Emotional perseveration: An update on prefrontal-amygdala interactions in fear extinction

Learning and Memory

Volumn 11, Issue 5, 2004, Pages 525-535

  Sotres Bayon, Francisco ^a   Bush, David E A ^a   LeDoux, Joseph E ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; AMYGDALOID NUCLEUS; CONDITIONING; EMOTION; FEAR; HIPPOCAMPUS; HUMAN; LEARNING; MODEL; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; REINFORCEMENT; REVIEW;

AMYGDALA; ANIMALS; EMOTIONS; EXTINCTION, PSYCHOLOGICAL; FEAR; INHIBITION (PSYCHOLOGY); MALE; NEURAL INHIBITION; NEURAL PATHWAYS; PREFRONTAL CORTEX; PSYCHOLOGICAL THEORY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 4644296720     PISSN: 10720502     EISSN: None     Source Type: Journal    
DOI: 10.1101/lm.79504     Document Type: Review

References (183)

1. Abercrombie, H.C., Schaefer, S.M., Larson, C.L., Oakes, T.R., Lindgren, K.A., Holden, J.E., Perlman, S.B., Turski, P.A., Krahn, D.D., Benca, R.M., et al. 1998. Metabolic rate in the right amygdala predicts negative affect in depressed patients. Neuroreport 9: 3301-3307.
2. Amaral, D.G., Price, J.L., Pitkänen, A., and Carmichael, S.T. 1992. Anatomical organization of the primate amygdaloid complex. In The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction (ed. J.P. Aggleton), pp. 1-66. Wiley-Liss, Inc. New York.
3. Amorapanth, P., LeDoux, J.E., and Nader, K. 2000. Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus. Nat. Neurosci. 3: 74-79.
4. Anagnostaras, S.G., Maren, S., and Fanselow, M.S. 1999. Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: Within-subjects examination. J. Neurosci. 19: 1106-1114.
5. Anand, A. and Shekhar, A. 2003. Brain imaging studies in mood and anxiety disorders: Special emphasis on the amygdala. Ann. NY Acad. Sci. 985: 370-388.
6. Anglada-Figueroa, D., Milad, M.R., and Quirk, G.J. 2003. Basal amygdala lesions impair within-session extinction of conditioned fear. Soc. Neurosci. Abstr. 199.6.
7. Atkins, C.M., Selcher, J.C., Petraitis, J.J., Trzaskos, J.M., and Sweatt, J.D. 1998. The MAPK cascade is required for mammalian associative learning. Nat. Neurosci. 1: 602-609.
8. Barrett, D., Shumake, J., Jones, D., and Gonzalez-Lima, F. 2003. Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response. J. Neurosci. 23: 5740-5749.
9. Bechara, A., Damasio, H., Tranel, D., and Anderson, S.W. 1998. Dissociation of working memory from decision making within the human prefrontal cortex. J. Neurosci. 18: 428-437.
10. Bechara, A., Damasio, H., and Damasio, A.R. 2000. Emotion, decision making and the orbitofrontal cortex. Cereb. Cortex 10: 295-307.
11. Berendse, H.W., Galis de Graaf, Y., and Groenewegen, H.J. 1992. Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J. Comp. Neurol. 316: 314-347.
12. Berman, D.E. and Dudai, Y. 2001. Memory extinction, learning anew, and learning the new: Dissociations in the molecular machinery of learning in cortex. Science 291: 2417-2419.
13. Berns, G.S., McClure, S.M., Pagnoni, G., and Montague, P.R. 2001. Predictability modulates human brain response to reward. J. Neurosci. 21: 2793-2798.
14. Blair, H.T., Schafe, G.E., Bauer, E.P., Rodrigues, S.M., and LeDoux, J.E. 2001. Synaptic plasticity in the lateral amygdala: A cellular hypothesis of fear conditioning. Learn. Mem. 8: 229-242.
15. Blair, H.T., Tinkelman, A., Moita, M.A., and LeDoux, J.E. 2003. Associative plasticity in neurons of the lateral amygdala during auditory fear conditioning. Ann. NY Acad. Sci. 985: 485-487.
16. Bliss, T.V. and Collingridge, G.L. 1993. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361: 31-39.
17. Botvinick, M., Nystrom, L.E., Fissell, K., Carter, C.S., and Cohen, J.D. 1999. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 402: 179-181.
18. Bouton, M.E. 1988. Context and ambiguity in the extinction of emotional learning: Implications for exposure therapy. Behav. Res. Ther. 26: 137-149.
19. -. 1993. Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol. Bull. 114: 80-99.
20. -. 2002. Context, ambiguity, and unlearning: Sources of relapse after behavioral extinction. Biol. Psychiatry 52: 976-986.
21. Bouton, M.E. and King, D.A. 1983. Contextual control of the extinction of conditioned fear: Tests for the associative value of the context. J. Exp. Psychol. Anim. Behav. Process 9: 248-265.
22. Bremner, J.D., Staib, L.H., Kaloupek, D., Southwick, S.M., Soufer, R., and Charney, D.S. 1999. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A Positron Emission Tomography study. Biol Psychiatry 45: 806-816.
23. Bush, G., Luu, P., and Posner, M. 2000. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 4: 215-222.
24. Carr, D.B. and Sesack, S.R. 1996. Hippocampal afferents to the rat prefrontal cortex: Synaptic targets and relation to dopamine terminals. J. Comp. Neurol. 369: 1-15.
25. Carter, C.S., Botvinick, M.M., and Cohen, J.D. 1999. The contribution of the anterior cingulate cortex to executive processes in cognition. Rev. Neurosci. 10: 49-57.
26. Chiba, T., Kayahara, T., and Nakano, K. 2001. Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata. Brain Res. 888: 83-101.
27. Cohen, J.D., Botvinick, M., and Carter, C.S. 2000. Anterior cingulate and prefrontal cortex: Who's in control? Nat. Neurosci. 3: 421-423.
28. Colino, A. and Fernandez de Molina, A. 1986a. Electrical activity generated in subicular and entorhinal cortices after electrical stimulation of the lateral and basolateral amygdala of the rat. Neuroscience 19: 573-580.
29. -. 1986b. Inhibitory response in entorhinal and subicular cortices after electrical stimulation of the lateral and basolateral amygdala of the rat. Brain Res. 378: 416-419.
30. Collins, D.R. and Paré, D. 1999. Reciprocal changes in the firing probability of lateral and central medial amygdala neurons, J. Neurosci. 19: 836-844.
31. -. Learn. Mem. 7: 97-103.
32. Conde, F., Maire Lepoivre, E., Audinat, E., and Crepel, F. 1995. Afferent connections of the medial frontal cortex of the rat. II. Cortical and subcortical afferents. J. Comp. Neurol. 352: 567-593.
33. Corcoran, K.A. and Maren, S. 2001. Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction. J. Neurosci. 21: 1720-1726.
34. Curtis, C.E. and D'Esposito, M. 2003. Success and failure suppressing reflexive behavior. J. Cogn. Neurosc. 15: 409-418.
35. Damasio, A.R. 1990. Synchronous activation in multiple cortical regions: A mechanism for recall. Semin. Neurosci. 2: 287-296.
36. Davidson, R.J. 2002a. Anxiety and affective style: Role of prefrontal cortex and amygdala. Biol. Psychiatry 51: 68-80.
37. -. 2002b. Depression: Perspectives from affective neuroscience. Annu. Rev. Psychol. 53: 545-574.
38. Davidson, R.J., Abercrombie, H., Nitschke, J.B., and Putnam, K. 1999. Regional brain function, emotion and disorders of emotion. Curr. Opin, Neurobiol. 9: 228-234.
39. Davidson, R.J., Putnam, K.M., and Larson, C.L. 2000. Dysfunction in the neural circuitry of emotion regulation-A possible prelude to violence. Science 289: 591-594.
40. Davis, M. 2002. Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: Clinical implications for exposure therapy. Eur. J. Neurosci. 16: 395-398.
41. Davis, M. and Myers, K.M. 2002. The role of glutamate and γ-aminobutyric acid in fear extinction: Clinical implications for exposure therapy. Biol. Psychiatry 52: 998-1007.
42. Davis, M. and Whalen, P.J. 2001. The amygdala: Vigilance and emotion. Mol. Psychiatry 6: 13-34.
43. Davis, M., Walker, D.L., and Myers, K.M. 2003. Role of the amygdala in fear extinction measured with potentiated startle. Ann. NY Acad. Sci. 985: 218-232.
44. Degenetais, E., Thierry, A.M., Glowinski, J., and Gioanni, Y. 2003. Synaptic influence of hippocampus on pyramidal cells of the rat prefrontal cortex: An in vivo intracellular recording study. Cerebral Cortex 13: 782-792.
45. D'Esposito, M., Postle, B.R., and Rypma, B. 2000. Prefrontal cortical contributions to working memory: Evidence from event-related fMRI studies. Exp. Brain Res. 133: 3-11.
46. Drevets, W.C. 1998. Functional neuroimaging studies of depression: The anatomy of melancholia. Ann. Rev. Med. 49: 341-361.
47. -. 1999. Prefrontal cortical-amygdalar metabolism in major depression. Ann. NY Acad. Sci. 877: 614-637.
48. -. 2001. Neuroimaging and neuropathological studies of depression: Implications for the cognitive-emotional features of mood disorders. Curr. Opin. Neurobiol. 11: 240-249.
49. -. 2003. Neuroimaging abnormalities in the amygdala in mood disorders. Ann. NY Acad. Sci. 985: 420-444.
50. Drevets, W.C., Videen, T.O., Price, J.L., Preskorn, S.H., Carmichael, S.T., and Raichle, M.E. 1992. A functional anatomical study of unipolar depression. J. Neurosci. 12: 3628-3641.
51. Drevets, W.C., Ongur, D., and Price, J.L. 1998. Neuroimaging abnormalities in the subgenual prefrontal cortex: Implications for the pathophysiology of familial mood disorders. Mol. Psychiatry 3: 220-226.
52. Everitt, B.J. and Robbins, T.W. 1992. Amygdala-ventral striatal interactions and reward related processes. In The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction (ed. J.P. Aggleton), pp. 400-429. Wiley-Liss, Inc., New York.
53. Falls, W.A., Miserendino, M.J., and Davis, M. 1992. Extinction of fear-potentiated startle: Blockade by infusion of an NMDA antagonist into the amygdala. J. Neurosci. 12: 854-863.
54. Fanselow, M.S. 1998. Pavlovian conditioning, negative feedback, and blocking: Mechanisms that regulate association formation. Neuron 20: 625-627.
55. Fernandez, M., Pissiota, A., Frans, O., von Knorring, L., Fischer, H., and Fredrikson, M. 2001. Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: A Positron Emission Tomography provocation study. Neurosci. Lett. 297: 101-104.
56. Frohardt, R.J., Guarraci, F.A., and Bouton, M.E. 2000. The effects of neurotoxic hippocampal lesions on two effects of context after fear extinction. Behav. Neurosci. 114: 227-240.
57. Garcia, R. 2002. Postextinction of conditioned fear: Between two CS-related memories. Learn. Mem. 9: 361-363.
58. Garcia, R., Vouimba, R.M., Baudry, M., and Thompson, R.F. 1999. The amygdala modulates prefrontal cortex activity relative to conditioned fear. Nature 402: 294-296.
59. Gewirtz, J.C., Falls, W.A., and Davis, M. 1997. Normal conditioned inhibition and extinction of freezing and fear-potentiated startle following electrolytic lesions of medical prefrontal cortex in rats. Behav. Neurosci. 111: 712-726.
60. Ghashghaei, H.T. and Barbas, H. 2002. Pathways for emotion: Interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience 115: 1261-1279.
61. Goldman-Rakic, P.S. 1987. Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In Handbook of physiology: The nervous system (ed. F. Plum), pp. 373-418. American Physiology Society, Bethesda, MD.
62. -. 1995. Architecture of the prefrontal cortex and the central executive. Ann. NY Acad. Sci. 769: 71-83.
63. Goosens, K.A. and Maren, S. 2001. Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats. Learn. Mem. 8: 148-155.
64. Goosens, K.A., Hobin, J.A., and Maren, S. 2003. Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: Mnemonic code or fear bias? Neuron 40: 1013-1022.
65. Grace, A.A. and Rosenkranz, J.A. 2002. Regulation of conditioned responses of basolateral amygdala neurons. Physiol. Behav. 77: 489-493.
66. Heidbreder, C.A. and Groenewegen, H.J. 2003. The medial prefrontal cortex in the rat: Evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neurosci. Biobehav. Rev. 27: 555-579.
67. Herry, C. and Garcia, R. 2002. Prefrontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice. J. Neurosci. 22: 577-583.
68. -. 2003. Behavioral and paired-pulse facilitation analyses of long-lasting depression at excitatory synapses in the medial prefrontal cortex in mice. Behav. Brain Res. 146: 89-96.
69. Herry, C., Vouimba, R.M., and Garcia, R. 1999. Plasticity in the mediodorsal thalamo-prefrontal cortical transmission in behaving mice. J. Neurophys. 82: 2827-2832.
70. Hobin, J.A., Goosens, K.A., and Maren, S. 2003. Context-dependent neuronal activity in the lateral amygdala represents fear memories after extinction. J. Neurosci. 23: 8410-8416.
71. Hugdahl, K., Berardi, A., Thompson, W.L., Kosslyn, S.M., Macy, R., Baker, O.P., Alpert, N.M., and LeDoux, J.E. 1995. Brain mechanisms in human classical conditioning: A PET blood flow study. Neuroreport 6: 1723-1728.
72. Hurley, K.M., Herbert, H., Moga, M.M., and Saper, C.B. 1991. Efferent projections of the infralimbic cortex of the rat. J. Comp. Neurol. 308: 249-276.
73. Ishikawa, A. and Nakamura, S. 2003, Convergence and interaction of hippocampal and amygdalar projections within the prefrontal cortex in the rat. J. Neurosci. 23: 9987-9995.
74. Jay, T.M. and Witter, M.P. 1991. Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin. J. Comp. Neurol. 313: 574-586.
75. Kim, J.J. and Fanselow, M.S. 1992. Modality-specific retrograde amnesia of fear. Science 256: 675-677.
76. Krettek, J.E. and Price, J.L. 1978. A description of the amygdaloid complex in the rat and cat with observations on intra-amygdaloid axonal connections. J. Comp. Neurol. 178: 255-280.
77. Lebron, K., Milad, M.R., and Quirk, G.J. 2003. Rats with lesions of the ventromedial prefrontal cortex can eventually recall extinction, with additional training. Soc. Neurosci. Abstr. 199.5.
78. Ledgerwood, L., Richardson, R., and Cranney, J. 2003. Effects of D-cycloserine on extinction of conditioned freezing. Behav. Neurosci. 117: 341-349.
79. LeDoux, J.E. 1996. The emotional brain: The mysterious underpinnings of emotional life, p. 384. Simon & Schuster, New York.
80. -. 2000. Emotion circuits in the brain. Annu. Rev. Neurosci. 23: 155-184.
81. LeDoux, J.E. and Gorman, J.M. 2001. A call to action: Overcoming anxiety through active coping. Am. J. Psychiatry 158: 1953-1955.
82. LeDoux, J.E., Romanski, L.M., and Xagoraris, A. 1989. Indelibility of subcortical emotional memories. J. Cogn. Neurosci. 8: 2517-2529.
83. Lee, H. and Kim, J.J. 1998. Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. J. Neurosci. 18: 8444-8454.
84. Levy, R. and Goldman-Rakic, P.S. 2000. Segregation of working memory functions within the dorsolateral prefrontal cortex. Exp. Brain Res. 133: 23-32.
85. Li, X.F., Phillips, R., and LeDoux, J.E. 1995. NMDA and non-NMDA receptors contribute to synaptic transmission between the medial geniculate body and the lateral nucleus of the amygdala. Exp. Brain. Res. 105: 87-100.
86. Li, X.F., Stutzmann, G.E., and LeDoux, J.E. 1996. Convergent but temporally separated inputs to lateral amygdala neurons from the auditory thalamus and auditory cortex use different postsynaptic receptors: In vivo intracellular and extracellular recordings in fear conditioning pathways. Learn. Mem. 3: 229-242.
87. Li, R., Nishijo, H., Ono, T., Ohtani, Y., and Ohtani, O. 2002. Synapses on GABAergic neurons in the basolateral nucleus of the rat amygdala: Double-labeling immunoelectron microscopy. Synapse 43: 42-50.
88. Lin, C.H., Lee, C.C., and Gean, P.W. 2003a. Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory. Mol. Pharmacol. 63: 44-52.
89. Lin, C.H., Yeh, S.H., Lu, H.Y., and Gean, P.W. 2003b. The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J. Neurosci. 23: 8310-8317.
90. Lu, K.T., Walker, D.L., and Davis, M. 2001. Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle. J. Neurosci. 21: RC162.
91. Luria, A.R. 1973a. The frontal lobes and the regulation of behavior. In Psychophysiology of the frontal lobes (ed. A.R. Luria), pp. 3-26. Academic Press. New York.
92. -. 1973b. The working brain. Basic Books, New York.
93. Maren, S. 2001. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 24: 897-931.
94. Maren, S. and Fanselow, M.S. 1995. Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J. Neurosci. 15: 7548-7564.
95. -. 1996. The amygdala and fear conditioning: Has the nut been cracked? Neuron 16: 237-240.
96. Maren, S., Aharonov, G., Stole, D.L., and Fanselow, M.S. 1996. N-Methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats. Behav. Neurosci. 110: 1365-1374.
97. Marsicano, G., Wotjak, C.T., Azad, S.C., Bisogno, T., Rammes, G., Cascio, M.G., Hermann, H., Tang, J., Hofmann, C, Zieglgansberger, W., et al. 2002. The endogenous cannabinoid system controls extinction of aversive memories. Nature 418: 530-534.
98. Martin, S.J., Grimwood, P.D., and Morris, R.G. 2000. Synaptic plasticity and memory: An evaluation of the hypothesis. Ann. Rev. Neurosci. 23: 649-711.
99. McDonald, A.J. 1985. Immunohistochemical identification of γaminobutyric acid-containing neurons in the rat basolateral amygdala. Neurosci. Lett. 53: 203-207.
100. -. 1991. Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat. Neuroscience 44: 1-14.
101. -. 1998. Cortical pathways to the mammalian amygdala. Prog. Neurobiol. 55: 257-332.
102. McDonald, A.J. and Augustine, J.R. 1993. Localization of GABA-like immunoreactivity in the monkey amygdala. Neuroscience 52: 281-294.
103. McDonald, A.J. and Betette, R.L. 2001. Parvalbumin-containing neurons in the rat basolateral amygdala: Morphology and co-localizalion of Calbindin-D(28k). Neuroscience 102: 413-425.
104. McDonald, A.J. and Mascagni, F. 1997. Projections of the lateral entorhinal cortex to the amygdala: A Phaseolus vulgaris leucoagglutinin study in the rat. Neuroscience 77: 445-459.
105. McDonald, A.J., Mascagni, F., and Guo, L. 1996. Projections of the medial and lateral prefrontal cortices to the amygdala: A Phaseolus vulgaris leucoagglutinin study in the rat. Neuroscience 71: 55-75.
106. Milad, M.R. and Quirk, G.J. 2002. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420: 70-74.
107. Milad, M.R., Vidal-Gonzalez, I., and Quirk, G.J. 2004. Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behav. Neurosci. 118: 389-394.
108. Miller, E.K. and Cohen, J.D. 2001. An integrative theory of prefrontal cortex function. Ann. Rev. Neurosci. 24: 167-202.
109. Miserendino, M.J., Sananes, C.B., Melia, K.R., and Davis, M. 1990. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345: 716-718.
110. Morgan, M.A. and LeDoux, J.E. 1995. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav. Neurosci. 109: 681-688.
111. Morgan, M.A., Romanski, L.M., and LeDoux, J.E.. 1993. Extinction of emotional learning: Contribution of medial prefrontal cortex. Neurosci. Lett. 163: 109-113.
112. Morgan, M.A., Schulkin, J., and LeDoux, J.E. 2003. Ventral medial prefrontal cortex and emotional perseveration: The memory for prior extinction training. Behav. Brain Res. 146: 121-130.
113. Morris, R.G. 1989. Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9: 3040-3057.
114. Morrow, B.A., Elsworth, J.D., Rasmusson, A.M., and Roth, R.H. 1999. The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience 92: 553-564.
115. Muller, N.G., Machado, L., and Knight, R.T. 2002. Contributions of subregions of the prefrontal cortex to working memory: Evidence from brain lesions in humans. J. Cogn. Neurosci. 14: 673-686.
116. Myers, K.M. and Davis, M. 2002. Behavioral and neural analysis of extinction. Neuron 36: 567-584.
117. Nader, K., Majidishad, P., Amorapanth, P., and LeDoux, J.E. 2001. Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning. Learn. Mem. 8: 156-163.
118. Nauta, W.J. 1971. The problem of the frontal lobe: A reinterpretation. J. Psychiatric Res. 8: 167-187.
119. Owen, A.M., Herrod, N.J., Menon, O.K., Clark, J.C., Downey, S.P., Carpenter, T.A., Minhas, P.S., Turkheimer, F.E., Williams, E.J., Robbins, T.W., et al. 1999. Redefining the functional organization of working memory processes within human lateral prefrontal cortex. Eur. J. Neurosci. 11: 567-574.
120. Paré, D. 2003. Role of the basolateral amygdala in memory consolidation. Prog. Neurobiol. 70: 409-420.
121. Paré, D. and Smith, Y. 1993. The intercalated cell masses project to the central and medial nuclei of the amygdala in cats. Neuroscience 57: 1077-1090.
122. -. 1998. Intrinsic circuitry of the amygdaloid complex: Common principles of organization in rats and cats. Trends Neurosci. 21: 240-241.
123. Paré, D., Smith, Y., and Paré, J.F. 1995. Intra-amygdaloid projections of the basolateral and basomedial nuclei in the cat: Phaseolus vulgaris-leucoagglutinin anterograde tracing at the light and electron microscopic level. Neuroscience 69: 567-583.
124. Paré, D., Royer, S., Smith, Y., and Lang, E.J. 2003. Contextual inhibitory gating of impulse traffic in the intra-amygdaloid network. .Ann. NY Acad. Sci. 985: 78-91.
125. Paré, D., Quirk, G.J., and LeDoux, J.E. 2004. New vistas on amygdala networks in conditioned fear. J. Neurophysiol. 92: 1-9.
126. Paxinos, G. and Watson, C. 1998. The rat brain in stereotaxic coordinates. Academic Press, New York.
127. Phelps, E.A., Delgado, M., Nearing, K., and LeDoux, J.E. 2004. Extinction learning in humans: Role of the amygdala and vmPFC. Neuron 43: 897-905.
128. Phillips, R.G. and LeDoux, J.E. 1992. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106: 274-285.
129. Pitkänen, A. 2001. Connectivity of the rat amygdaloid complex. In The amygdala: A functional analysis (ed. J.P. Aggleton), pp. 31-116. Oxford University Press, New York.
130. Pitkänen, A., Savander, V., and LeDoux, J.E. 1997. Organization of intra-amygdaloid circuitries in the rat: An emerging framework for understanding functions of the amygdala. Trends Neurosci. 20: 517-523.
131. Pitkänen, A., Jolkkonen, E., and Kemppainen, S. 2000a. Anatomic heterogeneity of the rat amygdaloid complex. Folia Morphol (Warsz) 59: 1-23.
132. Pitkänen, A., Pikkarainen, M., Nurminen, N., and Ylinen, A. 2000b. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review. Ann. NY Acad. Sci. 911: 369-391.
133. Pitkänen, A., Savander, M., Nurminen, N., and Ylinen, A. 2003. Intrinsic synaptic circuitry of the amygdala. Ann. NY Acad. Sci. 985: 34-49.
134. Posner, M. 1992. Attention as a cognitive and neural system. Curr. Dir. Psychol Sci. 1: 11-14.
135. Povinelli, D.J. and Preuss, T.M. 1995. Theory of mind: Evolutionary history of a cognitive specialization. Trends Neurosci. 18: 418-424.
136. Preuss, T.M. 1995. Do rats have prefrontal cortex? The Rose-Woolsey-Akert program reconsidered. J. Cogn. Neurosci. 7: 1-24.
137. Quirk, G.J. and Gehlert, D.R. 2003. Inhibition of the amygdala: Key to pathological states? Ann. NY Acad. Sci. 985: 263-272.
138. Quirk, G.J., Repa, C., and LeDoux, J.E. 1995. Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat. Neuron 15: 1029-1039.
139. Quirk, G.J., Russo, G.K., Barron, J.L., and Lebron, K. 2000. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J. Neurosci. 20: 6225-6231.
140. Quirk, G.J., Likhtik, E., Pelletier, J.G., and Paré, D. 2003. Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J. Neurosci. 23: 8800-8807.
141. Rainnie, D.G. 2003. Inhibitory and excitatory circuitries in amygdala nuclei: A synopsis of session II. Ann. NY Acad. Sci. 985: 59-66.
142. Repa, J.C., Muller, J., Apergis, J., Desrochers, T.M., Zhou, Y., and LeDoux, J.E. 2001. Two different lateral amygdala cell populations contribute to the initiation and storage of memory. Nat. Neurosci. 4: 724-731.
143. Rescorla, R.A. 2001. Retraining of extinguished Pavlovian stimuli. J. Exp. Psychol. Anim. Behav. Process. 27: 115-124.
144. Robbins, T.W. 1996. Dissociating executive functions of the prefrontal cortex. Philos. Trans. R. Soc. Land. B Biol. Sci. 351: 1463-1470.
145. Rodrigues, S.M., Schafe, G.E., and LeDoux, J.E. 2001. Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning. J. Neurosci. 21: 6889-6896.
146. Rogan, M.T., Staubli, U.V., and LeDoux, J.E. 1997. Fear conditioning induces associative long-term potentiation in the amygdala. Nature 390: 604-607.
147. Rogers, R.D., Owen, A.M., Middleton, H.C., Williams, E.J., Pickard, J.D., Sahakian, B.J., and Robbins, T.W. 1999. Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J. Neurosci. 19: 9029-9038.
148. Rolls, E.T. 1996. The orbitofrontal cortex. Philos. Trans. R. Soc. Lond. B Biol. Sci. 351: 1433-1443.
149. -. 2000. The orbitofrontal cortex and reward. Cereb. Cortex 10: 284-294.
150. Room, P., Russchen, F.T., Groenewegen, H.J., and Lohman, A.H. 1985. Efferent connections of the prelimbic (area 32) and the infralimbic (area 25) cortices: An anterograde tracing study in the cat. J. Comp. Neurol. 242: 40-55.
151. Rosenkranz, J.A. and Grace, A.A. 1999. Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo. J. Neurosci. 19: 11027-11039.
152. -. 2001. Dopamine attenuates prefrontal cortical suppression of sensory inputs to the basolateral amygdala of rats. J. Neurosci. 21: 4090-4103.
153. -. 2002. Cellular mechanisms of infralimbic and prelimbic prefrontal cortical inhibition and dopaminergic modulation of basolateral amygdala neurons in vivo. J. Neurosci. 22: 324-337.
154. Rosenkranz, J.A., Moore, H., and Grace, A.A. 2003. The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli. J. Neurosci. 23: 11054-11064.
155. Rothbaum, B.O. and Davis, M. 2003. Applying learning principles to the treatment of post-trauma reactions. Ann. NY Acad. Sci. 1008: 112-121.
156. Royer, S. and Paré, D. 2002. Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses. Neuroscience 115: 455-462.
157. Royer, S., Martina, M., and Paré, D. 1999. An inhibitory interface gates impulse traffic between the input and output stations of the amygdala. J. Neurosci. 19: 10575-10583.
158. Sah, P., Faber, E.S., Lopez De Armentia, M., and Power, J. 2003. The amygdaloid complex: Anatomy and physiology. Physiol. Rev. 83: 803-834.
159. Savander, V., Miettinen, R., Ledoux, J.E., and Pitkänen, A. 1997. Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: A light and electron microscopic study. Neuroscience 77: 767-781.
160. Schafe, G.E. and LeDoux, J.E. 2000. Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J. Neurosci. 20: RC96.
161. Schafe, G.E., Atkins, C.M., Swank, M.W., Bauer, E.P., Sweatt, J.D., and LeDoux, J.E. 2000. Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning. J. Neurosci. 20: 8177-8187.
162. Schafe, G.E., Nader, K., Blair, H.T., and LeDoux, J.E. 2001. Memory consolidation of Pavlovian fear conditioning: A cellular and molecular perspective. Trends Neurosci. 24: 540-546.
163. Seamans, J.K., Floresco, S.B., and Phillips, A.G. 1995. Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex. Behav. Neurosci. 109: 1063-1073.
164. Seiden, N.R., Everitt, B.J., Jarrard, L.E., and Robbins, T.W. 1991. Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience 42: 335-350.
165. Sesack, S.R., Deutch, A.Y., Roth, R.H., and Bunney, B.S. 1989. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 290: 213-242.
166. Shin, L.M., Whalen, P.J., Pitman, R.K., Bush, G., Macklin, M.L., Lasko, N.B., Orr, S.P., McInerney, S.C., and Rauch, S.L. 2001. An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biol. Psychiatry 50: 932-942.
167. Shinonaga, Y., Takada, M., and Mizuno, N. 1994. Topographic organization of collateral projections from the basolateral amygdaloid nucleus to both the prefrontal cortex and nucleus accumbens in the rat. Neuroscience 58: 389-397.
168. Shumyatsky, G.P., Tsvetkov, E., Malleret, G., Vronskaya, S., Hatton, M., Hampton, L., Battey, J.F., Dulac, C., Kandel, E.R., and Bolshakov, V.Y. 2002. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111: 905-918.
169. Siegle, G.J., Steinhauer, S.R., Thase, M.E., Stenger, V.A., and Carter, C.S. 2002. Can't shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol. Psychiatry 51: 693-707.
170. Siegle, G.J., Konecky, R.O., Thase, M.E., and Carter, C.S. 2003. Relationships between amygdala volume and activity during emotional information processing tasks in depressed and never-depressed individuals: An fMRI investigation. Ann. NY Acad. Sci. 985: 481-484.
171. Smith, E.E. and Jonides, J. 1999. Storage and executive processes in the frontal lobes. Science 283: 1657-1661.
172. Smith, Y. and Paré, D. 1994. Intra-amygdaloid projections of the lateral nucleus in the cat: PHA-L anterograde labeling combined with postembedding GABA and glutamate immunocytochemistry. J. Comp. Neurol. 342: 232-248.
173. Smith, Y., Paré, J.F., and Paré, D. 2000. Differential innervation of parvalbumin-immunoreactive interneurons of the basolateral amygdaloid complex by cortical and intrinsic inputs. J. Comp. Neurol. 416: 496-508.
174. Sotres-Bayon, F., Bush, D.E.A., and LeDoux, J.E. 2004. Blockade of the NR2B subunit of the NMDA receptor disrupts fear extinction learning. Soc. Neurosci. Abstr. 208.5.
175. Teich, A.H., McCabe, P.M., Gentile, C.C., Schneiderman, L.S., Winters, R.W., Liskowsky, D.R., and Schneiderman, N. 1989. Auditory cortex lesions prevent the extinction of Pavlovian differential heart rate conditioning to tonal stimuli in rabbits. Brain Res. 480: 210-218.
176. Uylings, H.B., Groenewegen, H.J., and Kolb, B. 2003. Do rats have a prefrontal cortex? Behav. Brain Res. 146: 3-17.
177. van Groen, T. and Wyss, J.M. 1990. Extrinsic projections from area CA1 of the rat hippocampus: Olfactory, cortical, subcortical, and bilateral hippocampal formation projections. J. Comp. Neurol. 302: 515-528.
178. Vertes, R.P. 2004. Differential projections of the infralimbic and prelimbic cortex in the rat. Synapse 51: 32-58.
179. Walker, D.L. and Davis, M. 2000. Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle. Behav. Neurosci. 114: 1019-1033.
180. -. 2002. The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction. Pharmacol. Biochem. Behav. 71: 379-392.
181. Walker, D.L., Ressler, K.J., Lu, K.T., and Davis, M. 2002. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J. Neurosci. 22: 2343-2351.
182. Weisskopf, M.G., Bauer, E.P., and LeDoux, J.E. 1999. L-type voltage-gated calcium channels mediate NMDA-independent associative long-term potentiation at thalamic input synapses to the amygdala. J. Neurosci. 19: 10512-10519.
183. Wilson, A., Brooks, D.C., and Bouton, M.E. 1995. The role of the rat hippocampal system in several effects of context in extinction. Behav. Neurosci. 109: 828-836.