메뉴 건너뛰기




Volumn 19, Issue 8, 2007, Pages 901-911

Impaired LPS-induced signaling in microglia overexpressing the Wiskott-Aldrich syndrome protein N-terminal domain

Author keywords

LPS; Microglia; Signaling; Wiskott Aldrich syndrome protein

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN; VASODILATOR STIMULATED PHOSPHOPROTEIN 1; WISKOTT ALDRICH SYNDROME PROTEIN;

EID: 34548553236     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm074     Document Type: Article
Times cited : (9)

References (48)
  • 2
    • 0029988146 scopus 로고    scopus 로고
    • Defects in Wiskott-Aldrich syndrome blood cells
    • Remold-O'Donnell, E., Rosen, F. S. and Kenney, D. M. 1996. Defects in Wiskott-Aldrich syndrome blood cells. Blood 87:2621.
    • (1996) Blood , vol.87 , pp. 2621
    • Remold-O'Donnell, E.1    Rosen, F.S.2    Kenney, D.M.3
  • 3
    • 0032528414 scopus 로고    scopus 로고
    • Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenyl-alanine
    • Badolato, R., Sozzani, S., Malacarne, F. et al. 1998. Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenyl-alanine. J. Immunol. 161:1026.
    • (1998) J. Immunol , vol.161 , pp. 1026
    • Badolato, R.1    Sozzani, S.2    Malacarne, F.3
  • 4
    • 0031831252 scopus 로고    scopus 로고
    • Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome
    • Zicha, D., Allen, W. E., Brickell, P. M. et al. 1998. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. Br. J. Haematol. 101:659.
    • (1998) Br. J. Haematol , vol.101 , pp. 659
    • Zicha, D.1    Allen, W.E.2    Brickell, P.M.3
  • 5
    • 0034192223 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
    • Lorenzi, R., Brickell, P. M., Katz, D. R., Kinnon, C. and Thrasher, A. J. 2000. Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. Blood 95:2943.
    • (2000) Blood , vol.95 , pp. 2943
    • Lorenzi, R.1    Brickell, P.M.2    Katz, D.R.3    Kinnon, C.4    Thrasher, A.J.5
  • 6
    • 0032118427 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
    • Snapper, S. B., Rosen, F. S., Mizoguchi, E. et al. 1998. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 9:81.
    • (1998) Immunity , vol.9 , pp. 81
    • Snapper, S.B.1    Rosen, F.S.2    Mizoguchi, E.3
  • 7
    • 0033230229 scopus 로고    scopus 로고
    • Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
    • Zhang, J., Shehabeldin, A., da Cruz, L. A. et al. 1999. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J. Exp. Med. 190:1329.
    • (1999) J. Exp. Med , vol.190 , pp. 1329
    • Zhang, J.1    Shehabeldin, A.2    da Cruz, L.A.3
  • 8
    • 0027444915 scopus 로고
    • T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses
    • Molina, I. J., Sancho, J., Terhorst, C., Rosen, F. S. and Remold-O'Donnell, E. 1993. T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses. J. Immunol. 151:4383.
    • (1993) J. Immunol , vol.151 , pp. 4383
    • Molina, I.J.1    Sancho, J.2    Terhorst, C.3    Rosen, F.S.4    Remold-O'Donnell, E.5
  • 9
    • 0030006284 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
    • Symons, M., Derry, J. M., Karlak, B. et al. 1996. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84:723.
    • (1996) Cell , vol.84 , pp. 723
    • Symons, M.1    Derry, J.M.2    Karlak, B.3
  • 10
    • 0029126878 scopus 로고
    • Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains
    • Rivero-Lezcano, O. M., Marcilla, A., Sameshima, J. H. and Robbins, K. C. 1995. Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol. Cell Biol. 15:5725.
    • (1995) Mol. Cell Biol , vol.15 , pp. 5725
    • Rivero-Lezcano, O.M.1    Marcilla, A.2    Sameshima, J.H.3    Robbins, K.C.4
  • 11
    • 0030793720 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells
    • She, H. Y., Rockow, S., Tang, J. et al. 1997. Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. Mol. Biol. Cell. 8:1709.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 1709
    • She, H.Y.1    Rockow, S.2    Tang, J.3
  • 12
    • 0030221475 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases
    • Banin, S., Truong, O., Katz, D. R., Waterfield, M. D., Brickell, P. M. and Gout, I. 1996. Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curr. Biol. 6:981.
    • (1996) Curr. Biol , vol.6 , pp. 981
    • Banin, S.1    Truong, O.2    Katz, D.R.3    Waterfield, M.D.4    Brickell, P.M.5    Gout, I.6
  • 14
    • 0030292702 scopus 로고    scopus 로고
    • Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
    • Cory, G. O., MacCarthy-Morrogh, L., Banin, S. et al. 1996. Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J. Immunol. 157:3791.
    • (1996) J. Immunol , vol.157 , pp. 3791
    • Cory, G.O.1    MacCarthy-Morrogh, L.2    Banin, S.3
  • 15
    • 0034720293 scopus 로고    scopus 로고
    • Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
    • Blanchoin, L., Amann, K. J., Higgs, H. N., Marchand, J. B., Kaiser, D. A. and Pollard, T. D. 2000. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Nature 404:1007.
    • (2000) Nature , vol.404 , pp. 1007
    • Blanchoin, L.1    Amann, K.J.2    Higgs, H.N.3    Marchand, J.B.4    Kaiser, D.A.5    Pollard, T.D.6
  • 16
    • 0035887776 scopus 로고    scopus 로고
    • Overexpression of the Wiskott-Aldrich syndrome protein N-terminal domain in transgenic mice inhibits T cell proliferative responses via TCR signaling without affecting cytoskeletal rearrangements
    • Sato, M., Tsuji, N. M., Gotoh, H. et al. 2001. Overexpression of the Wiskott-Aldrich syndrome protein N-terminal domain in transgenic mice inhibits T cell proliferative responses via TCR signaling without affecting cytoskeletal rearrangements. J. Immunol. 167:4701.
    • (2001) J. Immunol , vol.167 , pp. 4701
    • Sato, M.1    Tsuji, N.M.2    Gotoh, H.3
  • 17
    • 28244456225 scopus 로고    scopus 로고
    • Intrabodies against the EVH1 domain of Wiskott-Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells
    • Sato, M., Iwaya, R., Ogihara, K. et al. 2005. Intrabodies against the EVH1 domain of Wiskott-Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells. FEBS J. 272:6131.
    • (2005) FEBS J , vol.272 , pp. 6131
    • Sato, M.1    Iwaya, R.2    Ogihara, K.3
  • 18
    • 0023614999 scopus 로고
    • Ameboid microglia as effectors of inflammation in the central nervous system
    • Giulian, D. 1987. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 18:155.
    • (1987) J. Neurosci. Res , vol.18 , pp. 155
    • Giulian, D.1
  • 19
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer, P. L., Itagaki, S., Boyes, B. E. and McGeer, E. G. 1988. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285.
    • (1988) Neurology , vol.38 , pp. 1285
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 20
    • 0025302414 scopus 로고
    • Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease
    • Cras, P., Kawai, M., Siedlak, S. et al. 1990. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. Am. J. Pathol. 137:241.
    • (1990) Am. J. Pathol , vol.137 , pp. 241
    • Cras, P.1    Kawai, M.2    Siedlak, S.3
  • 22
    • 0029948229 scopus 로고    scopus 로고
    • Microglia-derived macrophages in early multiple sclerosis plaques
    • Li, H., Cuzner, M. L. and Newcombe, J. 1996. Microglia-derived macrophages in early multiple sclerosis plaques. Neuropathol. Appl. Neurobiol. 22:207.
    • (1996) Neuropathol. Appl. Neurobiol , vol.22 , pp. 207
    • Li, H.1    Cuzner, M.L.2    Newcombe, J.3
  • 23
    • 0023832296 scopus 로고
    • The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex
    • Price, R. W., Brew, B., Sidtis, J., Rosenblum, M., Scheck, A. C. and Cleary, P. 1988. The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex. Science 239:586.
    • (1988) Science , vol.239 , pp. 586
    • Price, R.W.1    Brew, B.2    Sidtis, J.3    Rosenblum, M.4    Scheck, A.C.5    Cleary, P.6
  • 24
  • 25
    • 0027156783 scopus 로고
    • In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells
    • Sebire, G., Emilie, D., Wallon, C. et al. 1993. In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells. J. Immunol. 150:1517.
    • (1993) J. Immunol , vol.150 , pp. 1517
    • Sebire, G.1    Emilie, D.2    Wallon, C.3
  • 26
    • 0027298505 scopus 로고
    • Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta
    • Lee, S. C., Liu, W., Dickson, D. W., Brosnan, C. F. and Berman, J. W. 1993. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J. Immunol. 150:2659.
    • (1993) J. Immunol , vol.150 , pp. 2659
    • Lee, S.C.1    Liu, W.2    Dickson, D.W.3    Brosnan, C.F.4    Berman, J.W.5
  • 27
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G. and Peterson, P. K. 1992. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 149:2736.
    • (1992) J. Immunol , vol.149 , pp. 2736
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Shaskan, E.G.4    Peterson, P.K.5
  • 28
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • Bhat, N. R., Zhang, P., Lee, J. C. and Hogan, E. L. 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18:1633.
    • (1998) J. Neurosci , vol.18 , pp. 1633
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 29
    • 0034646787 scopus 로고    scopus 로고
    • Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB
    • Heyen, J. R., Ye, S., Finck, B. N. and Johnson, R. W. 2000. Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB. Brain Res. Mol. Brain Res. 77:138.
    • (2000) Brain Res. Mol. Brain Res , vol.77 , pp. 138
    • Heyen, J.R.1    Ye, S.2    Finck, B.N.3    Johnson, R.W.4
  • 30
    • 0037063691 scopus 로고    scopus 로고
    • Go6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation
    • Jeohn, G. H., Cooper, C. L., Jang, K. J. et al. 2002. Go6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation. Neuroscience 114:689.
    • (2002) Neuroscience , vol.114 , pp. 689
    • Jeohn, G.H.1    Cooper, C.L.2    Jang, K.J.3
  • 31
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch, U. K. 2002. Microglia as a source and target of cytokines. Glia 40:140.
    • (2002) Glia , vol.40 , pp. 140
    • Hanisch, U.K.1
  • 32
    • 0023252003 scopus 로고
    • MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: Induction of Ia antigen expression by gamma-interferon
    • Suzumura, A., Mezitis, S. G., Gonatas, N. K. and Silberberg, D. H. 1987. MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: Induction of Ia antigen expression by gamma-interferon. J. Neuroimmunol. 15:263.
    • (1987) J. Neuroimmunol , vol.15 , pp. 263
    • Suzumura, A.1    Mezitis, S.G.2    Gonatas, N.K.3    Silberberg, D.H.4
  • 33
    • 27644520207 scopus 로고    scopus 로고
    • 2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglia cell line
    • 2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglia cell line. Biochim. Biophys. Acta 1726:177.
    • (2005) Biochim. Biophys. Acta , vol.1726 , pp. 177
    • Takenouchi, T.1    Ogihara, K.2    Sato, M.3    Kitani, H.4
  • 34
    • 0026050986 scopus 로고
    • Isolation and characterization of mouse neural precursor cells in primary culture
    • Kitani, H., Shiurba, R., Sakakura, T. and Tomooka, Y. 1991. Isolation and characterization of mouse neural precursor cells in primary culture. In Vitro Cell. Dev. Biol. 27A:615.
    • (1991) In Vitro Cell. Dev. Biol , vol.27 A , pp. 615
    • Kitani, H.1    Shiurba, R.2    Sakakura, T.3    Tomooka, Y.4
  • 35
    • 0034242819 scopus 로고    scopus 로고
    • Isolation and characterisation of fetal bovine brain cells in primary culture
    • Hashimoto, A., Onodera, T., Ikeda, H. and Kitani, H. 2000. Isolation and characterisation of fetal bovine brain cells in primary culture. Res. Vet. Sci. 69:39.
    • (2000) Res. Vet. Sci , vol.69 , pp. 39
    • Hashimoto, A.1    Onodera, T.2    Ikeda, H.3    Kitani, H.4
  • 36
    • 0031282491 scopus 로고    scopus 로고
    • Generation and characterization of a microglial cell line, MG5, derived from a p53-deficient mouse
    • Ohsawa, K., Imai, Y., Nakajima, K. and Kohsaka, S. 1997. Generation and characterization of a microglial cell line, MG5, derived from a p53-deficient mouse. Glia 21:285.
    • (1997) Glia , vol.21 , pp. 285
    • Ohsawa, K.1    Imai, Y.2    Nakajima, K.3    Kohsaka, S.4
  • 37
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K. and Kaisho, T. 2001. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat. Immunol. 2:675.
    • (2001) Nat. Immunol , vol.2 , pp. 675
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 38
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin, M. and Ben-Neriah, Y. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621.
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 621
    • Karin, M.1    Ben-Neriah, Y.2
  • 39
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
    • Sizemore, N., Leung, S. and Stark, G. R. 1999. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell Biol. 19:4798.
    • (1999) Mol. Cell Biol , vol.19 , pp. 4798
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 40
    • 11244285329 scopus 로고    scopus 로고
    • Constitutive and interleukin-1-inducible phosphorylation of p65 NF-κB at serine 536 is mediated by multiple protein kinases including IκB kinase (IKK)-α, IKKβ, IKKε, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription
    • Buss, H., Dorrie, A., Schmitz, M. L., Hoffmann, E., Resch, K. and Kracht, M. 2004. Constitutive and interleukin-1-inducible phosphorylation of p65 NF-κB at serine 536 is mediated by multiple protein kinases including IκB kinase (IKK)-α, IKKβ, IKKε, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J. Biol. Chem. 279:55633.
    • (2004) J. Biol. Chem , vol.279 , pp. 55633
    • Buss, H.1    Dorrie, A.2    Schmitz, M.L.3    Hoffmann, E.4    Resch, K.5    Kracht, M.6
  • 41
    • 14044276352 scopus 로고    scopus 로고
    • The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-κB (ReIA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement
    • Huang, W., Ochs, H. D., Dupont, B. and Vyas, Y. M. 2005. The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-κB (ReIA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement. J. Immunol. 174:2602.
    • (2005) J. Immunol , vol.174 , pp. 2602
    • Huang, W.1    Ochs, H.D.2    Dupont, B.3    Vyas, Y.M.4
  • 42
    • 0037492123 scopus 로고    scopus 로고
    • Bruton's Tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by Toll-like receptor 4
    • Jefferies, C. A., Doyle, S., Brunner, C. et al. 2003. Bruton's Tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by Toll-like receptor 4. J. Biol. Chem. 278:26258.
    • (2003) J. Biol. Chem , vol.278 , pp. 26258
    • Jefferies, C.A.1    Doyle, S.2    Brunner, C.3
  • 43
    • 0032996810 scopus 로고    scopus 로고
    • Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia
    • Sawada, M., Suzumura, A., Hosoya, H., Marunouchi, T. and Nagatsu, T. 1999. Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia. J. Neurochem. 72:1466.
    • (1999) J. Neurochem , vol.72 , pp. 1466
    • Sawada, M.1    Suzumura, A.2    Hosoya, H.3    Marunouchi, T.4    Nagatsu, T.5
  • 44
    • 0032102139 scopus 로고    scopus 로고
    • IL-10 down-regulates human microglial IL-8 by inhibition of NF-κB activation
    • Ehrlich, L. C., Hu, S., Peterson, P. K. and Chao, C. C. 1998. IL-10 down-regulates human microglial IL-8 by inhibition of NF-κB activation. Neuroreport 9:1723.
    • (1998) Neuroreport , vol.9 , pp. 1723
    • Ehrlich, L.C.1    Hu, S.2    Peterson, P.K.3    Chao, C.C.4
  • 45
    • 0034646787 scopus 로고    scopus 로고
    • Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-κB
    • Heyen, J. R., Ye, S., Finck, B. N. and Johnson, R. W. 2000. Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-κB. Brain Res. Mol. Brain Res. 77:138.
    • (2000) Brain Res. Mol. Brain Res , vol.77 , pp. 138
    • Heyen, J.R.1    Ye, S.2    Finck, B.N.3    Johnson, R.W.4
  • 46
    • 0035449358 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity
    • Bal-Price, A. and Brown, G. C. 2001. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neurosci. 21:6480.
    • (2001) J. Neurosci , vol.21 , pp. 6480
    • Bal-Price, A.1    Brown, G.C.2
  • 47
    • 1242284201 scopus 로고    scopus 로고
    • Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
    • Mizuno, T., Kurotani, T., Komatsu, Y. et al. 2004. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology 46:404.
    • (2004) Neuropharmacology , vol.46 , pp. 404
    • Mizuno, T.1    Kurotani, T.2    Komatsu, Y.3
  • 48
    • 0031303091 scopus 로고    scopus 로고
    • Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription
    • Parry, G. C. and Mackman, N. 1997. Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription. J. Immunol. 159:5450.
    • (1997) J. Immunol , vol.159 , pp. 5450
    • Parry, G.C.1    Mackman, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.