High heritability of bone size at the hip and spine in Chinese

Journal of Human Genetics

Volumn 49, Issue 2, 2004, Pages 87-91

  Jian, Wei Xia ^a   Long, Ji Rong ^b   Deng, Hong Wen ^a,b  

^a HUNAN NORMAL UNIVERSITY   (China)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone size; Genetic correlation; Heritability; Spine and hip

Indexed keywords

ADULT; AGED; ARTICLE; BONE STRENGTH; CHINESE; DUAL ENERGY X RAY ABSORPTIOMETRY; FAMILY; FEMALE; FRAGILITY FRACTURE; GENOME; HERITABILITY; HIP; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHENOTYPE; RISK FACTOR; SPINE;

ADULT; ANTHROPOMETRY; CHINA; DENSITOMETRY, X-RAY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HIP; HUMANS; MALE; OSTEOPOROSIS; SPINE;

EID: 1642504704     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-003-0113-4     Document Type: Article

References (25)

1. Cheng XG, Lowet G, Boonen S, Nicholson PHF, Brys P, Nijs J, Dequeker J (1997) Assessment of the strength of proximal femur in vitro: Relationship to femoral bone mineral density and femoral geometry. Bone 20:213-218
2. Cooper C, Campion G, Melton LJ 3rd (1992) Hip fractures in the elderly: a world-wide projection Osteoporos Int 2:285-289
3. Cordey J, Schneider M, Belendez C, Ziegler WJ, Rahn BA, Perren SM (1992) Effect of bone size, not density, on the stiffness of the proximal part of normal and osteoporotic human femora. J Bone Miner Res 7 [Suppl 2]437-444
4. Deng HW, Stegman MR, Davies KM, Conway T, Recker RR (1999) Genetic determination of variation and covariation of peak bone mass at hip and spine. J Clin Densitom 2:251-263
5. Deng HW, Deng XT, Conway T, Xu FH, Heaney R, Recker RR (2002a) Determination of bone size of hip, spine, and wrist in human pedigrees by genetic and lifestyle factors. J Clin Densitom 5:45-56
6. Deng HW, Shen H, Xu FH, Deng HY, Conway T, Zhang HT, Recker RR (2002b) Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. J Bone Miner Res17:678-686
7. Dennison E, Cooper C (2000) Epidemiology of OFs. Horm Res 54 [Suppl 1]:58-63
8. Edmondston SJ, Singer KP, Day RE, Price RI, Breidahl PD (1997) Ex vivo estimation of thoracolumbar vertebral body compressive strength: the relative contributions of bone densitometry and vertebral morphometry. Osteoporos Int 7:142-148
9. Falconer DS, Mackay T (1996) Introduction to quantitative genetics. Longman, New York
10. Flicker L, Faulkner KG, Hopper JL, Green RM, Kaymacki B, Nowson CA, Young D, Wark JD (1996) Determinants of hip axis length in women aged 10-89 years: a twin study. Bone 18:41-45
11. Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M (1996) Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 11:707-730
12. Gilsanz V, Loro ML, Roe TF, Sayre J, Gilsanz R, Schulz EE (1995) Vertebral size in elderly women with osteoporosis. J Clin Invest 95:2332-2337
13. Gong G, Johnson ML, Barger-Lux MJ, Heaney RP (1999) Association of bone dimensions with a parathyroid hormone gene polymorphism in women. Osteoporos Int 9:307-311
14. Heaney RP, Barger-Lux MJ, Davies KM, Ryan RA, Johnson ML, Gong G (1997) Bone dimensional change with age: interactions of genetic, hormonal, and body size variables. Osteoporos Int 7:426-431
15. Kalender WA (1992) Effective dose values in bone mineral measurements by photon absorptiometry and computed tomography. Osteoporos Int 2:82-87
16. Liu Z, Piao J, Pang L, Qing X, Nan S, Pan Z, Guo Y, Wang X, Li F, Liu J, Cheng X (2002) The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab 20:181-189
17. Lotz J, Hayes W (1990) The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. Am J Bone Joint Surg 72:689-700
18. Lynch M, Walsh B (1997) Genetics and analysis of quantitative traits. Sinauer, Sunderland
19. Mazess RB, Barden H, Mautalen C, Vega E (1994) Normalization of spine densitometry. J Bone Miner Res 9:541-548
20. Moller M, Horsman A, Harvald B, Hauge M, Henningsen K, Nordin BE (1978) Metacarpal morphometry in monozygotic dizygotic elderly twins. Calcif Tissue Res 25:197-201
21. Need AG, Horowitz M, Stiliano A, Scopacasa F, Morris HA, Chatterton BE (1996) Vitamin D receptor genotypes are related to bone size and bone density in men. Eur J Clin Invest 26:793-796
22. Qin YJ, Shen H, Huang QR, Zhao LJ, Zhou Q, Li MX, He JW, Mo XY, Lu JH, Recker RR, Deng HW (2003) Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. J Bone Miner Res 18:1028-1035
23. Sokal RR, Rohlf RJ (1981) Biometry. Freeman, New York
24. Tabensky AD, Williams J, Deluca V, Brigant E, Seeman E (1996) Bone mass, areal and volumetric bone density are equally accurate, sensitive, and specific surrogates of the breaking strength of the vertebral body: an in vitro study. J Bone Miner Res 11:1981-1988
25. Vega E, Ghiringhelli G, Mautalen C, Rey Valzacchi G, Scaglia H, Zylberstein C (1998) Bone mineral density and bone size in men with primary osteoporosis and vertebral fractures. Calcif Tissue Int 62:465-469