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Volumn 3, Issue 5, 2003, Pages 513-519

Targeting virulence for antimicrobial chemotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BACTERIAL VACCINE; BETA LACTAM ANTIBIOTIC; CHAPERONE INHIBOR; GALABIOSE DERIVATIVE; LACTOFERRIN; NEW DRUG; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

EID: 0141646503     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2003.04.001     Document Type: Review
Times cited : (70)

References (54)
  • 1
    • 0036360546 scopus 로고    scopus 로고
    • Evolution and spread of antibiotic resistance
    • Normark B.H. Normark S. Evolution and spread of antibiotic resistance J. Intern. Med. 252 2002 91-106
    • (2002) J. Intern. Med. , vol.252 , pp. 91-106
    • Normark, B.H.1    Normark, S.2
  • 2
    • 0003475277 scopus 로고
    • Antibiotics: Mechanisms of action and mechanisms of bacterial resistance
    • Washington DC: American Society for Microbiology
    • Salyers AA, Whitt DD: Antibiotics: mechanisms of action and mechanisms of bacterial resistance. In Bacterial Pathogenesis: A Molecular Approach. Washington DC: American Society for Microbiology; 1994:97-110.
    • (1994) Bacterial Pathogenesis: A Molecular Approach , pp. 97-110
    • Salyers, A.A.1    Whitt, D.D.2
  • 3
    • 0032851238 scopus 로고    scopus 로고
    • Pathogen virulence genes - Implications for vaccines and drug therapy
    • Tang C. Holden D. Pathogen virulence genes - implications for vaccines and drug therapy Br. Med. Bull 55 1999 387-400
    • (1999) Br. Med. Bull , vol.55 , pp. 387-400
    • Tang, C.1    Holden, D.2
  • 4
    • 0036604110 scopus 로고    scopus 로고
    • Morbidity of infections caused by antimicrobial-resistant bacteria
    • Travers K. Barza M. Morbidity of infections caused by antimicrobial-resistant bacteria Clin. Infect Dis. 34 2002 S131-S134
    • (2002) Clin. Infect. Dis. , vol.34
    • Travers, K.1    Barza, M.2
  • 5
    • 0037379524 scopus 로고    scopus 로고
    • Use of genetically engineered phage to deliver antimicrobial agents to bacteria: An alternative therapy for treatment of bacterial infections
    • Westwater C. Kasman L.M. Schofield D.A. Werner P.A. Dolan J.W. Schmidt M.G. Norris J.S. Use of genetically engineered phage to deliver antimicrobial agents to bacteria: an alternative therapy for treatment of bacterial infections Antimicrob Agents Chemother 47 2003 1301-1307
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1301-1307
    • Westwater, C.1    Kasman, L.M.2    Schofield, D.A.3    Werner, P.A.4    Dolan, J.W.5    Schmidt, M.G.6    Norris, J.S.7
  • 6
    • 0035990926 scopus 로고    scopus 로고
    • Virulence- and antibiotic resistance-associated two-component signal transduction systems of Gram-positive pathogenic bacteria as targets for antimicrobial therapy
    • Stephenson K. Hoch J.A. Virulence- and antibiotic resistance-associated two-component signal transduction systems of Gram-positive pathogenic bacteria as targets for antimicrobial therapy Pharmacol. Ther. 93 2002 293-305
    • (2002) Pharmacol. Ther. , vol.93 , pp. 293-305
    • Stephenson, K.1    Hoch, J.A.2
  • 7
    • 0037327813 scopus 로고    scopus 로고
    • Fatty acid and sterol metabolism: Potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa
    • Roberts C.W. McLeod R. Rice D.W. Ginger M. Chance M.L. Goad L.J. Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa Mol. Biochem. Parasitol. 126 2003 129-142
    • (2003) Mol. Biochem. Parasitol. , vol.126 , pp. 129-142
    • Roberts, C.W.1    McLeod, R.2    Rice, D.W.3    Ginger, M.4    Chance, M.L.5    Goad, L.J.6
  • 8
    • 0037158695 scopus 로고    scopus 로고
    • A bacteriolytic agent that detects and kills Bacillus anthracis
    • Schuch R. Nelson D. Fischetti V.A. A bacteriolytic agent that detects and kills Bacillus anthracis Nature 418 2002 884-889.
    • (2002) Nature , vol.418 , pp. 884-889
    • Schuch, R.1    Nelson, D.2    Fischetti, V.A.3
  • 9
    • 0030790687 scopus 로고    scopus 로고
    • Common themes in microbial pathogenicity revisited
    • Finlay B.B. Falkow S. Common themes in microbial pathogenicity revisited Microbiol. Mol. Biol. Rev. 61 1997 136-169
    • (1997) Microbiol. Mol. Biol. Rev. , vol.61 , pp. 136-169
    • Finlay, B.B.1    Falkow, S.2
  • 10
    • 0002941436 scopus 로고
    • Virulence factors that promote colonization
    • Washington DC: American Society for Microbiology
    • Salyers AA, Whitt DD: Virulence factors that promote colonization. In Bacterial Pathogenesis: A Molecular Approach. Washington DC: American Society for Microbiology; 1994:30-46.
    • (1994) Bacterial Pathogenesis: A Molecular Approach , pp. 30-46
    • Salyers, A.A.1    Whitt, D.D.2
  • 12
    • 0036230576 scopus 로고    scopus 로고
    • Bacterial adhesion: Seen any good biofilms lately?
    • Dunne W.M. Bacterial adhesion: seen any good biofilms lately? Clin. Microbiol. Rev. 15 2002 155-166
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 155-166
    • Dunne, W.M.1
  • 13
    • 0037431766 scopus 로고    scopus 로고
    • New ways to stop biofilm interactions
    • Stewart P.S. New ways to stop biofilm interactions Lancet 361 2003 97
    • (2003) Lancet , vol.361 , pp. 97
    • Stewart, P.S.1
  • 14
    • 0037198693 scopus 로고    scopus 로고
    • A component of innate immunity prevents bacterial biofilm development
    • Singh P.K. Parsek M.R. Greenberg E.P. Welsh M.J. A component of innate immunity prevents bacterial biofilm development Nature 417 2002 552-555
    • (2002) Nature , vol.417 , pp. 552-555
    • Singh, P.K.1    Parsek, M.R.2    Greenberg, E.P.3    Welsh, M.J.4
  • 15
    • 0037388307 scopus 로고    scopus 로고
    • Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
    • Schilling J.D. Martin S.M. Hung C.S. Lorenz R.G. Hultgren S.J. Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli Proc. Natl. Acad. Sci. U.S.A. 100 2003 4203-4208
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 4203-4208
    • Schilling, J.D.1    Martin, S.M.2    Hung, C.S.3    Lorenz, R.G.4    Hultgren, S.J.5
  • 16
    • 0032725799 scopus 로고    scopus 로고
    • Genomic clues for defining bacterial pathogenicity
    • Salama N.R. Falkow S. Genomic clues for defining bacterial pathogenicity Microbe Infect 1 1999 615-619
    • (1999) Microbe Infect. , vol.1 , pp. 615-619
    • Salama, N.R.1    Falkow, S.2
  • 17
    • 0037350267 scopus 로고    scopus 로고
    • Targeting bacterial virulence: Inhibitors of type III secretion in Yersinia
    • Kauppi A.M. Nordfelth R. Uvell H. Wolf-Watz H. Elofsson M. Targeting bacterial virulence: inhibitors of type III secretion in Yersinia Chem. Biol. 10 2003 241-249
    • (2003) Chem. Biol. , vol.10 , pp. 241-249
    • Kauppi, A.M.1    Nordfelth, R.2    Uvell, H.3    Wolf-Watz, H.4    Elofsson, M.5
  • 18
    • 0036669959 scopus 로고    scopus 로고
    • Using small molecules to study big questions in cellular microbiology
    • Ward G.E. Carey K.L. Westwood N.J. Using small molecules to study big questions in cellular microbiology Cell Microbiol. 4 2002 471-482
    • (2002) Cell Microbiol. , vol.4 , pp. 471-482
    • Ward, G.E.1    Carey, K.L.2    Westwood, N.J.3
  • 19
    • 0034678033 scopus 로고    scopus 로고
    • Target-oriented and diversity-oriented organic synthesis in drug discovery
    • Schreiber S.L. Target-oriented and diversity-oriented organic synthesis in drug discovery Science 287 2000 1964-1969
    • (2000) Science , vol.287 , pp. 1964-1969
    • Schreiber, S.L.1
  • 20
    • 0033915678 scopus 로고    scopus 로고
    • Recent developments in structure-based drug design
    • Klebe G. Recent developments in structure-based drug design J. Mol. Med. 78 2000 269-281
    • (2000) J. Mol. Med. , vol.78 , pp. 269-281
    • Klebe, G.1
  • 21
    • 0037043290 scopus 로고    scopus 로고
    • Epidemiology of urinary tract infections: Incidence, morbidity, and economic costs
    • Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs Am. J. Med. 113 2002 5S-13S
    • (2002) Am. J. Med. , vol.113
    • Foxman, B.1
  • 22
    • 0037043306 scopus 로고    scopus 로고
    • Scientific and clinical challenges in the management of urinary tract infections
    • Stamm W.E. Scientific and clinical challenges in the management of urinary tract infections Am. J. Med. 113 2002 1S-4S
    • (2002) Am. J. Med. , vol.113
    • Stamm, W.E.1
  • 23
    • 0036258843 scopus 로고    scopus 로고
    • Adhesion and entry of uropathogenic Escherichia coli
    • Mulvey M.A. Adhesion and entry of uropathogenic Escherichia coli Cell Microbiol. 4 2002 257-271
    • (2002) Cell Microbiol. , vol.4 , pp. 257-271
    • Mulvey, M.A.1
  • 24
    • 0035283006 scopus 로고    scopus 로고
    • Structure and function of Escherichia coli type 1 pili: New insight into the pathogenesis of urinary tract infections
    • Schilling J.D. Mulvey M.A. Hultgren S.J. Structure and function of Escherichia coli type 1 pili: new insight into the pathogenesis of urinary tract infections J. Infect. Dis. 183 2001 S36-S40
    • (2001) J. Infect. Dis. , vol.183
    • Schilling, J.D.1    Mulvey, M.A.2    Hultgren, S.J.3
  • 25
    • 0036021968 scopus 로고    scopus 로고
    • Recent advances into the pathogenesis of recurrent urinary tract infections: The bladder as a reservoir for uropathogenic Escherichia coli
    • Schilling J.D. Hultgren S.J. Recent advances into the pathogenesis of recurrent urinary tract infections: the bladder as a reservoir for uropathogenic Escherichia coli Int. J. Antimicrob. Agents 19 2002 457-460
    • (2002) Int. J. Antimicrob. Agents , vol.19 , pp. 457-460
    • Schilling, J.D.1    Hultgren, S.J.2
  • 27
    • 0035875099 scopus 로고    scopus 로고
    • Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor
    • Dodson K.W. Pinkner J.S. Rose T. Magnusson G. Hultgren S.J. Waksman G. Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor Cell 105 2001 733-743
    • (2001) Cell , vol.105 , pp. 733-743
    • Dodson, K.W.1    Pinkner, J.S.2    Rose, T.3    Magnusson, G.4    Hultgren, S.J.5    Waksman, G.6
  • 29
    • 0036905866 scopus 로고    scopus 로고
    • Discovery of potent inhibitors of PapG adhesins from uropathogenic Escherichia coli through synthesis and evaluation of galabiose derivatives
    • Ohlsson J. Jass J. Uhlin B.E. Kihlberg J. Nilsson U.J. Discovery of potent inhibitors of PapG adhesins from uropathogenic Escherichia coli through synthesis and evaluation of galabiose derivatives Chembiochem 3 2002 772-779
    • (2002) Chembiochem. , vol.3 , pp. 772-779
    • Ohlsson, J.1    Jass, J.2    Uhlin, B.E.3    Kihlberg, J.4    Nilsson, U.J.5
  • 30
    • 0344490325 scopus 로고    scopus 로고
    • Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides
    • in press
    • Larsson A, Ohlsson J, Dodson KW, Hultgren SJ, Nilsson UJ, Kihlberg J: Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides. Bioorg Med Chem 2003, in press.
    • (2003) Bioorg. Med. Chem.
    • Larsson, A.1    Ohlsson, J.2    Dodson, K.W.3    Hultgren, S.J.4    Nilsson, U.J.5    Kihlberg, J.6
  • 31
    • 0030294903 scopus 로고    scopus 로고
    • PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as an isolated protein
    • Nilsson U.J. Striker R.T. Hultgren S.J. Magnusson G. PapG adhesin from E. coli J96 recognizes the same saccharide epitope when present on whole bacteria and as an isolated protein Bioorg. Med. Chem. 4 1996 1809-1817
    • (1996) Bioorg. Med. Chem. , vol.4 , pp. 1809-1817
    • Nilsson, U.J.1    Striker, R.T.2    Hultgren, S.J.3    Magnusson, G.4
  • 32
    • 0037112164 scopus 로고    scopus 로고
    • Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
    • Sauer F.G. Pinkner J. Waksman G. Hultgren S.J. Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation Cell 111 2002 543-551
    • (2002) Cell , vol.111 , pp. 543-551
    • Sauer, F.G.1    Pinkner, J.2    Waksman, G.3    Hultgren, S.J.4
  • 36
    • 0036842083 scopus 로고    scopus 로고
    • Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis
    • Thanassi D.G. Stathopoulos C. Dodson K. Geiger D. Hultgren S.J. Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis J. Bacteriol. 184 2002 6260-6269
    • (2002) J. Bacteriol. , vol.184 , pp. 6260-6269
    • Thanassi, D.G.1    Stathopoulos, C.2    Dodson, K.3    Geiger, D.4    Hultgren, S.J.5
  • 38
    • 0029738256 scopus 로고    scopus 로고
    • Molecular basis of two subfamilies of immunoglobulin-like chaperones
    • Hung D.L. Knight S.D. Woods R.M. Pinkner J.S. Hultgren S.J. Molecular basis of two subfamilies of immunoglobulin-like chaperones EMBO J. 15 1996 3792-3805
    • (1996) EMBO J. , vol.15 , pp. 3792-3805
    • Hung, D.L.1    Knight, S.D.2    Woods, R.M.3    Pinkner, J.S.4    Hultgren, S.J.5
  • 40
    • 0030848819 scopus 로고    scopus 로고
    • Bacterial protein secretion - A target for new antibiotics?
    • Stephens C. Shapiro L. Bacterial protein secretion - a target for new antibiotics? Chem. Biol. 4 1997 637-641
    • (1997) Chem. Biol. , vol.4 , pp. 637-641
    • Stephens, C.1    Shapiro, L.2
  • 43
    • 0030872740 scopus 로고    scopus 로고
    • Transferred nuclear Overhauser effect spectroscopy study of a peptide from the PapG pilus subunit bound by the Escherichia coli PapD chaperone
    • Walse B. Kihlberg J. Flemmer Karlsson K. Nilsson M. Wahnlund K.-G. Pinkner J.S. Hultgren S.J. Drakenberg T. Transferred nuclear Overhauser effect spectroscopy study of a peptide from the PapG pilus subunit bound by the Escherichia coli PapD chaperone FEBS Lett. 412 1997 115-120
    • (1997) FEBS Lett. , vol.412 , pp. 115-120
    • Walse, B.1    Kihlberg, J.2    Flemmer Karlsson, K.3    Nilsson, M.4    Wahnlund, K.-G.5    Pinkner, J.S.6    Hultgren, S.J.7    Drakenberg, T.8
  • 47
    • 0034643990 scopus 로고    scopus 로고
    • Stereoselective synthesis of optically active beta-lactans, potential inhibitors of pilus assembly in pathogenic bacteria
    • Emtenas H. Soto G.E. Hultgren S.J. Marshall G.R. Almqvist F. Stereoselective synthesis of optically active beta-lactans, potential inhibitors of pilus assembly in pathogenic bacteria Org Lett. 2 2000 2065-2067
    • (2000) Org. Lett. , vol.2 , pp. 2065-2067
    • Emtenas, H.1    Soto, G.E.2    Hultgren, S.J.3    Marshall, G.R.4    Almqvist, F.5
  • 48
    • 0141433694 scopus 로고    scopus 로고
    • Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria
    • Emtenas H. Carlsson M. Pinkner J.S. Hultgren S.J. Almqvist F. Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria Org. Biomol. Chem. 1 2003 1308-1314
    • (2003) Org. Biomol. Chem. , vol.1 , pp. 1308-1314
    • Emtenas, H.1    Carlsson, M.2    Pinkner, J.S.3    Hultgren, S.J.4    Almqvist, F.5
  • 49
    • 0035812804 scopus 로고    scopus 로고
    • An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones
    • Emtenas H. Alderin L. Almqvist F. An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones J. Org. Chem. 66 2001 6756-6761
    • (2001) J. Org. Chem. , vol.66 , pp. 6756-6761
    • Emtenas, H.1    Alderin, L.2    Almqvist, F.3
  • 50
    • 0034323657 scopus 로고    scopus 로고
    • Preparation of fluorinated linkers: Use of 19F NMR spectroscopy to establish conditions for solid-phase synthesis of pilicide libraries
    • Svensson A. Fex T. Kihlberg J. Preparation of fluorinated linkers: use of 19F NMR spectroscopy to establish conditions for solid-phase synthesis of pilicide libraries J. Comb. Chem. 2 2000 736-748
    • (2000) J. Comb. Chem. , vol.2 , pp. 736-748
    • Svensson, A.1    Fex, T.2    Kihlberg, J.3
  • 51
    • 0027085578 scopus 로고
    • Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly
    • Slonim L.N. Pinkner J.S. Branden C.I. Hultgren S.J. Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly EMBO J. 11 1992 4747-4756
    • (1992) EMBO J. , vol.11 , pp. 4747-4756
    • Slonim, L.N.1    Pinkner, J.S.2    Branden, C.I.3    Hultgren, S.J.4
  • 52
    • 0036832824 scopus 로고    scopus 로고
    • Design and parallel solid-phase synthesis of ring-fused 2-pyridones that target pilus biogenesis in pathogenic bacteria
    • Emtenas H. Ahlin K. Pinkner J.S. Hultgren S.J. Almqvist F. Design and parallel solid-phase synthesis of ring-fused 2-pyridones that target pilus biogenesis in pathogenic bacteria J. Comb. Chem. 4 2002 630-639
    • (2002) J. Comb. Chem. , vol.4 , pp. 630-639
    • Emtenas, H.1    Ahlin, K.2    Pinkner, J.S.3    Hultgren, S.J.4    Almqvist, F.5
  • 53
    • 0037253986 scopus 로고    scopus 로고
    • Molecular radio jamming: Autoinducer analogs
    • Fast W. Molecular radio jamming: autoinducer analogs Chem. Biol. 10 2003 1-2
    • (2003) Chem. Biol. , vol.10 , pp. 1-2
    • Fast, W.1


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