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Volumn 66, Issue 4, 2007, Pages 374-382

The immunological basis for treatment of multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ALPHA B CRYSTALLIN; AUTOANTIGEN; BETA1A INTERFERON; CLADRIBINE; CRYSTALLIN; CYCLOPHOSPHAMIDE; DACLIZUMAB; FINGOLIMOD; GLATIRAMER; GLOBULIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN G; INTERFERON BETA SERINE; LAMOTRIGINE; MBP 8298; MEMANTINE; MITOXANTRONE; MYELIN BASIC PROTEIN; MYELIN PROTEIN; NATALIZUMAB; OLIGOCLONAL BAND; PIOGLITAZONE; PROTEOLIPID PROTEIN; RITUXIMAB; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; VITAMIN D;

EID: 34548545064     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2007.01982.x     Document Type: Review
Times cited : (24)

References (100)
  • 1
    • 0001435965 scopus 로고
    • An elctrophoretic study of the protein components in cerebrospinal fluid and their relationship to serum proteins
    • Kabat E. An elctrophoretic study of the protein components in cerebrospinal fluid and their relationship to serum proteins. J Clin Invest 1942 21 : 571 7.
    • (1942) J Clin Invest , vol.21 , pp. 571-7
    • Kabat, E.1
  • 3
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006 9 : 899 910.
    • (2006) N Engl J Med , vol.9 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 4
    • 77955799815 scopus 로고    scopus 로고
    • Oral fingolimod (FTY720) for relapsing multiple sclerosis
    • Kappos L, Antel J, Comi G et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006 355 : 1124 40.
    • (2006) N Engl J Med , vol.355 , pp. 1124-40
    • Kappos, L.1    Antel, J.2    Comi, G.3
  • 5
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian M, Lo CG, Cinamon G et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004 427 : 355 60.
    • (2004) Nature , vol.427 , pp. 355-60
    • Matloubian, M.1    Lo, C.G.2    Cinamon, G.3
  • 7
    • 0025572239 scopus 로고
    • Speculations on mechanisms of HLA associations with autoimmune diseases and the specificity of 'autoreactive' T lymphocytes
    • Moller E, Bohme J, Valugerdi MA, Ridderstad A, Olerup O. Speculations on mechanisms of HLA associations with autoimmune diseases and the specificity of 'autoreactive' T lymphocytes. Immunol Rev 1990 118 : 5 19.
    • (1990) Immunol Rev , vol.118 , pp. 5-19
    • Moller, E.1    Bohme, J.2    Valugerdi, M.A.3    Ridderstad, A.4    Olerup, O.5
  • 8
    • 0015492877 scopus 로고
    • HLA antigens and multiple sclerosis
    • Jersild C, Svejgaard A, Fog T. HLA antigens and multiple sclerosis. Lancet 1972 1 : 1240 1.
    • (1972) Lancet , vol.1 , pp. 1240-1
    • Jersild, C.1    Svejgaard, A.2    Fog, T.3
  • 9
    • 0036151386 scopus 로고    scopus 로고
    • Genetic basis for clinical expression in multiple sclerosis
    • Barcellos LF, Oksenberg JR, Green AJ et al. Genetic basis for clinical expression in multiple sclerosis. Brain 2002 125 : 150 8.
    • (2002) Brain , vol.125 , pp. 150-8
    • Barcellos, L.F.1    Oksenberg, J.R.2    Green, A.J.3
  • 10
    • 0037371325 scopus 로고    scopus 로고
    • HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course
    • Barcellos LF, Oksenberg JR, Begovich AB et al. HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet 2003 72 : 710 6.
    • (2003) Am J Hum Genet , vol.72 , pp. 710-6
    • Barcellos, L.F.1    Oksenberg, J.R.2    Begovich, A.B.3
  • 11
    • 0027162522 scopus 로고
    • On the HLA-DQ (alpha 1*0501, beta 1*0201)-associated susceptibility in celiac disease: A possible gene dosage effect of DQB1*0201
    • Ploski R, Ek J, Thorsby E, Sollid LM. On the HLA-DQ (alpha 1*0501, beta 1*0201)-associated susceptibility in celiac disease: a possible gene dosage effect of DQB1*0201. Tissue Antigens 1993 41 : 173 7.
    • (1993) Tissue Antigens , vol.41 , pp. 173-7
    • Ploski, R.1    Ek, J.2    Thorsby, E.3    Sollid, L.M.4
  • 12
    • 0142091358 scopus 로고    scopus 로고
    • The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses
    • Vader W, Stepniak D, Kooy Y et al. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc Natl Acad Sci U S A 2003 100 : 12390 5.
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 12390-5
    • Vader, W.1    Stepniak, D.2    Kooy, Y.3
  • 13
    • 0030918147 scopus 로고    scopus 로고
    • The HLA-DQ (alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR (alpha 1*01, beta 1*1501) heterodimer
    • Spurkland A, Celius EG, Knutsen I, Beiske A, Thorsby E, Vartdal F. The HLA-DQ (alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR (alpha 1*01, beta 1*1501) heterodimer. Tissue Antigens 1997 50 : 15 22.
    • (1997) Tissue Antigens , vol.50 , pp. 15-22
    • Spurkland, A.1    Celius, E.G.2    Knutsen, I.3    Beiske, A.4    Thorsby, E.5    Vartdal, F.6
  • 15
    • 9144269888 scopus 로고    scopus 로고
    • Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
    • Oksenberg JR, Barcellos LF, Cree BA et al. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet 2004 74 : 160 7.
    • (2004) Am J Hum Genet , vol.74 , pp. 160-7
    • Oksenberg, J.R.1    Barcellos, L.F.2    Cree, B.A.3
  • 17
    • 33749653103 scopus 로고    scopus 로고
    • Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: A descriptive study
    • Barcellos LF, Kamdar BB, Ramsay PP et al. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol 2006 5 : 924 31.
    • (2006) Lancet Neurol , vol.5 , pp. 924-31
    • Barcellos, L.F.1    Kamdar, B.B.2    Ramsay, P.P.3
  • 18
    • 23944444890 scopus 로고    scopus 로고
    • IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    • Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005 202 : 473 7.
    • (2005) J Exp Med , vol.202 , pp. 473-7
    • Lennon, V.A.1    Kryzer, T.J.2    Pittock, S.J.3    Verkman, A.S.4    Hinson, S.R.5
  • 19
    • 28544450418 scopus 로고    scopus 로고
    • Role of return migration in the emergence of multiple sclerosis in the French West Indies
    • Cabre P, Signate A, Olindo S et al. Role of return migration in the emergence of multiple sclerosis in the French West Indies. Brain 2005 128 : 2899 910.
    • (2005) Brain , vol.128 , pp. 2899-910
    • Cabre, P.1    Signate, A.2    Olindo, S.3
  • 20
    • 0029121088 scopus 로고
    • A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group
    • Ebers GC, Sadovnick AD, Risch NJ. A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group. Nature 1995 377 : 150 1.
    • (1995) Nature , vol.377 , pp. 150-1
    • Ebers, G.C.1    Sadovnick, A.D.2    Risch, N.J.3
  • 21
    • 33644820800 scopus 로고    scopus 로고
    • Infectious mononucleosis and risk for multiple sclerosis: A meta-analysis
    • Thacker EL, Mirzaei F, Ascherio A. Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann Neurol 2006 59 : 499 503.
    • (2006) Ann Neurol , vol.59 , pp. 499-503
    • Thacker, E.L.1    Mirzaei, F.2    Ascherio, A.3
  • 22
    • 0020639761 scopus 로고
    • Epstein-Barr virus infection and antibody synthesis in patients with multiple sclerosis
    • Bray PF, Bloomer LC, Salmon VC, Bagley MH, Larsen PD. Epstein-Barr virus infection and antibody synthesis in patients with multiple sclerosis. Arch Neurol 1983 40 : 406 8.
    • (1983) Arch Neurol , vol.40 , pp. 406-8
    • Bray, P.F.1    Bloomer, L.C.2    Salmon, V.C.3    Bagley, M.H.4    Larsen, P.D.5
  • 23
    • 33845706602 scopus 로고    scopus 로고
    • High seroprevalence of Epstein-Barr virus in children with multiple sclerosis
    • Pohl D, Krone B, Rostasy K et al. High seroprevalence of Epstein-Barr virus in children with multiple sclerosis. Neurology 2006 67 : 2063 5.
    • (2006) Neurology , vol.67 , pp. 2063-5
    • Pohl, D.1    Krone, B.2    Rostasy, K.3
  • 24
    • 33745107637 scopus 로고    scopus 로고
    • Epstein-Barr virus and multiple sclerosis: Evidence of association from a prospective study with long-term follow-up
    • DeLorenze GN, Munger KL, Lennette ET, Orentreich N, Vogelman JH, Ascherio A. Epstein-Barr virus and multiple sclerosis: evidence of association from a prospective study with long-term follow-up. Arch Neurol 2006 63 : 839 44.
    • (2006) Arch Neurol , vol.63 , pp. 839-44
    • Delorenze, G.N.1    Munger, K.L.2    Lennette, E.T.3    Orentreich, N.4    Vogelman, J.H.5    Ascherio, A.6
  • 25
    • 0036793245 scopus 로고    scopus 로고
    • A functional and structural basis for TCR cross-reactivity in multiple sclerosis
    • Lang HL, Jacobsen H, Ikemizu S et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol 2002 3 : 940 3.
    • (2002) Nat Immunol , vol.3 , pp. 940-3
    • Lang, H.L.1    Jacobsen, H.2    Ikemizu, S.3
  • 26
    • 7244254454 scopus 로고    scopus 로고
    • Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein
    • Holmoy T, Kvale EO, Vartdal F. Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein. J Neurovirol 2004 10 : 278 83.
    • (2004) J Neurovirol , vol.10 , pp. 278-83
    • Holmoy, T.1    Kvale, E.O.2    Vartdal, F.3
  • 27
    • 76949120341 scopus 로고
    • Multiple sclerosis in rural Norway its geographic and occupational incidence in relation to nutrition
    • Swank RL, Lerstad O, Strøm A, Backer J. Multiple sclerosis in rural Norway its geographic and occupational incidence in relation to nutrition. N Engl J Med 1952 246 : 722 8.
    • (1952) N Engl J Med , vol.246 , pp. 722-8
    • Swank, R.L.1    Lerstad, O.2    Strøm, A.3    Backer, J.4
  • 28
    • 0028008933 scopus 로고
    • Epidemiology of multiple sclerosis in Australia. with NSW and SA survey results
    • McLeod JG, Hammond SR, Hallpike JF. Epidemiology of multiple sclerosis in Australia. With NSW and SA survey results. Med J Aust 1994 160 : 117 22.
    • (1994) Med J Aust , vol.160 , pp. 117-22
    • McLeod, J.G.1    Hammond, S.R.2    Hallpike, J.F.3
  • 29
    • 0042634407 scopus 로고    scopus 로고
    • Past exposure to sun, skin phenotype, and risk of multiple sclerosis: Case-control study
    • van dM I, Ponsonby AL, Dwyer T et al. Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ 2003 327 : 316.
    • (2003) BMJ , vol.327 , pp. 316
    • Van Dm, I.1    Ponsonby, A.L.2    Dwyer, T.3
  • 30
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006 296 : 2832 8.
    • (2006) JAMA , vol.296 , pp. 2832-8
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3    Howard, N.S.4    Ascherio, A.5
  • 32
    • 0021271732 scopus 로고
    • 1,25-dihydroxyvitamin D3: A novel immunoregulatory hormone
    • Tsoukas CD, Provvedini DM, Manolagas SC. 1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone. Science 1984 224 : 1438 40.
    • (1984) Science , vol.224 , pp. 1438-40
    • Tsoukas, C.D.1    Provvedini, D.M.2    Manolagas, S.C.3
  • 33
    • 0029821239 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
    • Cantorna MT, Hayes CE, Deluca HF. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A 1996 93 : 7861 4.
    • (1996) Proc Natl Acad Sci U S a , vol.93 , pp. 7861-4
    • Cantorna, M.T.1    Hayes, C.E.2    Deluca, H.F.3
  • 34
    • 33646339134 scopus 로고    scopus 로고
    • 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis
    • Muthian G, Raikwar HP, Rajasingh J, Bright JJ. 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis. J Neurosci Res 2006 83 : 1299 309.
    • (2006) J Neurosci Res , vol.83 , pp. 1299-309
    • Muthian, G.1    Raikwar, H.P.2    Rajasingh, J.3    Bright, J.J.4
  • 35
    • 33750314525 scopus 로고    scopus 로고
    • IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis
    • Spach KM, Nashold FE, Dittel BN, Hayes CE. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol 2006 177 : 6030 7.
    • (2006) J Immunol , vol.177 , pp. 6030-7
    • Spach, K.M.1    Nashold, F.E.2    Dittel, B.N.3    Hayes, C.E.4
  • 36
    • 0037223587 scopus 로고    scopus 로고
    • Cytokine profile in patients with multiple sclerosis following vitamin D supplementation
    • Mahon BD, Gordon SA, Cruz J, Cosman F, Cantorna MT. Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J Neuroimmunol 2003 134 : 128 32.
    • (2003) J Neuroimmunol , vol.134 , pp. 128-32
    • Mahon, B.D.1    Gordon, S.A.2    Cruz, J.3    Cosman, F.4    Cantorna, M.T.5
  • 37
    • 0024245664 scopus 로고
    • On the immunopathology of plaque development and repair in multiple sclerosis
    • Raine CS, Scheinberg LC. On the immunopathology of plaque development and repair in multiple sclerosis. J Neuroimmunol 1988 20 : 189 201.
    • (1988) J Neuroimmunol , vol.20 , pp. 189-201
    • Raine, C.S.1    Scheinberg, L.C.2
  • 39
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • Kawamata T, Akiyama H, Yamada T, McGeer PL. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol 1992 140 : 691 707.
    • (1992) Am J Pathol , vol.140 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 40
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    • Barnett MH, Prineas JW. Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol 2004 55 : 458 68.
    • (2004) Ann Neurol , vol.55 , pp. 458-68
    • Barnett, M.H.1    Prineas, J.W.2
  • 41
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 1999 5 : 49 55.
    • (1999) Nat Med , vol.5 , pp. 49-55
    • Moalem, G.1    Leibowitz-Amit, R.2    Yoles, E.3    Mor, F.4    Cohen, I.R.5    Schwartz, M.6
  • 42
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?
    • Kerschensteiner M, Gallmeier E, Behrens L et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 1999 189 : 865 70.
    • (1999) J Exp Med , vol.189 , pp. 865-70
    • Kerschensteiner, M.1    Gallmeier, E.2    Behrens, L.3
  • 43
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000 47 : 707 17.
    • (2000) Ann Neurol , vol.47 , pp. 707-17
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 44
    • 23744454283 scopus 로고    scopus 로고
    • Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
    • Keegan M, Konig F, McClelland R et al. Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange. Lancet 2005 366 : 579 82.
    • (2005) Lancet , vol.366 , pp. 579-82
    • Keegan, M.1    Konig, F.2    McClelland, R.3
  • 45
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005 23 : 683 747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 46
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990 346 : 183 7.
    • (1990) Nature , vol.346 , pp. 183-7
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    MacKin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 47
    • 0028238201 scopus 로고
    • Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide
    • Wucherpfennig KW, Zhang J, Witek C et al. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol 1994 152 : 5581 92.
    • (1994) J Immunol , vol.152 , pp. 5581-92
    • Wucherpfennig, K.W.1    Zhang, J.2    Witek, C.3
  • 48
    • 0033976207 scopus 로고    scopus 로고
    • Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: Epitope spreading versus clonal persistence
    • Goebels N, Hofstetter H, Schmidt S, Brunner C, Wekerle H, Hohlfeld R. Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence. Brain 2000 123 : 508 18.
    • (2000) Brain , vol.123 , pp. 508-18
    • Goebels, N.1    Hofstetter, H.2    Schmidt, S.3    Brunner, C.4    Wekerle, H.5    Hohlfeld, R.6
  • 49
    • 0032719206 scopus 로고    scopus 로고
    • A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
    • Madsen LS, Andersson EC, Jansson L et al. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet 1999 23 : 343 7.
    • (1999) Nat Genet , vol.23 , pp. 343-7
    • Madsen, L.S.1    Andersson, E.C.2    Jansson, L.3
  • 50
    • 0020551984 scopus 로고
    • Isolation of myelin basic protein-reactive T-cell lines from normal human blood
    • Burns J, Rosenzweig A, Zweiman B, Lisak RP. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. Cell Immunol 1983 81 : 435 40.
    • (1983) Cell Immunol , vol.81 , pp. 435-40
    • Burns, J.1    Rosenzweig, A.2    Zweiman, B.3    Lisak, R.P.4
  • 51
    • 0026641148 scopus 로고
    • Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity
    • Jingwu Z, Medaer R, Hashim GA, Chin Y, Berg-Loonen E, Raus JC. Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Ann Neurol 1992 32 : 330 8.
    • (1992) Ann Neurol , vol.32 , pp. 330-8
    • Jingwu, Z.1    Medaer, R.2    Hashim, G.A.3    Chin, Y.4    Berg-Loonen, E.5    Raus, J.C.6
  • 52
    • 0027144752 scopus 로고
    • Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
    • Kerlero dR, Milo R, Lees MB, Burger D, Bernard CC, Ben Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest 1993 92 : 2602 8.
    • (1993) J Clin Invest , vol.92 , pp. 2602-8
    • Dr, K.1    Milo, R.2    Lees, M.B.3    Burger, D.4    Bernard, C.C.5    Ben Nun, A.6
  • 53
    • 0037645940 scopus 로고    scopus 로고
    • T cells from multiple sclerosis patients recognize immunoglobulin G from cerebrospinal fluid
    • Holmoy T, Vandvik B, Vartdal F. T cells from multiple sclerosis patients recognize immunoglobulin G from cerebrospinal fluid. Mult Scler 2003 9 : 228 34.
    • (2003) Mult Scler , vol.9 , pp. 228-34
    • Holmoy, T.1    Vandvik, B.2    Vartdal, F.3
  • 54
    • 0025013169 scopus 로고
    • Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma
    • Olsson T, Zhi WW, Hojeberg B et al. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. J Clin Invest 1990 86 : 981 5.
    • (1990) J Clin Invest , vol.86 , pp. 981-5
    • Olsson, T.1    Zhi, W.W.2    Hojeberg, B.3
  • 55
    • 0027512672 scopus 로고
    • T cells recognizing multiple peptides of myelin basic protein are found in blood and enriched in cerebrospinal fluid in optic neuritis and multiple sclerosis
    • Soderstrom M, Link H, Sun JB et al. T cells recognizing multiple peptides of myelin basic protein are found in blood and enriched in cerebrospinal fluid in optic neuritis and multiple sclerosis. Scand J Immunol 1993 37 : 355 68.
    • (1993) Scand J Immunol , vol.37 , pp. 355-68
    • Soderstrom, M.1    Link, H.2    Sun, J.B.3
  • 56
    • 0034526179 scopus 로고    scopus 로고
    • Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis
    • Tejada-Simon MV, Zang YC, Yang D et al. Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis. Int Immunol 2000 12 : 1641 50.
    • (2000) Int Immunol , vol.12 , pp. 1641-50
    • Tejada-Simon, M.V.1    Zang, Y.C.2    Yang, D.3
  • 57
    • 0025138302 scopus 로고
    • T cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta M, Nicklas JA, Sriram S, Albertini RJ. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990 247 : 718 21.
    • (1990) Science , vol.247 , pp. 718-21
    • Allegretta, M.1    Nicklas, J.A.2    Sriram, S.3    Albertini, R.J.4
  • 58
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000 6 : 1167 75.
    • (2000) Nat Med , vol.6 , pp. 1167-75
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3
  • 59
    • 1842367972 scopus 로고    scopus 로고
    • The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion
    • Gay FW, Drye TJ, Dick GW, Esiri MM. The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion. Brain 1997 120 : 1461 83.
    • (1997) Brain , vol.120 , pp. 1461-83
    • Gay, F.W.1    Drye, T.J.2    Dick, G.W.3    Esiri, M.M.4
  • 60
    • 0034618094 scopus 로고    scopus 로고
    • Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • Babbe H, Roers A, Waisman A et al. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 2000 192 : 393 404.
    • (2000) J Exp Med , vol.192 , pp. 393-404
    • Babbe, H.1    Roers, A.2    Waisman, A.3
  • 61
    • 1442354894 scopus 로고    scopus 로고
    • Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood
    • Skulina C, Schmidt S, Dornmair K et al. Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci U S A 2004 10 : 2428 33.
    • (2004) Proc Natl Acad Sci U S a , vol.10 , pp. 2428-33
    • Skulina, C.1    Schmidt, S.2    Dornmair, K.3
  • 62
    • 0035877190 scopus 로고    scopus 로고
    • Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun D, Whitaker JN, Huang Z et al. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 2001 166 : 7579 87.
    • (2001) J Immunol , vol.166 , pp. 7579-87
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3
  • 63
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • Huseby ES, Liggitt D, Brabb T, Schnabel B, Ohlen C, Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med 2001 194 : 669 76.
    • (2001) J Exp Med , vol.194 , pp. 669-76
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlen, C.5    Goverman, J.6
  • 64
    • 0027988539 scopus 로고
    • Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis
    • Banki K, Colombo E, Sia F et al. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J Exp Med 1994 180 : 1649 63.
    • (1994) J Exp Med , vol.180 , pp. 1649-63
    • Banki, K.1    Colombo, E.2    Sia, F.3
  • 65
    • 34548554092 scopus 로고    scopus 로고
    • Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis
    • Zang YC, Li S, Rivera VM et al. Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis. J Immunol 2004 1725 : 120 7.
    • (2004) J Immunol , vol.1725 , pp. 120-7
    • Zang, Y.C.1    Li, S.2    Rivera, V.M.3
  • 66
    • 7144228787 scopus 로고
    • Prevention of experimental encephalomyelitis by prior injections of homologous spinal cord
    • Condie RM, Kelly JT, Campbell B, Good RA. Prevention of experimental encephalomyelitis by prior injections of homologous spinal cord. Fed Proc 1957 16 : 24.
    • (1957) Fed Proc , vol.16 , pp. 24
    • Condie, R.M.1    Kelly, J.T.2    Campbell, B.3    Good, R.A.4
  • 67
    • 0342812444 scopus 로고
    • Acquired resistance to experimental allergic encephalomyelitis
    • Svet-Moldavskaya IA, Svet-Moldavsky GJ. Acquired resistance to experimental allergic encephalomyelitis. Nature 1958 181 : 1536 7.
    • (1958) Nature , vol.181 , pp. 1536-7
    • Svet-Moldavskaya, I.A.1    Svet-Moldavsky, G.J.2
  • 68
    • 28744442319 scopus 로고    scopus 로고
    • Antigen-specific therapies in multiple sclerosis: Going beyond proteins and peptides
    • Fontoura P, Garren H, Steinman L. Antigen-specific therapies in multiple sclerosis: going beyond proteins and peptides. Int Rev Immunol 2005 24 : 415 46.
    • (2005) Int Rev Immunol , vol.24 , pp. 415-46
    • Fontoura, P.1    Garren, H.2    Steinman, L.3
  • 69
    • 28744438738 scopus 로고    scopus 로고
    • Antigen-specific therapies in multiple sclerosis
    • Sospedra M, Martin R. Antigen-specific therapies in multiple sclerosis. Int Rev Immunol 2005b 24 : 393 413.
    • (2005) Int Rev Immunol , vol.24 , pp. 393-413
    • Sospedra, M.1    Martin, R.2
  • 70
    • 33746446276 scopus 로고    scopus 로고
    • Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA class II-defined cohort of patients with progressive multiple sclerosis: Results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment
    • Warren KG, Catz I, Ferenczi LZ, Krantz MJ. Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment. Eur J Neurol 2006 13 : 887 95.
    • (2006) Eur J Neurol , vol.13 , pp. 887-95
    • Warren, K.G.1    Catz, I.2    Ferenczi, L.Z.3    Krantz, M.J.4
  • 71
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. the Altered Peptide Ligand in Relapsing MS Study Group
    • Kappos L, Comi G, Panitch H et al. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat Med 2000 6 : 1176 82.
    • (2000) Nat Med , vol.6 , pp. 1176-82
    • Kappos, L.1    Comi, G.2    Panitch, H.3
  • 72
    • 0019487117 scopus 로고
    • Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein
    • Ben-Nun A, Wekerle H, Cohen IR. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature 1981 292 : 60 1.
    • (1981) Nature , vol.292 , pp. 60-1
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 73
    • 0023864061 scopus 로고
    • Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis
    • Lider O, Reshef T, Beraud E, Ben Nun A, Cohen IR. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 1988 239 : 181 3.
    • (1988) Science , vol.239 , pp. 181-3
    • Lider, O.1    Reshef, T.2    Beraud, E.3    Ben Nun, A.4    Cohen, I.R.5
  • 74
    • 0027448708 scopus 로고
    • MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
    • Zhang J, Medaer R, Stinissen P, Hafler D, Raus J. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 1993 261 : 1451 4.
    • (1993) Science , vol.261 , pp. 1451-4
    • Zhang, J.1    Medaer, R.2    Stinissen, P.3    Hafler, D.4    Raus, J.5
  • 75
    • 0024363480 scopus 로고
    • Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells
    • Lohse AW, Mor F, Karin N, Cohen IR. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science 1989 244 : 820 2.
    • (1989) Science , vol.244 , pp. 820-2
    • Lohse, A.W.1    Mor, F.2    Karin, N.3    Cohen, I.R.4
  • 76
    • 33747038380 scopus 로고    scopus 로고
    • Anti-ergotypic immunoregulation
    • Quintana FJ, Cohen IR. Anti-ergotypic immunoregulation. Scand J Immunol 2006 64 : 205 10.
    • (2006) Scand J Immunol , vol.64 , pp. 205-10
    • Quintana, F.J.1    Cohen, I.R.2
  • 77
    • 33847074154 scopus 로고    scopus 로고
    • Vaccination with selected synovial T cells in rheumatoid arthritis
    • Chen G, Li N, Zang YC et al. Vaccination with selected synovial T cells in rheumatoid arthritis. Arthritis Rheum 2007 56 : 453 63.
    • (2007) Arthritis Rheum , vol.56 , pp. 453-63
    • Chen, G.1    Li, N.2    Zang, Y.C.3
  • 78
    • 0000131029 scopus 로고    scopus 로고
    • Clinical results of a phase III trial in of oral myelin in relapsing remitting multiple sclerosis
    • Oral Myelin Study Group.
    • Panitch H, Francis G, Oral Myelin Study Group. Clinical results of a phase III trial in of oral myelin in relapsing remitting multiple sclerosis. Ann Neurol 1997 42 : 467.
    • (1997) Ann Neurol , vol.42 , pp. 467
    • Panitch, H.1    Francis, G.2
  • 79
    • 0027467440 scopus 로고
    • Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis
    • Weiner HL, Mackin GA, Matsui M et al. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 1993 259 : 1321 4.
    • (1993) Science , vol.259 , pp. 1321-4
    • Weiner, H.L.1    MacKin, G.A.2    Matsui, M.3
  • 80
    • 31544467633 scopus 로고    scopus 로고
    • The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy
    • Coles AJ, Cox A, Le PE et al. The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol 2006 253 : 98 108.
    • (2006) J Neurol , vol.253 , pp. 98-108
    • Coles, A.J.1    Cox, A.2    Le, P.E.3
  • 81
    • 0029060142 scopus 로고
    • The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis [see comments]
    • van Noort JM, van Sechel AC, Bajramovic JJ et al. The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis [see comments]. Nature 1995 375 : 798 801.
    • (1995) Nature , vol.375 , pp. 798-801
    • Van Noort, J.M.1    Van Sechel, A.C.2    Bajramovic, J.J.3
  • 82
    • 0034655237 scopus 로고    scopus 로고
    • Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: An early event following inflammatory demyelination
    • Bajramovic JJ, Plomp AC, Goes A et al. Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: an early event following inflammatory demyelination. J Immunol 2000 164 : 4359 66.
    • (2000) J Immunol , vol.164 , pp. 4359-66
    • Bajramovic, J.J.1    Plomp, A.C.2    Goes, A.3
  • 83
    • 0034237144 scopus 로고    scopus 로고
    • Differential expression of stress proteins in human adult astrocytes in response to cytokines
    • Bajramovic JJ, Bsibsi M, Geutskens SB et al. Differential expression of stress proteins in human adult astrocytes in response to cytokines. J Neuroimmunol 2000 106 : 14 22.
    • (2000) J Neuroimmunol , vol.106 , pp. 14-22
    • Bajramovic, J.J.1    Bsibsi, M.2    Geutskens, S.B.3
  • 84
    • 0034212893 scopus 로고    scopus 로고
    • Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis
    • van Noort JM, Bajramovic JJ, Plomp AC, van Stipdonk MJ. Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis. J Neuroimmunol 2000 105 : 46 57.
    • (2000) J Neuroimmunol , vol.105 , pp. 46-57
    • Van Noort, J.M.1    Bajramovic, J.J.2    Plomp, A.C.3    Van Stipdonk, M.J.4
  • 85
    • 0032909236 scopus 로고    scopus 로고
    • EBV-induced expression and HLA-DR-restricted presentation by human B cells of alpha B-crystallin, a candidate autoantigen in multiple sclerosis
    • van Sechel AC, Bajramovic JJ, van Stipdonk MJ, Persoon-Deen C, Geutskens SB, van Noort JM. EBV-induced expression and HLA-DR-restricted presentation by human B cells of alpha B-crystallin, a candidate autoantigen in multiple sclerosis. J Immunol 1999 162 : 129 35.
    • (1999) J Immunol , vol.162 , pp. 129-35
    • Van Sechel, A.C.1    Bajramovic, J.J.2    Van Stipdonk, M.J.3    Persoon-Deen, C.4    Geutskens, S.B.5    Van Noort, J.M.6
  • 86
    • 33746040093 scopus 로고    scopus 로고
    • AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic
    • Wang C, Chou YK, Rich CM et al. AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic. J Neuroimmunol 2006 176 : 51 62.
    • (2006) J Neuroimmunol , vol.176 , pp. 51-62
    • Wang, C.1    Chou, Y.K.2    Rich, C.M.3
  • 87
    • 33847389766 scopus 로고    scopus 로고
    • Induction of EAE by T cells specific for alpha B-crystallin depends on prior viral infection in the CNS
    • Verbeek R, van Dongen H, Wawrousek EF, Amor S, van Noort JM. Induction of EAE by T cells specific for alpha B-crystallin depends on prior viral infection in the CNS. Int Immunol 2007 19 : 277 85.
    • (2007) Int Immunol , vol.19 , pp. 277-85
    • Verbeek, R.1    Van Dongen, H.2    Wawrousek, E.F.3    Amor, S.4    Van Noort, J.M.5
  • 88
    • 0026031205 scopus 로고
    • MHC class II-restricted presentation of intracellular antigen
    • Weiss S, Bogen B. MHC class II-restricted presentation of intracellular antigen. Cell 1991 64 : 767 76.
    • (1991) Cell , vol.64 , pp. 767-76
    • Weiss, S.1    Bogen, B.2
  • 90
    • 0021792297 scopus 로고
    • T helper cell recognition of idiotopes on lambda 2 light chains of M315 and T952: Evidence for dependence on somatic mutations in the third hypervariable region
    • Bogen B, Jorgensen T, Hannestad K. T helper cell recognition of idiotopes on lambda 2 light chains of M315 and T952: evidence for dependence on somatic mutations in the third hypervariable region. Eur J Immunol 1985 15 : 278 81.
    • (1985) Eur J Immunol , vol.15 , pp. 278-81
    • Bogen, B.1    Jorgensen, T.2    Hannestad, K.3
  • 91
    • 0024121520 scopus 로고
    • Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype
    • Mendlovic S, Brocke S, Shoenfeld Y et al. Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype. Proc Natl Acad Sci U S A 1988 85 : 2260 4.
    • (1988) Proc Natl Acad Sci U S a , vol.85 , pp. 2260-4
    • Mendlovic, S.1    Brocke, S.2    Shoenfeld, Y.3
  • 92
    • 23444460434 scopus 로고    scopus 로고
    • Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig V region-specific T cells
    • Munthe LA, Corthay A, Os A, Zangani M, Bogen B. Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig V region-specific T cells. J Immunol 2005 175 : 2391 400.
    • (2005) J Immunol , vol.175 , pp. 2391-400
    • Munthe, L.A.1    Corthay, A.2    Os, A.3    Zangani, M.4    Bogen, B.5
  • 93
    • 0014865992 scopus 로고
    • Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system
    • Laterre EC, Callewaert A, Heremans JF, Sfaello Z. Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system. Neurology 1970 20 : 982 90.
    • (1970) Neurology , vol.20 , pp. 982-90
    • Laterre, E.C.1    Callewaert, A.2    Heremans, J.F.3    Sfaello, Z.4
  • 94
    • 0018928783 scopus 로고
    • Viral and bacterial antibody responses in multiple sclerosis
    • Vartdal F, Vandvik B, Norrby E. Viral and bacterial antibody responses in multiple sclerosis. Ann Neurol 1980 8 : 248 55.
    • (1980) Ann Neurol , vol.8 , pp. 248-55
    • Vartdal, F.1    Vandvik, B.2    Norrby, E.3
  • 95
    • 0021074325 scopus 로고
    • Multiple sclerosis: Subclasses of intrathecally synthesized IgG and measles and varicella zoster virus IgG antibodies
    • Vartdal F, Vandvik B. Multiple sclerosis: subclasses of intrathecally synthesized IgG and measles and varicella zoster virus IgG antibodies. Clin Exp Immunol 1983 54 : 641 7.
    • (1983) Clin Exp Immunol , vol.54 , pp. 641-7
    • Vartdal, F.1    Vandvik, B.2
  • 96
    • 0032167731 scopus 로고    scopus 로고
    • Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis
    • Qin Y, Duquette P, Zhang Y, Talbot P, Poole R, Antel J. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J Clin Invest 1998 102 : 1045 50.
    • (1998) J Clin Invest , vol.102 , pp. 1045-50
    • Qin, Y.1    Duquette, P.2    Zhang, Y.3    Talbot, P.4    Poole, R.5    Antel, J.6
  • 97
    • 0034724380 scopus 로고    scopus 로고
    • Comparison of immunoglobulin G heavy-chain sequences in MS and SSPE brains reveals an antigen-driven response
    • Smith-Jensen T, Burgoon MP, Anthony J, Kraus H, Gilden DH, Owens GP. Comparison of immunoglobulin G heavy-chain sequences in MS and SSPE brains reveals an antigen-driven response. Neurology 2000 54 : 1227 32.
    • (2000) Neurology , vol.54 , pp. 1227-32
    • Smith-Jensen, T.1    Burgoon, M.P.2    Anthony, J.3    Kraus, H.4    Gilden, D.H.5    Owens, G.P.6
  • 98
    • 20844443544 scopus 로고    scopus 로고
    • Cerebrospinal fluid T cell clones from patients with multiple sclerosis: Recognition of idiotopes on monoclonal IgG secreted by autologous cerebrospinal fluid B cells
    • Holmoy T, Fredriksen AB, Thompson KM, Hestvik AL, Bogen B, Vartdal F. Cerebrospinal fluid T cell clones from patients with multiple sclerosis: recognition of idiotopes on monoclonal IgG secreted by autologous cerebrospinal fluid B cells. Eur J Immunol 2005 35 : 1786 94.
    • (2005) Eur J Immunol , vol.35 , pp. 1786-94
    • Holmoy, T.1    Fredriksen, A.B.2    Thompson, K.M.3    Hestvik, A.L.4    Bogen, B.5    Vartdal, F.6
  • 99
    • 33646347357 scopus 로고    scopus 로고
    • Natalizumab effects on immune cell responses in multiple sclerosis
    • Niino M, Bodner C, Simard ML et al. Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol 2006 59 : 748 54.
    • (2006) Ann Neurol , vol.59 , pp. 748-54
    • Niino, M.1    Bodner, C.2    Simard, M.L.3
  • 100
    • 34047189953 scopus 로고    scopus 로고
    • New therapeutic approaches for multiple sclerosis
    • De Jager PL, Hafler DA. New therapeutic approaches for multiple sclerosis. Annu Rev Med 2007 58 : 417 32.
    • (2007) Annu Rev Med , vol.58 , pp. 417-32
    • De Jager, P.L.1    Hafler, D.A.2


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