Apoptosis of Murine Hepatocytes Induced by High Doses of Galactosamine

Journal of Veterinary Medical Science

Volumn 59, Issue 9, 1997, Pages 785-790

  Tsutsui, Shigeki ^a   Hirasawa, Kensuke ^a   Takeda, Makio ^a   Itagaki, Shin Ichi ^a   Kawamura, Seiji ^a   Maeda, Ken ^a   Mikami, Takeshi ^a   Doi, Kunio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; Galactosamine; Hepatotoxicity; Liver; Mouse

Indexed keywords

MURINAE;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DNA FRAGMENT; GALACTOSAMINE;

AGAR GEL ELECTROPHORESIS; ANIMAL; ANIMAL DISEASE; APOPTOSIS; ARTICLE; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CYTOCHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LIVER DISEASE; MALE; METHODOLOGY; MOUSE; NECROSIS; PATHOLOGY; TIME; ULTRASTRUCTURE;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; GALACTOSAMINE; HISTOCYTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; LIVER; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; NECROSIS; TIME FACTORS;

EID: 0031218412     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.59.785     Document Type: Article

References (27)

1. Aw, T. Y., Nicotera, P., Manzo, L., and Orrenius, S. 1990. Tributylin stimulates apoptosis in rat thymocytes. Arch. Biochem. Biophys. 283: 46-50.
2. Corcoran, G. B., Fix, L., Jones, D. P., Moslen, M. T., Nicotera, P., Oberhammer, F. A., and Buttyan, R. 1994. Apoptosis: molecular control point in toxicity. Toxicol. Appl. Pharmacol. 128: 169-181.
3. Decker, K. and Keppler, D. 1972. Galactosamine induced liver injury. pp. 183-199. In: Progress in Liver Disease, vol. IV (Hopper, H. and Schaffner, F. eds.), Grune and Stratton, New York.
4. Fukuda, K., Kojiro, M., and Chiu, J. F. 1993. Induction of apoptosis by transforming growth factor-βl in the rat hepatoma cell line McA-RH7777: a possible association with tissue transglutaminase expression. Hepatology 18: 945-953.
5. Gougeon, M. L. and Montagnier, L. 1993. Apoptosis in AIDS. Science 260: 1269-1270.
6. Hirata, K., Ogata, I., Ohta, Y., and Fujiwara, K. 1989. Hepatic sinusoidal cell destruction in the development of intravascular coagulation in acute liver failure of rat J. Pathol. 158: 157-165.
7. Hockenberry, D. 1995. Defining apoptosis. Am. J. Pathol. 146: 16-19.
8. Kerr, J. F. R. 1969. An electron-microscope study of liver cell necrosis due to heliotrine. J. Pathol. 97: 557-561.
9. Ledda-Columbano, G. M., Coni, P., Curto, M., Giacomini, L., Faa, G., Oliverio, S., Piacentini, M., and Columbano, A. 1991. Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide. Am. J. Pathol. 139: 1099-1109.
10. Leist, M., Gantner, F., Bohlinger, I., Germann, P. G., Tiegs, G., and Wendel, A. 1994. Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J. Immunol. 153: 1778-1788.
11. Levin, S. 1995. A toxicologic pathologist's view of apoptosis or I used to call it necrosis, but now I'm singing the apoptosis blues. Toxicol. Pathol. 23: 533-539.
12. Martin, D. P., Ito, A., Horigome, K., Lampe, P. A., and Johnson, E. M. Jr. 1993. Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons. J. Neurobiol. 23: 1205-1220.
13. 2+-Mediated mediated endonuclease activation. Science 242: 256-259.
14. Moor, J. V. 1987. Death of cells and necrosis of tumors. pp. 295-325 In: Perspectives in Mammalian Cell Death (Potten, C. S. ed.), Oxford University Press, Oxford.
15. Ni, R., Tomita, Y., Matsuda, K., Ichihara, A., Ishimura, K., Ogasawara, J., and Nagata, S. 1994. Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp. Cell Res. 215: 332-337.
16. Oberhammer, F., Bursch, W., Tiefenbacher, R., Froschl, G., Pavelka, M., Purchio, T., and Schulte-Hermann, R. 1993. Apoptosis is induced by transforming growth factor-βl within 5 hours in regressing liver without significant fragmentation of the DNA. Hepatology 18: 1238-1246.
17. Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., and Nagata, S. 1993. Lethal effect of the anti-Fas antibody in mice. Nature (Lond.) 364: 806-809.
18. Pritchard, D. J. and Butler, W. H. 1989. Apoptosis-the mechanism of cell death in dimethylnitrosamine-induced hepatotoxicity. J. Pathol. 158: 253-260.
19. ++-endonuclease and poly (ADP-ribose) polymerase inhibitors in mice. J. Pharm. Exp. Therapeutics 263: 387-394.
20. 2+-antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. FASEB J. 7: 453-463.
21. Reynolds, E. S., Kanz, M. F., Chieco, P., and Moslen, M. T. 1984. 1,1-Dichloro ethylene: an apoptotic hepatotoxin? Environ. Health Perspect. 57: 313-320.
22. Sarraf, C. E. and Bowen, I. D. 1988. Proportions of mitotic and apoptotic cells in a range of untreated experimental tumors. Cell Tissue Kinet. 21: 45-49.
23. Searle, J., Harmon, B. V., Bishop, C. J., and Kerr, J. F. R. 1987. The significance of cell death by apoptosis in hepatobiliary disease. J. Gastroenterol. Hepatol. 2: 77-96.
24. Seegers, J. C., Böhmer, L. H., Kruger, M. C., Lottering, M-L., and de Kock, M. 1994. A comparative study of Ochratoxin A-induced apoptosis in hamster kidney and HeLa cells. Toxicol. Appl. Pharmacol. 129: 1-11.
25. 2+ accumulation and early DNA fragmentation with cell death. Toxicol. Appl. Pharmacol. III: 242-254.
26. Tsukidate, K., Yamamoto, K., Snyder, J. W., and Farber, J. L. 1993. Microtubule antagonists activate programmed cell death (apoptosis) in cultured tat hepatocytes. Am. J. Pathol. 143: 918-925.
27. Tsutsui, S., Hirasawa, K., Takeda, M., Itagaki, S., Kawamura, S., Maeda, K., Mikami, T., and Doi, K. 1997. Galactosamine-induced apoptosis in the primary mouse hepatocyte cultures. Exp. Toxicol. Pathol. 48: (in press).