Statistical molecular design, parallel synthesis, and biological evaluation of a library of thrombin inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3424-3439

  Linusson, A ^a   Gottfries, J ^a   Olsson, T ^a   Ornskov E ^a   Folestad, S ^a   Norden B ^a   Wold, S ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBIN INHIBITOR; TRYPSIN;

ARTICLE; CAPILLARY ELECTROPHORESIS; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MEMBRANE PERMEABILITY; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PKA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS;

ANIMALS; BENZENESULFONATES; BINDING SITES; CATTLE; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SERINE PROTEINASE INHIBITORS; STATISTICS; THROMBIN; TRYPSIN;

EID: 0035846071     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010833f     Document Type: Article

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