메뉴 건너뛰기




Volumn 15, Issue 12, 2005, Pages 851-859

Interaction magnitude, pharmacokinetics and pharmacodynamics of ticlopidine in relation to CYP2C19 genotypic status

Author keywords

CYP2C19; Pharmacodynamics; Pharmacogenetics; Pharmacokinetics; Ticlopidine

Indexed keywords

ADENOSINE DIPHOSPHATE; CYTOCHROME P450 2C19; OMEPRAZOLE; OMEPRAZOLE DERIVATIVE; TICLOPIDINE;

EID: 27944496080     PISSN: 17446872     EISSN: None     Source Type: Journal    
DOI: 10.1097/01213011-200512000-00003     Document Type: Article
Times cited : (31)

References (39)
  • 1
    • 2942641718 scopus 로고    scopus 로고
    • Platelet ADP receptor antagonists: Ticlopidine and clopidogrel
    • Jacobson AK. Platelet ADP receptor antagonists: ticlopidine and clopidogrel. Best Pract Res Clin Haematol 2004; 17:55-64.
    • (2004) Best Pract Res Clin Haematol , vol.17 , pp. 55-64
    • Jacobson, A.K.1
  • 3
    • 0024396437 scopus 로고
    • A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients
    • Ticlopidine Aspirin Stroke Study Group
    • Hass WK, Easton JD, Adams HP Jr, Pryse-Phillips W, Molony BA, Anderson S, et al. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. N Engl J Med 1989; 321:501-507.
    • (1989) N Engl J Med , vol.321 , pp. 501-507
    • Hass, W.K.1    Easton, J.D.2    Adams Jr., H.P.3    Pryse-Phillips, W.4    Molony, B.A.5    Anderson, S.6
  • 4
    • 0025345221 scopus 로고
    • Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial
    • Balsano F, Rizzon P, Violi F, Scrutinio D, Cimminiello C, Aguglia F, et al. Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. Circulation 1990; 82:17-26.
    • (1990) Circulation , vol.82 , pp. 17-26
    • Balsano, F.1    Rizzon, P.2    Violi, F.3    Scrutinio, D.4    Cimminiello, C.5    Aguglia, F.6
  • 6
    • 0029111888 scopus 로고
    • Reduction of requirement for leg vascular surgery during long-term treatment of claudicant patients with ticlopidine: Results from the Swedish Ticlopidine Multicentre Study (STIMS)
    • Bergqvist D, Almgren B, Dickinson JP. Reduction of requirement for leg vascular surgery during long-term treatment of claudicant patients with ticlopidine: results from the Swedish Ticlopidine Multicentre Study (STIMS). Eur J Vasc Endovasc Surg 1995; 10:69-76.
    • (1995) Eur J Vasc Endovasc Surg , vol.10 , pp. 69-76
    • Bergqvist, D.1    Almgren, B.2    Dickinson, J.P.3
  • 7
    • 9244251971 scopus 로고    scopus 로고
    • A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents
    • Schomig A, Neumann FJ, Kastrati A, Schuhlen H, Blasini R, Hadamitzky M, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 1996; 334:1084-1089.
    • (1996) N Engl J Med , vol.334 , pp. 1084-1089
    • Schomig, A.1    Neumann, F.J.2    Kastrati, A.3    Schuhlen, H.4    Blasini, R.5    Hadamitzky, M.6
  • 8
    • 0032481092 scopus 로고    scopus 로고
    • A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting
    • Stent Anticoagulation Restenosis Study Investigators
    • Leon MB, Baim DS, Popma JJ, Gordon PC, Cutlip DE, Ho KK, et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. N Engl J Med 1998; 339:1665-1671.
    • (1998) N Engl J Med , vol.339 , pp. 1665-1671
    • Leon, M.B.1    Baim, D.S.2    Popma, J.J.3    Gordon, P.C.4    Cutlip, D.E.5    Ho, K.K.6
  • 9
    • 7844220998 scopus 로고    scopus 로고
    • Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study
    • Bertrand ME, Legrand V, Boland J, Fleck E, Bonnier J, Emmanuelson H, et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study. Circulation 1998; 98:1597-1603.
    • (1998) Circulation , vol.98 , pp. 1597-1603
    • Bertrand, M.E.1    Legrand, V.2    Boland, J.3    Fleck, E.4    Bonnier, J.5    Emmanuelson, H.6
  • 10
    • 0028299993 scopus 로고
    • Clinical pharmacokinetics of ticlopidine
    • Desager JP. Clinical pharmacokinetics of ticlopidine. Clin Pharmacokinet 1994; 26:347-355.
    • (1994) Clin Pharmacokinet , vol.26 , pp. 347-355
    • Desager, J.P.1
  • 11
    • 0026659288 scopus 로고
    • Pharmacokinetics of ticlopidine during chronic oral administration to healthy volunteers and its effects on antipyrine pharmacokinetics
    • Knudsen JB, Bastain W, Sefton CM, Allen JG, Dickinson JP. Pharmacokinetics of ticlopidine during chronic oral administration to healthy volunteers and its effects on antipyrine pharmacokinetics. Xenobiotica. 1992; 22:579-589.
    • (1992) Xenobiotica , vol.22 , pp. 579-589
    • Knudsen, J.B.1    Bastain, W.2    Sefton, C.M.3    Allen, J.G.4    Dickinson, J.P.5
  • 14
    • 20444458419 scopus 로고    scopus 로고
    • Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation
    • Turpeinen M, Tolonen A, Uusitalo J, Jalonen J, Pelkonen O, Laine K. Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation. Clin Pharmacol Ther 2005; 77:553-559.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 553-559
    • Turpeinen, M.1    Tolonen, A.2    Uusitalo, J.3    Jalonen, J.4    Pelkonen, O.5    Laine, K.6
  • 15
    • 0034128040 scopus 로고    scopus 로고
    • In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: Potent effect on CYP2C19 and CYP2D6
    • Ko JW, Desta Z, Soukhova NV, Tracy T, Flockhart DA. In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. Br J Clin Pharmacol 2000; 49:343-351.
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 343-351
    • Ko, J.W.1    Desta, Z.2    Soukhova, N.V.3    Tracy, T.4    Flockhart, D.A.5
  • 17
    • 0028078626 scopus 로고
    • Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid
    • Lopez-Garcia MP, Dansette PM, Mansuy D. Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid. Biochemistry 1994; 33:166-175.
    • (1994) Biochemistry , vol.33 , pp. 166-175
    • Lopez-Garcia, M.P.1    Dansette, P.M.2    Mansuy, D.3
  • 19
    • 1642498326 scopus 로고    scopus 로고
    • Characterization of novel dihydrothienopyridinium and thienopyridinium metabolites of ticlopidine in vitro: Role of peroxidases, cytochromes p450, and monoamine oxidases
    • Dalvie DK, O'Connell TN. Characterization of novel dihydrothienopyridinium and thienopyridinium metabolites of ticlopidine in vitro: role of peroxidases, cytochromes p450, and monoamine oxidases. Drug Metab Dispos 2004; 32:49-57.
    • (2004) Drug Metab Dispos , vol.32 , pp. 49-57
    • Dalvie, D.K.1    O'Connell, T.N.2
  • 20
    • 0346367328 scopus 로고
    • Aggregation of blood platelets by adenosine diphosphate and its reversal
    • Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194:927-929.
    • (1962) Nature , vol.194 , pp. 927-929
    • Born, G.V.R.1
  • 21
    • 0031430539 scopus 로고    scopus 로고
    • Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19
    • Donahue SR, Flockhart DA, Abernethy DR, Ko JW. Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Clin Pharmacol Ther 1997; 62:572-577.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 572-577
    • Donahue, S.R.1    Flockhart, D.A.2    Abernethy, D.R.3    Ko, J.W.4
  • 22
    • 33748969511 scopus 로고    scopus 로고
    • Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19
    • Yu KS, Yim DS, Cho JY, Park SS, Park JY, Lee KH, et al. Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19. Clin Pharmacol Ther 2001; 69:266-273.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 266-273
    • Yu, K.S.1    Yim, D.S.2    Cho, J.Y.3    Park, S.S.4    Park, J.Y.5    Lee, K.H.6
  • 23
    • 12644276395 scopus 로고    scopus 로고
    • Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide
    • Jeppesen U, Rasmussen BB, Brosen K. Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide. Clin Pharmacol Ther 1997; 62:279-286.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 279-286
    • Jeppesen, U.1    Rasmussen, B.B.2    Brosen, K.3
  • 24
    • 0013389471 scopus 로고    scopus 로고
    • Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: Possible effect of age, liver disease and length of therapy
    • Kimura M, Ieiri I, Wada Y, Mamiya K, Urae A, Iimori E, et al. Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy. Br J Clin Pharmacol 1999; 47:115-119.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 115-119
    • Kimura, M.1    Ieiri, I.2    Wada, Y.3    Mamiya, K.4    Urae, A.5    Iimori, E.6
  • 26
    • 0021151090 scopus 로고
    • Pharmacokinetic and metabolic characteristics of ticlopidine in relation to its inhibitory properties on platelet function
    • Gordon JL (editors): Basel: Birkhauser Verlag
    • Picard-Fraire C. Pharmacokinetic and metabolic characteristics of ticlopidine in relation to its inhibitory properties on platelet function. In: Gordon JL (editors): Agents and Action Supplements, Vol. 15. Basel: Birkhauser Verlag; 1984, pp. 68-75.
    • (1984) Agents and Action Supplements , vol.15 , pp. 68-75
    • Picard-Fraire, C.1
  • 27
    • 0031854723 scopus 로고    scopus 로고
    • Cholestatic hepatitis due to ticlopidine: Clinical and histological recovery after drug withdrawal. Case report and review of the literature
    • Grieco A, Vecchio FM, Greco AV, Gasbarrini G. Cholestatic hepatitis due to ticlopidine: clinical and histological recovery after drug withdrawal. Case report and review of the literature. Eur J Gastroenterol Hepatol 1998; 10:713-715.
    • (1998) Eur J Gastroenterol Hepatol , vol.10 , pp. 713-715
    • Grieco, A.1    Vecchio, F.M.2    Greco, A.V.3    Gasbarrini, G.4
  • 29
    • 0032826443 scopus 로고    scopus 로고
    • Successful use of clopidogrel for cerebrovascular accident in a patient with suspected ticlopidine-induced hepatotoxicity
    • Zeolla MM, Carson JJ. Successful use of clopidogrel for cerebrovascular accident in a patient with suspected ticlopidine-induced hepatotoxicity. Ann Pharmacother 1999; 33:939-941.
    • (1999) Ann Pharmacother , vol.33 , pp. 939-941
    • Zeolla, M.M.1    Carson, J.J.2
  • 30
    • 0021355271 scopus 로고
    • A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis
    • Homberg JC, Andre C, Abuaf N. A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis. Clin Exp Immunol 1984; 55:561-570.
    • (1984) Clin Exp Immunol , vol.55 , pp. 561-570
    • Homberg, J.C.1    Andre, C.2    Abuaf, N.3
  • 31
    • 0028298121 scopus 로고
    • Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: Comparison with two directly hepatotoxic drugs
    • Lecoeur S, Bonierbale E, Challine D, Gautier JC, Valadon P, Dansette PM, et al. Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs. Chem Res Toxicol 1994; 7:434-442.
    • (1994) Chem Res Toxicol , vol.7 , pp. 434-442
    • Lecoeur, S.1    Bonierbale, E.2    Challine, D.3    Gautier, J.C.4    Valadon, P.5    Dansette, P.M.6
  • 32
    • 0029790276 scopus 로고    scopus 로고
    • Tienilic acid-induced autoimmune hepatitis: Anti-liver and -kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9
    • Lecoeur S, Andre C, Beaune PH. Tienilic acid-induced autoimmune hepatitis: anti-liver and -kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9. Mol Pharmacol 1996; 50:326-333.
    • (1996) Mol Pharmacol , vol.50 , pp. 326-333
    • Lecoeur, S.1    Andre, C.2    Beaune, P.H.3
  • 33
    • 0242668517 scopus 로고
    • Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug
    • Beaune P, Dansette PM, Mansuy D, Kiffel L, Finck M, Amar C, Leroux JP, et al. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. Proc Natl Acad Sci U S A 1987; 84:551-555.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 551-555
    • Beaune, P.1    Dansette, P.M.2    Mansuy, D.3    Kiffel, L.4    Finck, M.5    Amar, C.6    Leroux, J.P.7
  • 34
    • 0030432945 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens
    • Obermayer-Straub P, Manns MP. Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens. Mol Biol Rep 1996; 23:235-242.
    • (1996) Mol Biol Rep , vol.23 , pp. 235-242
    • Obermayer-Straub, P.1    Manns, M.P.2
  • 35
    • 0019847868 scopus 로고
    • The effects of ticlopidine hydrochloride on bleeding time and platelet function in man
    • Ellis DJ, Roe RL, Bruno JJ, Cranston BJ, McSpadden MM. The effects of ticlopidine hydrochloride on bleeding time and platelet function in man. Thromb Haemost 1981; 46:176.
    • (1981) Thromb Haemost , vol.46 , pp. 176
    • Ellis, D.J.1    Roe, R.L.2    Bruno, J.J.3    Cranston, B.J.4    McSpadden, M.M.5
  • 36
    • 0021024134 scopus 로고
    • Ticlopidine: A promise for the prevention and treatment of thrombosis and its complications
    • Panak E, Maffrand JP, Picard-Fraire C, Vallee E, Blanchard J, Roncucci R. Ticlopidine: a promise for the prevention and treatment of thrombosis and its complications. Haemostasis 1983; 13(Suppl 1):1-54.
    • (1983) Haemostasis , vol.13 , Issue.1 SUPPL. , pp. 1-54
    • Panak, E.1    Maffrand, J.P.2    Picard-Fraire, C.3    Vallee, E.4    Blanchard, J.5    Roncucci, R.6
  • 37
    • 0024549237 scopus 로고
    • Ticlopidine in China: Comparative study on the effect of two dose levels on bleeding time and platelet function in healthy volunteers
    • Ruan C, Destelle G, Wang Z, Wan H, He Y, Cheng D, et al. Ticlopidine in China: comparative study on the effect of two dose levels on bleeding time and platelet function in healthy volunteers. Haemostasis 1989; 19:94-99.
    • (1989) Haemostasis , vol.19 , pp. 94-99
    • Ruan, C.1    Destelle, G.2    Wang, Z.3    Wan, H.4    He, Y.5    Cheng, D.6
  • 38
    • 0022002270 scopus 로고
    • Functionally thrombasthenic state in normal platelets following the administration of ticlopidine
    • Di Minno G, Cerbone AM, Mattioli PL, Turco S, Iovine C, Mancini M. Functionally thrombasthenic state in normal platelets following the administration of ticlopidine. J Clin Invest 1985; 75:328-338.
    • (1985) J Clin Invest , vol.75 , pp. 328-338
    • Di Minno, G.1    Cerbone, A.M.2    Mattioli, P.L.3    Turco, S.4    Iovine, C.5    Mancini, M.6
  • 39
    • 3042744028 scopus 로고    scopus 로고
    • Identification of the active metabolite of ticlopidine from rat in vitro metabolites
    • Yoneda K, Iwamura R, Kishi H, Mizukami Y, Mogami K, Kobayashi S. Identification of the active metabolite of ticlopidine from rat in vitro metabolites. Br J Pharmacol 2004; 142:551-557.
    • (2004) Br J Pharmacol , vol.142 , pp. 551-557
    • Yoneda, K.1    Iwamura, R.2    Kishi, H.3    Mizukami, Y.4    Mogami, K.5    Kobayashi, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.