich JL, et al. Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood 2005;105:1717-23.
24. Suh YA, Arnold RS, Lassegue B, et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 1999;401:79-82.
25. Weinstein J, Sundaram S, Wang X, et al. A point mutation causes mistargeting of Golgi GlcNAc-TV in the Lec4A Chinese hamster ovary glycosylation mutant. J Biol Chem 1996;271:27462-9.
26. Roberts EC, Shapiro PS, Nahreini TS, et al. Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol Cell Biol 2002;22:7226-41.
27. Vander Heiden MG, Plas DR, Rathmell JC, et al. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 2001;21:5899-912.
28. Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005;202:654-62.
29. Cheung P, Pawling J, Partridge EA, et al. Metabolic homeostasis and tissue renewal are dependent on β1,6GlcNAc-branched N-glycans. Glycobiology 2007;17:828-37.
30. Hahn-Windgassen A, Nogueira V, Chen CC, et al. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 2005;280:32081-9.
31. Ohanna M, Sobering AK, Lapointe T, et al. Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol 2005;7:286-94.
32. Wang X, Li W, Williams M, et al. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 2001;20:4370-9.
33. McLeod LE, Proud CG. ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling. FEBS Lett 2002;531:448-52.
34. Kops GJ, Dansen TB, Polderman PE, et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002;419:316-21.
35. Buckhaults P, Chen L, Fregien N, Pierce M. Transcriptional regulation of N-acetylglucosaminyltransferase V by the src Oncogene. J Biol Chem 1997;272:19575-81.
36. Takamatsu S, Oguri S, Minowa MT, et al. Unusually high expression of N-acetylglucosaminyltransferase-IV a in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain. Cancer Res 1999;59:3949-53.
37. Ishida H, Togayachi A, Sakai T, et al. A novel β1,3-N- acetylglucosaminyltransferase (β3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. FEBS Lett 2005;579:71-8.
38. Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat Rev Cancer 2003;3:807-21.
39. Morita K, Flemming AJ, Sugihara Y, et al. A Caenorhabditis elegans TGF-β, DBL-1, controls the expression of LON-1, a PR-related protein, that regulates polyploidization and body length. EMBO J 2002;21:1063-73.
40. Reiling JH, Sabatini DM. Stress and mTORture signaling. Oncogene 2006;25:6373-83.
41. Ruvinsky I, Sharon N, Lerer T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 2005;19:2199-211.
42. Mirouse V, Swick LL, Kazgan N, St Johnston D, Brenman JE. LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol 2007;177:387-92.
43. Sarbassov DD, Sabatini DM. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J Biol Chem 2005;280:39505-9.
44. Ravid T, Sweeney C, Gee P, Carraway KL III, Goldkorn T. Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated downregulation. J Biol Chem 2002;277:31214-9.
45. 1. Proc Natl Acad Sci U S A 2007;104:1230-5.
46. Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-5.
47. Essers MA, de Vries-Smits LM, Barker N, et al. Functional interaction between β-catenin and FOXO in oxidative stress signaling. Science 2005;308:1181-4.
48. Tran H, Brunet A, Grenier JM, et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002;296:530-4.