Cytoprotective properties of α-tocopherol are related to gene regulation in cultured d-galactosamine-treated human hepatocytes

Free Radical Biology and Medicine

Volumn 43, Issue 10, 2007, Pages 1439-1452

  González, Raul ^a   Collado, Juan Antonio ^a   Nell, Sandra ^b   Briceño, Javier ^a   Tamayo, María José ^c   Fraga, Enrique ^a   Bernardos, Ángel ^c   López Cillero, Pedro ^a   Pascussi, Jean Marc ^d   Rufián, Sebastián ^a   Vilarem, Marie José ^d   Mata, Manuel De la ^a   Brigelius Flohe, Regina ^b   Maurel, Patrick ^d   Muntané, Jordi ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^d INSERM   (France)

Author keywords

Cell death; CPT1; CYP3A4; Free radicals; Hepatocytes; NF B; NOS 2; PPAR ; PXR; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; CARNITINE PALMITOYLTRANSFERASE; COLLAGENASE; GALACTOSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KETOCONAZOLE; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; RIFAMPICIN;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VITAMIN METABOLISM;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; APOPTOSIS; CARNITINE O-PALMITOYLTRANSFERASE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; CYTOPROTECTION; GALACTOSAMINE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PPAR ALPHA; REACTIVE OXYGEN SPECIES; RECEPTORS, STEROID;

EID: 35148863166     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.07.023     Document Type: Article

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