What is the role of regulatory T cells in the success of implantation and early pregnancy?

Journal of Assisted Reproduction and Genetics

Volumn 24, Issue 9, 2007, Pages 379-386

  Saito, Shigeru ^a,b   Shima, Tomoko ^a   Nakashima, Akitoshi ^a   Shiozaki, Arihiro ^a   Ito, Mika ^a   Sasaki, Yasushi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Center of Excellence COE 21st Program   (Japan)

Author keywords

CD4+CD25+ regulatory T cell; CTLA 4; Decidua; IDO; Miscarriage; Preeclampsia

Indexed keywords

CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR8; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; CD4+ CD25+ T LYMPHOCYTE; DENDRITIC CELL; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; FETUS WASTAGE; FIRST TRIMESTER PREGNANCY; HUMAN; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSTIMULATION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; NIDATION; NONHUMAN; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW; SPONTANEOUS ABORTION; TROPHOBLAST;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; EMBRYO IMPLANTATION; FEMALE; HUMANS; IMMUNE TOLERANCE; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MAJOR HISTOCOMPATIBILITY COMPLEX; MODELS, BIOLOGICAL; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY TRIMESTER, FIRST; T-LYMPHOCYTES, REGULATORY; TROPHOBLASTS;

ANIMALIA;

EID: 34848913096     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10815-007-9140-y     Document Type: Review

References (64)

1. Tafuri A, Alferink J, Moller P, Hammerling GJ, Arnold B. T cell awareness of paternal alloantigens during pregnancy. Science 1995;270:630-3.
2. Salha O, Sharma V, Dada T, Nugent D, Rutherford AJ, Tomlinson AJ, et al. The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 1999;14:2268-73.
3. Toner JP, Grainger DA, Frazier LM. Clinical outcomes among recipients of donated eggs: an analysis of the U.S. national experience, 1996-1998. Fertil Steril 2002;78:1038-45.
4. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-62.
5. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003;3:199-210.
6. Saito S, Nishikawa K, Morii T, Narita N, Enomoto M, Ichijo M. Expression of activation antigens CD69, HLA-DR, interleukin-2 receptor-alpha (IL-2Rα) and IL-2Rβ on T cells of human decidua at an early stage of pregnancy. Immunology 1992;75:710-2.
7. Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 2004;5:266-71.
8. + T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 2005;166:811-22.
9. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998;281:1191-3.
10. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999;189:1363-72.
11. Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002;297:1867-70.
12. Kudo Y, Boyd CA, Spyropoulou I, Redman CW, Takikawa O, Katsuki T, et al. Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta. J Reprod Immunol 2004;61:87-98.
13. Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002;3:1097-101.
14. Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 2003;4:1206-12.
15. Jiang SP, Vacchio MS. Multiple mechanisms of peripheral T cell tolerance to the fetal "allograft". J Immunol 1998;160:3086-90.
16. Hunt JS, Vassmer D, Ferguson TA, Miller L. Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus. J Immunol 1997;158:4122-8.
17. Abrahams VM, Kim YM, Straszewski SL, Romero R, Mor G. Macrophages and apoptotic cell clearance during pregnancy. Am J Reprod Immunol 2004;51:275-82.
18. Bouteiller PL, Pizzato N, Barakonyi A, Solier C. HLA-G, pre-eclampsia, immunity and vascular events. J Reprod Immunol 2003;59:219-34.
19. + T cell regulatory mechanism. Proc Natl Acad Sci USA 2001;98:12150-5.
20. Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol 2002;2:656-63.
21. Adams KM, Yan Z, Stevens AM, Nelson JL. The changing maternal "self" hypothesis: a mechanism for maternal tolerance of the fetus. Placenta 2007;28:378-382.
22. Huppertz B, Kingdom J, Caniggia I, Desoye G, Black S, Korr H, et al. Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation. Placenta 2003;24:181-90.
23. Ranella A, Vassiliadis S, Mastora C, Valentina M, Dionyssopoulou E, Athanassakis I. Constitutive intracellular expression of human leukocyte antigen (HLA)-DO and HLA-DR but not HLA-DM in trophoblast cells. Hum Immunol 2005;66:43-55.
24. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I. Immunosuppressive effects of apoptotic cells. Nature 1997;390:350-1.
25. Shao L, Jacobs AR, Johnson VV, Mayer L. Activation of CD8+ regulatory T cells by human placental trophoblasts. J Immunol 2005;174:7539-47.
26. + 'effector' regulatory T cells in the gravid uterus. Proc Natl Acad Sci USA 2007;104:594-9.
27. + regulatory/suppressor T cells prevent allogeneic fetus rejection in mice. Immunol Lett 2006;102:106-9.
28. + regulatory T cells induces a scurfy-like disease. J Exp Med 2007;204:57-63.
29. Kim JM, Rasmussen JP, Rudensky A. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007;8:191-7.
30. + high regulatory cells in human peripheral blood. J Immunol 2001;167:1245-53.
31. + regulatory T cells in early pregnancy subjects and spontaneous abortion. Mol Hum Reprod 2004;10:347-53.
32. + regulatory T-cell subset. Immunology 2004;112:38-43.
33. Heikkinen J, Mottonen M, Alanen A, Lassila O. Phenotype characterization of regulatory T cells in the human decidua. Clin Exp Immunol 2004;136:373-8.
34. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61.
35. + regulatory T cell compartment. J Immunol 2004;173:2227-30.
36. + regulatory T cells by promoting their proliferation. Immunology 2006;118:58-65.
37. Jasper MJ, Tremellen KP, Robertson SA. Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006;12:301-8.
38. + regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol 2007;178:291-300.
39. + regulatory T cells bear functional skin-homing receptors. J Immunol 2006;177:4488-94.
40. + regulatory and Th2 effector lymphocytes. J Immunol 2006;177:6940-51.
41. bright cells to the decidualizing uterus-new tricks for old dogmas? J Reprod Immunol 2005;67:21-34.
42. + regulatory T cells abrogates their function in vivo. J Immunol 2006;177:4376-83.
43. Miwa N, Hayakawa S, Miyazaki S, Myojo S, Sasaki Y, Sakai M, et al. IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion. Mol Hum Reprod 2005;11:865-70.
44. Terness P, Chuang JJ, Bauer T, Jiga L, Opelz G. Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO. Blood 2005;105:2480-6.
45. + regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001;194:629-44.
46. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 2002;196:237-46.
47. Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, et al. Role of LAG-3 in regulatory T cells. Immunity 2004;21:503-13.
48. + T cells. Blood 2007;109:2058-65.
49. Dosiou C, Giudice LC. Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr Rev 2005;26:44-62.
50. Petroff MG. Immune interactions at the maternal-fetal interface. J Reprod Immunol 2005;68:1-13.
51. Guleria I, Khosroshahi A, Ansari MJ, Habicht A, Azuma M, Yagita H, et al. A critical role for the programmed death ligand 1 in fetomaternal tolerance. J Exp Med 2005;202:231-7.
52. Yang Y, Huang CT, Huang X, Pardoll DM. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol 2004;5:508-15.
53. + regulatory T cell function. Science 2005;309:1380-4.
54. bright regulatory T cells in pre-eclampsia. Clin Exp Immunol 2007;149:139-145.
55. Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007;445:936-40.
56. Marson A, Kretscher K, Frampton GM, Jacobsen ES, Polansky JK, Macisaac KD, et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007;445:931-5.
57. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-11.
58. + natural regulatory T cells revealed by DNA microarray analysis. Int Immunol 2006;18:1197-209.
59. + regulatory T cells during the follicular phase of menstrual cycle: implications for human reproduction. J Immunol 2007;178:2572-8.
60. Miura Y, Thoburn CJ, Bright EC, Phelps ML, Shin T, Matsui EC, et al. Association of Foxp3 regulatory gene expression with graft-versus-host disease. Blood 2004;104:2187-93.
61. + T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005;105:735-41.
62. Huan J, Culbertson N, Spencer L, Bartholomew R, Burrow GG, Chou YK, et al. Decreased FOXP3 levels in multiple sclerosis. J Neurosci Res 2005;81:45-52.
63. Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007;445:766-70.
64. Stallmach T, Hebisch G. Placental pathology: its impact on explaining prenatal and perinatal death. Virchows Arch 2004;445:9-16.