A molecular thermodynamic view of DNA-drug interactions: A case study of 25 minor-groove binders

Archives of Biochemistry and Biophysics

Volumn 429, Issue 1, 2004, Pages 81-99

  Shaikh, Saher Afshan ^a   Ahmed, Sajeedha Reshmi ^a   Jayaram, B ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

A T specificity; Binding affinity; DNA drug interactions; Free energy component analysis; Hydrogen bonds; Molecular dynamics; Shape complementarity

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; 4',6 DIAMIDINO 2 PHENYLINDOLE; AMIDINE; CONGOCIDINE; CYCLOBUTYL BISFURAMIDINE; CYCLOHEXYL BISFURAMIDINE; CYCLOPROPYL BISFURAMIDINE; DIMINAZENE ACETURATE; DISTAMYCIN A; ETHYL BISFURAMIDINE; GAMMA OXAPENTAMIDINE; GUANYL BISFURAMIDINE; HOE 33342; ISOPROPYL BISFURAMIDINE; LEXITROPSIN; MONOIMIDAZOLE LEXITROPSIN; PENTAMIDINE; PENTAMIDINE DERIVATIVE; PIPERIDINOETHYL BISFURAMIDINE; PROPAMIDINE; SN 7167; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CORRELATION ANALYSIS; DNA DRUG COMPLEX; DRUG DNA INTERACTION; DRUG STRUCTURE; ELECTRICITY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REACTION ANALYSIS; STATISTICAL SIGNIFICANCE; THERMODYNAMICS;

BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DNA; DRUG DESIGN; DRUG EVALUATION; ELECTROSTATICS; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, CHEMICAL; MODELS, MOLECULAR; MOTION; PHARMACEUTICAL PREPARATIONS; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3543040694     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.abb.2004.05.019     Document Type: Article

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