All-trans retinoic acid directly up-regulates thrombopoietin transcription in human bone marrow stromal cells

Experimental Hematology

Volumn 32, Issue 1, 2004, Pages 45-51

  Kinjo, Kentaro ^a   Miyakawa, Yoshitaka ^a   Uchida, Hideo ^a   Kitajima, Shigetaka ^b   Ikeda, Yasuo ^a   Kizaki, Masahiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H4; LUCIFERASE; MESSENGER RNA; NUCLEAR PROTEIN; PHOSPHORUS 32; RETINOIC ACID; THROMBOPOIETIN;

ARTICLE; CANCER CELL CULTURE; CELL LABELING; CELL STRAIN HEPG2; CHROMATIN; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; HEMATOPOIETIC STEM CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; STROMA CELL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

ATRA;

EID: 0346938587     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2003.10.009     Document Type: Article

References (36)

1. Tallman M.S., Nabhan C., Feusner J.H., Rowe J.M. Acute promyelocytic leukemia: evolving therapeutic strategies. Blood. 99:2002;759-767.
2. Warrell R.P. Jr., Frankel S.R., Miller W.H. Jr., et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med. 324:1991;1385-1393.
3. Warrell R.P. Jr. Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies, and implications. Blood. 82:1993;1949-1953.
4. Losada R., Espinosa E., Hernandez C., Dorticos E., Hernandez P. Thrombocytosis in patients with acute promyelocytic leukaemia during all-trans retinoic acid treatment. Br J Haematol. 95:1996;704-705.
5. Kentos A., le Moine F., Crenier L., et al. All-trans retinoic acid induced thrombocytosis in a patient with acute promyelocytic leukaemia. Br J Haematol. 97:1997;685.
6. Kinjo K., Kizaki M., Takayama N., et al. Serum thrombopoietin and erythropoietin levels in patients with acute promyelocytic leukaemia during all-trans retinoic acid treatment. Br J Haematol. 105:1999;382-387.
7. Bartley T.D., Bogenberger J., Hunt P., et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor, Mpl. Cell. 77:1994;1117-1124.
8. Kaushansky K., Lok S., Holly R.D., et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature. 369:1994;568-571.
9. Lok S., Kaushansky K., Holly R.D., et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 369:1994;565-568.
10. de Sauvage F.J., Hass P.E., Spencer S.D., et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature. 369:1994;533-538.
11. Wendling F., Maraskovsky E., Debili N., et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature. 369:1994;571-574.
12. Kato T., Ogami K., Shimada Y., et al. Purification and characterization of thrombopoietin. J Biochem (Tokyo). 118:1995;229-236.
13. Sungaran R., Markovic B., Chong B.H. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood. 89:1997;101-107.
14. Hirayama Y., Sakamaki S., Matsunaga T., et al. Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells. Blood. 92:1998;46-52.
15. McCarty J.M., Sprugel K.H., Fox N.E., Sabath E.D., Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood. 86:1995;3668-3675.
16. Kuter D.J., Rosenberg R.D. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood. 85:1995;2720-2730.
17. Shivdasani R.A., Rosenblatt M.F., Zucker-Franklin D., et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 81:1995;695-704.
18. Stoffel R., Wiestner A., Skoda R.C. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood. 87:1996;567-573.
19. Mader S., Leroy P., Chen J.Y., Chambon P. Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors. J Biol Chem. 268:1993;591-600.
20. Umesono K., Murakami K.K., Thompson C.C., Evans R.M. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell. 65:1991;1255-1266.
21. Kamura T., Handa H., Hamasaki N., Kitajima S. Characterization of the human thrombopoietin gene promoter. A possible role of an Ets transcription factor, E4TF1/GABP. J Biol Chem. 272:1997;11361-11368.
22. Harigaya K., Handa H. Generation of functional clonal cell lines from human bone marrow stroma. Proc Natl Acad Sci USA. 82:1985;3477-3480.
23. Dignam J.P., Lebowitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
24. de The H., Vivanco-Ruizm M.M., Tiollais P., Stunnenberg H., Dejean A. Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature. 343:1990;177-180.
25. Leroy P., Nakshatri H., Chambon P. Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element. Proc Natl Acad Sci USA. 88:1991;10138-10142.
26. Astrom A., Pettersson U., Chambon P., Voorhees J.J. Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing. J Biol Chem. 269:1994;22334-22339.
27. So E.N., Crowe D.L. Characterization of a retinoic acid responsive element in the human ets-1 promoter. IUBMB Life. 50:2000;365-370.
28. Zhu J., Gianni M., Kopf E., et al. Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins. Proc Natl Acad Sci USA. 96:1999;14807-14812.
29. Lin R.J., Nagy L., Inoue S., Shao W., Miller W.H. Jr., Evans R.M. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature. 391:1998;811-814.
30. Grignani F., De Matteis S., Nervi C., et al. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature. 391:1998;815-818.
31. Tanaka K., Tanaka T., Ogawa S., et al. Increased expression of AML1 during retinoic-acid-induced differentiation of U937 cells. Biochem Biophys Res Commun. 211:1995;1023-1030.
32. Hromas R., Collins S.J., Hickstein D., et al. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem. 266:1991;14183-14187.
33. Sakamaki S., Hirayama Y., Matsunaga T., et al. Transforming growth factor-β1 (TGF-β1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-β receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-β itself with high specificity. Blood. 94:1999;1961-1970.
34. Kambe T., Tada-Kambe J., Kuge Y., Yamaguchi-Iwai Y., Nagao M., Sasaki R. Retinoic acid stimulates erythropoietin gene transcription in embryonal carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer. Blood. 96:2000;3265-3271.
35. Ishibashi T., Koziol J.A., Burstein S.A. Human recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro. J Clin Invest. 79:1987;286-289.
36. Visani G., Ottaviani E., Zauli G., et al. All-trans retinoic acid at low concentration directly stimulates normal adult megakaryocytopoiesis in the presence of thrombopoietin or combined cytokines. Eur J Haematol. 63:1999;149-153.