Chemical mutagenesis induced two high bone density mouse mutants map to a concordant distal chromosome 4 locus

Bone

Volumn 41, Issue 5, 2007, Pages 860-868

  Mohan, S ^a,b   Chest, V ^a   Chadwick, R B ^a,b   Wergedal, J E ^a,b   Srivastava, A K ^a,b  

^a Loma Linda VA Healthcare System   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Areal bone mineral density; Bone resorption; High bone density; Mouse; Mutation; N ethyl N nitrosourea; Quantitative trait loci

Indexed keywords

ETHYLNITROSOUREA;

ANIMAL EXPERIMENT; ARTICLE; BONE DENSITY; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMOSOME 4; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE MAPPING; GENE MUTATION; MALE; MORPHOMETRICS; MOUSE; MUTAGENESIS; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PHENOTYPE; PROGENY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BONE DENSITY; CELL PROLIFERATION; CHROMOSOME MAPPING; GENE EXPRESSION PROFILING; LOD SCORE; MICE; MUTAGENS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; QUANTITATIVE TRAIT LOCI; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 35348850141     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.07.016     Document Type: Article

References (49)

1. Abe K., Fuchs H., Lisse T., Hans W., and Hrabe de Angelis M. New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse. Mamm Genome 17 (2006) 915-926
2. Beamer W.G., Shultz K.L., Churchill G.A., Frankel W.N., Baylink D.J., Rosen C.J., et al. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome 10 (1999) 1043-1049
3. Beamer W.G., Shultz K.L., Donahue L.R., Churchill G.A., Sen S., Wergedal J.R., et al. Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res 16 (2001) 1195-1206
4. Beamer W.G., Shultz K.L., Donahue L.R., Churchill G.A., Sen S., Wergedal J.R., et al. Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3h/HeJ inbred strains of mice. J Bone Miner Res 20 (2001) 1701-1712 [discussion 1700; 2005]
5. Benes H., Weinstein R.S., Zheng W., Thaden J.J., Jilka R.L., Manolagas S.C., et al. Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. J Bone Miner Res 15 (2000) 626-633
6. Bouxsein M.L., Uchiyama T., Rosen C.J., Shultz K.L., Donahue L.R., Turner C.H., et al. Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res 19 (2004) 587-599
7. Bower A.L., Lang D.H., Vogler G.P., Vandenbergh D.J., Blizard D.A., Stout J.T., et al. QTL analysis of trabecular bone in BXD F2 and RI mice. J Bone Miner Res 21 (2003) 1267-1275
8. Chadwick R.B., Bu L., Yu H., Hu Y., Wergedal J.E., Mohan S., et al. Digit tip regrowth and differential gene expression in MRL/Mpj, DBA/2, and C57BL/6 mice. Wound Repair Regen 15 (2007) 275-284
9. Chen W., Yang S., Abe Y., Li M., Wang Y., Shao J., et al. Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence. Hum Mol Genet 16 (2007) 410-423
10. Cummings S.R., Bates D., and Black D.M. Clinical use of bone densitometry: scientific review. JAMA 288 (2002) 1889-1897
11. Cummings S.R., Black D.M., Nevitt M.C., Browner W., Cauley J., Ensrud K., et al. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet 341 (1993) 72-75
12. Edderkaoui B., Baylink D.J., Beamer W.G., Wergedal J.E., Porte R., Chaudhuri A., et al. Identification of mouse Duffy Antigen Receptor for Chemokines (Darc) as a BMD QTL gene. Genome Res 17 (2007) 577-585
13. Ferrari S.L., Deutsch S., Choudhury U., Chevalley T., Bonjour J.P., Dermitzakis E.T., et al. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am J Hum Genet 74 (2004) 866-875
14. Flint J., Valdar W., Shifman S., and Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 6 (2007) 271-286
15. Godinho S.I., and Nolan P.M. The role of mutagenesis in defining genes in behaviour. Eur J Hum Genet 14 (2006) 651-659
16. Govoni K.E., Lee S.K., Chadwick R.B., Yu H., Kasukawa Y., Baylink D.J., et al. Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation. Am J Physiol Endocrinol Metab 291 (2006) E128-E136
17. Hoyne G.F., and Goodnow C.C. The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunol Rev 210 (2006) 27-39
18. Ishimori N., Li R., Walsh K.A., Korstanje R., Rollins J.A., Petkov P., et al. Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice. J Bone Miner Res 21 (2006) 105-112
19. Jian W.X., Long J.R., and Deng H.W. High heritability of bone size at the hip and spine in Chinese. J Hum Genet 49 (2004) 87-91
20. Kermany M.H., Parker L.L., Guo Y.K., Miller D., Swanson D.J., Yoo T.J., et al. Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen. Hear Res 220 (2006) 76-86
21. Khatri P., Draghici S., Ostermeier G.C., and Krawetz S.A. Profiling gene expression using onto-express. Genomics 79 (2002) 266-270
22. Kiernan A.E., Erven A., Voegeling S., Peters J., Nolan P., Hunter J., et al. ENU mutagenesis reveals a highly mutable locus on mouse chromosome 4 that affects ear morphogenesis. Mamm Genome 13 (2002) 142-148
23. Klein R.F., Allard J., Avnur Z., Nikolcheva T., Rotstein D., Carlos A.S., et al. Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303 (2004) 229-232
24. Klein R.F., Mitchell S.R., Phillips T.J., Belknap J.K., and Orwoll E.S. Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res 13 (1998) 1648-1656
25. Klein R.F., Turner R.J., Skinner L.D., Vartanian K.A., Serang M., Carlos A.S., et al. Mapping quantitative trait loci that influence femoral cross-sectional area in mice. J Bone Miner Res 17 (2002) 1752-1760
26. Lang D.H., Sharkey N.A., Mack H.A., Vogler G.P., Vandenbergh D.J., Blizard D.A., et al. Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res 20 (2005) 88-99
27. Masinde G.L., Li X., Gu W., Wergedal J., Mohan S., and Baylink D.J. Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice. Calcif Tissue Int 71 (2002) 421-428
28. Melton III L.J., Atkinson E.J., Khosla S., Oberg A.L., and Riggs B.L. Evaluation of a prediction model for long-term fracture risk. J Bone Miner Res 20 (2005) 551-556
29. Miyazaki T., Neff L., Tanaka S., Horne W.C., and Baron R. Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol 160 (2003) 709-718
30. Mohan S., Kapoor A., Singgih A., Zhang Z., Taylor T., Yu H., et al. Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency. J Bone Miner Res 20 (2005) 1597-1610
31. Nolan P.M., Peters J., Vizor L., Strivens M., Washbourne R., Hough T., et al. Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource. Mamm Genome 11 (2000) 500-506
32. Recker R.R., and Deng H.W. Role of genetics in osteoporosis. Endocrine 17 (2002) 55-66
33. Rubio-Aliaga I., Soewarto D., Wagner S., Klaften M., Fuchs H., Kalaydjiev S., et al. A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics 175 (2007) 1451-1463
34. Rundle C.H., Wang H., Yu H., Chadwick R.B., Davis E.I., Wergedal J.E., et al. Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair. Bone 38 (2006) 521-529
35. Satterthwaite A.B., Willis F., Kanchanastit P., Fruman D., Cantley L.C., Helgason C.D., et al. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A 97 (2000) 6687-6692
36. Sen S., and Churchill G.A. A statistical framework for quantitative trait mapping. Genetics 159 (2001) 371-387
37. Sheng M.H., Baylink D.J., Beamer W.G., Donahue L.R., Rosen C.J., Lau K.H., et al. Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. Bone 25 (1999) 421-429
38. Sheng M.H., Lau K.H., Beamer W.G., Baylink D.J., and Wergedal J.E. In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells. Bone 35 (2004) 711-719
39. Srivastava A.K., Kapur S., Mohan S., Yu H., Wergedal J., and Baylink D.J. Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size. J Bone Miner Res 20 (2005) 1041-1050
40. Srivastava A.K., Mohan S., Wergedal J.E., and Baylink D.J. A genomewide screening of N-ethyl-N-nitrosourea-mutagenized mice for musculoskeletal phenotypes. Bone 33 (2003) 179-191
41. Tchekneva E.E., Rinchik E.M., Polosukhina D., Davis L.S., Kadkina V., Mohamed Y., et al. A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. J Am Soc Nephrol 18 (2007) 103-112
42. Toye A.A., Moir L., Hugill A., Bentley L., Quarterman J., Mijat V., et al. A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Diabetes 53 (2004) 1577-1583
43. Uitterlinden A.G., Weel A.E., Burger H., Fang Y., van Duijn C.M., Hofman A., et al. Interaction between the vitamin D receptor gene and collagen type Ialpha1 gene in susceptibility for fracture. J Bone Miner Res 16 (2001) 379-385
44. Vitarius J.A., Sehayek E., and Breslow J.L. Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A 103 (2006) 19860-19865
45. Wergedal J.E., Ackert-Bicknell C.L., Beamer W.G., Mohan S., Baylink D.J., and Srivastava A.K. Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains. J Lipid Res 48 (2007) 1724-1734
46. Wergedal J.E., Ackert-Bicknell C.L., Tsaih S.W., Sheng M.H., Li R., Mohan S., et al. Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry. J Bone Miner Res 21 (2006) 1256-1266
47. Williams F.M., and Spector T.D. Recent advances in the genetics of osteoporosis. J Musculoskelet Neuronal Interact 6 (2006) 27-35
48. Wu J.Y., Kao H.J., Li S.C., Stevens R., Hillman S., Millington D., et al. ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. J Clin Invest 113 (2004) 434-440
49. Zhao Q., Shao J., Chen W., and Li Y.P. Osteoclast differentiation and gene regulation. Front Biosci 12 (2007) 2519-2529