Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 935-945

  Larsson, Andreas ^a   Johansson, Susanne M C ^a   Pinkner, Jerome S ^c   Hultgren, Scott J ^c   Almqvist, Fredrik ^a   Kihlberg, Jan ^a,b   Linusson, Anna ^a,b  

^a UMEÅ UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; AMINO ACID; CHAPERONE; FIMC PROTEIN; FIMH PROTEIN; NONAPEPTIDE; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY; PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM PILUS; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; PROTEIN PROTEIN INTERACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SOLID PHASE SYNTHESIS; STATISTICAL ANALYSIS; STATISTICAL MOLECULAR DESIGN; UROPATHOGENIC ESCHERICHIA COLI;

ADHESINS, ESCHERICHIA COLI; BACTERIAL PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIMBRIAE PROTEINS; MODELS, MOLECULAR; MULTIVARIATE ANALYSIS; PEPTIDES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13944271829     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040818l     Document Type: Article

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