Femur mechanical properties in the F2 progeny of an NZB/B1NJ × RF/J cross are regulated predominantly by genetic loci that regulate bone geometry

Journal of Bone and Mineral Research

Volumn 21, Issue 8, 2006, Pages 1256-1266

  Wergedal, Jon E ^a,c   Ackert Bicknell, Cheryl L ^b   Tsaih, Shirng Wern ^b   Sheng, Matilda H C ^a   Li, Renhua ^b   Mohan, Subburamen ^a   Beamer, Wesley G ^b   Churchill, Gary A ^b   Baylink, David J ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

BMD; Cross sectional size; Genes; Mechanical properties; Strength

Indexed keywords

MOLECULAR MARKER;

ANIMAL CELL; ARTICLE; BIOMECHANICS; BODY SIZE; CHROMOSOMAL LOCALIZATION; DENSITOMETRY; FEMUR; GENE LOCUS; GENETIC MARKER; GENETIC REGULATION; GEOMETRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROGENY; QUANTITATIVE TRAIT LOCUS; VOLUMETRY;

ANIMALS; BONE DENSITY; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; FEMUR; MICE; MICE, INBRED NZB; PHENOTYPE; PHYLOGENY; QUANTITATIVE TRAIT LOCI; STRESS, MECHANICAL;

EID: 33746401934     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.060510     Document Type: Article

References (27)

1. Koller DL, Schriefer J, Sun Q, Shultz KL, Donahue LR, Rosen CJ, Foroud T, Beamer WG, Turner CH 2003 Genetic effects for femoral biomechanics, structure, and density in C57BL/6J and C3H/HeJ inbred mouse strains. J Bone Miner Res 18:1758-1765.
2. Wergedal JE, Sheng MHC, Ackert-Bicknell CL, Beamer WG, Baylink DJ 2005 Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density. Bone 36:111-122.
3. Blank RD 2001 Breaking down bone strength: A perspective on the future of skeletal genetics. J Bone Miner Res 16:1207-1211.
4. Huang QY, Recker RR, Deng HW 2003 Searching for osteoporosis genes in the post-genome era: Progress and challenges. Osteoporos Int 14:701-715.
5. Klein RF, Turner RJ, Skinner LD, Vartanian KA, Serang M, Carlos AS, Shea M, Belknap JK, Orwoll ES 2002 Mapping quantitative trait loci that influence femoral cross-sectional area in mice. J Bone Miner Res 17:1752-1760.
6. Drake TA, Hannani K, Kabo JM, Villa V, Krass K, Lusis AJ 2001 Genetic loci influencing natural variations in femoral bone morphometry in mice. J Orthop Res 19:511-517.
7. Volkman SK, Galecki AT, Burke DT, Paczas MR, Moalli MR, Miller RA, Goldstein SA 2003 Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res 18:1497-1505.
8. Masinde GL, Wergedal J, Davidson H, Mohan S, Li R, Li X, Baylink DJ 2003 Quantitative trait loci for periosteal circumference (PC): Identification of single loci and epistatic effects in F2 MRL/SJL mice. Bone 32:554-560.
9. Lander ES, Botstein D 1989 Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199.
10. Dietrich WF, Miller J, Steen R, Merchant MA, Damron-Boles D, Husain Z, Dredge R, Daly MJ, Ingalls KA, O'Connor TJ 1996 A comprehensive genetic map of the mouse genome. Nature 380:149-152.
11. Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ 2002 Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains. Bone 31:670-674.
12. Beamer WG, Donahue LR, Rosen CJ, Baylink DJ 1996 Genetic variability in adult bone density among inbred strains of mice. Bone 18:397-403.
13. Turner CH, Roeder RK, Wieczorek A, Foroud T, Liu G, Peacock M 2001 Variability in skeletal mass, structure, and biomechanical properties among inbred strains of rats. J Bone Miner Res 16:1532-1539.
14. Sen S, Churchill GA 2001 A statistical framework for quantitative trait mapping. Genetics 159:371-387.
15. Ward J 1963 Hierarchical grouping to optimize an objective function. J Am Stat Assoc 58:236-244.
16. Churchill GA, Doerge RW 1994 Empirical threshold values for quantitative trait mapping. Genetics 138:963-971.
17. Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, Paigen B 2001 Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71:70-77.
18. Kao CH, Zeng ZB, Teasdale RD 1999 Multiple interval mapping for quantitative trait loci. Genetics 152:1203-1216.
19. Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ 2001 Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res 16:1195-1206.
20. Jansen RC 1993 Interval mapping of multiple quantitative trait loci. Genetics 135:205-211.
21. Lang DH, Sharkey NA, Lionikas A, Mack HA, Larsson L, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, Stitt JP, McClearn GE 2005 Adjusting data to body size: A comparison of methods as applied to quantitative trait loci analysis of musculoskeletal phenotypes. J Bone Miner Res 20:748-757.
22. Li X, Masinde G, Gu W, Wergedal J, Mohan S, Baylink DJ 2002 Genetic dissection of femur breaking strength in a large population (MRL/Mpj × SJL/J) of F2 mice: Single QTL effects, epistasis, and pleiotropy. Genomics 79:734-740.
23. Li X, Masinde G, Gu W, Wergedal J, Hamilton-Ulland M, Xu S, Mohan S, Baylink DJ 2002 Chromosomal regions harboring gene for the work to femur failure in mice. Func Integr Genomics 1:367-374.
24. Drake TA, Schadt E, Hannani K, Kabo JM, Krass K, Colinayo V, Greaser LE III, Goldin J, Lusis AJ 2001 Genetic Loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics 5:205-215.
25. Lang DH, Sharkey NA, Mack HA, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, McClearn GE 2004 Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res 20:88-99.
26. Volkman SK, Galecki AT, Burke DT, Miller RA, Goldstein SA 2004 Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population. J Bone Miner Res 19:1497-1505.
27. Yershov Y, Baldini TH, Villagomez S, Young T, Martin ML, Bockman RS, Peterson MGE, Blank RD 2001 Bone strength and related traits in HcB/Dem recombinant congenic mice. J Bone Miner Res 16:992-1003.