Vitamin E decreases hepatic levels of aldehyde-derived peroxidation products in rats with iron overload

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 270, Issue 2 33-2, 1996, Pages

  Parkkila, Seppo ^b   Niemelä, Onni ^b   Britton, Robert S ^b   Brown, Kyle E ^b   Ylä Herttuala, Seppo ^b   O'Neill, Rosemary ^b   Bacon, Bruce R ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

^b NONE

Author keywords

aldehyde adducts; antioxidants; hemochromatosis; immunohistochemistry; liver

Indexed keywords

ALDEHYDE; ALPHA TOCOPHEROL; CARBONYL IRON; IRON; MALONALDEHYDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; CONTROLLED STUDY; DIET SUPPLEMENTATION; IMMUNOHISTOCHEMISTRY; IRON OVERLOAD; KUPFFER CELL; LIPID PEROXIDATION; LIVER CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0029876789     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.2.g376     Document Type: Article

References (38)

1. Alho, H., J. Koistinaho, H. M. Laaksonen, and A. Hervonen. Effect of lifelong selenium and vitamin E deficiency or supplementation on pigment accumulation in rat peripheral tissues. Adv. Exp. Med. Biol. 266: 143-156, 1990.
2. Armstrong, D. Free radical involvement in the formation of lipopigments. In: Free Radicals in Molecular Biology, Aging and Disease, edited by D. Armstrong, R. S. Sohal, R. G. Cutler, and T. F. Slater. New York: Raven, 1984, p. 129-141.
3. Bacon, B. R., and R. S. Britton. The pathology of iron overload: a free radical-mediated process? Hepatology 11: 127-137, 1990.
4. Bacon, B. R., and A. S. Tavill. Hemochromatosis and the iron overload syndromes. In: Hepatology. A Textbook of Liver Disease, edited by D. Zakim and T. D. Boyer. Philadelphia, PA: Saunders, In press.
5. Bacon, B. R., A. S. Tavill, G. M. Brittenham, C. H. Park, and R. O. Recknagel. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J. Clin. Invest. 71: 429-439, 1983.
6. Bast, A., G. R. M. M. Haenen, and C. J. A. Doelman. Oxidants and antioxidants: state of the art. Am. J. Med. 91, Suppl. 3C: 2S-13S, 1991.
7. Britton, R. S., and B. R. Bacon. Role of free radicals in liver diseases and hepatic fibrosis. Hepato-Gastroenterol. 4: 343-348, 1994.
8. Britton, R. S., R. O'Neill, and B. R. Bacon. Hepatic mitochondrial malondialdehyde metabolism in rats with chronic iron overload. Hepatology 11: 93-97, 1990.
9. Britton, R. S., A. S. Tavill, and B. R. Bacon. Mechanisms of iron toxicity. In: Iron Metabolism in Health and Disease, edited by J. H. Brock, J. W. Halliday, M. J. Pippard, and L. W. Powell. London: Saunders, 1994, p. 311-351.
10. Chojkier, M., K. Houglum, J. Solis-Herruzo, and D. A. Brenner. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? J. Biol. Chem. 264: 16957-16962, 1989.
11. Deugnier, Y. M., O. Loréal, B. Turlin, D. Guyader, H. Jouanolle, R. Moirand, C. Jacquelinet, and P. Brissot. Liver pathology in genetic heinochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 102: 2050-2059, 1992.
12. Dillard, C. J., J. E. Downey, and A. L. Tappell. Effects of antioxidants on lipid peroxidation in iron-loaded rats. Lipids 19: 127-133, 1984.
13. Fraenkel-Konrad, H., and B. Singer. Nucleoside adducts are formed by cooperative reaction of acetaldehyde and alcohols: possible mechanism for the role of ethanol in carcinogenesis. Proc. Natl. Acad. Sci. USA 85: 3759-3761, 1988.
14. Halsted, C. H., J. Villanueva, C. J. Chandler, B. Ruebner, R. J. Munn, S. Parkkila, and O. Niemelä. Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. Hepatology 18: 954-960, 1993.
15. Holstege, A., P. Bedossa, T. Poynard, M. Kollinger, J. C. Chaput, K. Houglum, and M. Chojkier. Acetaldehyde-modified epitopes in liver biopsy specimens of alcoholic and nonalcoholic patients: localization and progression of liver fibrosis. Hepatology 19: 367-374, 1994.
16. Houglum, K., M. Filip, J. L. Witztum, and M. Chojkier. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J Clin. Invest. 86: 1991-1998, 1990.
17. Israel, Y., H. Orrego, and O. Niemelä. Immune responses to alcohol metabolites. Pathologic and diagnostic implications. Semin. Liver Dis. 8: 81-90, 1988.
18. Jose, P. J., and T. F. Slater. Increased concentrations of malonaldehyde in the livers of rats treated with carbon tetrachloride (Abstract). Biochem. J. 128: 141P, 1972.
19. Kamimura, S., K. Gaal, R. S. Britton, B. R. Bacon, G. Triadafilopoulos, and H. Tsukamoto. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. Hepatology 16: 448-453, 1992.
20. Moshage, H., A. Casini, and C. S. Lieber. Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology 12: 511-518, 1990.
21. Mostow, N. D., R. O'Neill, D. L. Noon, and B. R. Bacon. Determination of α-tocopherol in rat liver by high performance liquid chromatography utilizing ultraviolet detection. J. Chromatogr. 344: 137-143, 1985.
22. Niemelä, O., J. Juvonen, and S. Parkkila. Immunohistochemical demonstration of acetaldehyde-modified epitopes in human liver after alcohol consumption. J. Clin. Invest. 87: 1367-1374, 1991.
23. Niemelä, O., S. Parkkila, S. Ylä-Herttuala, C. Halsted, J. L. Witztum, A. Lanca, and Y. Israel. Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation. Lab. Invest. 70: 537-546, 1994.
24. Palinski, W., S. Ylä-Herttuala, S. Rosenfeld, S. W. Butler, S. S. Socher, S. Parthasarathy, L. K. Curtiss, and J. L. Witztum. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Arteriosclerosis 10: 325-335, 1990.
25. Park, C. H., B. R. Bacon, G. M. Brittenham, and A. S. Tavill. Pathology of dietary carbonyl iron overload in rats. Lab. Invest 57: 555-563, 1987.
26. Parola, M., M. Pinzani, A. Casini, E. Albano, G. Poli, A. Gentilini, P. Gentilini, and M. U. Dianzani. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen α1 (I) gene expression in human liver fat-storing cells. Biochem. Biophys. Res. Commun. 194: 1044-1050, 1993.
27. Pietrangelo, A., R. Gualdi, G. Casalgrandi, G. Montosi, and E. Ventura. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. J. Clin. Invest. 95: 1824-1831, 1995.
28. Pietrangelo, A. E., E. Rocchi, L. Schiaffonati, E. Ventura, and G. Cairo. Liver gene expression during chronic dietary iron overload in rats. Hepatology 11: 798-804, 1990.
29. Rachmilewitz, E. A., B. H. Lubin, and S. B. Shoet. Lipid membrane peroxidation in β-thalassemia major. Blood 47: 495-505, 1976.
30. Recknagel, R. O., E. A. Glende, Jr., R. L. Waller, and K. Lowrey. Lipid peroxidation: biochemistry, measurement, and significance in liver cell injury. In: Toxicology of the Liver, edited by G. Plaa and W. R. Hewitt. New York: Raven, 1982, p. 213-241.
31. Rubin, E., and J. L. Farber. The liver and biliary system. In: Pathology, edited by E. Rubin and J. L. Farber. Philadelphia, PA: Lippincott, 1988, p. 722-807.
32. Sohal, R., and U. Brunk. Lipofuscin as an indicator of oxidative stress and aging. Adv. Exp. Med. Biol. 266: 17-29, 1990.
33. Stadtman, E. R. Protein oxidation and aging. Science Wash. DC 257: 1220-1224, 1992.
34. Steinbrecher, U. P., M. Fisher, J. L. Witztum, and L. K. Curtiss. Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for the derivatized lysine. J. Lipid Res. 20: 1109-1116, 1984.
35. Tappel, A. L. Vitamin E and selenium protection from in vivo lipidperoxidation. Ann. NY Acad. Sci. 355: 18-31, 1980.
36. Torrance, J. D., and T. H. Bothwell. Tissue iron stores. In: Iron, edited by J. D. Cook. New York: Churchill-Livingstone, 1980, p. 90-115.
37. Tsukamoto, H., K. Gaal, and S. W. French. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12: 599-608, 1990.
38. Young, I. S., T. G. Trouton, J. J. Torney, D. McMaster, M. E. Callender, and E. R. Trimble. Antioxidant status and lipid peroxidation in hereditary haemochromatosis. Free Rad. Biol. Med. 16: 393-397, 1994.