Mechanisms of regulatory T-cell induction by antigen-IgG-transduced splenocytes

Scandinavian Journal of Immunology

Volumn 66, Issue 5, 2007, Pages 515-522

  Wang, R ^a   Song, L ^a   Han, G ^a   Wang, J ^a   Chen, G ^a   Xu, R ^a   Yu, M ^a   Qian, J ^b   Shen, B ^a   Li, Y ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE 65; IMMUNOGLOBULIN G; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GENETIC TRANSDUCTION; IN VITRO STUDY; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL;

ANIMALS; ANTIGENS; B-LYMPHOCYTES; CELL TRANSPLANTATION; DIABETES MELLITUS, TYPE 1; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE THERAPY; GLUTAMATE DECARBOXYLASE; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; INTERFERON TYPE II; MICE; MICE, INBRED NOD; RECOMBINANT FUSION PROTEINS; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRANSDUCTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 35348997448     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2007.02004.x     Document Type: Article

References (32)

1. Song L, Wang J, Wang R et al. Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta? Gene Ther 2004 11 : 1487 96.
2. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995 155 : 1151 64.
3. Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996 183 : 2669 74.
4. Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000 192 : 295 302.
5. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002 420 : 502 7.
6. Jiang S, Camara N, Lombardi G, Lechler RI. Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. Blood 2003 102 : 2180 6.
7. Taams LS, Vukmanovic-Stejic M, Smith J et al. Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. Eur J Immunol 2002 32 : 1621 30.
8. Oldenhove G, de-Heusch M, Urbain-Vansanten G et al. CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J Exp Med 2003 198 : 259 66.
9. Read S, Powrie F. CD4(+) regulatory T cells. Curr Opin Immunol 2001 13 : 644 9.
10. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003 4 : 330 6.
11. Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003 4 : 337 42.
12. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003 299 : 1057 61.
13. Sakaguchi S. Regulatory T cells: Meden Agan. Immunol Rev 2006 212 : 5 7.
14. Zambidis ET, Scott DW. Epitope-specific tolerance induction with an engineered immunoglobulin. Proc Natl Acad Sci U S A 1996 93 : 5019 24.
15. Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996 184 : 387 96.
16. Lepault F, Gagnerault MC. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J Immunol 2000 164 : 240 7.
17. Aoki CA, Roifman CM, Lian ZX et al. IL-2 receptor alpha deficiency and features of primary biliary cirrhosis. J Autoimmun 2006 27 : 50 3.
18. Woods CC, Sundar K, Tessler C et al. Tissue inhibitor of metalloproteinase-2 inhibits T-cell infiltration and preserves pancreatic beta-cell function in an in vitro type 1 diabetes mellitus model. J Autoimmun 2006 27 : 28 37.
19. Herman AE, Freeman GJ, Mathis D, Benoist C. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med 2004 199 : 1479 89.
20. Gregori S, Giarratana N, Smiroldo S, Adorini L. Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol 2003 171 : 4040 7.
21. Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest 2004 114 : 979 87.
22. Jiang H, Chess L. Regulation of immune responses by T cells. N Engl J Med 2006 354 : 1166 76.
23. Nelson BH, Martyak TP, Thompson LJ, Moon JJ, Wang T. Uncoupling of promitogenic and antiapoptotic functions of IL-2 by Smad-dependent TGF-beta signaling. J Immunol 2003 170 : 5563 70.
24. Hill N, Sarvetnick N. Cytokines: promoters and dampeners of autoimmunity. Curr Opin Immunol 2002 14 : 791 7.
25. Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A 2004 101 : 4572 7.
26. Schramm C, Huber S, Protschka M et al. TGF-beta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo. Int Immunol 2004 16 : 1241 9.
27. Chen W, Jin W, Hardegen N et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003 198 : 1875 86.
28. Fu S, Zhang N, Yopp AC et al. TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors. Am J Transplant 2004 4 : 1614 27.
29. Wood KJ, Sawitzki B. Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol 2006 27 : 183 7.
30. Ogawa N, Minamimura K, Kodaka T, Maki T. Short administration of polyclonal anti-T cell antibody (ALS) in NOD mice with extensive insulitis prevents subsequent development of autoimmune diabetes. J Autoimmun 2006 26 : 225 31.
31. Morris GP, Kong YC. Interference with CD4+CD25+ T-cell-mediated tolerance to experimental autoimmune thyroiditis by glucocorticoid-induced tumor necrosis factor receptor monoclonal antibody. J Autoimmun 2006 26 : 24 31.
32. Jaeckel E, von-Boehmer H, Manns MP. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 2005 54 : 306 10.